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Items: 1 to 20 of 294

1.
Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock
Jiameng Sun, Yiming Zhang, Joshua A. Adams, Cassandra B. Higgins, Shannon C. Kelly, Hao Zhang, Kevin Y. Cho, Ulysses G. Johnson, Benjamin M. Swarts, Shun-lchi Wada, Gary J. Patti, Leah P. Shriver, Brian N. Finck, Erik D. Herzog, Brian J. DeBosch
Cell Rep. Author manuscript; available in PMC 2024 Nov 27.
Published in final edited form as: Cell Rep. 2024 Oct 22; 43(10): 114865. Published online 2024 Oct 16. doi: 10.1016/j.celrep.2024.114865
PMCID:
PMC11601098
AbstractArticlePDF–2.9M
2.
BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21
Hong Zheng, Xi Zhang, Chen Li, Die Wang, Yuying Shen, Jiahui Lu, Liangcai Zhao, Xiaokun Li, Hongchang Gao
Microbiome. 2024; 12: 157. Published online 2024 Aug 24. doi: 10.1186/s40168-024-01872-3
PMCID:
PMC11344321
AbstractArticlePDF–3.5M
3.
FGF21 overexpression alleviates VSMC senescence in diabetic mice by modulating the SYK-NLRP3 inflammasome-PPARγ-catalase pathway: FGF21 alleviates high glucose-induced VSMC senescence
Yanyan Heng, Wei Wei, Linzhong Cheng, Feifei Wu, Haoyu Dong, Jingxia Li, Jianing Fu, Bingjie Yang, Xinyue Liang, Chunyan Liu, Haiju Li, Haihua Liu, Pengfei Zhang
Acta Biochim Biophys Sin (Shanghai) 2024 Jun 25; 56(6): 892–904. Published online 2024 May 10. doi: 10.3724/abbs.2024032
PMCID:
PMC11214975
AbstractArticlePDF–3.5M
4.
FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway
Yue Ma, Zhiqin Liu, Lele Deng, Jingjing Du, Zenghui Fan, Tian Ma, Jing Xiong, Xue Xiuyun, Naibing Gu, Zhengli Di, Yu Zhang
J Transl Med. 2024; 22: 436. Published online 2024 May 8. doi: 10.1186/s12967-024-05239-y
PMCID:
PMC11077765
AbstractArticlePDF–13M
5.
Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation
Irini Manoli, Justin R. Sysol, PamelaSara E. Head, Madeline W. Epping, Oksana Gavrilova, Melissa K. Crocker, Jennifer L. Sloan, Stefanos A. Koutsoukos, Cindy Wang, Yiouli P. Ktena, Sophia Mendelson, Alexandra R. Pass, Patricia M. Zerfas, Victoria Hoffmann, Hilary J. Vernon, Laura A. Fletcher, James C. Reynolds, Maria G. Tsokos, Constantine A. Stratakis, Stephan D. Voss, Kong Y. Chen, Rebecca J. Brown, Ada Hamosh, Gerard T. Berry, Xiaoyuan Shawn Chen, Jack A. Yanovski, Charles P. Venditti
JCI Insight. 2024 Feb 22; 9(4): e174097. Published online 2024 Feb 22. doi: 10.1172/jci.insight.174097
PMCID:
PMC10967474
AbstractArticlePDF–4.5M
6.
FGF21 and autophagy coordinately counteract kidney disease progression during aging and obesity
Satoshi Minami, Shinsuke Sakai, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Atsushi Takahashi, Jun Matsuda, Hiroaki Yonishi, Jun Nakamura, Shihomi Maeda, Sho Matsui, Isao Matsui, Yoshitaka Isaka
Autophagy. 2024; 20(3): 489–504. Published online 2023 Sep 18. doi: 10.1080/15548627.2023.2259282
PMCID:
PMC10936614
AbstractArticlePDF–7.5M
7.
Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R
Camilla Lund, Pablo Ranea-Robles, Sarah Falk, Dylan M. Rausch, Grethe Skovbjerg, Victoria Kamma Vibe-Petersen, Nathalie Krauth, Jacob Lercke Skytte, Vasiliki Vana, Urmas Roostalu, Tune H. Pers, Jens Lund, Christoffer Clemmensen
Nat Commun. 2024; 15: 1192. Published online 2024 Feb 8. doi: 10.1038/s41467-024-45223-0
PMCID:
PMC10853283
AbstractArticlePDF–2.2M
8.
Transplantation of committed pre-adipocytes from brown adipose tissue improves whole-body glucose homeostasis
Revati S. Dewal, Felix T. Yang, Lisa A. Baer, Pablo Vidal, Diego Hernandez-Saavedra, Nickolai P. Seculov, Adhideb Ghosh, Falko Noé, Olivia Togliatti, Lexis Hughes, Megan K. DeBari, Michael D. West, Richard Soroko, Hal Sternberg, Nafees N. Malik, Estella Puchulu-Campanella, Huabao Wang, Pearlly Yan, Christian Wolfrum, Rosalyn D. Abbott, Kristin I. Stanford
iScience. 2024 Feb 16; 27(2): 108927. Published online 2024 Jan 17. doi: 10.1016/j.isci.2024.108927
PMCID:
PMC10847743
AbstractArticlePDF–6.4M
9.
Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21
Thomas Agius, Raffaella Emsley, Arnaud Lyon, Michael R. MacArthur, Kevin Kiesworo, Anna Faivre, Louis Stavart, Martine Lambelet, David Legouis, Sophie de Seigneux, Déla Golshayan, Francois Lazeyras, Heidi Yeh, James F. Markmann, Korkut Uygun, Alejandro Ocampo, Sarah J. Mitchell, Florent Allagnat, Sébastien Déglise, Alban Longchamp
Nat Commun. 2024; 15: 1073. Published online 2024 Feb 5. doi: 10.1038/s41467-024-44866-3
PMCID:
PMC10844297
AbstractArticlePDF–6.7M
10.
Parkin depletion prevents the age-related alterations in the FGF21 system and the decline in white adipose tissue thermogenic function in mice
Alejandro Delgado-Anglés, Albert Blasco-Roset, Francisco J. Godoy-Nieto, Montserrat Cairó, Francesc Villarroya, Marta Giralt, Joan Villarroya
J Physiol Biochem. 2024; 80(1): 41–51. Published online 2023 Nov 2. doi: 10.1007/s13105-023-00977-x
PMCID:
PMC10808413
AbstractArticlePDF–3.1M
11.
ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms
Sarah H. Bjorkman, Alex Marti, Jayashree Jena, Luis Miguel García-Peña, Eric T. Weatherford, Kevin Kato, Jivan Koneru, Jason Chen, Ayushi Sood, Matthew J. Potthoff, Christopher M. Adams, E. Dale Abel, Renata O. Pereira
Sci Rep. 2024; 14: 1563. Published online 2024 Jan 18. doi: 10.1038/s41598-024-52004-8
PMCID:
PMC10796914
AbstractArticlePDF–2.5M
12.
Non-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21
Yue Sui, Qingqing Liu, Cong Xu, Kumar Ganesan, Zhen Ye, Yan Li, Jianmin Wu, Bing Du, Fei Gao, Cailu Song, Jianping Chen
Cell Death Dis. 2024 Jan; 15(1): 67. Published online 2024 Jan 18. doi: 10.1038/s41419-023-06386-8
PMCID:
PMC10796330
AbstractArticlePDF–5.8M
13.
FGF21 Modulates Hippocampal Cold-Shock Proteins and CA2-Subregion Proteins in Neonatal Mice with Hypoxia-Ischemia
Jeremy R. Herrmann, Patrick M. Kochanek, Vincent A. Vagni, Keri Janesko-Feldman, Jason Stezoski, Kiersten Gorse, Travis C. Jackson
Pediatr Res. Author manuscript; available in PMC 2024 Apr 1.
Published in final edited form as: Pediatr Res. 2023 Oct; 94(4): 1355–1364. Published online 2023 May 16. doi: 10.1038/s41390-023-02652-9
PMCID:
PMC10690493
AbstractArticlePDF–2.1M
14.
Hepatic sialic acid synthesis modulates glucose homeostasis in both liver and skeletal muscle
Jun Peng, Liming Yu, Linzhang Huang, Vivian A. Paschoal, Haiyan Chu, Camila O. de Souza, Joseph V. Varre, Da Young Oh, Jennifer J. Kohler, Xue Xiao, Lin Xu, William L. Holland, Philip W. Shaul, Chieko Mineo
Mol Metab. 2023 Dec; 78: 101812. Published online 2023 Sep 28. doi: 10.1016/j.molmet.2023.101812
PMCID:
PMC10583174
AbstractArticlePDF–4.0M
15.
Hepatic-Specific FGF21 Knockout Abrogates Ovariectomy-Induced Obesity by Reversing Corticosterone Production
Jiayu Xu, Xinyu Shao, Haozhe Zeng, Chengxi Wang, Jiayi Li, Xiaoqin Peng, Yong Zhuo, Lun Hua, Fengyan Meng, Xingfa Han
Int J Mol Sci. 2023 Oct; 24(19): 14922. Published online 2023 Oct 5. doi: 10.3390/ijms241914922
PMCID:
PMC10573867
AbstractArticlePDF–3.3M
16.
Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development
Angelica S. Martinez-Ramirez, Thomas L. Borders, Leena Paul, Matthew Schipma, Xinkun Wang, Farida Korobova, Christopher V. Wright, Beatriz Sosa-Pineda
Gastro Hep Adv. 2022; 1(5): 807–823. Published online 2022 May 26. doi: 10.1016/j.gastha.2022.05.013
PMCID:
PMC10569262
AbstractArticlePDF–6.7M
17.
GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes
Jayashree Jena, Luis Miguel García-Peña, Eric T Weatherford, Alex Marti, Sarah H Bjorkman, Kevin Kato, Jivan Koneru, Jason H Chen, Randy J Seeley, E Dale Abel, Renata O Pereira
eLife. 2023; 12: e86452. Published online 2023 Oct 11. doi: 10.7554/eLife.86452
PMCID:
PMC10567111
AbstractArticlePDF–4.6M
18.
The roles of FGF21 and GDF15 in mediating the mitochondrial integrated stress response
Jayashree Jena, Luis Miguel García-Peña, Renata O. Pereira
Front Endocrinol (Lausanne) 2023; 14: 1264530. Published online 2023 Sep 25. doi: 10.3389/fendo.2023.1264530
PMCID:
PMC10561105
AbstractArticlePDF–763K
19.
FGF21 alleviates adipose stem cell senescence via CD90 glycosylation-dependent glucose influx in remodeling healthy white adipose tissue
Zixin Zhou, Huiying Zhang, Yan Tao, Jinhao Zang, Jingyuan Zhao, Huijie Li, Yalin Wang, Tianci Wang, Hui Zhao, Fuwu Wang, Chun Guo, Faliang Zhu, Haiting Mao, Fengming Liu, Lining Zhang, Qun Wang
Redox Biol. 2023 Nov; 67: 102877. Published online 2023 Sep 9. doi: 10.1016/j.redox.2023.102877
PMCID:
PMC10497791
AbstractArticlePDF–13M
20.
Development of muscle weakness in a mouse model of critical illness: does fibroblast growth factor 21 play a role?
Wouter Vankrunkelsven, Steven Thiessen, Sarah Derde, Ellen Vervoort, Inge Derese, Isabel Pintelon, Hanne Matheussen, Alexander Jans, Chloë Goossens, Lies Langouche, Greet Van den Berghe, Ilse Vanhorebeek
Skelet Muscle. 2023; 13: 12. Published online 2023 Aug 4. doi: 10.1186/s13395-023-00320-4
PMCID:
PMC10401744
AbstractArticlePDF–8.4M

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