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Select item 115195261.

TGF-β signaling in the cranial neural crest affects late-stage mandibular bone resorption and length

Claire J. Houchen, Saif Ghanem, Vesa Kaartinen, Erin Ealba Bumann

Front Physiol. 2024; 15: 1435594. Published online 2024 Oct 15. doi: 10.3389/fphys.2024.1435594

PMCID:: PMC11519526

Abstract Article PDF–2.8M

Select item 113616422.

FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton

Asra Almubarak, Qiuwan Zhang, Cheng-Hai Zhang, Noor Abdelwahab, Tsutomu Kume, Andrew B. Lassar, Fred B. Berry

Development. 2024 Aug 15; 151(16): dev202798. Published online 2024 Aug 22. doi: 10.1242/dev.202798

PMCID:: PMC11361642

Abstract Article

Select item 113314273.

14-3-3ζ suppresses RANKL signaling by destabilizing TRAF6

R. Ayyasamy, S. Fan, P. Czernik, B. Lecka-Czernik, S. Chattopadhyay, R. Chakravarti

J Biol Chem. 2024 Jul; 300(7): 107487. Published online 2024 Jun 21. doi: 10.1016/j.jbc.2024.107487

PMCID:: PMC11331427

Abstract Article PDF–2.7M

Select item 112277054.

Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation

M. L. Schiavone, L. Crisafulli, C. Camisaschi, G. De Simone, F. R. Liberati, E. Palagano, N. Rucci, F. Ficara, Cristina Sobacchi

Stem Cell Res Ther. 2024; 15: 203. Published online 2024 Jul 6. doi: 10.1186/s13287-024-03803-3

PMCID:: PMC11227705

Abstract Article PDF–2.8M

Select item 111408535.

Osteocyte RANKL Drives Bone Resorption in Mouse Ligature‐Induced Periodontitis

Mizuho Kittaka, Tetsuya Yoshimoto, Marcus E Levitan, Rina Urata, Roy B Choi, Yayoi Teno, Yixia Xie, Yukiko Kitase, Matthew Prideaux, Sarah L Dallas, Alexander G Robling, Yasuyoshi Ueki

J Bone Miner Res. 2023 Oct 1; 38(10): 1521–1540. Published online 2023 Oct 1. doi: 10.1002/jbmr.4897

PMCID:: PMC11140853

Abstract Article PDF–4.2M

Select item 106199386.

RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes

Nagesha Guthalu Kondegowda, Joanna Filipowska, Jeong-su Do, Nancy Leon-Rivera, Rosemary Li, Rollie Hampton, Selassie Ogyaadu, Camilla Levister, Josef M. Penninger, Helena Reijonen, Carol J. Levy, Rupangi C. Vasavada

Sci Adv. 2023 Nov 3; 9(44): eadf5238. Published online 2023 Nov 1. doi: 10.1126/sciadv.adf5238

PMCID:: PMC10619938

Abstract Article PDF–1.9M

Select item 105617227.

Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation

Qiang Fu, Nancy C. Bustamante-Gomez, Humberto Reyes-Pardo, Igor Gubrij, Diana Escalona-Vargas, Jeff D. Thostenson, Michela Palmieri, Joseph J. Goellner, Intawat Nookaew, C. Lowry Barnes, Jeffrey B. Stambough, Elena Ambrogini, Charles A. O’Brien

JCI Insight. 2023 Sep 22; 8(18): e167790. Published online 2023 Sep 22. doi: 10.1172/jci.insight.167790

PMCID:: PMC10561722

Abstract Article PDF–12M

Select item 104998798.

Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development

Yongzhen Lai, Yan Guo, Caiyu Liao, Chuanqing Mao, Jing Liu, Chengyan Ren, Wen Yang, Lin Luo, Weihui Chen

Sci Rep. 2023; 13: 15170. Published online 2023 Sep 13. doi: 10.1038/s41598-023-42423-4

PMCID:: PMC10499879

Abstract Article PDF–6.8M

Select item 104437949.

Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to pagetic lesion formation

Kazuaki Miyagawa, Hirofumi Tenshin, Patrick L. Mulcrone, Jesus Delgado-Calle, Mark A. Subler, Jolene J. Windle, John M. Chirgwin, G. David Roodman, Noriyoshi Kurihara

JCI Insight. 2023 Jul 24; 8(14): e159838. Published online 2023 Jul 24. doi: 10.1172/jci.insight.159838

PMCID:: PMC10443794

Abstract Article PDF–3.5M

Select item 1041741510.

Α Humanized RANKL Transgenic Mouse Model of Progestin-Induced Mammary Carcinogenesis for Evaluation of Novel Therapeutics

Anthi Kolokotroni, Evi Gkikopoulou, Vagelis Rinotas, Lydia Ntari, Danae Zareifi, Maritina Rouchota, Sophia Sarpaki, Ilias Lymperopoulos, Leonidas G. Alexopoulos, George Loudos, Maria C. Denis, Niki Karagianni, Eleni Douni

Cancers (Basel) 2023 Aug; 15(15): 4006. Published online 2023 Aug 7. doi: 10.3390/cancers15154006

PMCID:: PMC10417415

Abstract Article PDF–3.9M

Select item 1041580611.

CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system

Dominique J. Laster, Nisreen S. Akel, James A. Hendrixson, Alicen James, Julie A. Crawford, Qiang Fu, Stuart B. Berryhill, Jeff D. Thostenson, Intawat Nookaew, Charles A. O’Brien, Melda Onal

iScience. 2023 Aug 18; 26(8): 107428. Published online 2023 Jul 20. doi: 10.1016/j.isci.2023.107428

PMCID:: PMC10415806

Abstract Article PDF–4.8M

Select item 1025583012.

Histopathologic and Transcriptomic Phenotypes of a Conditional RANKL Transgenic Mouse Thymus

Maria M. Szwarc, Lan Hai, Vineet K. Maurya, Kimal Rajapakshe, Dimuthu Perera, Michael M. Ittmann, Qianxing Mo, Yong Lin, Matthew L. Bettini, Cristian Coarfa, John P. Lydon

Cytokine. Author manuscript; available in PMC 2023 Jun 9.

Published in final edited form as: Cytokine. 2022 Dec; 160: 156022. Published online 2022 Sep 11. doi: 10.1016/j.cyto.2022.156022

PMCID:: PMC10255830

Abstract Article PDF–1.9M

Select item 1025322513.

RANKL Inhibition Reduces Cardiac Hypertrophy in mdx Mice and Possibly in Children with Duchenne Muscular Dystrophy

Laetitia Marcadet, Emma Sara Juracic, Nasrin Khan, Zineb Bouredji, Hideo Yagita, Leanne M. Ward, A. Russell Tupling, Anteneh Argaw, Jérôme Frenette

Cells. 2023 Jun; 12(11): 1538. Published online 2023 Jun 3. doi: 10.3390/cells12111538

PMCID:: PMC10253225

Abstract Article PDF–4.5M

Select item 1025275714.

Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice

Verena Fischer, Jasmin Maria Bülow, Benjamin Thilo Krüger, Deniz Ragipoglu, Anna Vikman, Melanie Haffner-Luntzer, Konstantinos Katsoulis-Dimitriou, Anne Dudeck, Anita Ignatius

Int J Mol Sci. 2023 Jun; 24(11): 9135. Published online 2023 May 23. doi: 10.3390/ijms24119135

PMCID:: PMC10252757

Abstract Article PDF–6.3M

Select item 996781915.

Crucial Role of Lysine-Specific Histone Demethylase 1 in RANKL-Mediated Osteoclast Differentiation

Mina Ding, Zhihao Chen, Eunjin Cho, Sang-Wook Park, Tae-Hoon Lee

Int J Mol Sci. 2023 Feb; 24(4): 3605. Published online 2023 Feb 10. doi: 10.3390/ijms24043605

PMCID:: PMC9967819

Abstract Article PDF–6.7M

Select item 972466416.

A20 controls RANK‐dependent osteoclast formation and bone physiology

Arne Martens, Pieter Hertens, Dario Priem, Vagelis Rinotas, Theodore Meletakos, Meropi Gennadi, Lisette Van Hove, Els Louagie, Julie Coudenys, Amélie De Muynck, Djoere Gaublomme, Mozes Sze, Jolanda van Hengel, Leen Catrysse, Esther Hoste, Jeffrey D Zajac, Rachel A Davey, Luc Van Hoorebeke, Tino Hochepied, Mathieu J M Bertrand, Marietta Armaka, Dirk Elewaut, Geert van Loo

EMBO Rep. 2022 Dec; 23(12): e55233. Published online 2022 Oct 4. doi: 10.15252/embr.202255233

PMCID:: PMC9724664

Abstract Article PDF–3.0M

Select item 930372417.

Excessive osteoclast activation by osteoblast paracrine factor RANKL is a major cause of the abnormal long bone phenotype in Apert syndrome model mice

Hye‐Rim Shin, Bong‐Soo Kim, Hyun‐Jung Kim, Heein Yoon, Woo‐Jin Kim, Je‐Yong Choi, Hyun‐Mo Ryoo

J Cell Physiol. 2022 Apr; 237(4): 2155–2168. Published online 2022 Jan 20. doi: 10.1002/jcp.30682

PMCID:: PMC9303724

Abstract Article PDF–13M

Select item 929399118.

Periosteal stem cells control growth plate stem cells during postnatal skeletal growth

Masayuki Tsukasaki, Noriko Komatsu, Takako Negishi-Koga, Nam Cong-Nhat Huynh, Ryunosuke Muro, Yutaro Ando, Yuka Seki, Asuka Terashima, Warunee Pluemsakunthai, Takeshi Nitta, Takashi Nakamura, Tomoki Nakashima, Shinsuke Ohba, Haruhiko Akiyama, Kazuo Okamoto, Roland Baron, Hiroshi Takayanagi

Nat Commun. 2022; 13: 4166. Published online 2022 Jul 18. doi: 10.1038/s41467-022-31592-x