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Select item 111317451.

The pathogenic role of interleukin-27 in autoimmune diabetes

R. Wang, G. Han, J. Wang, G. Chen, R. Xu, L. Wang, X. Li, B. Shen, Y. Li

Cell Mol Life Sci. 2008 Dec; 65(23): 3851–3860. Published online 2008 Oct 20. doi: 10.1007/s00018-008-8540-1

PMCID:: PMC11131745

Abstract Article PDF–755K

Select item 111056222.

Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases

Yukino Chiba, Izuru Mizoguchi, Hideaki Hasegawa, Mio Ohashi, Naoko Orii, Taro Nagai, Miyaka Sugahara, Yasunori Miyamoto, Mingli Xu, Toshiyuki Owaki, Takayuki Yoshimoto

Cell Mol Life Sci. 2018 Apr; 75(8): 1363–1376. Published online 2017 Dec 7. doi: 10.1007/s00018-017-2724-5

PMCID:: PMC11105622

Abstract Article PDF–3.1M

Select item 110740493.

IL-27 Alleviates Airway Inflammation and Airway Hyperresponsiveness in Asthmatic Mice by Targeting the CD39/ATP Axis of Dendritic Cells

Yifei Chen, Miaojuan Zhu, Jiahao Hu, Shaojun He, Shuhua Li, Bing Liu, Jiong Yang

Inflammation. 2024; 47(2): 807–821. Published online 2023 Dec 20. doi: 10.1007/s10753-023-01945-9

PMCID:: PMC11074049

Abstract Article PDF–2.2M

Select item 110580694.

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of T_H17 cell immunity

Chia-Hao Lin, Cheng-Jang Wu, Sunglim Cho, Rasika Patkar, William J. Huth, Ling-Li Lin, Mei-Chi Chen, Elisabeth Israelsson, Joanne Betts, Magdalena Niedzielska, Shefali A. Patel, Han G. Duong, Romana R. Gerner, Chia-Yun Hsu, Matthew Catley, Rose A. Maciewicz, Hiutung Chu, Manuela Raffatellu, John T. Chang, Li-Fan Lu

Nat Immunol. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Nat Immunol. 2023 Dec; 24(12): 2108–2120. Published online 2023 Nov 6. doi: 10.1038/s41590-023-01667-y

PMCID:: PMC11058069

Abstract Article PDF–4.9M

Select item 109364225.

Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells

Daniel L. Aldridge, Devapregasan Moodley, Jeongho Park, Anthony T. Phan, Matthew Rausch, Kerry F. White, Yue Ren, Karin Golin, Enrico Radaelli, Ross Kedl, Pamela M. Holland, Jonathan Hill, Christopher A. Hunter

mBio. 2024 Mar; 15(3): e00083-24. Published online 2024 Feb 20. doi: 10.1128/mbio.00083-24

PMCID:: PMC10936422

Abstract Article PDF–4.0M

Select item 109176606.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108818687.

IL-27 alters inflammatory cytokine expression and limits protective immunity against Mycobacterium tuberculosis in a neonatal BCG vaccination model

Shelby D. Bradford, Kenneth J. Ryan, Ashley M. Divens, Jessica M. Povroznik, Sunilkanth Bonigala, Cory M. Robinson

Front Immunol. 2024; 15: 1217098. Published online 2024 Feb 8. doi: 10.3389/fimmu.2024.1217098

PMCID:: PMC10881868

Abstract Article PDF–2.4M

Select item 107735358.

IL-27 increases energy storage in white adipocytes by enhancing glucose uptake and fatty acid esterification

Chiara Scaffidi, Annie Srdic, Daniel Konrad, Stephan Wueest

Adipocyte. 2023; 12(1): 2276346. Published online 2023 Nov 10. doi: 10.1080/21623945.2023.2276346

PMCID:: PMC10773535

Abstract Article PDF–2.0M

Select item 107016059.

IL‐27 produced during acute malaria infection regulates Plasmodium‐specific memory CD4⁺ T cells

Maria Lourdes Macalinao, Shin‐Ichi Inoue, Sanjaadorj Tsogtsaikhan, Hirotaka Matsumoto, Ganchimeg Bayarsaikhan, Jiun‐Yu Jian, Kazumi Kimura, Yoshiaki Yasumizu, Tsuyoshi Inoue, Hiroki Yoshida, Julius Hafalla, Daisuke Kimura, Katsuyuki Yui

EMBO Mol Med. 2023 Dec; 15(12): e17713. Published online 2023 Oct 19. doi: 10.15252/emmm.202317713

PMCID:: PMC10701605

Abstract Article PDF–3.3M

Select item 1062057910.

Interleukin-27 potentiates CD8⁺ T-cell-mediated antitumor immunity in chronic lymphocytic leukemia

Giulia Pagano, Iria Fernandez Botana, Marina Wierz, Philipp M. Roessner, Nikolaos Ioannou, Xiangda Zhou, Gheed Al-Hity, Coralie Borne, Ernesto Gargiulo, Susanne Gonder, Bin Qu, Basile Stamatopoulos, Alan G. Ramsay, Martina Seiffert, Anne Largeot, Etienne Moussay, Jerome Paggetti

Haematologica. 2023 Nov 1; 108(11): 3011–3024. Published online 2023 Jun 22. doi: 10.3324/haematol.2022.282474

PMCID:: PMC10620579

Abstract Article PDF–2.1M

Select item 1061949211.

An aging-susceptible circadian rhythm controls cutaneous antiviral immunity

Stephen J. Kirchner, Vivian Lei, Paul T. Kim, Meera Patel, Jessica L. Shannon, David Corcoran, Dalton Hughes, Diana K. Waters, Kafui Dzirasa, Detlev Erdmann, Jörn Coers, Amanda S. MacLeod, Jennifer Y. Zhang

JCI Insight. 2023 Oct 23; 8(20): e171548. Published online 2023 Oct 23. doi: 10.1172/jci.insight.171548

PMCID:: PMC10619492

Abstract Article PDF–6.6M

Select item 1055660512.

Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27

Dennis R. Riehl, Arjun Sharma, Julian Roewe, Florian Murke, Clemens Ruppert, Sabine A. Eming, Tobias Bopp, Hartmut Kleinert, Markus P. Radsak, Giuseppe Colucci, Saravanan Subramaniam, Christoph Reinhardt, Bernd Giebel, Immo Prinz, Andreas Guenther, Dennis Strand, Matthias Gunzer, Ari Waisman, Peter A. Ward, Wolfram Ruf, Katrin Schäfer, Markus Bosmann

Proc Natl Acad Sci U S A. 2023 Oct 3; 120(40): e2215421120. Published online 2023 Sep 27. doi: 10.1073/pnas.2215421120

PMCID:: PMC10556605

Abstract Article PDF–1.7M

Select item 1015715613.

IL-27 induces an IFN-like signature in murine macrophages which in turn modulate colonic epithelium

Caroline Andrews, Mairi H. McLean, Julie A. Hixon, Sergio M. Pontejo, Tregei Starr, Courtney Malo, Margaret Cam, Lisa Ridnour, Heather Hickman, Olivia Steele-Mortimer, David A. Wink, Howard A. Young, Daniel W. McVicar, Wenqing Li, Scott K. Durum

Front Immunol. 2023; 14: 1021824. Published online 2023 Apr 20. doi: 10.3389/fimmu.2023.1021824

PMCID:: PMC10157156

Abstract Article PDF–2.5M

Select item 1003065114.

Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival

Luigi D'Antonio, Cristiano Fieni, Stefania Livia Ciummo, Simone Vespa, Lavinia Lotti, Carlo Sorrentino, Emma Di Carlo

J Immunother Cancer. 2023; 11(3): e006056. Published online 2023 Mar 16. doi: 10.1136/jitc-2022-006056

PMCID:: PMC10030651

Abstract Article PDF–26M

Select item 998660615.

Interleukin-27-dependent transcriptome signatures during neonatal sepsis

Jessica M. Povroznik, Halima Akhter, Jordan K. Vance, Madhavi Annamanedi, Sebastian A. Dziadowicz, Lei Wang, Ashley M. Divens, Gangqing Hu, Cory M. Robinson

Front Immunol. 2023; 14: 1124140. Published online 2023 Feb 20. doi: 10.3389/fimmu.2023.1124140