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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 94316952.

EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia

Magdalena L. Bochenek, Rajinikanth Gogiraju, Stefanie Großmann, Janina Krug, Jennifer Orth, Sabine Reyda, George S. Georgiadis, Henri M. Spronk, Stavros Konstantinides, Thomas Münzel, John H. Griffin, Philipp Wild, Christine Espinola-Klein, Wolfram Ruf, Katrin Schäfer

JCI Insight. 2022 Jul 22; 7(14): e157701. Published online 2022 Jul 22. doi: 10.1172/jci.insight.157701

PMCID:: PMC9431695

Abstract Article PDF–4.9M

Select item 94201513.

Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression

Moh’d Mohanad Al-Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Jayakumar Manoharan, Sameen Fatima, Sumra Nazir, Constantin Schwab, Ronny Baber, Markus Scholz, Robert Geffers, Peter Rene Mertens, Peter P. Nawroth, John H. Griffin, Maria Keller, Chris Dockendorff, Shrey Kohli, Berend Isermann

Nat Commun. 2022; 13: 5062. Published online 2022 Aug 27. doi: 10.1038/s41467-022-32477-9

PMCID:: PMC9420151

Abstract Article PDF–6.2M

Select item 89155104.

Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses

Meng-Shan Tsai, Li-Chiu Wang, Hua-Lin Wu, Shun-Fen Tzeng, Edward M. Conway, Sheng-Min Hsu, Shun-Hua Chen

J Neuroinflammation. 2022; 19: 66. Published online 2022 Mar 11. doi: 10.1186/s12974-022-02426-w

PMCID:: PMC8915510

Abstract Article PDF–7.2M

Select item 79804095.

Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells

Hemant Giri, Sumith R. Panicker, Xiaofeng Cai, Indranil Biswas, Hartmut Weiler, Alireza R. Rezaie

Proc Natl Acad Sci U S A. 2021 Mar 16; 118(11): e2022248118. Published online 2021 Mar 8. doi: 10.1073/pnas.2022248118

PMCID:: PMC7980409

Abstract Article PDF–2.0M

Select item 78208716.

Tissue factor pathway inhibitor is required for cerebrovascular development in mice

Susan A. Maroney, Randal J. Westrick, Audrey C. Cleuren, Nicholas D. Martinez, Amy E. Siebert, Mark Zogg, David Ginsburg, Hartmut Weiler, Alan E. Mast

Blood. 2021 Jan 14; 137(2): 258–268. Prepublished online 2020 Jul 31. doi: 10.1182/blood.2020006054

PMCID:: PMC7820871

Abstract Article

Select item 72939247.

The Spatiotemporal Expression Pattern of Syndecans in Murine Embryonic Teeth

Jingyi Wu, Hong Li, Lu Han, Tianyu Sun, Ye Tian, Xiaofang Wang

Gene Expr Patterns. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: Gene Expr Patterns. 2020 Jun; 36: 119109. Published online 2020 Mar 24. doi: 10.1016/j.gep.2020.119109

PMCID:: PMC7293924

Abstract Article PDF–1.2M

Select item 69405138.

Role of Thrombomodulin expression on hematopoietic stem cells

Sreemanti Basu, H.P. Helena Liang, Irene Hernandez, Mark Zogg, British Fields, Jennifer May, Yamini Ogoti, Tine Wyseure, Laurent O. Mosnier, Robert T. Burns, Karen Carlson, Hartmut Weiler

J Thromb Haemost. Author manuscript; available in PMC 2021 Jan 1.

Published in final edited form as: J Thromb Haemost. 2020 Jan; 18(1): 123–135. Published online 2019 Nov 6. doi: 10.1111/jth.14663

PMCID:: PMC6940513

Abstract Article PDF–2.4M

Select item 68251349.

The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

C. Peghaire, N. P. Dufton, M. Lang, I. I. Salles-Crawley, J. Ahnström, V. Kalna, C. Raimondi, C. Pericleous, L. Inuabasi, R. Kiseleva, V. R. Muzykantov, J. C. Mason, G. M. Birdsey, A. M. Randi

Nat Commun. 2019; 10: 5014. Published online 2019 Nov 1. doi: 10.1038/s41467-019-12897-w

PMCID:: PMC6825134

Abstract Article PDF–5.3M

Select item 633787910.

Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice

Miguel Alejandro Lopez-Ramirez, Angela Pham, Romuald Girard, Tine Wyseure, Preston Hale, Atsuki Yamashita, Janne Koskimäki, Sean Polster, Laleh Saadat, Ignacio A. Romero, Charles T. Esmon, Frederic Lagarrigue, Issam A. Awad, Laurent O. Mosnier, Mark H. Ginsberg

Blood. 2019 Jan 17; 133(3): 193–204. Prepublished online 2018 Nov 15. doi: 10.1182/blood-2018-06-856062

PMCID:: PMC6337879

Abstract Article

Select item 629804011.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 573462012.

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Thati Madhusudhan, Hongjie Wang, Sanchita Ghosh, Wei Dong, Varun Kumar, Moh'd Mohanad Al-Dabet, Jayakumar Manoharan, Sumra Nazir, Ahmed Elwakiel, Fabian Bock, Shrey Kohli, Andi Marquardt, Ibrahim Sögüt, Khurrum Shahzad, Andreas J. Müller, Charles T. Esmon, Peter P. Nawroth, Jochen Reiser, Triantafyllos Chavakis, Wolfram Ruf, Berend Isermann

Blood. 2017 Sep 21; 130(12): 1445–1455. Prepublished online 2017 Jul 7. doi: 10.1182/blood-2017-02-767921

PMCID:: PMC5734620

Abstract Article

Select item 560015013.

Variable phenotypic penetrance of thrombosis in adult mice after tissue-selective and temporally controlled Thbd gene inactivation

Thijs E. van Mens, Hai-Po H. Liang, Sreemanti Basu, Irene Hernandez, Mark Zogg, Jennifer May, Min Zhan, Qiuhui Yang, Jamie Foeckler, Shawn Kalloway, Rashmi Sood, Caren Sue Karlson, Hartmut Weiler

Blood Adv. 2017 Jun 27; 1(15): 1148–1158. Published online 2017 Jun 23. doi: 10.1182/bloodadvances.2017005058

PMCID:: PMC5600150

Abstract Article PDF–2.0M

Select item 553141514.

Thrombin promotes diet-induced obesity through fibrin-driven inflammation

Anna K. Kopec, Sara R. Abrahams, Sherry Thornton, Joseph S. Palumbo, Eric S. Mullins, Senad Divanovic, Hartmut Weiler, A. Phillip Owens, III, Nigel Mackman, Ashley Goss, Joanne van Ryn, James P. Luyendyk, Matthew J. Flick

J Clin Invest. 2017 Aug 1; 127(8): 3152–3166. Published online 2017 Jul 24. doi: 10.1172/JCI92744

PMCID:: PMC5531415

Abstract Article PDF–2.6M

Select item 541563715.

Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewis^y

Wei-Ling Lin, Chia-Chi Chen, Guey-Yueh Shi, Chih-Yuan Ma, Chuan-Fa Chang, Hua-Lin Wu

Immunol Cell Biol. 2017 Apr; 95(4): 372–379. Prepublished online 2016 Nov 3. Published online 2016 Nov 29. doi: 10.1038/icb.2016.110

PMCID:: PMC5415637

Abstract Article PDF–1.7M

Select item 511303416.

Anti-thrombotic Effects of Nur77 and Nor1 Are Mediated through Upregulating Thrombomodulin Expression in Endothelial Cells

Ping Yang, Xin Wei, Jian Zhang, Bing Yi, Guan-Xin Zhang, Litian Yin, Xiao-Feng Yang, Jianxin Sun

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2): 361–369. Published online 2015 Dec 3. doi: 10.1161/ATVBAHA.115.306891

PMCID:: PMC5113034

Abstract Article PDF–1.7M

Select item 477676917.

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

Shiri Gur-Cohen, Tomer Itkin, Sagarika Chakrabarty, Claudine Graf, Orit Kollet, Aya Ludin, Karin Golan, Alexander Kalinkovich, Guy Ledergor, Eitan Wong, Elisabeth Niemeyer, Ziv Porat, Ayelet Erez, Irit Sagi, Charles T Esmon, Wolfram Ruf, Tsvee Lapidot

Nat Med. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Nat Med. 2015 Nov; 21(11): 1307–1317. Published online 2015 Oct 12. doi: 10.1038/nm.3960