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Select item 105656401.

Systemic gene therapy rescues retinal dysfunction and hearing loss in a model of Norrie disease

Valda Pauzuolyte, Aara Patel, James R Wawrzynski, Neil J Ingham, Yeh Chwan Leong, Rajvinder Karda, Maria Bitner‐Glindzicz, Wolfgang Berger, Simon N Waddington, Karen P Steel, Jane C Sowden

EMBO Mol Med. 2023 Oct; 15(10): e17393. Published online 2023 Aug 29. doi: 10.15252/emmm.202317393

PMCID:: PMC10565640

Abstract Article PDF–5.5M

Select item 102385272.

Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD₄-selective WNT surrogate in mice

Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo

Nat Commun. 2023; 14: 2947. Published online 2023 Jun 2. doi: 10.1038/s41467-023-37689-1

PMCID:: PMC10238527

Abstract Article PDF–3.4M

Select item 97149713.

Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

Zhongxiao Wang, Felix Yemanyi, Alexandra K Blomfield, Kiran Bora, Shuo Huang, Chi-Hsiu Liu, William R Britton, Steve S Cho, Yohei Tomita, Zhongjie Fu, Jian-xing Ma, Wen-hong Li, Jing Chen

eLife. 2022; 11: e73105. Published online 2022 Dec 1. doi: 10.7554/eLife.73105

PMCID:: PMC9714971

Abstract Article PDF–15M

Select item 91845984.

Three dimensional reconstruction of the mouse cerebellum in Hedgehog-driven medulloblastoma models to identify Norrin-dependent effects on preneoplasia

Nenad T. Pokrajac, Akshay Gurdita, Nobuhiko Tachibana, Nicholas J. A. Tokarew, Valerie A. Wallace

Commun Biol. 2022; 5: 569. Published online 2022 Jun 9. doi: 10.1038/s42003-022-03507-5

PMCID:: PMC9184598

Abstract Article PDF–9.4M

Select item 84886805.

Norrie disease protein is essential for cochlear hair cell maturation

Yushi Hayashi, Hao Chiang, ChunJie Tian, Artur A. Indzhykulian, Albert S. B. Edge

Proc Natl Acad Sci U S A. 2021 Sep 28; 118(39): e2106369118. Published online 2021 Sep 20. doi: 10.1073/pnas.2106369118

PMCID:: PMC8488680

Abstract Article PDF–3.2M

Select item 83745246.

InVision: An optimized tissue clearing approach for three-dimensional imaging and analysis of intact rodent eyes

Akshay Gurdita, Philip E.B. Nickerson, Neno T. Pokrajac, Arturo Ortín-Martínez, En Leh Samuel Tsai, Lacrimioara Comanita, Nicole E. Yan, Parnian Dolati, Nobuhiko Tachibana, Zhongda C. Liu, Joel D. Pearson, Danian Chen, Rod Bremner, Valerie A. Wallace

iScience. 2021 Aug 20; 24(8): 102905. Published online 2021 Jul 26. doi: 10.1016/j.isci.2021.102905

PMCID:: PMC8374524

Abstract Article PDF–7.7M

Select item 83132397.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 79387708.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74551819.

Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Zhongxiao Wang, Chi-Hsiu Liu, Shuo Huang, Zhongjie Fu, Yohei Tomita, William R. Britton, Steve S. Cho, Chuck T. Chen, Ye Sun, Jian-xing Ma, Xi He, Jing Chen

Sci Adv. 2020 Aug; 6(35): eaba7457. Published online 2020 Aug 28. doi: 10.1126/sciadv.aba7457

PMCID:: PMC7455181

Abstract Article PDF–1.9M

Select item 741005910.

Deficiency of MFSD7c results in microcephaly-associated vasculopathy in Fowler syndrome

Pazhanichamy Kalailingam, Kai Qi Wang, Xiu Ru Toh, Toan Q. Nguyen, Madhuvanthi Chandrakanthan, Zafrul Hasan, Clair Habib, Aharon Schif, Francesca Clementina Radio, Bruno Dallapiccola, Karin Weiss, Long N. Nguyen

J Clin Invest. 2020 Aug 3; 130(8): 4081–4093. Published online 2020 Jun 22. doi: 10.1172/JCI136727

PMCID:: PMC7410059

Abstract Article PDF–29M

Select item 722702811.

Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss

Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs

Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931

PMCID:: PMC7227028

Abstract Article PDF–5.4M

Select item 675877612.

Vascular Defects and Sensorineural Deafness in a Mouse Model of Norrie Disease

Heidi L. Rehm, Duan-Sun Zhang, M. Christian Brown, Barbara Burgess, Chris Halpin, Wolfgang Berger, Cynthia C. Morton, David P. Corey, Zheng-Yi Chen

J Neurosci. 2002 Jun 1; 22(11): 4286–4292. doi: 10.1523/JNEUROSCI.22-11-04286.2002

PMCID:: PMC6758776

Abstract Article PDF–1.4M

Select item 672593113.

Ectopic Norrin Induces Growth of Ocular Capillaries and Restores Normal Retinal Angiogenesis in Norrie Disease Mutant Mice

Andreas Ohlmann, Michael Scholz, Andreas Goldwich, Bharesh K. Chauhan, Kristiane Hudl, Anne V. Ohlmann, Eberhart Zrenner, Wolfgang Berger, Aleš Cvekl, Mathias W. Seeliger, Ernst R. Tamm

J Neurosci. 2005 Feb 16; 25(7): 1701–1710. doi: 10.1523/JNEUROSCI.4756-04.2005

PMCID:: PMC6725931

Abstract Article PDF–788K

Select item 671537714.

Roles of HIFs and VEGF in angiogenesis in the retina and brain

Amir Rattner, John Williams, Jeremy Nathans

J Clin Invest. 2019 Sep 3; 129(9): 3807–3820. Published online 2019 Aug 12. doi: 10.1172/JCI126655

PMCID:: PMC6715377

Abstract Article PDF–20M

Select item 663260615.

Norrin Mediates Neuroprotective Effects on Retinal Ganglion Cells via Activation of the Wnt/β-Catenin Signaling Pathway and the Induction of Neuroprotective Growth Factors in Müller Cells

Roswitha Seitz, Simon Hackl, Thomas Seibuchner, Ernst R. Tamm, Andreas Ohlmann

J Neurosci. 2010 Apr 28; 30(17): 5998–6010. doi: 10.1523/JNEUROSCI.0730-10.2010

PMCID:: PMC6632606

Abstract Article PDF–2.8M

Select item 655120916.

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin

Sean J. Miller, Thomas Philips, Namho Kim, Raha Dastgheyb, Zhuoxun Chen, Yi-Chun Hsieh, J. Gavin Daigle, Malika Datta, Jeannie Chew, Svetlana Vidensky, Jacqueline T. Pham, Ethan G. Hughes, Michael B. Robinson, Rita Sattler, Raju Tomer, Jung Soo Suk, Dwight E. Bergles, Norman Haughey, Mikhail Pletnikov, Justin Hanes, Jeffrey D. Rothstein

Nat Neurosci. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: Nat Neurosci. 2019 May; 22(5): 741–752. Published online 2019 Apr 1. doi: 10.1038/s41593-019-0366-7