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Select item 112218101.

Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function

Grace A. Blair, Xiaobo Wu, Chandra Bain, Mark Warren, Gregory S. Hoeker, Steven Poelzing

Am J Physiol Heart Circ Physiol. 2024 Mar 1; 326(3): H724–H734. Published online 2024 Jan 12. doi: 10.1152/ajpheart.00211.2023

PMCID:: PMC11221810

Abstract Article

Select item 109535652.

Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes

Changzhu Li, Yang Zhang, Jingling Shen, Hairong Bao, Yue Zhao, Desheng Li, Sijia Li, Yining Liu, Jiming Yang, Zhiwen Zhou, Kangyi Gao, Lexin Zhao, Yao Pei, Yanjie Lu, Zhenwei Pan, Benzhi Cai

Adv Sci (Weinh) 2024 Mar; 11(11): 2305992. Published online 2024 Jan 9. doi: 10.1002/advs.202305992

PMCID:: PMC10953565

Abstract Article PDF–5.8M

Select item 108465023.

Intracardiac electrophysiology to characterize susceptibility to ventricular arrhythmias in murine models

Marine C. Ferrand, Gauthier Giordano, Nathalie Mougenot, Pierre-Léo Laporte, Nicolas Vignier, Arnaud Leclerc, Vincent Algalarrondo, Fabrice Extramiana, Flavien Charpentier, Nathalie Neyroud

Front Physiol. 2024; 15: 1326663. Published online 2024 Jan 23. doi: 10.3389/fphys.2024.1326663

PMCID:: PMC10846502

Abstract Article PDF–3.0M

Select item 105757754.

MYT1L haploinsufficiency in human neurons and mice causes autism-associated phenotypes that can be reversed by genetic and pharmacologic intervention

Bettina Weigel, Jana F. Tegethoff, Sarah D. Grieder, Bryce Lim, Bhuvaneswari Nagarajan, Yu-Chao Liu, Jule Truberg, Dimitris Papageorgiou, Juan M. Adrian-Segarra, Laura K. Schmidt, Janina Kaspar, Eric Poisel, Elisa Heinzelmann, Manu Saraswat, Marleen Christ, Christian Arnold, Ignacio L. Ibarra, Joaquin Campos, Jeroen Krijgsveld, Hannah Monyer, Judith B. Zaugg, Claudio Acuna, Moritz Mall

Mol Psychiatry. 2023; 28(5): 2122–2135. Published online 2023 Feb 14. doi: 10.1038/s41380-023-01959-7

PMCID:: PMC10575775

Abstract Article PDF–9.5M

Select item 101667615.

Enhanced sodium channel inactivation by temperature and FHF2 deficiency blocks heat nociception

Christopher Marra, Timothy V. Hartke, Matthias Ringkamp, Mitchell Goldfarb

Pain. 2023 Jun; 164(6): 1321–1331. Published online 2022 Nov 9. doi: 10.1097/j.pain.0000000000002822

PMCID:: PMC10166761

Abstract Article PDF–1.1M

Select item 100623606.

Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide

Molly O’Reilly, Laura C Sommerfeld, C O’Shea, S Broadway-Stringer, S Andaleeb, J S Reyat, S N Kabir, D Stastny, A Malinova, D Delbue, L Fortmueller, K Gehmlich, D Pavlovic, B V Skryabin, A P Holmes, P Kirchhof, L Fabritz

Europace. 2023 Mar; 25(3): 1152–1161. Published online 2022 Dec 12. doi: 10.1093/europace/euac218

PMCID:: PMC10062360

Abstract Article PDF–4.5M

Select item 83132397.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 82982928.

Targeting the Microtubule EB1-CLASP2 Complex Modulates Na_V1.5 at Intercalated Discs

Gerard A. Marchal, Mariam Jouni, David Y. Chiang, Marta Pérez-Hernández, Svitlana Podliesna, Nuo Yu, Simona Casini, Franck Potet, Christiaan C. Veerman, Mischa Klerk, Elisabeth M. Lodder, Isabella Mengarelli, Kaomei Guan, Carlos G. Vanoye, Eli Rothenberg, Flavien Charpentier, Richard Redon, Alfred L. George, Jr., Arie O. Verkerk, Connie R. Bezzina, Calum A. MacRae, Paul W. Burridge, Mario Delmar, Niels Galjart, Vincent Portero, Carol Ann Remme

Circ Res. Author manuscript; available in PMC 2022 Jul 23.

Published in final edited form as: Circ Res. 2021 Jul 23; 129(3): 349–365. Published online 2021 Jun 7. doi: 10.1161/CIRCRESAHA.120.318643

PMCID:: PMC8298292

Abstract Article PDF–3.3M

Select item 82652169.

Cardiomyocyte Deletion of Bmal1 Exacerbates QT- and RR-Interval Prolongation in Scn5a^+/ΔKPQ Mice

Elizabeth A. Schroder, Jennifer L. Wayland, Kaitlyn M. Samuels, Syed F. Shah, Don E. Burgess, Tanya Seward, Claude S. Elayi, Karyn A. Esser, Brian P. Delisle

Front Physiol. 2021; 12: 681011. Published online 2021 Jun 24. doi: 10.3389/fphys.2021.681011

PMCID:: PMC8265216

Abstract Article PDF–1.9M

Select item 800537710.

Phospho-ablation of cardiac sodium channel Na_v1.5 mitigates susceptibility to atrial fibrillation and improves glucose homeostasis under conditions of diet-induced obesity

Revati S. Dewal, Amara Greer-Short, Cemantha Lane, Shinsuke Nirengi, Pedro Acosta Manzano, Diego Hernández-Saavedra, Katherine R. Wright, Drew Nassal, Lisa A. Baer, Peter J. Mohler, Thomas J. Hund, Kristin I. Stanford

Int J Obes (Lond) 2021; 45(4): 795–807. Published online 2021 Jan 26. doi: 10.1038/s41366-021-00742-4

PMCID:: PMC8005377

Abstract Article PDF–1.1M

Select item 793877011.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 786487212.

Structural and Functional Characterization of A Na_v1.5-Mitochondrial Couplon

Marta Pérez-Hernández, Alejandra Leo-Macias, Sarah Keegan, Mariam Jouni, Joon-Chul Kim, Esperanza Agullo-Pascual, Sarah Vermij, Mingliang Zhang, Feng-Xia Liang, Paul Burridge, David Fenyö, Eli Rothenberg, Mario Delmar

Circ Res. Author manuscript; available in PMC 2022 Feb 5.

Published in final edited form as: Circ Res. 2021 Feb 5; 128(3): 419–432. Published online 2020 Dec 21. doi: 10.1161/CIRCRESAHA.120.318239

PMCID:: PMC7864872

Abstract Article PDF–2.3M

Select item 781714313.

GATA6 is a regulator of sinus node development and heart rhythm

Lara Gharibeh, Abir Yamak, Jamieson Whitcomb, Aizhu Lu, Mathieu Joyal, Hiba Komati, Wenbin Liang, Céline Fiset, Mona Nemer

Proc Natl Acad Sci U S A. 2021 Jan 5; 118(1): e2007322118. Published online 2020 Dec 28. doi: 10.1073/pnas.2007322118

PMCID:: PMC7817143

Abstract Article PDF–2.6M

Select item 768790114.

Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling

Louisa Mezache, Heather L. Struckman, Amara Greer-Short, Stephen Baine, Sándor Györke, Przemysław B. Radwański, Thomas J. Hund, Rengasayee Veeraraghavan

Sci Rep. 2020; 10: 20463. Published online 2020 Nov 24. doi: 10.1038/s41598-020-77562-5

PMCID:: PMC7687901

Abstract Article PDF–7.1M

Select item 765465815.

Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice

Martina Comelli, Marianna Meo, Daniel O. Cervantes, Emanuele Pizzo, Aaron Plosker, Peter J. Mohler, Thomas J. Hund, Jason T. Jacobson, Olivier Meste, Marcello Rota

Am J Physiol Heart Circ Physiol. 2020 Oct 1; 319(4): H893–H905. Published online 2020 Sep 4. doi: 10.1152/ajpheart.00379.2020

PMCID:: PMC7654658

Abstract Article

Select item 754453216.

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a^1798insD/+ mice

Mathilde R Rivaud, Gerard A Marchal, Rianne Wolswinkel, John A Jansen, Ingeborg van der Made, Leander Beekman, Adrián Ruiz-Villalba, Antonius Baartscheer, Sridharan Rajamani, Luiz Belardinelli, Toon A B van Veen, Cristina Basso, Gaetano Thiene, Esther E Creemers, Connie R Bezzina, Carol Ann Remme

Europace. 2020 Oct; 22(10): 1579–1589. Published online 2020 Aug 10. doi: 10.1093/europace/euaa127

PMCID:: PMC7544532

Abstract Article PDF–1.4M

Select item 736566417.

Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction

Jan Hendrik van Weerd, Rajiv A Mohan, Karel van Duijvenboden, Ingeborg B Hooijkaas, Vincent Wakker, Bastiaan J Boukens, Phil Barnett, Vincent M Christoffels

eLife. 2020; 9: e56697. Published online 2020 Jul 16. doi: 10.7554/eLife.56697

PMCID:: PMC7365664

Abstract Article PDF–1.8M

Select item 730003518.

Inhibition of G protein-gated K⁺ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia

Isabelle Bidaud, Antony Chung You Chong, Agnes Carcouet, Stephan De Waard, Flavien Charpentier, Michel Ronjat, Michel De Waard, Dirk Isbrandt, Kevin Wickman, Anne Vincent, Matteo E. Mangoni, Pietro Mesirca

Sci Rep. 2020; 10: 9835. Published online 2020 Jun 17. doi: 10.1038/s41598-020-66673-8

PMCID:: PMC7300035

Abstract Article PDF–1.8M

Select item 726920119.

A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure

Heba Shawer, Esther Aiyelaagbe, Christopher Clowes, Samantha C. Lean, Yinhui Lu, Karl E. Kadler, Alan Kerby, Mark R. Dilworth, Kathryn E. Hentges, Alexander E. P. Heazell

PLoS One. 2020; 15(6): e0233007. Published online 2020 Jun 3. doi: 10.1371/journal.pone.0233007

PMCID:: PMC7269201

Abstract Article PDF–3.0M

Select item 709885220.

Aberrant expression of a non-muscle RBFOX2 isoform triggers cardiac conduction defects in myotonic dystrophy

Chaitali Misra, Sushant Bangru, Feikai Lin, Kin Lam, Sara N. Koenig, Ellen R. Lubbers, Jamila Hedhli, Nathaniel P. Murphy, Darren J. Parker, Lawrence W. Dobrucki, Thomas A. Cooper, Emad Tajkhorshid, Peter J. Mohler, Auinash Kalsotra

Dev Cell. Author manuscript; available in PMC 2021 Mar 23.

Published in final edited form as: Dev Cell. 2020 Mar 23; 52(6): 748–763.e6. Published online 2020 Feb 27. doi: 10.1016/j.devcel.2020.01.037

PMCID:: PMC7098852

Abstract Article PDF–3.4M

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