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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 98012192.

Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas

Aneta M. Dobosz, Justyna Janikiewicz, Ewelina Krogulec, Anna Dziewulska, Anna Ajduk, Marcin Szpila, Hanna Nieznańska, Andrzej A. Szczepankiewicz, Dorota Wypych, Agnieszka Dobrzyn

Mol Metab. 2023 Jan; 67: 101659. Published online 2022 Dec 15. doi: 10.1016/j.molmet.2022.101659

PMCID:: PMC9801219

Abstract Article PDF–3.9M

Select item 91498703.

Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation in Utero

Hong-Ming Zhou, Simon J. Conway

J Dev Biol. 2022 Jun; 10(2): 19. Published online 2022 May 17. doi: 10.3390/jdb10020019

PMCID:: PMC9149870

Abstract Article PDF–3.7M

Select item 91032124.

Conversion of Gastrointestinal Somatostatin-Expressing D Cells Into Insulin-Producing Beta-Like Cells Upon Pax4 Misexpression

Anna Garrido-Utrilla, Chaïma Ayachi, Marika Elsa Friano, Josipa Atlija, Shruti Balaji, Tiziana Napolitano, Serena Silvano, Noémie Druelle, Patrick Collombat

Front Endocrinol (Lausanne) 2022; 13: 861922. Published online 2022 Apr 29. doi: 10.3389/fendo.2022.861922

PMCID:: PMC9103212

Abstract Article PDF–8.1M

Select item 82688375.

NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the Pancreas

Romana Bohuslavova, Ondrej Smolik, Jessica Malfatti, Zuzana Berkova, Zaneta Novakova, Frantisek Saudek, Gabriela Pavlinkova

Int J Mol Sci. 2021 Jul; 22(13): 6713. Published online 2021 Jun 23. doi: 10.3390/ijms22136713

PMCID:: PMC8268837

Abstract Article PDF–4.9M

Select item 82515626.

Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease

Evans Quilichini, Mélanie Fabre, Christoffer Nord, Thassadite Dirami, Axelle Le Marec, Silvia Cereghini, Raymond C Pasek, Maureen Gannon, Ulf Ahlgren, Cécile Haumaitre

J Pathol. 2021 May; 254(1): 31–45. Published online 2021 Mar 18. doi: 10.1002/path.5629

PMCID:: PMC8251562

Abstract Article PDF–46M

Select item 69513147.

FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression

Noriko Kodani, Jun Nakae, Masaki Kobayashi, Osamu Kikuchi, Tadahiro Kitamura, Hiroshi Itoh

iScience. 2020 Jan 24; 23(1): 100798. Published online 2019 Dec 23. doi: 10.1016/j.isci.2019.100798

PMCID:: PMC6951314

Abstract Article PDF–20M

Select item 67287668.

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

Julie Piccand, Constance Vagne, Florence Blot, Aline Meunier, Anthony Beucher, Perrine Strasser, Mari L. Lund, Sabitri Ghimire, Laure Nivlet, Céline Lapp, Natalia Petersen, Maja S. Engelstoft, Christelle Thibault-Carpentier, Céline Keime, Sara Jimenez Correa, Valérie Schreiber, Nacho Molina, Thue W. Schwartz, Adèle De Arcangelis, Gérard Gradwohl

Mol Metab. 2019 Nov; 29: 24–39. Published online 2019 Aug 13. doi: 10.1016/j.molmet.2019.08.007

PMCID:: PMC6728766

Abstract Article PDF–3.3M

Select item 65288109.

Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells

Martin F. Rath, Michael J. Bailey, Jong-So Kim, Steven L. Coon, David C. Klein, Morten Møller

J Neurochem. Author manuscript; available in PMC 2019 May 21.

Published in final edited form as: J Neurochem. 2009 Jan; 108(1): 285–294. Published online 2008 Nov 19. doi: 10.1111/j.1471-4159.2008.05765.x

PMCID:: PMC6528810

Abstract Article PDF–1.7M

Select item 603406410.

Secretagogin protects Pdx1 from proteasomal degradation to control a transcriptional program required for β cell specification

Katarzyna Malenczyk, Edit Szodorai, Robert Schnell, Gert Lubec, Gábor Szabó, Tomas Hökfelt, Tibor Harkany

Mol Metab. 2018 Aug; 14: 108–120. Published online 2018 Jun 5. doi: 10.1016/j.molmet.2018.05.019

PMCID:: PMC6034064

Abstract Article PDF–4.0M

Select item 571628311.

Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis

Noémie Druelle, Andhira Vieira, Aidin Shabro, Monica Courtney, Magali Mondin, Samah Rekima, Tiziana Napolitano, Serena Silvano, Sergi Navarro-Sanz, Biljana Hadzic, Fabio Avolio, Minoo Rassoulzadegan, Herbert A. Schmid, Ahmed Mansouri, Patrick Collombat

J Cell Biol. 2017 Dec 4; 216(12): 4299–4311. doi: 10.1083/jcb.201704044

PMCID:: PMC5716283

Abstract Article PDF–3.1M

Select item 539475712.

The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine cell specification and postnatal β-cell maturation

Yu-Ping Yang, Mark A. Magnuson, Roland Stein, Christopher V. E. Wright

Development. 2017 Jan 15; 144(2): 248–257. doi: 10.1242/dev.143123

PMCID:: PMC5394757

Abstract Article

Select item 533843113.

Myofibril breakdown during atrophy is a delayed response requiring the transcription factor PAX4 and desmin depolymerization

Alexandra Volodin, Idit Kosti, Alfred Lewis Goldberg, Shenhav Cohen

Proc Natl Acad Sci U S A. 2017 Feb 21; 114(8): E1375–E1384. Published online 2017 Jan 17. doi: 10.1073/pnas.1612988114

PMCID:: PMC5338431

Abstract Article PDF–1.3M

Select item 529582114.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 522492115.

Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development

Angela J Churchill, Giselle Dominguez Gutiérrez, Ruth A Singer, David S Lorberbaum, Kevin A Fischer, Lori Sussel

eLife. 2017; 6: e20010. Published online 2017 Jan 10. doi: 10.7554/eLife.20010

PMCID:: PMC5224921

Abstract Article PDF–1.9M

Select item 491741916.

Threshold-dependent cooperativity of Pdx1 and Oc1 in pancreatic progenitors establishes competency for endocrine differentiation and β-cell function

Kathryn D. Henley, Diana E. Stanescu, Peter A. Kropp, Christopher V.E. Wright, Kyoung-Jae Won, Doris A. Stoffers, Maureen Gannon

Cell Rep. Author manuscript; available in PMC 2016 Jun 22.

Published in final edited form as: Cell Rep. 2016 Jun 21; 15(12): 2637–2650. Published online 2016 Jun 9. doi: 10.1016/j.celrep.2016.05.040

PMCID:: PMC4917419

Abstract Article PDF–1.1M

Select item 484486317.

Transcriptome of the inner circular smooth muscle of the developing mouse intestine: evidence for regulation of visceral smooth muscle genes by the Hedgehog target gene, cJun

Katherine Gurdziel, Kyle R. Vogt, Katherine D. Walton, Gary K. Schneider, Deborah L. Gumucio

Dev Dyn. Author manuscript; available in PMC 2017 May 1.

Published in final edited form as: Dev Dyn. 2016 May; 245(5): 614–626. Published online 2016 Mar 17. doi: 10.1002/dvdy.24399

PMCID:: PMC4844863

Abstract Article PDF–2.1M

Select item 477913518.

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus

José Manuel Mellado-Gil, Carmen María Jiménez-Moreno, Alejandro Martin-Montalvo, Ana Isabel Alvarez-Mercado, Esther Fuente-Martin, Nadia Cobo-Vuilleumier, Petra Isabel Lorenzo, Eva Bru-Tari, Irene de Gracia Herrera-Gómez, Livia López-Noriega, Javier Pérez-Florido, Javier Santoyo-López, Andreas Spyrantis, Paolo Meda, Bernhard O. Boehm, Ivan Quesada, Benoit R. Gauthier

Diabetologia. 2016; 59: 755–765. Published online 2016 Jan 26. doi: 10.1007/s00125-016-3864-0

PMCID:: PMC4779135

Abstract Article PDF–1.9M

Select item 476414819.

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

Leena Paul, Emily M. Walker, Yiannis Drosos, Holly A. Cyphert, Geoffrey Neale, Roland Stein, Jack South, Gerard Grosveld, Pedro L. Herrera, Beatriz Sosa-Pineda

Diabetes. 2016 Mar; 65(3): 687–698. Published online 2015 Dec 2. doi: 10.2337/db15-0713

PMCID:: PMC4764148

Abstract Article PDF–2.3M

Select item 476311120.

β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development

Ahmed M. Abdellatif, Hisashi Oishi, Takahiro Itagaki, Yunshin Jung, Hossam H. Shawki, Yukari Okita, Yoshikazu Hasegawa, Hiroyuki Suzuki, Salah E. El-Morsy, Mesbah A. El-Sayed, Mahmoud B. Shoaib, Fumihiro Sugiyama, Satoru Takahashi

PLoS One. 2016; 11(2): e0150010. Published online 2016 Feb 22. doi: 10.1371/journal.pone.0150010

PMCID:: PMC4763111

Abstract Article PDF–14M

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