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Select item 109578971.

An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway

Grace Y. Liu, Patrick Jouandin, Raymond E. Bahng, Norbert Perrimon, David M. Sabatini

Nat Commun. 2024; 15: 2517. Published online 2024 Mar 21. doi: 10.1038/s41467-024-46680-3

PMCID:: PMC10957897

Abstract Article PDF–2.0M

Select item 101127102.

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila

Xin Gu, Patrick Jouandin, Pranav V. Lalgudi, Rich Binari, Max L. Valenstein, Michael A. Reid, Annamarie E. Allen, Nolan Kamitaki, Jason W. Locasale, Norbert Perrimon, David M. Sabatini

Nature. Author manuscript; available in PMC 2023 Apr 18.

Published in final edited form as: Nature. 2022 Aug; 608(7921): 209–216. Published online 2022 Jul 20. doi: 10.1038/s41586-022-04960-2

Correction in:: Nature. 2022 Sep 13

PMCID:: PMC10112710

Abstract Article PDF–4.7M

Select item 99104873.

Wdr59 promotes or inhibits TORC1 activity depending on cellular context

Yingbiao Zhang, Chun-Yuan Ting, Shu Yang, John Reich, Karenne Fru, Mary A. Lilly

Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2212330120. Published online 2022 Dec 28. doi: 10.1073/pnas.2212330120

PMCID:: PMC9910487

Abstract Article PDF–7.5M

Select item 98600834.

Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs

Tommy H. Taslim, Abdiasis M. Hussein, Riya Keshri, Julien R. Ishibashi, Tung C. Chan, Bich N. Nguyen, Shuozhi Liu, Daniel Brewer, Stuart Harper, Scott Lyons, Ben Garver, Jimmy Dang, Nanditaa Balachandar, Samriddhi Jhajharia, Debra del Castillo, Julie Mathieu, Hannele Ruohola-Baker

Stem Cell Reports. 2023 Jan 10; 18(1): 269–288. Published online 2022 Dec 8. doi: 10.1016/j.stemcr.2022.11.004

PMCID:: PMC9860083

Abstract Article PDF–6.8M

Select item 91947935.

Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa‐Porthos axis in Drosophila

Shamsi Emtenani, Elliot T Martin, Attila Gyoergy, Julia Bicher, Jakob‐Wendelin Genger, Thomas Köcher, Maria Akhmanova, Mariana Guarda, Marko Roblek, Andreas Bergthaler, Thomas R Hurd, Prashanth Rangan, Daria E Siekhaus

EMBO J. 2022 Jun; 41(12): e109049. Published online 2022 Mar 23. doi: 10.15252/embj.2021109049

PMCID:: PMC9194793

Abstract Article PDF–8.4M

Select item 89261556.

Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting

Patrick Jouandin, Zvonimir Marelja, Yung-Hsin Shih, Andrey A Parkhitko, Miriam Dambowsky, John M Asara, Ivan Nemazanyy, Christian C. Dibble, Matias Simons, Norbert Perrimon

Science. Author manuscript; available in PMC 2022 Aug 18.

Published in final edited form as: Science. 2022 Feb 18; 375(6582): eabc4203. Published online 2022 Feb 18. doi: 10.1126/science.abc4203

PMCID:: PMC8926155

Abstract Article PDF–2.4M

Select item 88330927.

An intestinal zinc sensor regulates food intake and developmental growth

Siamak Redhai, Clare Pilgrim, Pedro Gaspar, Lena van Giesen, Tatiana Lopes, Olena Riabinina, Théodore Grenier, Alexandra Milona, Bhavna Chanana, Jacob B. Swadling, Yi-Fang Wang, Farah Dahalan, Michaela Yuan, Michaela Wilsch-Brauninger, Wei-hsiang Lin, Nathan Dennison, Paolo Capriotti, Mara K.N. Lawniczak, Richard A. Baines, Tobias Warnecke, Nikolai Windbichler, Francois Leulier, Nicholas Bellono, Irene Miguel-Aliaga

Nature. Author manuscript; available in PMC 2022 Feb 11.

Published in final edited form as: Nature. 2020 Apr; 580(7802): 263–268. Published online 2020 Mar 18. doi: 10.1038/s41586-020-2111-5

PMCID:: PMC8833092

Abstract Article PDF–6.2M

Select item 86644868.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 81728529.

FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila

Ying Zhou, Jian Guo, Xinyu Wang, Yang Cheng, Jianwen Guan, Priyam Barman, Ming-An Sun, Yuanyuan Fu, Wanhong Wei, Congjing Feng, Mary A. Lilly, Youheng Wei

Cell Death Dis. 2021 Jun; 12(6): 571. Published online 2021 Jun 2. doi: 10.1038/s41419-021-03860-z

PMCID:: PMC8172852

Abstract Article PDF–2.5M

Select item 807915010.

Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila

Hiroshi Nishida, Morihiro Okada, Lynna Yang, Tomomi Takano, Sho Tabata, Tomoyoshi Soga, Diana M Ho, Jongkyeong Chung, Yasuhiro Minami, Sa Kan Yoo

eLife. 2021; 10: e59809. Published online 2021 Apr 27. doi: 10.7554/eLife.59809

PMCID:: PMC8079150

Abstract Article PDF–6.6M

Select item 696157811.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 687446612.

The TORC1 inhibitor Nprl2 protects age-related digestive function in Drosophila

Junmeng Xi, Jiadong Cai, Yang Cheng, Yuanyuan Fu, Wanhong Wei, Zhenbo Zhang, Ziheng Zhuang, Yue Hao, Mary A. Lilly, Youheng Wei

Aging (Albany NY) 2019 Nov 15; 11(21): 9811–9828. Published online 2019 Nov 11. doi: 10.18632/aging.102428

PMCID:: PMC6874466

Abstract Article PDF–3.6M

Select item 683436813.

The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

Youheng Wei, Lucia Bettedi, Chun-Yuan Ting, Kuikwon Kim, Yingbiao Zhang, Jiadong Cai, Mary A Lilly

eLife. 2019; 8: e42149. Published online 2019 Oct 25. doi: 10.7554/eLife.42149

PMCID:: PMC6834368

Abstract Article PDF–5.1M

Select item 570780514.

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Piero Sanfilippo, Jiayu Wen, Eric C. Lai

Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0

PMCID:: PMC5707805

Abstract Article PDF–3.2M

Select item 568900215.

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira

RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117

PMCID:: PMC5689002

Abstract Article PDF–4.0M

Select item 514495716.

The GATOR1 Complex Regulates Metabolic Homeostasis and the Response to Nutrient Stress in Drosophila melanogaster

Youheng Wei, Brad Reveal, Weili Cai, Mary A. Lilly

G3 (Bethesda) 2016 Dec; 6(12): 3859–3867. Published online 2016 Sep 26. doi: 10.1534/g3.116.035337

PMCID:: PMC5144957

Abstract Article PDF–1.2M

Select item 488965817.

mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster

Gildas Lepennetier, Francesco Catania

G3 (Bethesda) 2016 Jun; 6(6): 1617–1626. Published online 2016 Mar 28. doi: 10.1534/g3.116.029231

PMCID:: PMC4889658

Abstract Article PDF–1.5M

Select item 486424118.

The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function

Weili Cai, Youheng Wei, Michal Jarnik, John Reich, Mary A. Lilly

PLoS Genet. 2016 May; 12(5): e1006036. Published online 2016 May 11. doi: 10.1371/journal.pgen.1006036

PMCID:: PMC4864241

Abstract Article PDF–6.9M

Select item 478811619.

Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet

Ibrahim Ömer Çiçek, Samir Karaca, Marko Brankatschk, Suzanne Eaton, Henning Urlaub, Halyna R. Shcherbata

Genetics. 2016 Mar; 202(3): 1167–1183. Published online 2016 Jan 22. doi: 10.1534/genetics.115.185371

PMCID:: PMC4788116

Abstract Article PDF–4.7M

Select item 452833020.

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders

Madeline A. Crosby, L. Sian Gramates, Gilberto dos Santos, Beverley B. Matthews, Susan E. St. Pierre, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, David B. Emmert, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1737–1749. Published online 2015 Jun 24. doi: 10.1534/g3.115.018937

PMCID:: PMC4528330

Abstract Article PDF–2.2M

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