PMC Links for GEO Profiles (Select 64239775) - PMC

Kamila Guimarães-Pinto, Monique Leandro, Antonia Corrêa, Ester P. Maia, Leticia Rodrigues, André Luiz Amorim da Costa, Jesuino Rafael Machado Ferreira, Estefannia Claudio-Etienne, Ulrich Siebenlist, Jianping He, Thaís da Silva Rigoni, Tatiana Paula Teixeira Ferreira, Yago Amigo Pinho Jannini-Sa, Herbert Leonel Matos-Guedes, Ana Caroline Costa-da-Silva, Marcela Freitas Lopes, Patricia Machado Rodrigues Silva, Brian Lee Kelsall, Alessandra Almeida Filardy

Front Immunol. 2024; 15: 1380628. Published online 2024 May 7. doi: 10.3389/fimmu.2024.1380628

PMCID:: PMC11106457

Abstract Article PDF–4.6M

Select item 108976105.

Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma

Shun Wang, Le Zhu, Tianen Li, Xinxin Lin, Yan Zheng, Da Xu, Yu Guo, Ze Zhang, Yan Fu, Hao Wang, Xufeng Wang, Tiantian Zou, Xiaotian Shen, Lumin Zhang, Nannan Lai, Lu Lu, Lunxiu Qin, Qiongzhu Dong

Cell Rep Med. 2024 Feb 20; 5(2): 101415. Published online 2024 Feb 20. doi: 10.1016/j.xcrm.2024.101415

PMCID:: PMC10897610

Abstract Article PDF–9.0M

Select item 106266886.

Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS

Linda T. Nguyen, Andrea Aprico, Eze Nwoke, Alexander D. Walsh, Farrah Blades, Raphael Avneri, Elodie Martin, Bernard Zalc, Trevor J. Kilpatrick, Michele D. Binder

J Neuroinflammation. 2023; 20: 253. Published online 2023 Nov 6. doi: 10.1186/s12974-023-02921-8

PMCID:: PMC10626688

Abstract Article PDF–21M

Select item 104507957.

Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis

Sreeparna Chakraborty, Abhalaxmi Singh, Li Wang, Xinge Wang, Mark A. Sanborn, Zijing Ye, Mark Maienschein-Cline, Amitabha Mukhopadhyay, Balaji B. Ganesh, Asrar B. Malik, Jalees Rehman

J Exp Med. 2023 Nov 6; 220(11): e20221388. Published online 2023 Aug 24. doi: 10.1084/jem.20221388

PMCID:: PMC10450795

Abstract Article PDF–8.3M

Select item 103989218.

Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis

Liang Gao, Chao He, Aizhen Yang, Haibin Zhou, Qingxian Lu, Raymond B. Birge, Yi Wu

Cell Commun Signal. 2023; 21: 195. Published online 2023 Aug 3. doi: 10.1186/s12964-023-01133-0

Correction in:: Cell Commun Signal. 2023; 21: 225.

PMCID:: PMC10398921

Abstract Article PDF–3.1M

Select item 103512409.

Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs

Aaron Silva–Sanchez, Selene Meza–Perez, Mingyong Liu, Sara L Stone, Leopoldo Flores–Romo, Eric Ubil, Frances E. Lund, Alexander F. Rosenberg, Troy D. Randall

Sci Immunol. Author manuscript; available in PMC 2023 Dec 23.

Published in final edited form as: Sci Immunol. 2023 Jun 23; 8(84): eadc9081. Published online 2023 Jun 16. doi: 10.1126/sciimmunol.adc9081

PMCID:: PMC10351240

Abstract Article PDF–1.7M

Select item 1033004610.

Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens

Gavyn Chern Wei Bee, Kristen L. Lokken-Toyli, Stephen T. Yeung, Lucie Rodriguez, Tonia Zangari, Exene E. Anderson, Sourav Ghosh, Carla V. Rothlin, Petter Brodin, Kamal M. Khanna, Jeffrey N. Weiser

Immunity. Author manuscript; available in PMC 2024 Jun 13.

Published in final edited form as: Immunity. 2023 Jun 13; 56(6): 1255–1268.e5. Published online 2023 Apr 13. doi: 10.1016/j.immuni.2023.03.018

PMCID:: PMC10330046

Abstract Article PDF–1.8M

Select item 1014843311.

Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis

Yixin She, Xin Xu, Qingyang Yu, Xiangsheng Yang, Jianxing He, Xiao Xiao Tang

Respir Res. 2023; 24: 118. Published online 2023 Apr 29. doi: 10.1186/s12931-023-02424-3

PMCID:: PMC10148433

Abstract Article PDF–3.7M

Select item 1011379212.

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling

Le May Thai, Liam O’Reilly, Saskia Reibe-Pal, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz-Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris, Belinda Yau, Xuan Zhang, Kailun Lee, Chenxu Yan, Yan-Chuan Shi, Melkam A. Kebede, Robert Brink, Gregory J. Cooney, Katharine M. Irvine, Samuel N. Breit, Tri G. Phan, Alexander Swarbrick, Trevor J. Biden

iScience. 2023 Apr 21; 26(4): 106477. Published online 2023 Mar 22. doi: 10.1016/j.isci.2023.106477

PMCID:: PMC10113792

Abstract Article PDF–4.9M

Select item 1002770413.

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment

Joselyn Cruz Cruz, Kristen C. Allison, Lauren S. Page, Alexis J. Jenkins, Xiaodong Wang, H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Michael R. Verneris, Alisa B. Lee-Sherick

Front Immunol. 2023; 14: 1146721. Published online 2023 Mar 7. doi: 10.3389/fimmu.2023.1146721

PMCID:: PMC10027704

Abstract Article PDF–16M

Select item 999936514.

Axl and Mertk receptors cooperate to promote breast cancer progression by combined oncogenic signaling and evasion of host anti-tumor immunity

Viralkumar Davra, Sushil Kumar, Ke Geng, David Calianese, Dhriti Mehta, Varsha Gadiyar, Canan Kasikara, Kevin C. Lahey, Yun-juan Chang, Michael Wichroski, Chan Gao, Mariana S. De Lorenzo, Sergei V. Kotenko, Tessa Bergsbaken, Pankaj K. Mishra, William C. Gause, Michael Quigley, Thomas E. Spires, Raymond B. Birge

Cancer Res. Author manuscript; available in PMC 2023 Mar 10.

Published in final edited form as: Cancer Res. 2021 Feb 1; 81(3): 698–712. Published online 2020 Nov 25. doi: 10.1158/0008-5472.CAN-20-2066

PMCID:: PMC9999365

Abstract Article PDF–3.0M

Select item 987008415.

Gsk3β regulates the resolution of liver ischemia/reperfusion injury via MerTK

Hanwen Zhang, Ming Ni, Han Wang, Jing Zhang, Dan Jin, Ronald W. Busuttil, Jerzy W. Kupiec-Weglinski, Wei Li, Xuehao Wang, Yuan Zhai

JCI Insight. 2023 Jan 10; 8(1): e151819. Published online 2023 Jan 10. doi: 10.1172/jci.insight.151819

PMCID:: PMC9870084

Abstract Article PDF–16M

Select item 985849416.

Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa

Maria E. Mercau, Yemsratch T. Akalu, Francesca Mazzoni, Gavin Gyimesi, Emily J. Alberto, Yong Kong, Brian P. Hafler, Silvia C. Finnemann, Carla V. Rothlin, Sourav Ghosh

Sci Adv. 2023 Jan; 9(3): eade9459. Published online 2023 Jan 20. doi: 10.1126/sciadv.ade9459

PMCID:: PMC9858494

Abstract Article PDF–2.7M

Select item 980058317.

Axl receptor induces efferocytosis, dampens M1 macrophage responses and promotes heart pathology in Trypanosoma cruzi infection

Thaís S. Rigoni, Natália S. Vellozo, Kamila Guimarães-Pinto, Mariela Cabral-Piccin, Laryssa Fabiano-Coelho, Thayane C. Matos-Silva, Alessandra A. Filardy, Christina M. Takiya, Marcela F. Lopes

Commun Biol. 2022; 5: 1421. Published online 2022 Dec 29. doi: 10.1038/s42003-022-04401-w

PMCID:: PMC9800583

Abstract Article PDF–9.7M

Select item 974487518.

Regulation of bone homeostasis by MERTK and TYRO3

Janik Engelmann, Jennifer Zarrer, Victoria Gensch, Kristoffer Riecken, Nikolaus Berenbrok, The Vinh Luu, Antonia Beitzen-Heineke, Maria Elena Vargas-Delgado, Klaus Pantel, Carsten Bokemeyer, Somasekhar Bhamidipati, Ihab S. Darwish, Esteban Masuda, Tal Burstyn-Cohen, Emily J. Alberto, Sourav Ghosh, Carla Rothlin, Eric Hesse, Hanna Taipaleenmäki, Isabel Ben-Batalla, Sonja Loges

Nat Commun. 2022; 13: 7689. Published online 2022 Dec 12. doi: 10.1038/s41467-022-33938-x

PMCID:: PMC9744875

Abstract Article PDF–3.8M

Select item 956432519.

Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling

Youtong Huang, Greg Lemke

Proc Natl Acad Sci U S A. 2022 Oct 11; 119(41): e2204306119. Published online 2022 Oct 3. doi: 10.1073/pnas.2204306119

PMCID:: PMC9564325

Abstract Article PDF–1.6M

Select item 943308920.

Tissue-specific modifier alleles determine Mertk loss-of-function traits

Yemsratch T Akalu, Maria E Mercau, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh

eLife. 2022; 11: e80530. Published online 2022 Aug 15. doi: 10.7554/eLife.80530

PMCID:: PMC9433089

Abstract Article PDF–3.0M

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