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Select item 109489361.

SIRT4 as a novel interactor and candidate suppressor of C-RAF kinase in MAPK signaling

Mehrnaz Mehrabipour, Saeideh Nakhaei-Rad, Radovan Dvorsky, Alexander Lang, Patrick Verhülsdonk, Mohammad R Ahmadian, Roland P Piekorz

Life Sci Alliance. 2024 Jun; 7(6): e202302507. Published online 2024 Mar 18. doi: 10.26508/lsa.202302507

PMCID:: PMC10948936

Abstract Article PDF–2.4M

Select item 104998212.

Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets

Filip Mihalič, Caroline Benz, Eszter Kassa, Richard Lindqvist, Leandro Simonetti, Raviteja Inturi, Hanna Aronsson, Eva Andersson, Celestine N. Chi, Norman E. Davey, Anna K. Överby, Per Jemth, Ylva Ivarsson

Nat Commun. 2023; 14: 5636. Published online 2023 Sep 13. doi: 10.1038/s41467-023-41312-8

PMCID:: PMC10499821

Abstract Article PDF–2.6M

Select item 101128023.

Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1)

Jiale Shi, Xuemei Jia, Yujia He, Xinyue Ma, Xiaoyu Qi, Wan Li, Shou-Jiang Gao, Qin Yan, Chun Lu

PLoS Pathog. 2023 Apr; 19(4): e1011324. Published online 2023 Apr 6. doi: 10.1371/journal.ppat.1011324

PMCID:: PMC10112802

Abstract Article PDF–4.4M

Select item 99503744.

Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway

Juan Li, Hanxiang Zhan, Yidan Ren, Maoxiao Feng, Qin Wang, Qinlian Jiao, Yuli Wang, Xiaoyan Liu, Shujun Zhang, Lutao Du, Yunshan Wang, Chuanxin Wang

Cell Death Differ. 2023 Feb; 30(2): 313–326. Published online 2022 Oct 8. doi: 10.1038/s41418-022-01063-3

PMCID:: PMC9950374

Abstract Article PDF–7.0M

Select item 93352245.

Deacetylation of MTHFD2 by SIRT4 senses stress signal to inhibit cancer cell growth by remodeling folate metabolism

Fan Zhang, Di Wang, Jintao Li, Ying Su, Suling Liu, Qun-Ying Lei, Miao Yin

J Mol Cell Biol. 2022 Apr; 14(4): mjac020. Published online 2022 Mar 29. doi: 10.1093/jmcb/mjac020

PMCID:: PMC9335224

Abstract Article PDF–1.0M

Select item 92885106.

SIRT4 functions as a tumor suppressor during prostate cancer by inducing apoptosis and inhibiting glutamine metabolism

Guohao Cai, Zhuhui Ge, Yunqiu Xu, Liangliang Cai, Pingliang Sun, Guoyu Huang

Sci Rep. 2022; 12: 12208. Published online 2022 Jul 16. doi: 10.1038/s41598-022-16610-8

PMCID:: PMC9288510

Abstract Article PDF–7.2M

Select item 83830367.

Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR-1276/SIRT4 axis

Lingli Xu, Ke Xu, Lijun Xiang, Jiamei Yan

Mol Med Rep. 2021 Oct; 24(4): 728. Published online 2021 Aug 13. doi: 10.3892/mmr.2021.12367

PMCID:: PMC8383036

Abstract Article PDF–1.3M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74499259.

Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells

Lutao Du, Xiaoyan Liu, Yidan Ren, Juan Li, Peilong Li, Qinlian Jiao, Peng Meng, Fang Wang, Yuli Wang, Yun-shan Wang, Chuanxin Wang

Theranostics. 2020; 10(21): 9458–9476. Published online 2020 Jul 25. doi: 10.7150/thno.44688

PMCID:: PMC7449925

Abstract Article PDF–4.1M

Select item 725604510.

Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth

Ming-Zhu Lei, Xu-Xu Li, Ye Zhang, Jin-Tao Li, Fan Zhang, Yi-Ping Wang, Miao Yin, Jia Qu, Qun-Ying Lei

Signal Transduct Target Ther. 2020; 5: 70. Published online 2020 May 29. doi: 10.1038/s41392-020-0168-0

PMCID:: PMC7256045

Abstract Article PDF–2.0M

Select item 694447011.

Anabolic SIRT4 Exerts Retrograde Control over TORC1 Signaling by Glutamine Sparing in the Mitochondria

Eisha Shaw, Manasi Talwadekar, Zeenat Rashida, Nitya Mohan, Aishwarya Acharya, Subhash Khatri, Sunil Laxman, Ullas Kolthur-Seetharam

Mol Cell Biol. 2020 Jan; 40(2): e00212-19. Prepublished online 2019 Nov 4. Published online 2020 Jan 3. doi: 10.1128/MCB.00212-19

PMCID:: PMC6944470

Abstract Article PDF–4.5M

Select item 686274612.

SIRT4 silencing in tumor-associated macrophages promotes HCC development via PPARδ signalling-mediated alternative activation of macrophages

Zhi Li, He Li, Zhi-Bo Zhao, Wei Zhu, Pan-Pan Feng, Xi-Wen Zhu, Jian-Ping Gong

J Exp Clin Cancer Res. 2019; 38: 469. Published online 2019 Nov 19. doi: 10.1186/s13046-019-1456-9

PMCID:: PMC6862746

Abstract Article PDF–5.7M

Select item 585465813.

Mitochondrial Sirtuin 4 Resolves Immune Tolerance in Monocytes by Rebalancing Glycolysis and Glucose Oxidation Homeostasis

Jie Tao, Jingpu Zhang, Yun Ling, Charles E. McCall, Tie Fu Liu

Front Immunol. 2018; 9: 419. Published online 2018 Mar 9. doi: 10.3389/fimmu.2018.00419

PMCID:: PMC5854658

Abstract Article PDF–1.4M

Select item 568056114.

SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy

Alexander Lang, Ruchika Anand, Simone Altinoluk-Hambüchen, Hakima Ezzahoini, Anja Stefanski, Afshin Iram, Laura Bergmann, Jennifer Urbach, Philip Böhler, Jan Hänsel, Manuel Franke, Kai Stühler, Jean Krutmann, Jürgen Scheller, Björn Stork, Andreas S. Reichert, Roland P. Piekorz

Aging (Albany NY) 2017 Oct; 9(10): 2163–2189. Published online 2017 Oct 29. doi: 10.18632/aging.101307

Correction in:: Aging (Albany NY). 2018 Sep; 10(9): 2536.

PMCID:: PMC5680561

Abstract Article PDF–1.6M

Select item 557675215.

Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans

Rachele Sangaletti, Massimo D’Amico, Jeff Grant, David Della-Morte, Laura Bianchi

PLoS Genet. 2017 Aug; 13(8): e1006965. Published online 2017 Aug 18. doi: 10.1371/journal.pgen.1006965

PMCID:: PMC5576752

Abstract Article PDF–7.0M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 532576317.

HSP90 shapes the consequences of human genetic variation

Georgios I. Karras, Song Yi, Nidhi Sahni, Máté Fischer, Jenny Xie, Marc Vidal, Alan D. D'Andrea, Luke Whitesell, Susan Lindquist

Cell. Author manuscript; available in PMC 2018 Feb 23.

Published in final edited form as: Cell. 2017 Feb 23; 168(5): 856–866.e12. Published online 2017 Feb 16. doi: 10.1016/j.cell.2017.01.023

PMCID:: PMC5325763

Abstract Article PDF–2.4M

Select item 483314118.

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

Alexander Lang, Susanne Grether-Beck, Madhurendra Singh, Fabian Kuck, Sascha Jakob, Andreas Kefalas, Simone Altinoluk-Hambüchen, Nina Graffmann, Maren Schneider, Antje Lindecke, Heidi Brenden, Ingo Felsner, Hakima Ezzahoini, Alessandra Marini, Sandra Weinhold, Andrea Vierkötter, Julia Tigges, Stephan Schmidt, Kai Stühler, Karl Köhrer, Markus Uhrberg, Judith Haendeler, Jean Krutmann, Roland P. Piekorz

Aging (Albany NY) 2016 Mar; 8(3): 484–505. Published online 2016 Feb 26. doi: 10.18632/aging.100905

PMCID:: PMC4833141

Abstract Article PDF–4.0M

Select item 481144919.

Assessing sirtuin expression in endometrial carcinoma and non-neoplastic endometrium

Carla Bartosch, Sara Monteiro-Reis, Diogo Almeida-Rios, Renata Vieira, Armando Castro, Manuel Moutinho, Marta Rodrigues, Inês Graça, José Manuel Lopes, Carmen Jerónimo

Oncotarget. 2016 Jan 12; 7(2): 1144–1154. Published online 2015 Dec 19. doi: 10.18632/oncotarget.6691

PMCID:: PMC4811449

Abstract Article PDF–5.3M

Select item 466978020.

CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4

L Wang, H Zhou, Y Wang, G Cui, L-j Di

Cell Death Dis. 2015 Jan; 6(1): e1620. Published online 2015 Jan 29. doi: 10.1038/cddis.2014.587

PMCID:: PMC4669780

Abstract Article PDF–2.4M

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