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Select item 114941001.

PFKFB3 ameliorates ischemia-induced neuronal damage by reducing reactive oxygen species and inhibiting nuclear translocation of Cdk5

Hyun Jung Kwon, Kyu Ri Hahn, Seung Myung Moon, Dae Young Yoo, Dae Won Kim, In Koo Hwang

Sci Rep. 2024; 14: 24694. Published online 2024 Oct 21. doi: 10.1038/s41598-024-75031-x

PMCID:: PMC11494100

Abstract Article PDF–8.5M

Select item 114683532.

Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission

Jiejie Zhang, Shan Wang, Haitao Zhang, Xiaotong Yang, Xin Ren, Lei Wang, Yihan Yang, Yi Yang, Ya Wen

Mol Med. 2024; 30: 173. Published online 2024 Oct 10. doi: 10.1186/s10020-024-00948-y

PMCID:: PMC11468353

Abstract Article PDF–5.8M

Select item 111075523.

CDK5 downregulation enhances synaptic plasticity

Rafael Andrés Posada-Duque, Omar Ramirez, Steffen Härtel, Nibaldo C. Inestrosa, Felipe Bodaleo, Christian González-Billault, Alfredo Kirkwood, Gloria Patricia Cardona-Gómez

Cell Mol Life Sci. 2017 Jan; 74(1): 153–172. Published online 2016 Aug 9. doi: 10.1007/s00018-016-2333-8

PMCID:: PMC11107552

Abstract Article PDF–13M

Select item 110072064.

Timing dependent neuronal migration is regulated by Cdk5-mediated phosphorylation of JIP1

Qinglin Fei, Doo Soon Im, Yiwen Xu, Tianwen Huang, Dianbo Qu

Front Cell Dev Biol. 2024; 12: 1371568. Published online 2024 Mar 28. doi: 10.3389/fcell.2024.1371568

PMCID:: PMC11007206

Abstract Article PDF–1.4M

Select item 108477465.

Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice

Takahiro Eguchi, Tohru Tezuka, Yuji Watanabe, Akane Inoue-Yamauchi, Hiroshi Sagara, Manabu Ozawa, Yuji Yamanashi

iScience. 2024 Feb 16; 27(2): 108997. Published online 2024 Jan 26. doi: 10.1016/j.isci.2024.108997

PMCID:: PMC10847746

Abstract Article PDF–5.7M

Select item 106799966.

CDK5 destabilizes PD-L1 via chaperon-mediated autophagy to control cancer immune surveillance in hepatocellular carcinoma

Ruonan Zhang, Jie Wang, Yu Du, Ze Yu, Yihan Wang, Yixiao Jiang, Yixin Wu, Ting Le, Ziqi Li, Guoqiang Zhang, Lei Lv, Haijie Ma

J Immunother Cancer. 2023; 11(11): e007529. Published online 2023 Nov 24. doi: 10.1136/jitc-2023-007529

PMCID:: PMC10679996

Abstract Article PDF–7.0M

Select item 106661477.

Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy

Nimrod Miller, Zhaofa Xu, Katharina A. Quinlan, Amy Ji, Jered V. McGivern, Zhihua Feng, Han Shi, Chien-Ping Ko, Li-Huei Tsai, Charles J. Heckman, Allison D. Ebert, Yongchao C. Ma

Proc Natl Acad Sci U S A. 2023 Nov 21; 120(47): e2300308120. Published online 2023 Nov 17. doi: 10.1073/pnas.2300308120

PMCID:: PMC10666147

Abstract Article PDF–3.9M

Select item 106519848.

Cdk5 phosphorylation‐dependent C9orf72 degradation promotes neuronal death in Parkinson's disease models

Xingfeng Xu, Mao Li, Yan Su, Qi Wang, Peifang Qin, Haitao Huang, Yuting Zhang, Yali Zhou, Jianguo Yan

CNS Neurosci Ther. 2023 Dec; 29(12): 3952–3966. Published online 2023 Jun 23. doi: 10.1111/cns.14319

PMCID:: PMC10651984

Abstract Article PDF–9.4M

Select item 106217679.

Regulation of NLGN3 and the Synaptic Rho-GEF Signaling Pathway by CDK5

Jaehoon Jeong, Wenyan Han, Eunhye Hong, Saurabh Pandey, Yan Li, Wei Lu, Katherine W. Roche

J Neurosci. 2023 Nov 1; 43(44): 7264–7275. doi: 10.1523/JNEUROSCI.2309-22.2023

PMCID:: PMC10621767

Abstract Article PDF–2.9M

Select item 1035287410.

Inhibition of hippocampal cyclin‐dependent kinase 5 activity ameliorates learning and memory dysfunction in a mouse model of bronchopulmonary dysplasia

Fang‐Fei Tao, Zi‐Yu Wang, Ying Wang, Qian‐Ru Lv, Peng‐Peng Cai, Hai‐Wen Min, Jian‐Wei Ge, Chun‐Yu Yin, Rui Cheng

CNS Neurosci Ther. 2023 Aug; 29(8): 2339–2354. Published online 2023 Mar 25. doi: 10.1111/cns.14185

PMCID:: PMC10352874

Abstract Article PDF–23M

Select item 1030785211.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 1003982912.

MicroRNA-650 Regulates the Pathogenesis of Alzheimer’s Disease Through Targeting Cyclin-Dependent Kinase 5

Li Lin, Xiaodong Liu, Xuejun Cheng, Yujing Li, Marla Gearing, Allan Levey, Xiaoli Huang, Ying Li, Peng Jin, Xuekun Li

Mol Neurobiol. 2023; 60(5): 2426–2441. Published online 2023 Jan 19. doi: 10.1007/s12035-023-03224-y

PMCID:: PMC10039829

Abstract Article PDF–8.5M

Select item 982058313.

Loss of CDKL5 Causes Synaptic GABAergic Defects That Can Be Restored with the Neuroactive Steroid Pregnenolone-Methyl-Ether

Roberta De Rosa, Serena Valastro, Clara Cambria, Isabella Barbiero, Carolina Puricelli, Marco Tramarin, Silvia Randi, Massimiliano Bianchi, Flavia Antonucci, Charlotte Kilstrup-Nielsen

Int J Mol Sci. 2023 Jan; 24(1): 68. Published online 2022 Dec 21. doi: 10.3390/ijms24010068

PMCID:: PMC9820583

Abstract Article PDF–2.6M

Select item 977015014.

Blocking MG53^S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury

Fengxiang Lv, Yingfan Wang, Dan Shan, Sile Guo, Gengjia Chen, Li Jin, Wen Zheng, Han Feng, Xiaohu Zeng, Shuo Zhang, Yan Zhang, Xinli Hu, Rui-Ping Xiao

Circ Res. 2022 Dec 2; 131(12): 962–976. Published online 2022 Nov 7. doi: 10.1161/CIRCRESAHA.122.321055

PMCID:: PMC9770150

Abstract Article PDF–7.3M

Select item 971188115.

Cyclin G1 induces maladaptive proximal tubule cell dedifferentiation and renal fibrosis through CDK5 activation

Kensei Taguchi, Bertha C. Elias, Sho Sugahara, Snehal Sant, Benjamin S. Freedman, Sushrut S. Waikar, Ambra Pozzi, Roy Zent, Raymond C. Harris, Samir M. Parikh, Craig R. Brooks

J Clin Invest. 2022 Dec 1; 132(23): e158096. Published online 2022 Dec 1. doi: 10.1172/JCI158096

PMCID:: PMC9711881

Abstract Article PDF–21M

Select item 955395116.

Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

Danyang Chong, Yayun Gu, Tongyu Zhang, Yu Xu, Dandan Bu, Zhong Chen, Na Xu, Liangkui Li, Xiyu Zhu, Haiquan Wang, Yangqing Li, Feng Zheng, Dongjin Wang, Peng Li, Li Xu, Zhibin Hu, Chaojun Li

Cell Discov. 2022; 8: 106. Published online 2022 Oct 11. doi: 10.1038/s41421-022-00447-6

PMCID:: PMC9553951

Abstract Article PDF–3.8M

Select item 940249217.

Cdk5 regulates IP3R1-mediated Ca²⁺ dynamics and Ca²⁺-mediated cell proliferation

Saranya NavaneethaKrishnan, Vincent Law, Jungkwon Lee, Jesusa L. Rosales, Ki-Young Lee

Cell Mol Life Sci. 2022 Sep; 79(9): 495. Published online 2022 Aug 24. doi: 10.1007/s00018-022-04515-8

PMCID:: PMC9402492

Abstract Article PDF–5.9M

Select item 919525518.

Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice

Hu Zhou, Jingxin Zhang, Huaxiang Shi, Pengfei Li, Xin Sui, Yongan Wang, Liyun Wang

Mol Brain. 2022; 15: 53. Published online 2022 Jun 14. doi: 10.1186/s13041-022-00939-2

PMCID:: PMC9195255

Abstract Article PDF–12M

Select item 908284119.

Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease

Dongmei Chen, Guihua Lan, Ruomeng Li, Yingxue Mei, Xindong Shui, Xi Gu, Long Wang, Tao Zhang, Chen-Ling Gan, Yongfang Xia, Li Hu, Yuan Tian, Mi Zhang, Tae Ho Lee

Transl Neurodegener. 2022; 11: 27. Published online 2022 May 9. doi: 10.1186/s40035-022-00302-4