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Select item 110770831.

Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette

Nucleic Acids Res. 2024 May 8; 52(8): 4167–4184. Published online 2024 Feb 7. doi: 10.1093/nar/gkae071

PMCID:: PMC11077083

Abstract Article PDF–3.3M

Select item 110066922.

CaMKⅡγ和CaMKⅡδ通过PI3K/Akt/Erk信号通路减轻小鼠神经元缺血再灌注损伤

刘昊铭, 林子诗, 叶靖

Nan Fang Yi Ke Da Xue Xue Bao. 2024 Mar 20; 44(3): 563–570. Chinese. doi: 10.12122/j.issn.1673-4254.2024.03.18

PMCID:: PMC11006692

Abstract Article PDF–2.1M

Select item 108429883.

Elimination of CaMKIIδ autophosphorylation by CRISPR-Cas9 base editing improves survival and cardiac function in heart failure in mice

Simon Lebek, Xurde M. Caravia, Francesco Chemello, Wei Tan, John R. McAnally, Kenian Chen, Lin Xu, Ning Liu, Rhonda Bassel-Duby, Eric N. Olson

Circulation. Author manuscript; available in PMC 2024 Nov 7.

Published in final edited form as: Circulation. 2023 Nov 7; 148(19): 1490–1504. Published online 2023 Sep 15. doi: 10.1161/CIRCULATIONAHA.123.065117

PMCID:: PMC10842988

Abstract Article PDF–3.3M

Select item 107835754.

Using CRISPR-Cas9/phosphoproteomics to identify substrates of calcium/calmodulin-dependent kinase 2δ

Euijung Park, Chin-Rang Yang, Viswanathan Raghuram, Lihe Chen, Chung-Lin Chou, Mark A. Knepper

J Biol Chem. 2023 Dec; 299(12): 105371. Published online 2023 Oct 20. doi: 10.1016/j.jbc.2023.105371

PMCID:: PMC10783575

Abstract Article PDF–2.7M

Select item 103078525.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 96434386.

Oxidative stress–induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain

Nathália Rocco-Machado, Lo Lai, Geumsoo Kim, Yi He, Elizabeth D. Luczak, Mark E. Anderson, Rodney L. Levine

J Biol Chem. 2022 Nov; 298(11): 102579. Published online 2022 Oct 8. doi: 10.1016/j.jbc.2022.102579

PMCID:: PMC9643438

Abstract Article PDF–2.1M

Select item 96361507.

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

Yinuo Wang, Adel Elsherbiny, Linda Kessler, Julio Cordero, Haojie Shi, Heike Serke, Olga Lityagina, Felix A. Trogisch, Mona Malek Mohammadi, Ibrahim El-Battrawy, Johannes Backs, Thomas Wieland, Joerg Heineke, Gergana Dobreva

Nat Commun. 2022; 13: 6663. Published online 2022 Nov 4. doi: 10.1038/s41467-022-34366-7

PMCID:: PMC9636150

Abstract Article PDF–8.9M

Select item 96038608.

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3

Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany

Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527

PMCID:: PMC9603860

Abstract Article PDF–3.4M

Select item 89831439.

Dendritic cell immunoreceptor drives atopic dermatitis by modulating oxidized CaMKII-involved mast cell activation

Xiaoyan Luo, Jingsi Chen, Huan Yang, Xinyue Hu, Martin P. Alphonse, Yingchun Shen, Yuko Kawakami, Xiaoying Zhou, Wei Tu, Toshiaki Kawakami, Mei Wan, Nathan K. Archer, Hua Wang, Peisong Gao

JCI Insight. 2022 Mar 8; 7(5): e152559. Published online 2022 Mar 8. doi: 10.1172/jci.insight.152559

PMCID:: PMC8983143

Abstract Article PDF–16M

Select item 869386310.

ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion

Tamar Eigler, Giulia Zarfati, Emmanuel Amzallag, Sansrity Sinha, Nadav Segev, Yishaia Zabary, Assaf Zaritsky, Avraham Shakked, Kfir-Baruch Umansky, Eyal D. Schejter, Douglas P. Millay, Eldad Tzahor, Ori Avinoam

Dev Cell. 2021 Dec 20; 56(24): 3349–3363.e6. doi: 10.1016/j.devcel.2021.11.022

PMCID:: PMC8693863

Abstract Article

Select item 846102911.

The oxidation‐resistant CaMKII‐MM281/282VV mutation does not prevent arrhythmias in CPVT1

Mani Sadredini, Ravinea Manotheepan, Stephan E. Lehnart, Mark E. Anderson, Ivar Sjaastad, Mathis K. Stokke

Physiol Rep. 2021 Sep; 9(18): e15030. Published online 2021 Sep 23. doi: 10.14814/phy2.15030

PMCID:: PMC8461029

Abstract Article PDF–1.5M

Select item 836552612.

Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance

Wen Dai, Mayank Choubey, Sonal Patel, Harold A. Singer, Lale Ozcan

Mol Metab. 2021 Nov; 53: 101300. Published online 2021 Jul 22. doi: 10.1016/j.molmet.2021.101300

PMCID:: PMC8365526

Abstract Article PDF–2.9M

Select item 834924513.

Hyperglycemia regulates cardiac K⁺ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways

Bence Hegyi, Johanna M. Borst, Logan R. J. Bailey, Erin Y. Shen, Austen J. Lucena, Manuel F. Navedo, Julie Bossuyt, Donald M. Bers

Basic Res Cardiol. Author manuscript; available in PMC 2021 Nov 25.

Published in final edited form as: Basic Res Cardiol. 2020 Nov 25; 115(6): 71. Published online 2020 Nov 25. doi: 10.1007/s00395-020-00834-8

PMCID:: PMC8349245

Abstract Article PDF–5.4M

Select item 822373914.

CaMKIIδ is upregulated by proinflammatory cytokine IL-6 in a JAK/STAT3-dependent manner to promote angiogenesis

Brendan J. O’Brien, Harold A. Singer, Alejandro P. Adam, Roman G. Ginnan

FASEB J. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: FASEB J. 2021 Apr; 35(4): e21437. doi: 10.1096/fj.202002755R

PMCID:: PMC8223739

Abstract Article PDF–2.4M

Select item 822153915.

CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia

Bence Hegyi, Anna Fasoli, Christopher Y. Ko, Benjamin W. Van, Chidera C. Alim, Erin Y. Shen, Marisa M. Ciccozzi, Srinivas Tapa, Crystal M. Ripplinger, Jeffrey R. Erickson, Julie Bossuyt, Donald M. Bers

Circ Res. 2021 Jun 25; 129(1): 98–113. Published online 2021 Apr 30. doi: 10.1161/CIRCRESAHA.120.318402

PMCID:: PMC8221539

Abstract Article PDF–10M

Select item 793877016.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 773649017.

CaMKII exacerbates heart failure progression by activating class I HDACs

Manling Zhang, Xue Yang, Raymond J. Zimmerman, Qin Wang, Mark A. Ross, Jonathan M. Granger, Elizabeth D. Luczak, Djahida Bedja, Hong Jiang, Ning Feng

J Mol Cell Cardiol. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: J Mol Cell Cardiol. 2020 Dec; 149: 73–81. Published online 2020 Sep 22. doi: 10.1016/j.yjmcc.2020.09.007

PMCID:: PMC7736490

Abstract Article PDF–1.8M

Select item 771970818.

Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-δ in sepsis-associated liver injury

Tao Tian, Danhua Yao, Lei Zheng, Zhiyuan Zhou, Yantao Duan, Bin Liu, Pengfei Wang, Yousheng Li

Cell Death Dis. 2020 Dec; 11(12): 1037. Published online 2020 Dec 6. doi: 10.1038/s41419-020-03255-6

PMCID:: PMC7719708

Abstract Article PDF–2.6M

Select item 745624419.

MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII

Klitos Konstantinidis, Vassilios J. Bezzerides, Lo Lai, Holly M. Isbell, An-Chi Wei, Yuejin Wu, Meera C. Viswanathan, Ian D. Blum, Jonathan M. Granger, Danielle Heims-Waldron, Donghui Zhang, Elizabeth D. Luczak, Kevin R. Murphy, Fujian Lu, Daniel H. Gratz, Bruno Manta, Qiang Wang, Qinchuan Wang, Alex L. Kolodkin, Vadim N. Gladyshev, Thomas J. Hund, William T. Pu, Mark N. Wu, Anthony Cammarato, Mario A. Bianchet, Madeline A. Shea, Rodney L. Levine, Mark E. Anderson

J Clin Invest. 2020 Sep 1; 130(9): 4663–4678. Published online 2020 Aug 4. doi: 10.1172/JCI133181

PMCID:: PMC7456244

Abstract Article PDF–5.9M

Select item 721007820.

Hyperglycemia Acutely Increases Cytosolic Reactive Oxygen Species via O-linked GlcNAcylation and CaMKII Activation in Mouse Ventricular Myocytes

Shan Lu, Zhandi Liao, Xiyuan Lu, Dörthe M. Katschinski, Mark Mercola, Ju Chen, Joan Heller Brown, Jeffery D. Molkentin, Julie Bossuyt, Donald M. Bers

Circ Res. Author manuscript; available in PMC 2021 May 8.

Published in final edited form as: Circ Res. 2020 May 8; 126(10): e80–e96. Published online 2020 Mar 5. doi: 10.1161/CIRCRESAHA.119.316288

PMCID:: PMC7210078

Abstract Article PDF–3.0M

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