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Select item 93571001.

Mannan binding lectin promotes murine graft versus host disease by amplifying lipopolysaccharide-initiated inflammation

David Heja, Dongchang Zhao, Evan Cody, Arun Cumpelik, Pik Chin Lim, Mariano Prado-Acosta, Liv Palma, Sergio Dellepiane, Nicholas Chun, James Ferrara, Peter S. Heeger

Transplant Cell Ther. Author manuscript; available in PMC 2023 Aug 1.

Published in final edited form as: Transplant Cell Ther. 2022 Aug; 28(8): 472.e1–472.e11. Published online 2022 May 25. doi: 10.1016/j.jtct.2022.05.031

PMCID:: PMC9357100

Abstract Article PDF–1.0M

Select item 88051472.

Mannose-binding lectin and complement mediate follicular localization and enhanced immunogenicity of diverse protein nanoparticle immunogens

Benjamin J. Read, Lori Won, John C. Kraft, Isaac Sappington, Aereas Aung, Shengwei Wu, Julia Bals, Chengbo Chen, Kelly K. Lee, Daniel Lingwood, Neil P. King, Darrell J. Irvine

Cell Rep. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Cell Rep. 2022 Jan 11; 38(2): 110217. doi: 10.1016/j.celrep.2021.110217

PMCID:: PMC8805147

Abstract Article PDF–2.2M

Select item 82975563.

Dynamic regulation of B cell Complement Signaling is Integral to Germinal Center Responses

Arun Cumpelik, David Heja, Yuan Hu, Gabriele Varano, Farideh Ordikhani, Mark P. Roberto, Zhengxiang He, Dirk Homann, Sergio A. Lira, David Dominguez-Sola, Peter S. Heeger

Nat Immunol. Author manuscript; available in PMC 2021 Nov 24.

Published in final edited form as: Nat Immunol. 2021 Jun; 22(6): 757–768. Published online 2021 May 24. doi: 10.1038/s41590-021-00926-0

PMCID:: PMC8297556

Abstract Article PDF–4.9M

Select item 80851194.

Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres

Jozef Pisko, Alexandra Špirková, Štefan Čikoš, Lucia Olexiková, Veronika Kovaříková, Zuzana Šefčíková, Dušan Fabian

Sci Rep. 2021; 11: 9228. Published online 2021 Apr 29. doi: 10.1038/s41598-021-88752-0

PMCID:: PMC8085119

Abstract Article PDF–1.6M

Select item 70522505.

Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury

Laura Neglia, Marco Oggioni, Domenico Mercurio, Maria-Grazia De Simoni, Stefano Fumagalli

Cell Mol Immunol. 2020 Mar; 17(3): 218–226. Published online 2019 Apr 9. doi: 10.1038/s41423-019-0225-1

PMCID:: PMC7052250

Abstract Article PDF–1.4M

Select item 69443896.

Herpes simplex encephalitis in adult patients with MASP-2 deficiency

Stéphanie Bibert, Jocelyne Piret, Mathieu Quinodoz, Emilie Collinet, Vincent Zoete, Olivier Michielin, Rafik Menasria, Pascal Meylan, Titus Bihl, Véronique Erard, Florence Fellmann, Carlo Rivolta, Guy Boivin, Pierre-Yves Bochud

PLoS Pathog. 2019 Dec; 15(12): e1008168. Published online 2019 Dec 23. doi: 10.1371/journal.ppat.1008168

PMCID:: PMC6944389

Abstract Article PDF–2.4M

Select item 68585667.

The Fungal Mycobiome Promotes Pancreatic Oncogenesis via MBL Activation

Berk Aykut, Smruti Pushalkar, Ruonan Chen, Qianhao Li, Raquel Abengozar, Jacqueline I. Kim, Sorin A. Shadaloey, Dongling Wu, Pamela Preiss, Narendra Verma, Yuqi Guo, Anjana Saxena, Mridula Vardhan, Brian Diskin, Wei Wang, Joshua Leinwand, Emma Kurz, Juan A. Kochen Rossi, Mautin Hundeyin, Constantinos Zambrinis, Xin Li, Deepak Saxena, George Miller

Nature. Author manuscript; available in PMC 2020 Apr 2.

Published in final edited form as: Nature. 2019 Oct; 574(7777): 264–267. Published online 2019 Oct 2. doi: 10.1038/s41586-019-1608-2

PMCID:: PMC6858566

Abstract Article PDF–3.4M

Select item 66159918.

Murine T cell maturation entails protection from MBL2, but complement proteins do not drive clearance of cells that fail maturation in the absence of NKAP.

Barsha Dash, Paul J. Belmonte, Sydney R. Fine, Michael J. Shapiro, Ji Young Chung, Aaron D. Schwab, Shaylene A. McCue, Matthew J. Rajcula, Virginia Smith Shapiro

J Immunol. Author manuscript; available in PMC 2020 Jul 15.

Published in final edited form as: J Immunol. 2019 Jul 15; 203(2): 408–417. Published online 2019 Jun 7. doi: 10.4049/jimmunol.1801443

PMCID:: PMC6615991

Abstract Article PDF–1.0M

Select item 64207199.

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Talar Tokatlian, Benjamin J. Read, Christopher A. Jones, Daniel W. Kulp, Sergey Menis, Jason Y.H. Chang, Jon M. Steichen, Sudha Kumari, Joel D. Allen, Eric L. Dane, Alessia Liguori, Maya Sangesland, Daniel Lingwood, Max Crispin, William R. Schief, Darrell J. Irvine

Science. Author manuscript; available in PMC 2019 Aug 8.

Published in final edited form as: Science. 2019 Feb 8; 363(6427): 649–654. Published online 2018 Dec 20. doi: 10.1126/science.aat9120

PMCID:: PMC6420719

Abstract Article PDF–1.6M

Select item 636373910.

The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato

Jeroen Coumou, Alex Wagemakers, Sukanya Narasimhan, Tim J. Schuijt, Jasmin I. Ersoz, Anneke Oei, Onno J. de Boer, Joris J. T. H. Roelofs, Erol Fikrig, Joppe W. Hovius

Sci Rep. 2019; 9: 1431. Published online 2019 Feb 5. doi: 10.1038/s41598-018-37922-8

PMCID:: PMC6363739

Abstract Article PDF–3.1M

Select item 622139511.

Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α

Franca Orsini, Stefano Fumagalli, Eszter Császár, Krisztina Tóth, Daiana De Blasio, Rosalia Zangari, Nikolett Lénárt, Ádám Dénes, Maria-Grazia De Simoni

Arterioscler Thromb Vasc Biol. 2018 Nov; 38(11): 2678–2690. Published online 2018 Oct 4. doi: 10.1161/ATVBAHA.118.311058

PMCID:: PMC6221395

Abstract Article PDF–1.8M

Select item 581847012.

The Complement System Is Critical in Maintaining Retinal Integrity during Aging

Ryo Mukai, Yoko Okunuki, Deeba Husain, Clifford B. Kim, John D. Lambris, Kip M. Connor

Front Aging Neurosci. 2018; 10: 15. Published online 2018 Feb 15. doi: 10.3389/fnagi.2018.00015

PMCID:: PMC5818470

Abstract Article PDF–12M

Select item 556110713.

Interleukin-17 receptor A (IL-17RA) as a central regulator of the protective immune response against Giardia

Oonagh Paerewijck, Brecht Maertens, Leentje Dreesen, Frederik Van Meulder, Iris Peelaers, Dariusz Ratman, Robert W. Li, Erik Lubberts, Karolien De Bosscher, Peter Geldhof

Sci Rep. 2017; 7: 8520. Published online 2017 Aug 17. doi: 10.1038/s41598-017-08590-x

PMCID:: PMC5561107

Abstract Article PDF–1.8M

Select item 550725314.

Tissue plasminogen activator mediates deleterious complement cascade activation in stroke

Xue-Jun Zhao, Timothy M. Larkin, Molly A. Lauver, Saif Ahmad, Andrew F. Ducruet

PLoS One. 2017; 12(7): e0180822. Published online 2017 Jul 10. doi: 10.1371/journal.pone.0180822

PMCID:: PMC5507253

Abstract Article PDF–3.7M

Select item 521458215.

Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

M Adamiak, A Abdelbaset-Ismail, M Suszynska, A Abdel-Latif, J Ratajczak, M Z Ratajczak

Leukemia. 2017 Jan; 31(1): 262–265. Prepublished online 2016 Oct 13. Published online 2016 Nov 4. doi: 10.1038/leu.2016.278

PMCID:: PMC5214582

Article PDF–332K

Select item 500527216.

Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone

Jonathan M. Ciencewicki, Kirsten C. Verhein, Kevin Gerrish, Zachary R. McCaw, Jianying Li, Pierre R. Bushel, Steven R. Kleeberger

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1; 311(2): L280–L291. Published online 2016 Apr 22. doi: 10.1152/ajplung.00205.2015

PMCID:: PMC5005272

Abstract Article

Select item 475041317.

The alternative complement pathway aids in vascular regression during the early stages of a murine model of proliferative retinopathy

Clifford Kim, Kaylee E. Smith, Alexandra Castillejos, Daniel Diaz-Aguilar, Magali Saint-Geniez, Kip M. Connor

FASEB J. 2016 Mar; 30(3): 1300–1305. Published online 2015 Nov 30. doi: 10.1096/fj.15-280834

PMCID:: PMC4750413

Abstract Article

Select item 430517818.

Human Mannose-Binding Lectin Inhibitor Prevents Myocardial Injury and Arterial Thrombogenesis in a Novel Animal Model

Vasile I. Pavlov, Ying S. Tan, Erin E. McClure, Laura R. La Bonte, Chenhui Zou, William B. Gorsuch, Gregory L. Stahl

Am J Pathol. 2015 Feb; 185(2): 347–355. doi: 10.1016/j.ajpath.2014.10.015

PMCID:: PMC4305178

Abstract Article PDF–1.3M

Select item 424262719.

Lysyl Hydroxylase 3 Modifies Lysine Residues to Facilitate Oligomerization of Mannan-Binding Lectin

Maija Risteli, Heli Ruotsalainen, Ulrich Bergmann, Umakhanth Venkatraman Girija, Russell Wallis, Raili Myllylä

PLoS One. 2014; 9(11): e113498. Published online 2014 Nov 24. doi: 10.1371/journal.pone.0113498

PMCID:: PMC4242627

Abstract Article PDF–738K

Select item 399071820.

Deficient IFN Signaling by Myeloid Cells Leads to MAVS-Dependent Virus-Induced Sepsis

Amelia K. Pinto, Hilario J. Ramos, Xiaobo Wu, Shilpa Aggarwal, Bimmi Shrestha, Matthew Gorman, Kristin Y. Kim, Mehul S. Suthar, John P. Atkinson, Michael Gale Jr, Michael S. Diamond

PLoS Pathog. 2014 Apr; 10(4): e1004086. Published online 2014 Apr 17. doi: 10.1371/journal.ppat.1004086

PMCID:: PMC3990718

Abstract Article PDF–2.3M

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