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Items: 1 to 20 of 344

1.
TLR and IKK complex mediated innate immune signaling inhibits stress granule assembly
Parimal Samir, David E. Place, R. K. Subbarao Malireddi, Thirumala-Devi Kanneganti
J Immunol. Author manuscript; available in PMC 2024 Dec 10.
Published in final edited form as: J Immunol. 2021 Jul 1; 207(1): 115–124. Published online 2021 Jun 18. doi: 10.4049/jimmunol.2100115
PMCID:
PMC11631289
AbstractArticlePDF–4.5M
2.
Periostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway
Satoshi Nunomura, Daisuke Uta, Isao Kitajima, Yasuhiro Nanri, Kosuke Matsuda, Naoko Ejiri, Midori Kitajima, Hitoshi Ikemitsu, Misaki Koga, Sayaka Yamamoto, Yuko Honda, Hironobu Takedomi, Tsugunobu Andoh, Simon J. Conway, Kenji Izuhara
Cell Rep. Author manuscript; available in PMC 2024 Oct 17.
Published in final edited form as: Cell Rep. 2023 Jan 31; 42(1): 111933. Published online 2023 Jan 6. doi: 10.1016/j.celrep.2022.111933
PMCID:
PMC11486451
AbstractArticlePDF–2.8M
3.
Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice
Daniel A.C. Fisher, Angelo B.A. Laranjeira, Tim Kong, Steven C. Snyder, Kevin Shim, Mary C. Fulbright, Stephen T. Oh
Exp Hematol. Author manuscript; available in PMC 2024 Jul 6.
Published in final edited form as: Exp Hematol. 2023 Dec; 128: 48–66. Published online 2023 Aug 21. doi: 10.1016/j.exphem.2023.08.005
PMCID:
PMC11227100
AbstractArticlePDF–3.9M
4.
Activation of the IKK2/NF-κB pathway in VSMCs inhibits calcified vascular stiffness in CKD
Shinobu Miyazaki-Anzai, Masashi Masuda, Audrey L. Keenan, Yuji Shiozaki, Jose G. Miranda, Makoto Miyazaki
JCI Insight. 2024 Apr 8; 9(7): e174977. Published online 2024 Mar 12. doi: 10.1172/jci.insight.174977
PMCID:
PMC11128211
AbstractArticlePDF–7.5M
5.
Sustained activation of NF-κB through constitutively active IKKβ leads to senescence bypass in murine dermal fibroblasts
Masayuki Harada, Kanae Su-Harada, Takeshi Kimura, Koh Ono, Noboru Ashida
Cell Cycle. 2024; 23(3): 308–327. Published online 2024 Mar 10. doi: 10.1080/15384101.2024.2325802
PMCID:
PMC11057680
AbstractArticlePDF–1.9M
6.
IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model
Chelisa Cardinez, Yuwei Hao, Kristy Kwong, Ainsley R. Davies, Morgan B. Downes, Nadia A. Roberts, Jason D. Price, Raquel A. Hernandez, Jessica Lovell, Rochna Chand, Zhi-Ping Feng, Anselm Enders, Carola G. Vinuesa, Bahar Miraghazadeh, Matthew C. Cook
Nat Commun. 2024; 15: 2345. Published online 2024 Mar 25. doi: 10.1038/s41467-024-45870-3
PMCID:
PMC10963799
AbstractArticlePDF–6.0M
7.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
8.
IKKβ deletion from CNS macrophages increases neuronal excitability and accelerates the onset of EAE, while from peripheral macrophages reduces disease severity
Maria Avloniti, Maria Evangelidou, Maria Gomini, Theodore Loupis, Mary Emmanouil, Adamantia Mitropoulou, Theodore Tselios, Hans Lassmann, Agnès Gruart, José M. Delgado-García, Lesley Probert, Vasiliki Kyrargyri
J Neuroinflammation. 2024; 21: 34. Published online 2024 Jan 27. doi: 10.1186/s12974-024-03023-9
PMCID:
PMC10821407
AbstractArticlePDF–7.0M
9.
IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation
Yohei Iguchi, Yuhei Takahashi, Jiayi Li, Kunihiko Araki, Yoshinobu Amakusa, Yu Kawakami, Kenta Kobayashi, Satoshi Yokoi, Masahisa Katsuno
J Cell Biol. 2024 Feb 5; 223(2): e202302048. Published online 2024 Jan 10. doi: 10.1083/jcb.202302048
PMCID:
PMC10783433
AbstractArticlePDF–6.5M
10.
Endothelial-specific loss of IKKβ disrupts pulmonary endothelial angiogenesis and impairs postnatal lung growth
Shailaja Rao, Min Liu, Cristiana Iosef, Carsten Knutsen, Cristina M. Alvira
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 1; 325(3): L299–L313. Published online 2023 Jun 13. doi: 10.1152/ajplung.00034.2023
PMCID:
PMC10625829
AbstractArticle
11.
Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance
John D. Douglass, Kelly M. Ness, Martin Valdearcos, Alice Wyse-Jackson, Mauricio D. Dorfman, Jeremy M. Frey, Rachael D. Fasnacht, Olivia D. Santiago, Anzela Niraula, Jineta Banerjee, Megan Robblee, Suneil K. Koliwad, Joshua P. Thaler
Cell Metab. Author manuscript; available in PMC 2024 Sep 5.
Published in final edited form as: Cell Metab. 2023 Sep 5; 35(9): 1613–1629.e8. Published online 2023 Aug 11. doi: 10.1016/j.cmet.2023.07.008
PMCID:
PMC10528677
AbstractArticlePDF–1.5M
12.
Differential Modulation of miR-122 Transcription by TGFβ1/BMP6: Implications for Nonresolving Inflammation and Hepatocarcinogenesis
Martha Paluschinski, Claus Kordes, Mihael Vucur, Veronika Buettner, Christoph Roderburg, Haifeng C. Xu, Prashant V. Shinte, Philipp A. Lang, Tom Luedde, Mirco Castoldi
Cells. 2023 Aug; 12(15): 1955. Published online 2023 Jul 27. doi: 10.3390/cells12151955
PMCID:
PMC10416984
AbstractArticlePDF–4.8M
13.
Microglia-specific knock-out of NF-κB/IKK2 increases accumulation of misfolded α-synuclein through inhibition of p62/SQSTM-1-dependent autophagy in the rotenone model of Parkinson’s disease
Savannah M. Rocha, Kelly S. Kirkley, Debotri Chatterjee, Tawfik A. Aboellail, Richard J. Smeyne, Ronald B. Tjalkens
Glia. Author manuscript; available in PMC 2024 Sep 1.
Published in final edited form as: Glia. 2023 Sep; 71(9): 2154–2179. Published online 2023 May 18. doi: 10.1002/glia.24385
PMCID:
PMC10330367
AbstractArticlePDF–5.4M
14.
E3 ligase HECTD3 promotes RNA virus replication and virus-induced inflammation via K33-linked polyubiquitination of PKR
Jiaying Huang, Zhou Yu, Xuelian Li, Mingjin Yang, Qian Fang, Zheng Li, Chunmei Wang, Taoyong Chen, Xuetao Cao
Cell Death Dis. 2023 Jul; 14(7): 396. Published online 2023 Jul 4. doi: 10.1038/s41419-023-05923-9
PMCID:
PMC10319860
AbstractArticlePDF–3.7M
15.
Toll-like receptors 2, 4, and 9 modulate promoting effect of COPD-like airway inflammation on K-ras-driven lung cancer through activation of the MyD88/NF-ĸB pathway in the airway epithelium
Walter V. Velasco, Nasim Khosravi, Susana Castro-Pando, Nelly Torres-Garza, Maria T. Grimaldo, Avantika Krishna, Michael J. Clowers, Misha Umer, Sabah Tariq Amir, Diana Del Bosque, Soudabeh Daliri, Maria Miguelina De La Garza, Marco Ramos-Castaneda, Scott E. Evans, Seyed Javad Moghaddam
Front Immunol. 2023; 14: 1118721. Published online 2023 May 22. doi: 10.3389/fimmu.2023.1118721
PMCID:
PMC10240392
AbstractArticlePDF–3.5M
16.
Macrophage DCLK1 promotes atherosclerosis via binding to IKKβ and inducing inflammatory responses
Zhuqi Huang, Sirui Shen, Xue Han, Weixin Li, Wu Luo, Liming Lin, Mingjiang Xu, Yi Wang, Weijian Huang, Gaojun Wu, Guang Liang
EMBO Mol Med. 2023 May; 15(5): e17198. Published online 2023 Mar 10. doi: 10.15252/emmm.202217198
PMCID:
PMC10165355
AbstractArticlePDF–3.6M
17.
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
Kenta Kuramoto, Huijia Liang, Jung-Hwa Hong, Congcong He
Cell Metab. Author manuscript; available in PMC 2024 Apr 4.
Published in final edited form as: Cell Metab. 2023 Apr 4; 35(4): 620–632.e5. Published online 2023 Feb 21. doi: 10.1016/j.cmet.2023.01.011
PMCID:
PMC10079584
AbstractArticlePDF–2.5M
18.
Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ
Magda Spella, Giannoula Ntaliarda, Georgios Skiadas, Anne-Sophie Lamort, Malamati Vreka, Antonia Marazioti, Ioannis Lilis, Eleni Bouloukou, Georgia A. Giotopoulou, Mario A. A. Pepe, Stefanie A. I. Weiss, Agnese Petrera, Stefanie M. Hauck, Ina Koch, Michael Lindner, Rudolph A. Hatz, Juergen Behr, Kristina A. M. Arendt, Ioanna Giopanou, David Brunn, Rajkumar Savai, Dieter E. Jenne, Maarten de Château, Fiona E. Yull, Timothy S. Blackwell, Georgios T. Stathopoulos
Cancers (Basel) 2023 Mar; 15(6): 1866. Published online 2023 Mar 20. doi: 10.3390/cancers15061866
PMCID:
PMC10047096
AbstractArticlePDF–6.8M
19.
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer
Chenxi Zhong, Guosheng Xiong, Haitang Yang, Xiaohua Du, Jiankui Du, Feng Yao, Wentao Fang, Yuezhen Deng
Int J Biol Sci. 2023; 19(4): 1110–1122. Published online 2023 Feb 5. doi: 10.7150/ijbs.82015
PMCID:
PMC10008690
AbstractArticlePDF–6.9M
20.
Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB
Gretchen A Meyer, Stavros Thomopoulos, Yousef Abu-Amer, Karen C Shen
eLife. 2022; 11: e82016. Published online 2022 Dec 12. doi: 10.7554/eLife.82016
PMCID:
PMC9873255
AbstractArticlePDF–14M

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