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Items: 1 to 20 of 42

1.
Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing
Rahul Singh, Yuan Wu, Alba Herrero del Valle, Kendra E. Leigh, Sai Mong, Mark T.K. Cheng, Brian J. Ferguson, Yorgo Modis
J Biol Chem. 2024 Mar; 300(3): 105711. Published online 2024 Feb 1. doi: 10.1016/j.jbc.2024.105711
PMCID:
PMC10909783
AbstractArticlePDF–8.3M
2.
Unraveling blunt-end RNA binding and ATPase-driven translocation activities of the RIG-I family helicase LGP2
Kuan-Ying Lee, Candice Craig, Smita S Patel
Nucleic Acids Res. 2024 Jan 11; 52(1): 355–369. Published online 2023 Nov 28. doi: 10.1093/nar/gkad1106
PMCID:
PMC10783506
AbstractArticlePDF–2.7M
3.
K63‐linked polyubiquitination of LGP2 by Riplet regulates RIG‐I‐dependent innate immune response
Takahisa Kouwaki, Tasuku Nishimura, Guanming Wang, Reiko Nakagawa, Hiroyuki Oshiumi
EMBO Rep. 2023 Feb; 24(2): e54844. Published online 2022 Dec 14. doi: 10.15252/embr.202254844
PMCID:
PMC9900346
AbstractArticlePDF–1.9M
4.
Genetic variants of IFIH1 and DHX58 affect the chronicity of hepatitis C in the Chinese Han population
Peng Huang, Jing-Jing Wu, Jin-Wei Zhang, Yu-Qing Hou, Ping Zhu, Rong Yin, Rong-Bin Yu, Yun Zhang, Ming Yue, Wei Hou
PeerJ. 2023; 11: e14740. Published online 2023 Jan 30. doi: 10.7717/peerj.14740
PMCID:
PMC9893905
AbstractArticlePDF–9.6M
5.
Function conservation and disparities of zebrafish and human LGP2 genes in fish and mammalian cells responsive to poly(I:C)
Xiu-Ying Gong, Zi-Ling Qu, Yi-Lin Li, Hao-Yu Sun, Xiang Zhao, Cheng Dan, Jian-Fang Gui, Yi-Bing Zhang
Front Immunol. 2022; 13: 985792. Published online 2022 Aug 17. doi: 10.3389/fimmu.2022.985792
PMCID:
PMC9428467
AbstractArticlePDF–12M
6.
RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency
Jorn E Stok, Timo Oosenbrug, Laurens R ter Haar, Dennis Gravekamp, Christian P Bromley, Santiago Zelenay, Caetano Reis e Sousa, Annemarthe G van der Veen
EMBO J. 2022 Mar 15; 41(6): e109760. Published online 2022 Feb 14. doi: 10.15252/embj.2021109760
PMCID:
PMC8922249
AbstractArticlePDF–1.8M
7.
Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases
Kazuki Kato, Sadeem Ahmad, Zixiang Zhu, Janet M. Young, Xin Mu, Sehoon Park, Harmit S. Malik, Sun Hur
Mol Cell. Author manuscript; available in PMC 2021 Jun 7.
Published in final edited form as: Mol Cell. 2021 Feb 4; 81(3): 599–613.e8. Published online 2020 Dec 28. doi: 10.1016/j.molcel.2020.11.047
PMCID:
PMC8183676
AbstractArticlePDF–3.6M
8.
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
GuanQun Liu, Jung-Hyun Lee, Zachary M. Parker, Dhiraj Acharya, Jessica J. Chiang, Michiel van Gent, William Riedl, Meredith E. Davis-Gardner, Effi Wies, Cindy Chiang, Michaela U. Gack
Nat Microbiol. Author manuscript; available in PMC 2021 Oct 1.
Published in final edited form as: Nat Microbiol. 2021 Apr; 6(4): 467–478. Published online 2021 Mar 16. doi: 10.1038/s41564-021-00884-1
PMCID:
PMC8103894
AbstractArticlePDF–3.9M
9.
SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors
Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier
Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118
PMCID:
PMC8017720
AbstractArticlePDF–1.9M
10.
Spatiotemporal dynamics of innate immune signaling via RIG-I–like receptors
Katharina Esser-Nobis, Lauren D. Hatfield, Michael Gale, Jr
Proc Natl Acad Sci U S A. 2020 Jul 7; 117(27): 15778–15788. Published online 2020 Jun 22. doi: 10.1073/pnas.1921861117
PMCID:
PMC7354926
AbstractArticlePDF–2.7M
11.
LGP2 virus sensor enhances apoptosis by upregulating apoptosis regulatory genes through TRBP-bound miRNAs during viral infection
Tomoko Takahashi, Yuko Nakano, Koji Onomoto, Mitsutoshi Yoneyama, Kumiko Ui-Tei
Nucleic Acids Res. 2020 Feb 20; 48(3): 1494–1507. Published online 2019 Dec 8. doi: 10.1093/nar/gkz1143
PMCID:
PMC7026649
AbstractArticlePDF–3.8M
12.
RNA Helicase LGP2 Negatively Regulates RIG-I Signaling by Preventing TRIM25-Mediated Caspase Activation and Recruitment Domain Ubiquitination
Kendra M. Quicke, Kristin Y. Kim, Curt M. Horvath, Mehul S. Suthar
J Interferon Cytokine Res. 2019 Nov 1; 39(11): 669–683. Published online 2019 Oct 29. doi: 10.1089/jir.2019.0059
PMCID:
PMC6820871
AbstractArticlePDF–1.2M
13.
Innate immune sensor laboratory of genetics and physiology 2 suppresses tumor cell growth and functions as a prognostic marker in neuroblastoma
Li‐Ling Lin, Chao‐Cheng Huang, Min‐Tsui Wu, Wen‐Ming Hsu, Jiin‐Haur Chuang
Cancer Sci. 2018 Nov; 109(11): 3494–3502. Published online 2018 Oct 4. doi: 10.1111/cas.13790
PMCID:
PMC6215871
AbstractArticlePDF–978K
14.
LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs
Tomoko Takahashi, Yuko Nakano, Koji Onomoto, Fuminori Murakami, Chiaki Komori, Yutaka Suzuki, Mitsutoshi Yoneyama, Kumiko Ui-Tei
Nucleic Acids Res. 2018 Sep 28; 46(17): 9134–9147. Published online 2018 Jun 25. doi: 10.1093/nar/gky575
PMCID:
PMC6158488
AbstractArticlePDF–1.3M
15.
RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling
Jean‐Patrick Parisien, Jessica J Lenoir, Roli Mandhana, Kenny R Rodriguez, Kenin Qian, Annie M Bruns, Curt M Horvath
EMBO Rep. 2018 Jun; 19(6): e45176. Published online 2018 Apr 16. doi: 10.15252/embr.201745176
PMCID:
PMC5989757
AbstractArticlePDF–2.2M
16.
The RIG‐I‐like receptor LGP2 inhibits Dicer‐dependent processing of long double‐stranded RNA and blocks RNA interference in mammalian cells
Annemarthe G van der Veen, Pierre V Maillard, Jan Marten Schmidt, Sonia A Lee, Safia Deddouche‐Grass, Annabel Borg, Svend Kjær, Ambrosius P Snijders, Caetano Reis e Sousa
EMBO J. 2018 Feb 15; 37(4): e97479. Published online 2018 Jan 19. doi: 10.15252/embj.201797479
PMCID:
PMC5813259
AbstractArticlePDF–2.5M
17.
Nonencapsidated 5′ Copy-Back Defective Interfering Genomes Produced by Recombinant Measles Viruses Are Recognized by RIG-I and LGP2 but Not MDA5
Marie Mura, Chantal Combredet, Valérie Najburg, Raul Y. Sanchez David, Frédéric Tangy, Anastassia V. Komarova
J Virol. 2017 Oct 15; 91(20): e00643-17. Prepublished online 2017 Aug 2. Published online 2017 Sep 27. doi: 10.1128/JVI.00643-17
PMCID:
PMC5625507
AbstractArticlePDF–4.2M
18.
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2
Yonghong Liu, Linlin Qu, Yuanyuan Liu, Bernard Roizman, Grace Guoying Zhou
Proc Natl Acad Sci U S A. 2017 Aug 15; 114(33): E6902–E6911. Published online 2017 Jul 31. doi: 10.1073/pnas.1708713114
PMCID:
PMC5565464
AbstractArticlePDF–1.8M
19.
Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells
M. J. Corby, Michael R. Stoneman, Gabriel Biener, Joel D. Paprocki, Rajesh Kolli, Valerica Raicu, David N. Frick
J Biol Chem. 2017 Jul 7; 292(27): 11165–11177. Published online 2017 May 8. doi: 10.1074/jbc.M117.777045
PMCID:
PMC5500786
AbstractArticlePDF–2.0M
20.
LGP2 Synergy with MDA5 in RLR-Mediated RNA Recognition and Antiviral Signaling
Annie M. Bruns, Curt M. Horvath
Cytokine. Author manuscript; available in PMC 2016 Aug 1.
Published in final edited form as: Cytokine. 2015 Aug; 74(2): 198–206. Published online 2015 Mar 18. doi: 10.1016/j.cyto.2015.02.010
PMCID:
PMC4475439
AbstractArticlePDF–353K

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