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Select item 115743501.

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea

Sandra de Haan, Agustin A. Corbat, Christopher R. Cederroth, Lisa G. Autrum, Simona Hankeova, Elizabeth C. Driver, Barbara Canlon, Matthew W. Kelley, Emma R. Andersson

Development. 2024 Nov 1; 151(21): dev202949. Published online 2024 Nov 5. doi: 10.1242/dev.202949

PMCID:: PMC11574350

Abstract Article

Select item 115546752.

Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects

Jan Mašek, Iva Filipovic, Noémi Van Hul, Lenka Belicová, Markéta Jiroušková, Daniel V Oliveira, Anna Maria Frontino, Simona Hankeova, Jingyan He, Fabio Turetti, Afshan Iqbal, Igor Červenka, Lenka Sarnová, Elisabeth Verboven, Tomáš Brabec, Niklas K Björkström, Martin Gregor, Jan Dobeš, Emma R Andersson

EMBO Mol Med. 2024 Nov; 16(11): 2946–2975. Published online 2024 Oct 2. doi: 10.1038/s44321-024-00145-8

PMCID:: PMC11554675

Abstract Article PDF–8.1M

Select item 114639623.

Dose-dependent responses to canonical Wnt transcriptional complexes in the regulation of mammalian nephron progenitors

Helena Bugacov, Balint Der, Bohdana-Myroslava Briantseva, Qiuyu Guo, Sunghyun Kim, Nils O. Lindström, Andrew P. McMahon

Development. 2024 Sep 15; 151(18): dev202279. Published online 2024 Sep 30. doi: 10.1242/dev.202279

PMCID:: PMC11463962

Abstract Article

Select item 114239124.

A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2

Caryl A. Young, Emily Burt, Vidhya Munnamalai

Development. 2024 Sep 1; 151(17): dev202635. Published online 2024 Sep 10. doi: 10.1242/dev.202635

PMCID:: PMC11423912

Abstract Article

Select item 113852185.

Jagged-1+ skin Tregs modulate cutaneous wound healing

Prudence PokWai Lui, Jessie Z. Xu, Hafsah Aziz, Monica Sen, Niwa Ali

Sci Rep. 2024; 14: 20999. Published online 2024 Sep 9. doi: 10.1038/s41598-024-71512-1

PMCID:: PMC11385218

Abstract Article PDF–5.8M

Select item 110963756.

Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool

Haidi Huang, Yu Jiang, Jiangying Liu, Dan Luo, Jianghong Yuan, Rongzi Mu, Xiang Yu, Donglei Sun, Jihong Lin, Qiyue Chen, Xinjing Li, Ming Jiang, Jianming Xu, Bo Chu, Chengqian Yin, Lei Zhang, Youqiong Ye, Bo Cao, Qiong Wang, Yongchun Zhang

Nat Commun. 2024; 15: 4124. Published online 2024 May 15. doi: 10.1038/s41467-024-48347-5

PMCID:: PMC11096375

Abstract Article PDF–9.5M

Select item 108849597.

Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins

Hannah L. Sunshine, Andrew C. Cicchetto, Karolina Elżbieta Kaczor-Urbanowicz, Feiyang Ma, Danielle Pi, Chloe Symons, Martin Turner, Vipul Shukla, Heather R. Christofk, Thomas A. Vallim, M. Luisa Iruela-Arispe

Cell Rep. Author manuscript; available in PMC 2024 Feb 23.

Published in final edited form as: Cell Rep. 2024 Jan 23; 43(1): 113627. Published online 2023 Dec 28. doi: 10.1016/j.celrep.2023.113627

PMCID:: PMC10884959

Abstract Article PDF–4.0M

Select item 108820558.

Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic hematopoietic stem cell fate

Roshana Thambyrajah, Maria Maqueda, Wen Hao Neo, Kathleen Imbach, Yolanda Guillén, Daniela Grases, Zaki Fadlullah, Stefano Gambera, Francesca Matteini, Xiaonan Wang, Fernando J. Calero-Nieto, Manel Esteller, Maria Carolina Florian, Eduard Porta, Rui Benedito, Berthold Göttgens, Georges Lacaud, Lluis Espinosa, Anna Bigas

Nat Commun. 2024; 15: 1604. Published online 2024 Feb 21. doi: 10.1038/s41467-024-45716-y

PMCID:: PMC10882055

Abstract Article PDF–6.6M

Select item 108774069.

β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice

Nina Suda, Alberto Bartolomé, Jiani Liang, Jinsook Son, Yoko Yagishita, Christian Siebel, Domenico Accili, Hongxu Ding, Utpal B. Pajvani

Mol Metab. 2024 Mar; 81: 101894. Published online 2024 Feb 3. doi: 10.1016/j.molmet.2024.101894

PMCID:: PMC10877406

Abstract Article PDF–1.4M

Select item 1087664810.

PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development

Jong Geol Lee, Jung-Min Yon, Globinna Kim, Seul-Gi Lee, C-Yoon Kim, Seung-A Cheong, Hyun-Yi Kim, Jiyoung Yu, Kyunggon Kim, Young Hoon Sung, Hyun Ju Yoo, Dong-Cheol Woo, Jin Kyung Rho, Chang Hoon Ha, Chan-Gi Pack, Seak Hee Oh, Joon Seo Lim, Yu Mi Han, Eui-Ju Hong, Je Kyung Seong, Han-Woong Lee, Sang-Wook Lee, Ki-Up Lee, Chong Jai Kim, Sang-Yoon Nam, You Sook Cho, In-Jeoung Baek

Nat Commun. 2024; 15: 1487. Published online 2024 Feb 19. doi: 10.1038/s41467-024-45647-8

PMCID:: PMC10876648

Abstract Article PDF–10M

Select item 1086914911.

EBF1 Limits the Numbers of Cochlear Hair and Supporting Cells and Forms the Scala Tympani and Spiral Limbus during Inner Ear Development

Hiroki Kagoshima, Hiroe Ohnishi, Ryosuke Yamamoto, Akiyoshi Yasumoto, Yosuke Tona, Takayuki Nakagawa, Koichi Omori, Norio Yamamoto

J Neurosci. 2024 Feb 14; 44(7): e1060232023. doi: 10.1523/JNEUROSCI.1060-23.2023

PMCID:: PMC10869149

Abstract Article PDF–20M

Select item 1084653912.

eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling

Lorraine Eley, Rachel V. Richardson, Ahlam Alqahtani, Bill Chaudhry, Deborah J. Henderson

Dis Model Mech. 2024 Jan 1; 17(1): dmm050265. Published online 2024 Jan 22. doi: 10.1242/dmm.050265

PMCID:: PMC10846539

Abstract Article

Select item 1069332113.

Jagged1 acts as an RBP-J target and feedback suppresses TNF-mediated inflammatory osteoclastogenesis

Courtney Ng, Yongli Qin, Yuhan Xia, Xiaoyu Hu, Baohong Zhao

J Immunol. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: J Immunol. 2023 Nov 1; 211(9): 1340–1347. doi: 10.4049/jimmunol.2300317

PMCID:: PMC10693321

Abstract Article PDF–2.5M

Select item 1056339114.

Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease

Soichiro Kimura, Zadia Dupee, Felipe Lima, Ronald Allen, Soha Kazmi, Nickolas Diodati, Nicholas W. Lukacs, Steven L. Kunkel, Matthew Schaller

Immunohorizons. 2023 Feb 1; 7(2): 168–176. Published online 2023 Feb 2. doi: 10.4049/immunohorizons.2300001

PMCID:: PMC10563391

Abstract Article PDF–1.6M

Select item 1055862415.

Antisense oligonucleotide silencing of a glycosyltransferase, Poglut1, improves the liver phenotypes in mouse models of Alagille syndrome

Nima Niknejad, Duncan Fox, Jennifer L. Burwinkel, Neda Zarrin-Khameh, Soomin Cho, Armand Soriano, Ashley E. Cast, Mario F. Lopez, Kari A. Huppert, Frank Rigo, Stacey S. Huppert, Paymaan Jafar-Nejad, Hamed Jafar-Nejad

Hepatology. Author manuscript; available in PMC 2024 Nov 1.

Published in final edited form as: Hepatology. 2023 Nov 1; 78(5): 1337–1351. Published online 2023 Apr 7. doi: 10.1097/HEP.0000000000000380