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Select item 114249781.

DDI2 protease controls embryonic development and inflammation via TCF11/NRF1

Monika Nedomova, Stefanie Haberecht-Müller, Sophie Möller, Simone Venz, Michaela Prochazkova, Jan Prochazka, Frantisek Sedlak, Kallayanee Chawengsaksophak, Elke Hammer, Petr Kasparek, Michael Adamek, Radislav Sedlacek, Jan Konvalinka, Elke Krüger, Klara Grantz Saskova

iScience. 2024 Oct 18; 27(10): 110893. Published online 2024 Sep 5. doi: 10.1016/j.isci.2024.110893

PMCID:: PMC11424978

Abstract Article PDF–6.1M

Select item 113617082.

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

Teruhiko Yoshida, Khun Zaw Latt, Avi Z Rosenberg, Briana A Santo, Komuraiah Myakala, Yu Ishimoto, Yongmei Zhao, Shashi Shrivastav, Bryce A Jones, Xiaoping Yang, Xiaoxin X Wang, Vincent M Tutino, Pinaki Sarder, Moshe Levi, Koji Okamoto, Cheryl A Winkler, Jeffrey B Kopp

eLife. 2024; 12: RP91260. Published online 2024 Aug 29. doi: 10.7554/eLife.91260

PMCID:: PMC11361708

Abstract Article PDF–9.0M

Select item 110364083.

Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24

Sophia Davidson, Chien-Hsiung Yu, Annemarie Steiner, Frédéric Ebstein, Paul J. Baker, Valentina Jarur-Chamy, Katja Hrovat Schaale, Pawat Laohamonthonkul, Klara Kong, Dale J. Calleja, Cassandra R. Harapas, Katherine R. Balka, Jacob Mitchell, Jacob T. Jackson, Niall D. Geoghegan, Fiona Moghaddas, Kelly L. Rogers, Katrin D. Mayer-Barber, Adriana A. De Jesus, Dominic De Nardo, Benjamin T. Kile, Anthony J. Sadler, M. Cecilia Poli, Elke Krüger, Raphaela Goldbach Mansky, Seth L. Masters

Sci Immunol. Author manuscript; available in PMC 2024 Apr 23.

Published in final edited form as: Sci Immunol. 2022 Feb 11; 7(68): eabi6763. Published online 2022 Feb 11. doi: 10.1126/sciimmunol.abi6763

PMCID:: PMC11036408

Abstract Article PDF–1.6M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 109069155.

Aberrant RNA sensing in regulatory T cells causes systemic autoimmunity

Domnica Luca, Sumin Lee, Keiji Hirota, Yasutaka Okabe, Junji Uehori, Kazushi Izawa, Anna-Lisa Lanz, Verena Schütte, Burcu Sivri, Yuta Tsukamoto, Fabian Hauck, Rayk Behrendt, Axel Roers, Takashi Fujita, Ryuta Nishikomori, Min Ae Lee-Kirsch, Hiroki Kato

Sci Adv. 2024 Mar 1; 10(9): eadk0820. Published online 2024 Mar 1. doi: 10.1126/sciadv.adk0820

PMCID:: PMC10906915

Abstract Article PDF–4.5M

Select item 103198606.

E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR

Jiaying Huang, Zhou Yu, Xuelian Li, Mingjin Yang, Qian Fang, Zheng Li, Chunmei Wang, Taoyong Chen, Xuetao Cao

Cell Death Dis. 2023 Jul; 14(7): 396. Published online 2023 Jul 4. doi: 10.1038/s41419-023-05923-9

PMCID:: PMC10319860

Abstract Article PDF–3.7M

Select item 99817927.

The protein kinase R modifies gut physiology to limit colitis

Howard Chi Ho Yim, Arindam Chakrabarti, Sean Kessler, Hiroyuki Morimoto, Die Wang, Dhanya Sooraj, Afsar U. Ahmed, Carol de la Motte, Robert H. Silverman, Bryan RG. Williams, Anthony J. Sadler

Front Immunol. 2023; 14: 1106737. Published online 2023 Feb 17. doi: 10.3389/fimmu.2023.1106737

PMCID:: PMC9981792

Abstract Article PDF–3.1M

Select item 98604898.

PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation

Zhouyangfan Peng, Xiqing Tan, Liangpeng Xie, Ze Li, Sufang Zhou, Yapei Li

iScience. 2023 Jan 20; 26(1): 105909. Published online 2022 Dec 30. doi: 10.1016/j.isci.2022.105909

PMCID:: PMC9860489

Abstract Article PDF–4.9M

Select item 95593179.

A variant NS1 protein from H5N2 avian influenza virus suppresses PKR activation and promotes replication and virulence in mammals

Yun-Ting Chung, Chih-Ying Kuan, Guan-Ru Liao, Randy A. Albrecht, Yeu-Yang Tseng, Yu-Chen Hsu, Shan-Chia Ou, Wei-Li Hsu

Emerg Microbes Infect. 2022; 11(1): 2291–2303. Published online 2022 Oct 9. doi: 10.1080/22221751.2022.2114853

PMCID:: PMC9559317

Abstract Article PDF–2.6M

Select item 900692910.

Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation

Berto Tejera-Hernández, Danielle E. Goodman, Juan M. Nevarez, Katherine R. Spindler

J Virol. 2022 Apr; 96(7): e02063-21. Published online 2022 Mar 14. doi: 10.1128/jvi.02063-21

Correction in:: J Virol. 2023 Oct; 97(10): e01265-23.

PMCID:: PMC9006929

Abstract Article PDF–1.0M

Select item 875422811.

The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation

Junchao Shi, Zi Li, Rongyi Xu, Jing Zhang, Qianyu Zhou, Rui Gao, Huijun Lu, Yungang Lan, Kui Zhao, Hongbin He, Feng Gao, Wenqi He

J Virol. 2022 Jan; 96(1): e01695-21. Prepublished online 2021 Oct 13. Published online 2022 Jan 12. doi: 10.1128/JVI.01695-21

PMCID:: PMC8754228

Abstract Article PDF–6.3M

Select item 844633512.

Protein Kinase R and the Integrated Stress Response drive immunopathology caused by mutations in the RNA deaminase ADAR1

Megan Maurano, Jessica M. Snyder, Caitlin Connelly, Jorge Henao-Mejia, Carmela Sidrauski, Daniel B. Stetson

Immunity. Author manuscript; available in PMC 2022 Sep 14.

Published in final edited form as: Immunity. 2021 Sep 14; 54(9): 1948–1960.e5. Published online 2021 Aug 2. doi: 10.1016/j.immuni.2021.07.001

PMCID:: PMC8446335

Abstract Article PDF–3.6M

Select item 793877013.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 787932014.

Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis

Yanliang Yang, Lingli Xie, Yanjun Zhong, Xiaoli Zhong, Ran Meng, Qianqian Xue, Fang Liang, Kai Zhao, Yiting Tang

J Innate Immun. 2021 Jan; 13(1): 26–37. Published online 2020 Dec 17. doi: 10.1159/000507932

PMCID:: PMC7879320

Abstract Article PDF–679K

Select item 785452415.

Maternal Immune Activation in Mice Disrupts Proteostasis in the Fetal Brain

Brian T. Kalish, Eunha Kim, Benjamin Finander, Erin E. Duffy, Hyunju Kim, Casey K. Gilman, Yeong Shin Yim, Lilin Tong, Randal J. Kaufman, Eric C. Griffith, Gloria B. Choi, Michael E. Greenberg, Jun R. Huh

Nat Neurosci. Author manuscript; available in PMC 2021 Jun 23.

Published in final edited form as: Nat Neurosci. 2021 Feb; 24(2): 204–213. Published online 2020 Dec 23. doi: 10.1038/s41593-020-00762-9