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Select item 114629531.

Protein phosphatase 6 promotes stemness of colorectal cancer cells

Nobuyuki Fujiwara, Ryouichi Tsunedomi, Yuta Kimura, Masao Nakajima, Shinobu Tomochika, Shuhei Enjoji, Takashi Ohama, Koichi Sato, Hiroaki Nagano

Cancer Sci. 2024 Sep; 115(9): 3067–3078. Published online 2024 Jul 16. doi: 10.1111/cas.16271

PMCID:: PMC11462953

Abstract Article PDF–7.0M

Select item 114472562.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 111151703.

The tyrosine phosphatase SHP-1 negatively regulates cytotrophoblast proliferation in first-trimester human placenta by modulating EGFR activation

Karen Forbes, Laura Skinner, John D. Aplin, Melissa Westwood

Cell Mol Life Sci. 2012 Dec; 69(23): 4029–4040. Published online 2012 Jul 15. doi: 10.1007/s00018-012-1067-5

PMCID:: PMC11115170

Abstract Article PDF–1.0M

Select item 105644084.

Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma

Xiaonan Zhang, Jie Chen, Ming Zhang, Saisai Liu, Tao Wang, Tianyu Wu, Baiqing Li, Shidi Zhao, Hongtao Wang, Li Li, Chun Wang, Li Huang

Aging (Albany NY) 2023 Sep 30; 15(18): 9822–9841. Published online 2023 Sep 21. doi: 10.18632/aging.205052

PMCID:: PMC10564408

Abstract Article PDF–4.6M

Select item 97176595.

Enhanced SHP-1 Expression in Podocyturia Is Associated with Kidney Dysfunction in Patients with Diabetes

Farah Lizotte, Stéphanie Robillard, Nicolas Lavoie, Marina Rousseau, Benoit Denhez, Julie Moreau, Sarah Higgins, Robert Sabbagh, Anne-Marie Côté, Pedro Geraldes

Kidney360. 2022 Oct 27; 3(10): 1710–1719. Published online 2022 Aug 31. doi: 10.34067/KID.0002152022

PMCID:: PMC9717659

Abstract Article PDF–1.0M

Select item 96239796.

Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality

Arti T. Navare, Fred D. Mast, Jean Paul Olivier, Thierry Bertomeu, Maxwell L. Neal, Lindsay N. Carpp, Alexis Kaushansky, Jasmin Coulombe-Huntington, Mike Tyers, John D. Aitchison

J Cell Biol. 2022 Nov 7; 221(11): e202011050. Published online 2022 Oct 28. doi: 10.1083/jcb.202011050

PMCID:: PMC9623979

Abstract Article PDF–3.7M

Select item 95882327.

SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways

Xiaonan Zhuang, Jun Ma, Gezhi Xu, Zhongcui Sun

Mol Med. 2022; 28: 125. Published online 2022 Oct 22. doi: 10.1186/s10020-022-00554-w

PMCID:: PMC9588232

Abstract Article PDF–2.9M

Select item 95312958.

SHP‐1 dephosphorylates histone H2B to facilitate its ubiquitination during transcription

Prajakta Tathe, K V S Rammohan Chowdary, Krushna Chandra Murmu, Punit Prasad, Subbareddy Maddika

EMBO J. 2022 Oct; 41(19): e109720. Published online 2022 Aug 8. doi: 10.15252/embj.2021109720

PMCID:: PMC9531295

Abstract Article PDF–2.7M

Select item 94748259.

A LILRB1 variant with a decreased ability to phosphorylate SHP-1 leads to autoimmune diseases

Thivaratana Sinthuwiwat, Supranee Buranapraditkun, Wuttichart Kamolvisit, Siraprapa Tongkobpetch, Wanna Chetruengchai, Chalurmpon Srichomthong, Adjima Assawapitaksakul, Chureerat Phokaew, Patipark Kueanjinda, Tanapat Palaga, Tadech Boonpiyathad, Kanya Suphapeetiporn, Nattiya Hirankarn, Vorasuk Shotelersuk

Sci Rep. 2022; 12: 15420. Published online 2022 Sep 14. doi: 10.1038/s41598-022-19334-x

PMCID:: PMC9474825

Abstract Article PDF–2.6M

Select item 943792810.

The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse

Inbar Azoulay-Alfaguter, Marianne Strazza, Michael Peled, Hila K. Novak, James Muller, Michael L. Dustin, Adam Mor

Sci Signal. Author manuscript; available in PMC 2022 Sep 2.

Published in final edited form as: Sci Signal. 2017 Aug 8; 10(491): eaal2880. Published online 2017 Aug 8. doi: 10.1126/scisignal.aal2880

PMCID:: PMC9437928

Abstract Article PDF–1.8M

Select item 935880311.

Interfering B cell receptor signaling via SHP-1/p-Lyn axis shows therapeutic potential in diffuse large B-cell lymphoma

Ji-Lin Chen, Pei-Yi Chu, Chun-Teng Huang, Tzu-Ting Huang, Wan-Lun Wang, Yu-Hsuan Lee, Yuan-Ya Chang, Ming-Shen Dai, Chung-Wai Shiau, Chun-Yu Liu

Mol Med. 2022; 28: 93. Published online 2022 Aug 8. doi: 10.1186/s10020-022-00518-0

PMCID:: PMC9358803

Abstract Article PDF–4.5M

Select item 927928512.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 876907213.

Proteome‐scale mapping of binding sites in the unstructured regions of the human proteome

Caroline Benz, Muhammad Ali, Izabella Krystkowiak, Leandro Simonetti, Ahmed Sayadi, Filip Mihalic, Johanna Kliche, Eva Andersson, Per Jemth, Norman E Davey, Ylva Ivarsson

Mol Syst Biol. 2022 Jan; 18(1): e10584. Published online 2022 Jan 19. doi: 10.15252/msb.202110584

PMCID:: PMC8769072

Abstract Article PDF–2.9M

Select item 875280514.

HIV-1 Vif suppresses antiviral immunity by targeting STING

Yu Wang, Gui Qian, Lingyan Zhu, Zhuo Zhao, Yinan Liu, Wendong Han, Xiaokai Zhang, Yihua Zhang, Tingrong Xiong, Hao Zeng, Xianghui Yu, Xiaofang Yu, Xiaoyan Zhang, Jianqing Xu, Quanming Zou, Dapeng Yan

Cell Mol Immunol. 2022 Jan; 19(1): 108–121. Published online 2021 Nov 22. doi: 10.1038/s41423-021-00802-9

PMCID:: PMC8752805

Abstract Article PDF–4.6M

Select item 875161315.

METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6

Cheng Cheng, Haoping Zhang, Jia Zheng, Yi Jin, Donghui Wang, Zhipeng Dai

Aging (Albany NY) 2021 Dec 31; 13(24): 25903–25919. Published online 2021 Dec 15. doi: 10.18632/aging.203778

PMCID:: PMC8751613

Abstract Article PDF–1.8M

Select item 849671116.

Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the inhibition of macrophage foam cell formation

Sumit Kumar, Ravikanth Nanduri, Ella Bhagyaraj, Rashi Kalra, Nancy Ahuja, Anuja P. Chacko, Drishti Tiwari, Kanupriya Sethi, Ankita Saini, Vemika Chandra, Monika Jain, Shalini Gupta, Deepak Bhatt, Pawan Gupta

Autophagy. 2021; 17(9): 2273–2289. Published online 2020 Sep 24. doi: 10.1080/15548627.2020.1822088

PMCID:: PMC8496711

Abstract Article PDF–11M

Select item 844752317.

Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling

Peng-Wei Guo, Hai-Ting Huang, Jing Ma, Yao Zuo, Dan Huang, Lin-Lin He, Zi-Ming Wan, Cheng Chen, Fa-Fen Yang, Yan-Wu You

Mol Med. 2021; 27: 113. Published online 2021 Sep 17. doi: 10.1186/s10020-021-00372-6

PMCID:: PMC8447523

Abstract Article PDF–7.2M

Select item 834298718.

TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity

Xueer Wang, Honghai Zhang, Zhugui Shao, Wanxin Zhuang, Chao Sui, Feng Liu, Xiaorong Chen, Jinxiu Hou, Lingli Kong, Hansen Liu, Yi Zheng, Bingyu Liu, Tian Chen, Lei Zhang, Xinming Jia, Chengjiang Gao

Signal Transduct Target Ther. 2021; 6: 298. Published online 2021 Aug 6. doi: 10.1038/s41392-021-00711-3

PMCID:: PMC8342987

Abstract Article PDF–6.2M

Select item 832170119.

CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP

Kanako Nishiyama, Masashi Maekawa, Tomoya Nakagita, Jun Nakayama, Takeshi Kiyoi, Mami Chosei, Akari Murakami, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada, Shigeki Higashiyama

Life Sci Alliance. 2021 Sep; 4(9): e202101095. Published online 2021 Jun 29. doi: 10.26508/lsa.202101095

PMCID:: PMC8321701

Abstract Article PDF–4.8M

Select item 825687220.

The Inhibitory Receptor CLEC12A Regulates PI3K-Akt Signaling to Inhibit Neutrophil Activation and Cytokine Release

Guillaume Paré, Julien Vitry, Michael L. Merchant, Myriam Vaillancourt, Andréa Murru, Yunyun Shen, Sabine Elowe, Mireille H. Lahoud, Paul H. Naccache, Kenneth R. McLeish, Maria J. Fernandes

Front Immunol. 2021; 12: 650808. Published online 2021 Jun 21. doi: 10.3389/fimmu.2021.650808