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Select item 104080571.

Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice

Deepa Mathew, Julia Barillas-Cerritos, Ana Nedeljkovic-Kurepa, Mabel Abraham, Matthew D. Taylor, Clifford S. Deutschman

Mol Med. 2023; 29: 106. Published online 2023 Aug 7. doi: 10.1186/s10020-023-00703-9

PMCID:: PMC10408057

Abstract Article PDF–1.0M

Select item 95837142.

Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart

Christian Riehle, Eric T. Weatherford, Nicholas S. McCarty, Alec Seei, Bharat P. Jaishy, Rajkumar Manivel, Paolo Galuppo, Chantal Allamargot, Tariq Hameed, Ryan L. Boudreau, Johann Bauersachs, Robert M. Weiss, E. Dale Abel

Mol Cell Biol. 2022 Oct; 42(10): e00163-22. Published online 2022 Sep 20. doi: 10.1128/mcb.00163-22

PMCID:: PMC9583714

Abstract Article PDF–4.4M

Select item 94819333.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 93823894.

Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism

Patrycja A Jazwiec, Violet S Patterson, Tatiane A Ribeiro, Erica Yeo, Katherine M Kennedy, Paulo C F Mathias, Jim J Petrik, Deborah M Sloboda

Biol Reprod. 2022 Aug; 107(2): 574–589. Published online 2022 Apr 4. doi: 10.1093/biolre/ioac066

PMCID:: PMC9382389

Abstract Article PDF–1.7M

Select item 85299535.

FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance

Oliver Stöhr, Rongya Tao, Ji Miao, Kyle D. Copps, Morris F. White

Cell Rep. Author manuscript; available in PMC 2021 Oct 21.

Published in final edited form as: Cell Rep. 2021 Mar 23; 34(12): 108893. doi: 10.1016/j.celrep.2021.108893

PMCID:: PMC8529953

Abstract Article PDF–1.4M

Select item 84101096.

The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions

Mayumi Nakahara, Homare Ito, John T. Skinner, Qing Lin, Rasa Tamosiuniene, Mark R. Nicolls, Achsah D. Keegan, Roger A. Johns, Kazuyo Yamaji-Kegan

Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1; 321(2): L416–L428. Published online 2021 Jun 30. doi: 10.1152/ajplung.00068.2020

PMCID:: PMC8410109

Abstract Article

Select item 84100997.

The transcriptional coregulator CITED2 suppresses expression of IRS-2 and impairs insulin signaling in endothelial cells

Britta Kunkemoeller, Kuangyang Chen, Sam M. Lockhart, Xuanchun Wang, Christian Rask-Madsen

Am J Physiol Endocrinol Metab. 2021 Aug 1; 321(2): E252–E259. Published online 2021 Jun 21. doi: 10.1152/ajpendo.00435.2020

PMCID:: PMC8410099

Abstract Article

Select item 83618458.

Irs2 deficiency alters hippocampus-associated behaviors during young adulthood

Daisuke Tanokashira, Wei Wang, Megumi Maruyama, Chiemi Kuroiwa, Morris F. White, Akiko Taguchi

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Aug 13.

Published in final edited form as: Biochem Biophys Res Commun. 2021 Jun 25; 559: 148–154. Published online 2021 Apr 30. doi: 10.1016/j.bbrc.2021.04.101

PMCID:: PMC8361845

Abstract Article PDF–1005K

Select item 81319289.

Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice

Tomozumi Takatani, Jun Shirakawa, Kimitaka Shibue, Manoj K. Gupta, Hyunki Kim, Shusheng Lu, Jiang Hu, Morris F. White, Robert T. Kennedy, Rohit N. Kulkarni

J Biol Chem. 2021 Jan-Jun; 296: 100646. Published online 2021 Apr 9. doi: 10.1016/j.jbc.2021.100646

PMCID:: PMC8131928

Abstract Article PDF–2.7M

Select item 771410010.

Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics

Seiji Hashimoto, Tomochika Maoka, Tetsuya Kawata, Toshio Mochizuki, Takao Koike, Takashi Shigematsu

PLoS One. 2020; 15(12): e0242332. Published online 2020 Dec 3. doi: 10.1371/journal.pone.0242332

PMCID:: PMC7714100

Abstract Article PDF–1.2M

Select item 770670811.

FGF signaling regulates development by processes beyond canonical pathways

Ayan T. Ray, Pierre Mazot, J. Richard Brewer, Catarina Catela, Colin J. Dinsmore, Philippe Soriano

Genes Dev. 2020 Dec 1; 34(23-24): 1735–1752. doi: 10.1101/gad.342956.120

Correction in:: Genes Dev. 2021 May 1; 35(9-10): 783.

PMCID:: PMC7706708

Abstract Article PDF–18M

Select item 760462612.

Repression of Irs2 by let‐7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium

Virginia Fernández, Maria Ángeles Martínez‐Martínez, Anna Prieto‐Colomina, Adrián Cárdenas, Rafael Soler, Martina Dori, Ugo Tomasello, Yuki Nomura, José P López‐Atalaya, Federico Calegari, Víctor Borrell

EMBO J. 2020 Nov 2; 39(21): e105479. Published online 2020 Sep 28. doi: 10.15252/embj.2020105479

PMCID:: PMC7604626

Abstract Article PDF–16M

Select item 722702813.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 721380314.

Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling

Christian Riehle, Eric T. Weatherford, Adam R. Wende, Bharat P. Jaishy, Alec W. Seei, Nicholas S. McCarty, Monika Rech, Qian Shi, Gopireddy R. Reddy, William J. Kutschke, Karen Oliveira, Karla Maria Pires, Joshua C. Anderson, Nikolaos A. Diakos, Robert M. Weiss, Morris F. White, Stavros G. Drakos, Yang K. Xiang, E. Dale Abel

JCI Insight. 2020 Mar 26; 5(6): e134920. Published online 2020 Mar 26. doi: 10.1172/jci.insight.134920

PMCID:: PMC7213803

Abstract Article PDF–32M

Select item 712796015.

Oncogenic ERG represses PI3K signaling through down-regulation of IRS2

Ninghui Mao, Dong Gao, Wenhuo Hu, Sunyana Gadal, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Patrick Sullivan, Zeda Zhang, Danielle Choi, Neal Rosen, Charles L Sawyers, Anuradha Gopalan, Yu Chen, Brett S Carver

Cancer Res. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Cancer Res. 2020 Apr 1; 80(7): 1428–1437. Published online 2020 Feb 3. doi: 10.1158/0008-5472.CAN-19-1394

PMCID:: PMC7127960

Abstract Article PDF–831K

Select item 683846216.

The beneficial effects of a muscarinic agonist on pancreatic β-cells

Yuzuru Ito, Mitsuyo Kaji, Eri Sakamoto, Yasuo Terauchi

Sci Rep. 2019; 9: 16180. Published online 2019 Nov 7. doi: 10.1038/s41598-019-52691-8

PMCID:: PMC6838462

Abstract Article PDF–1.6M

Select item 674067217.

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

Markus Schubert, Derek P. Brazil, Deborah J. Burks, Jake A. Kushner, Jing Ye, Carrie L. Flint, Janet Farhang-Fallah, Pieter Dikkes, Xavier M. Warot, Carlos Rio, Gabriel Corfas, Morris F. White

J Neurosci. 2003 Aug 6; 23(18): 7084–7092. doi: 10.1523/JNEUROSCI.23-18-07084.2003

PMCID:: PMC6740672

Abstract Article PDF–461K

Select item 672597418.

Insulin Receptor Substrate 2 Is Essential for Maturation and Survival of Photoreceptor Cells

Xianjin Yi, Markus Schubert, Neal S. Peachey, Kiyoshi Suzuma, Deborah J. Burks, Jake A. Kushner, Izumi Suzuma, Christopher Cahill, Carrie L. Flint, Matthew A. Dow, Rebecca L. Leshan, George L. King, Morris F. White

J Neurosci. 2005 Feb 2; 25(5): 1240–1248. doi: 10.1523/JNEUROSCI.3664-04.2005

PMCID:: PMC6725974

Abstract Article PDF–608K

Select item 667937619.

Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury

Andrea Villar-Lorenzo, Patricia Rada, Esther Rey, Patricia Marañón, Ana I. Arroba, Beatriz Santamaría, Jorge Sáiz, Francisco J. Rupérez, Coral Barbas, Carmelo García-Monzón, Ángela M. Valverde, Águeda González-Rodríguez

Dis Model Mech. 2019 Jul 1; 12(7): dmm038810. Published online 2019 Jul 16. doi: 10.1242/dmm.038810

PMCID:: PMC6679376

Abstract Article

Select item 645090520.

The influence of the lack of insulin receptor substrate 2 (IRS2) on the thyroid gland

Maria Carmen Iglesias-Osma, Enrique J. Blanco, Marta Carretero-Hernandez, Leonardo Catalano-Iniesta, Virginia Sanchez-Robledo, Maria Jose Garcia-Barrado, Teresa Vicente-Garcia, Deborah J. Burks, Jose Carretero

Sci Rep. 2019; 9: 5673. Published online 2019 Apr 5. doi: 10.1038/s41598-019-42198-7