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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 73755132.

Secreted phospholipase A₂ group X acts as an adjuvant for type-2 inflammation leading to an allergen-specific immune response in the lung

Herbert Luke Ogden, Ying Lai, James D. Nolin, Dowon An, Charles W. Frevert, Michael H. Gelb, William A. Altemeier, Teal S. Hallstrand

J Immunol. Author manuscript; available in PMC 2021 Jun 15.

Published in final edited form as: J Immunol. 2020 Jun 15; 204(12): 3097–3107. Published online 2020 Apr 27. doi: 10.4049/jimmunol.2000102

PMCID:: PMC7375513

Abstract Article PDF–1.9M

Select item 57522963.

Secreted PLA₂ group X orchestrates innate and adaptive immune responses to inhaled allergen

James D. Nolin, Ying Lai, Herbert Luke Ogden, Anne M. Manicone, Ryan C. Murphy, Dowon An, Charles W. Frevert, Farideh Ghomashchi, Gajendra S. Naika, Michael H. Gelb, Gail M. Gauvreau, Adrian M. Piliponsky, William A. Altemeier, Teal S. Hallstrand

JCI Insight. 2017 Nov 2; 2(21): e94929. Published online 2017 Nov 2. doi: 10.1172/jci.insight.94929

PMCID:: PMC5752296

Abstract Article PDF–1.3M

Select item 52958214.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 49570445.

Dual Roles of Group IID Phospholipase A₂ in Inflammation and Cancer

Yoshimi Miki, Yuh Kidoguchi, Mariko Sato, Yoshitaka Taketomi, Choji Taya, Kazuaki Muramatsu, Michael H. Gelb, Kei Yamamoto, Makoto Murakami

J Biol Chem. 2016 Jul 22; 291(30): 15588–15601. Published online 2016 May 21. doi: 10.1074/jbc.M116.734624

PMCID:: PMC4957044

Abstract Article PDF–3.9M

Select item 48072756.

Group X Secreted Phospholipase A₂ Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility

Remi Murase, Hiroyasu Sato, Kei Yamamoto, Ayako Ushida, Yasumasa Nishito, Kazutaka Ikeda, Tetsuyuki Kobayashi, Toshinori Yamamoto, Yoshitaka Taketomi, Makoto Murakami

J Biol Chem. 2016 Mar 25; 291(13): 6895–6911. Published online 2016 Jan 31. doi: 10.1074/jbc.M116.715672

PMCID:: PMC4807275

Abstract Article PDF–4.5M

Select item 47427687.

Progesterone-induced Acrosome Exocytosis Requires Sequential Involvement of Calcium-independent Phospholipase A₂β (iPLA₂β) and Group X Secreted Phospholipase A₂ (sPLA₂)

Roland Abi Nahed, Guillaume Martinez, Jessica Escoffier, Sandra Yassine, Thomas Karaouzène, Jean-Pascal Hograindleur, John Turk, George Kokotos, Pierre F. Ray, Serge Bottari, Gérard Lambeau, Sylviane Hennebicq, Christophe Arnoult

J Biol Chem. 2016 Feb 5; 291(6): 3076–3089. Published online 2015 Dec 11. doi: 10.1074/jbc.M115.677799

PMCID:: PMC4742768

Abstract Article PDF–2.7M

Select item 41837818.

Group X Secretory Phospholipase A₂ Regulates Insulin Secretion through a Cyclooxygenase-2-dependent Mechanism

Preetha Shridas, Lubna Zahoor, Kathy J. Forrest, Joseph D. Layne, Nancy R. Webb

J Biol Chem. 2014 Oct 3; 289(40): 27410–27417. Published online 2014 Aug 13. doi: 10.1074/jbc.M114.591735

PMCID:: PMC4183781

Abstract Article PDF–892K

Select item 41060429.

Lack of group X secreted phospholipase A₂ increases survival following pandemic H1N1 influenza infection

Alyson A. Kelvin, Norbert Degousee, David Banner, Eva Stefanski, Alberto J. Leόn, Denis Angoulvant, Stéphane G. Paquette, Stephen S.H. Huang, Ali Danesh, Clinton S. Robbins, Hossein Noyan, Mansoor Husain, Gerard Lambeau, Michael Gelb, David J. Kelvin, Barry B. Rubin

Virology. 2014 Apr; 454: 78–92. Published online 2014 Feb 25. doi: 10.1016/j.virol.2014.01.030

PMCID:: PMC4106042

Abstract Article PDF–9.2M

Select item 406530710.

Mast cell maturation is driven via a group III phospholipase A₂-prostaglandin D₂–DP1 receptor paracrine axis

Yoshitaka Taketomi, Noriko Ueno, Takumi Kojima, Hiroyasu Sato, Remi Murase, Kei Yamamoto, Satoshi Tanaka, Mariko Sakanaka, Masanori Nakamura, Yasumasa Nishito, Momoko Kawana, Naotomo Kambe, Kazutaka Ikeda, Ryo Taguchi, Satoshi Nakamizo, Kenji Kabashima, Michael H. Gelb, Makoto Arita, Takehiko Yokomizo, Motonao Nakamura, Kikuko Watanabe, Hiroyuki Hirai, Masataka Nakamura, Yoshimichi Okayama, Chisei Ra, Kosuke Aritake, Yoshihiro Urade, Kazushi Morimoto, Yukihiko Sugimoto, Takao Shimizu, Shuh Narumiya, Shuntaro Hara, Makoto Murakami

Nat Immunol. Author manuscript; available in PMC 2014 Jun 21.

Published in final edited form as: Nat Immunol. 2013 Jun; 14(6): 554–563. Published online 2013 Apr 28. doi: 10.1038/ni.2586

PMCID:: PMC4065307

Abstract Article PDF–1.0M

Select item 396495511.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 381221012.

Phospholipase A₂ in Experimental Allergic Bronchitis: A Lesson from Mouse and Rat Models

Rufayda Mruwat, Saul Yedgar, Iris Lavon, Amiram Ariel, Miron Krimsky, David Shoseyov

PLoS One. 2013; 8(10): e76641. Published online 2013 Oct 29. doi: 10.1371/journal.pone.0076641

PMCID:: PMC3812210

Abstract Article PDF–647K

Select item 357241013.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 315105015.

Blockade of Human Group X Secreted Phospholipase A₂ (GX-sPLA₂)-induced Airway Inflammation and Hyperresponsiveness in a Mouse Asthma Model by a Selective GX-sPLA₂ Inhibitor

William R. Henderson, Jr, Rob C. Oslund, James G. Bollinger, Xin Ye, Ying-tzang Tien, Jun Xue, Michael H. Gelb

J Biol Chem. 2011 Aug 12; 286(32): 28049–28055. Published online 2011 Jun 7. doi: 10.1074/jbc.M111.235812

PMCID:: PMC3151050

Abstract Article PDF–1.2M

Select item 311975516.

Group X Secretory Phospholipase A₂ Enhances Toll-Like Receptor 4 Signaling in Macrophages

Preetha Shridas, William M Bailey, Kayla R Talbott, Rob C Oslund, Michael H Gelb, Nancy R Webb

J Immunol. Author manuscript; available in PMC 2012 Jul 1.

Published in final edited form as: J Immunol. 2011 Jul 1; 187(1): 482–489. Published online 2011 May 27. doi: 10.4049/jimmunol.1003552

PMCID:: PMC3119755

Abstract Article PDF–479K

Select item 306421617.

Physiological Roles of Group X-secreted Phospholipase A₂ in Reproduction, Gastrointestinal Phospholipid Digestion, and Neuronal Function

Hiroyasu Sato, Yuki Isogai, Seiko Masuda, Yoshitaka Taketomi, Yoshimi Miki, Daisuke Kamei, Shuntaro Hara, Tetsuyuki Kobayashi, Yukio Ishikawa, Toshiharu Ishii, Kazutaka Ikeda, Ryo Taguchi, Yoshikazu Ishimoto, Noriko Suzuki, Yasunori Yokota, Kohji Hanasaki, Toshiko Suzuki-Yamamoto, Kei Yamamoto, Makoto Murakami

J Biol Chem. 2011 Apr 1; 286(13): 11632–11648. Published online 2011 Jan 25. doi: 10.1074/jbc.M110.206755

PMCID:: PMC3064216

Abstract Article PDF–3.8M

Select item 306421518.

Hair Follicular Expression and Function of Group X Secreted Phospholipase A₂ in Mouse Skin

Kei Yamamoto, Yoshitaka Taketomi, Yuki Isogai, Yoshimi Miki, Hiroyasu Sato, Seiko Masuda, Yasumasa Nishito, Kiyokazu Morioka, Yoshikazu Ishimoto, Noriko Suzuki, Yasunori Yokota, Kohji Hanasaki, Yukio Ishikawa, Toshiharu Ishii, Tetsuyuki Kobayashi, Kiyoko Fukami, Kazutaka Ikeda, Hiroki Nakanishi, Ryo Taguchi, Makoto Murakami

J Biol Chem. 2011 Apr 1; 286(13): 11616–11631. Published online 2011 Jan 25. doi: 10.1074/jbc.M110.206714

PMCID:: PMC3064215

Abstract Article PDF–4.7M

Select item 305861419.

A novel anti-inflammatory role for secretory phospholipase A₂ in immune complex-mediated arthritis

Eric Boilard, Ying Lai, Katherine Larabee, Barbara Balestrieri, Farideh Ghomashchi, Daisuke Fujioka, Reuben Gobezie, Jonathan S Coblyn, Michael E Weinblatt, Elena M Massarotti, Thomas S Thornhill, Maziar Divangahi, Heinz Remold, Gérard Lambeau, Michael H Gelb, Jonathan P Arm, David M Lee

EMBO Mol Med. 2010 May; 2(5): 172–187. doi: 10.1002/emmm.201000072

PMCID:: PMC3058614

Abstract Article PDF–874K

Select item 302253420.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582