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Select item 113881591.

Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development

Yuhan Yang, Logan Rivera, Shaohai Fang, Maryn Cavalier, Ashley Suris, Yubin Zhou, Yun Huang

iScience. 2024 Sep 20; 27(9): 110631. Published online 2024 Jul 31. doi: 10.1016/j.isci.2024.110631

PMCID:: PMC11388159

Abstract Article PDF–4.4M

Select item 112602472.

Muscle-building supplement β-hydroxy β-methylbutyrate stimulates the maturation of oligodendroglial progenitor cells to oligodendrocytes

Malabendu Jana, Shelby Prieto, Sukhamoy Gorai, Sridevi Dasarathy, Madhuchhanda Kundu, Kalipada Pahan

J Neurochem. Author manuscript; available in PMC 2024 Jul 21.

Published in final edited form as: J Neurochem. 2024 Jul; 168(7): 1340–1358. Published online 2024 Feb 28. doi: 10.1111/jnc.16084

PMCID:: PMC11260247

Abstract Article PDF–3.3M

Select item 112199693.

Activation of PPAR-α attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis and mitochondrial injury via upregulating 14-3-3η

Tie Hu, Wen-peng Yu, Xiu-qi Wang, Zi-yao Wang, Zhi-qiang Xu, Fa-jia Hu, Ji-chun Liu, Fan Yu, Li-jun Wang

Sci Rep. 2024; 14: 15246. Published online 2024 Jul 2. doi: 10.1038/s41598-024-64638-9

PMCID:: PMC11219969

Abstract Article PDF–9.3M

Select item 111192034.

CBFA2T3 Is PPARA Sensitive and Attenuates Fasting-Induced Lipid Accumulation in Mouse Liver

Donghwan Kim, Sang Keun Ha, Frank J. Gonzalez

Cells. 2024 May; 13(10): 831. Published online 2024 May 13. doi: 10.3390/cells13100831

PMCID:: PMC11119203

Abstract Article PDF–1.9M

Select item 110595145.

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Sofie J. Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M.F. Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher

Mol Metab. 2024 Jun; 84: 101938. Published online 2024 Apr 15. doi: 10.1016/j.molmet.2024.101938

PMCID:: PMC11059514

Abstract Article PDF–3.7M

Select item 110215886.

The lack of PPARα exacerbated the progression of non-alcoholic steatohepatitis in mice with spleen deficiency syndrome by triggering an inflammatory response

Jiawen Huang, Jiayu Li, Yuan Peng, Tianqi Cui, Jingyi Guo, Siwei Duan, Kaili Zhou, Shangyi Huang, Jiabing Chen, Qincheng Yi, Min Qiu, Tingting Chen, Xiaoqin Wu, Chenlu Ma, Ziyi Zhang, Yi Zheng, Xi Tang, Yanqing Pang, Lei Zhang, Chong Zhong, Yong Gao

Front Immunol. 2024; 15: 1381340. Published online 2024 Apr 3. doi: 10.3389/fimmu.2024.1381340

PMCID:: PMC11021588

Abstract Article PDF–6.5M

Select item 110042857.

Staphylococcus aureus oleate hydratase produces ligands that activate host PPARα

Christopher D. Radka, Matthew W. Frank, Tyler S. Simmons, Cydney N. Johnson, Jason W. Rosch, Charles O. Rock

Front Cell Infect Microbiol. 2024; 14: 1352810. Published online 2024 Mar 27. doi: 10.3389/fcimb.2024.1352810

PMCID:: PMC11004285

Abstract Article PDF–4.9M

Select item 109176608.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108942619.

NAAA-regulated lipid signaling in monocytes controls the induction of hyperalgesic priming in mice

Yannick Fotio, Alex Mabou Tagne, Erica Squire, Hye-lim Lee, Connor M. Phillips, Kayla Chang, Faizy Ahmed, Andrew S. Greenberg, S. Armando Villalta, Vanessa M. Scarfone, Gilberto Spadoni, Marco Mor, Daniele Piomelli

Nat Commun. 2024; 15: 1705. Published online 2024 Feb 24. doi: 10.1038/s41467-024-46139-5

PMCID:: PMC10894261

Abstract Article PDF–2.8M

Select item 1088541110.

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis

Jian Dong, Muzi Li, Runsheng Peng, Yuchuan Zhang, Zilin Qiao, Na Sun

J Transl Med. 2024; 22: 196. Published online 2024 Feb 23. doi: 10.1186/s12967-024-04942-0

PMCID:: PMC10885411

Abstract Article PDF–3.2M

Select item 1079997411.

PPARα and PPARγ are expressed in midbrain dopamine neurons and modulate dopamine- and cannabinoid-mediated behavior in mice

Briana Hempel, Madeline Crissman, Sruti Pari, Benjamin Klein, Guo-Hua Bi, Hannah Alton, Zheng-Xiong Xi

Mol Psychiatry. 2023; 28(10): 4203–4214. Published online 2023 Jul 21. doi: 10.1038/s41380-023-02182-0

PMCID:: PMC10799974

Abstract Article PDF–5.1M

Select item 1076330712.

Pan PPAR agonist stimulation of induced MSCs produces extracellular vesicles with enhanced renoprotective effect for acute kidney injury

Hongduk Kim, Seul Ki Lee, Sungok Hong, Tae Sub Park, Jimin Kim, Soo Kim, Tae Min Kim

Stem Cell Res Ther. 2024; 15: 9. Published online 2024 Jan 2. doi: 10.1186/s13287-023-03577-0

PMCID:: PMC10763307

Abstract Article PDF–2.8M

Select item 1068112013.

Keratin 79 is a PPARA target that is highly expressed by liver damage

Donghwan Kim, Inwook Choi, Sang Keun Ha, Frank J. Gonzalez

Biochem Biophys Res Commun. Author manuscript; available in PMC 2023 Nov 27.

Published in final edited form as: Biochem Biophys Res Commun. 2023 Apr 2; 650: 132–136. Published online 2023 Jan 30. doi: 10.1016/j.bbrc.2023.01.071

PMCID:: PMC10681120

Abstract Article PDF–1.0M

Select item 1059805314.

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells

Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer

Mol Metab. 2023 Dec; 78: 101821. Published online 2023 Oct 6. doi: 10.1016/j.molmet.2023.101821

PMCID:: PMC10598053

Abstract Article PDF–4.3M

Select item 1059212815.

Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism

Xue Chen, Krista L. Denning, Anna Mazur, Logan M. Lawrence, Xiaodong Wang, Yongke Lu

Free Radic Biol Med. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: Free Radic Biol Med. 2023 Nov 1; 208: 221–228. Published online 2023 Aug 9. doi: 10.1016/j.freeradbiomed.2023.08.016

PMCID:: PMC10592128

Abstract Article PDF–1.7M

Select item 1049227716.

Impaired autophagy contributes to the aggravated deterioration of osteoarthritis articular cartilage by peroxisome proliferator-activated receptor α deficiency, associated with decreased ERK and Akt activation

Yang Zhou, Li Li, Xiaolei Chen, Qiubo Zhao, Ning Qu, Bing Zhang, Xin Jin, Chun Xia

Eur J Med Res. 2023; 28: 332. Published online 2023 Sep 9. doi: 10.1186/s40001-023-01267-4

PMCID:: PMC10492277

Abstract Article PDF–3.0M

Select item 1044015817.

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice

Ramesh K. Paidi, Sumita Raha, Avik Roy, Kalipada Pahan

Cell Rep. Author manuscript; available in PMC 2023 Aug 20.

Published in final edited form as: Cell Rep. 2023 Jul 25; 42(7): 112717. Published online 2023 Jul 11. doi: 10.1016/j.celrep.2023.112717

PMCID:: PMC10440158

Abstract Article PDF–4.4M

Select item 1043551918.

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1

Min Yan Shi, Hwang Chan Yu, Chang Yeob Han, In Hyuk Bang, Ho Sung Park, Kyu Yun Jang, Sangkyu Lee, Jeong Bum Son, Nam Doo Kim, Byung-Hyun Park, Eun Ju Bae

Nat Commun. 2023; 14: 4987. Published online 2023 Aug 17. doi: 10.1038/s41467-023-40597-z

Correction in:: Nat Commun. 2023; 14: 7007.

PMCID:: PMC10435519

Abstract Article PDF–3.6M

Select item 1043340619.

PPARα activation partially drives NAFLD development in liver-specific Hnf4a-null mice

Carlos Ichiro Kasano-Camones, Masayuki Takizawa, Noriyasu Ohshima, Chinatsu Saito, Wakana Iwasaki, Yuko Nakagawa, Yoshio Fujitani, Ryo Yoshida, Yoshifumi Saito, Takashi Izumi, Shin-Ichi Terawaki, Masakiyo Sakaguchi, Frank J Gonzalez, Yusuke Inoue

J Biochem. 2023 May; 173(5): 393–411. Published online 2023 Jan 23. doi: 10.1093/jb/mvad005

PMCID:: PMC10433406

Abstract Article PDF–2.2M

Select item 1042613120.

Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

Michele M. Comerota, Manasee Gedam, Wen Xiong, Feng Jin, Lisheng Deng, Meng C. Wang, Jin Wang, Hui Zheng

Mol Neurodegener. 2023; 18: 56. Published online 2023 Aug 15. doi: 10.1186/s13024-023-00648-x

PMCID:: PMC10426131

Abstract Article PDF–11M

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