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Select item 111150811.

Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2

Yong Zhang, Guoyu Yu, Yanjie Wang, Yang Xiang, Qian Gao, Ping Jiang, Jie Zhang, Wenhui Lee, Yun Zhang

Cell Mol Life Sci. 2011 Nov; 68(22): 3771–3780. Published online 2011 Apr 3. doi: 10.1007/s00018-011-0678-6

PMCID:: PMC11115081

Abstract Article PDF–2.2M

Select item 105038012.

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes

Frederik Denorme, Nicole D. Armstrong, Michelle L. Stoller, Irina Portier, Emilia A. Tugolukova, Rikki M. Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L. Rustad, Abigail Ajanel, Neal D. Tolley, Darian C. Murray, Julie L. Boyle, Marvin T. Nieman, Steven E. McKenzie, Christian Con Yost, Leslie A. Lange, Mary Cushman, Marguerite R. Irvin, Paul F. Bray, Robert A. Campbell

J Clin Invest. 2023 Sep 15; 133(18): e169608. Published online 2023 Sep 15. doi: 10.1172/JCI169608

PMCID:: PMC10503801

Abstract Article PDF–8.2M

Select item 102197053.

Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study

Qi Su, Gufeng Shen, Guokang Xu

Medicine (Baltimore) 2023 May 26; 102(21): e33657. Published online 2023 May 26. doi: 10.1097/MD.0000000000033657

PMCID:: PMC10219705

Abstract Article PDF–516K

Select item 100729064.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 88124355.

Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function

Laura J. Corbin, Stephen J. White, Amy E. Taylor, Christopher M. Williams, Kurt Taylor, Marion T. van den Bosch, Jack E. Teasdale, Matthew Jones, Mark Bond, Matthew T. Harper, Louise Falk, Alix Groom, Georgina G.J. Hazell, Lavinia Paternoster, Marcus R. Munafò, Børge G. Nordestgaard, Anne Tybjærg-Hansen, Stig E. Bojesen, Caroline Relton, Josine L. Min, George Davey Smith, Andrew D. Mumford, Alastair W. Poole, Nicholas J. Timpson

Circ Res. 2022 Feb 4; 130(3): 384–400. Published online 2022 Jan 6. doi: 10.1161/CIRCRESAHA.121.318836

PMCID:: PMC8812435

Abstract Article PDF–2.1M

Select item 86532076.

Disruption of the biological activity of protease‐activated receptors2/4 in adults rather than children in SARS CoV‐2 virus‐mediated mortality in COVID‐19 infection

Yogendra Singh, Neeraj Kumar Fuloria, Shivkanya Fuloria, Vetriselvan Subramaniyan, Waleed Hassan Almalki, Gaurav Gupta, Mohammad Arshad Javed Shaikh, Mahaveer Singh, Fahad A. Al‐Abbasi, Imran Kazmi

Drug Dev Res. 2021 Dec; 82(8): 1075–1078. Published online 2021 Sep 1. doi: 10.1002/ddr.21874

PMCID:: PMC8653207

Abstract Article PDF–823K

Select item 80193507.

PAR-4/Ca²⁺-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes

Alessandra Giannella, Giulio Ceolotto, Claudia Maria Radu, Arianna Cattelan, Elisabetta Iori, Andrea Benetti, Fabrizio Fabris, Paolo Simioni, Angelo Avogaro, Saula Vigili de Kreutzenberg

Cardiovasc Diabetol. 2021; 20: 77. Published online 2021 Apr 3. doi: 10.1186/s12933-021-01267-w

PMCID:: PMC8019350

Abstract Article PDF–2.5M

Select item 77580508.

In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators

Jennifer L. Franks, Raquel C. Martinez-Chacin, Xianxi Wang, Rochelle L. Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L. Bolhuis, Taylor P. Enrico, Ryan D. Mouery, Jeffrey S. Damrauer, Feng Yan, Joseph S. Harrison, M. Ben Major, Katherine A. Hoadley, Aussie Suzuki, Scott B. Rothbart, Nicholas G. Brown, Michael J. Emanuele

PLoS Biol. 2020 Dec; 18(12): e3000975. Published online 2020 Dec 11. doi: 10.1371/journal.pbio.3000975

PMCID:: PMC7758050

Abstract Article PDF–4.2M

Select item 70395739.

Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4)

Pierre E. Thibeault, Jordan C. LeSarge, D'Arcy Arends, Michaela Fernandes, Peter Chidiac, Peter B. Stathopulos, Leonard G. Luyt, Rithwik Ramachandran

J Biol Chem. 2020 Feb 21; 295(8): 2520–2540. Published online 2019 Dec 31. doi: 10.1074/jbc.RA119.011461

PMCID:: PMC7039573

Abstract Article PDF–4.2M

Select item 658457010.

PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1

Haihong Guo, Fabian Treude, Oliver H. Krämer, Bernhard Lüscher, Jörg Hartkamp

Sci Rep. 2019; 9: 8755. Published online 2019 Jun 19. doi: 10.1038/s41598-019-45209-9

PMCID:: PMC6584570

Abstract Article PDF–3.0M

Select item 637499111.

Thrombin-induced platelet activation via PAR4: pivotal role for exosite II

Niklas Boknäs, Lars Faxälv, Daniel Sanchez Centellas, Maria Wallstedt, Sofia Ramström, Magnus Grenegård, Tomas L. Lindahl

Thromb Haemost. 2014 Sep; 112(3): 558–565. Published online 2017 Nov 20. doi: 10.1160/TH13-12-1013

PMCID:: PMC6374991

Abstract Article PDF–911K

Select item 630798412.

Frequency of PAR4 Ala120Thr variant associated with platelet reactivity significantly varies across sub-Saharan African populations

Menikae K. Heenkenda, Tomas L. Lindahl, Abdimajid Osman

Blood. 2018 Nov 8; 132(19): 2103–2106. Prepublished online 2018 Aug 24. doi: 10.1182/blood-2018-05-852335

PMCID:: PMC6307984

Abstract Article

Select item 609763213.

Effects of Genetic Variation in Protease Activated Receptor 4 after an Acute Coronary Syndrome: Analysis from the TRACER trial

Pierluigi Tricoci, Megan Neely, Michael J. Whitley, Leonard C. Edelstein, Lukas M. Simon, Chad Shaw, Paolo Fortina, David J. Moliterno, Paul W. Armstrong, Philip Aylward, Harvey White, Frans Van de Werf, Lisa K. Jennings, Lars Wallentin, Claes Held, Robert A Harrington, Kenneth W. Mahaffey, Paul F. Bray

Blood Cells Mol Dis. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Blood Cells Mol Dis. 2018 Sep; 72: 37–43. Published online 2018 Jul 21. doi: 10.1016/j.bcmd.2018.07.004

PMCID:: PMC6097632

Abstract Article PDF–521K

Select item 603093914.

DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons

Ayman Alhamdow, Christian Lindh, Jessika Hagberg, Pål Graff, Håkan Westberg, Annette M Krais, Maria Albin, Per Gustavsson, Håkan Tinnerberg, Karin Broberg

Carcinogenesis. 2018 Jul; 39(7): 869–878. Published online 2018 May 2. doi: 10.1093/carcin/bgy059

PMCID:: PMC6030939

Abstract Article PDF–863K

Select item 602376415.

Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics

Benjamin E. Tourdot, Hannah Stoveken, Derek Trumbo, Jennifer Yeung, Yogendra Kanthi, Leonard C. Edelstein, Paul F. Bray, Gregory G. Tall, Michael Holinstat

Arterioscler Thromb Vasc Biol. 2018 Jul; 38(7): 1632–1643. Published online 2018 Apr 5. doi: 10.1161/ATVBAHA.118.311112

PMCID:: PMC6023764

Abstract Article PDF–2.5M

Select item 582692616.

VIRMA mediates preferential m⁶A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yanan Yue, Jun Liu, Xiaolong Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, Tao Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu

Cell Discov. 2018; 4: 10. Published online 2018 Feb 27. doi: 10.1038/s41421-018-0019-0

PMCID:: PMC5826926

Abstract Article PDF–2.3M

Select item 540915617.

Performance of urine cotinine and hypomethylation of AHRR and F2RL3 as biomarkers for smoking exposure in a population-based cohort

Do-Hoon Lee, Sang-Hyun Hwang, Min Kyung Lim, Jin-Kyoung Oh, Da Young Song, E. Hwa Yun, Eun Young Park

PLoS One. 2017; 12(4): e0176783. Published online 2017 Apr 28. doi: 10.1371/journal.pone.0176783

PMCID:: PMC5409156

Abstract Article PDF–1.9M

Select item 519851518.

Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets

Matthew T. Duvernay, Kayla J. Temple, Jae G. Maeng, Anna L. Blobaum, Shaun R. Stauffer, Craig W. Lindsley, Heidi E. Hamm

Mol Pharmacol. 2017 Jan; 91(1): 39–47. Published online 2017 Jan. doi: 10.1124/mol.116.106666

PMCID:: PMC5198515

Abstract Article PDF–904K

Select item 500009019.

Protease-activated Receptor-4 Signaling and Trafficking Is Regulated by the Clathrin Adaptor Protein Complex-2 Independent of β-Arrestins

Thomas H. Smith, Luisa J. Coronel, Julia G. Li, Michael R. Dores, Marvin T. Nieman, JoAnn Trejo

J Biol Chem. 2016 Aug 26; 291(35): 18453–18464. Published online 2016 Jul 11. doi: 10.1074/jbc.M116.729285

PMCID:: PMC5000090

Abstract Article PDF–2.8M

Select item 465691420.

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα

Naadiya Carrim, Jane F. Arthur, Justin R. Hamilton, Elizabeth E. Gardiner, Robert K. Andrews, Niamh Moran, Michael C. Berndt, Pat Metharom

Redox Biol. 2015 Dec; 6: 640–647. Published online 2015 Oct 28. doi: 10.1016/j.redox.2015.10.009

PMCID:: PMC4656914

Abstract Article PDF–1.0M

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