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Items: 1 to 20 of 39

1.
Spt5 modulates cotranscriptional spliceosome assembly in Saccharomyces cerevisiae
Isabella E. Maudlin, Jean D. Beggs
RNA. 2019 Oct; 25(10): 1298–1310. doi: 10.1261/rna.070425.119
PMCID:
PMC6800482
AbstractArticlePDF–1.1M
2.
An Allosteric Network for Spliceosome Activation Revealed by High-Throughput Suppressor Analysis in Saccharomyces cerevisiae
David A. Brow
Genetics. 2019 May; 212(1): 111–124. Published online 2019 Mar 21. doi: 10.1534/genetics.119.301922
PMCID:
PMC6499515
AbstractArticlePDF–2.4M
3.
Prespliceosome structure provides insights into spliceosome assembly and regulation
Clemens Plaschka, Pei-Chun Lin, Clément Charenton, Kiyoshi Nagai
Nature. Author manuscript; available in PMC 2019 Jan 11.
Published in final edited form as: Nature. 2018 Jul; 559(7714): 419–422. Published online 2018 Jul 11. doi: 10.1038/s41586-018-0323-8
PMCID:
PMC6141012
AbstractArticlePDF–6.5M
4.
The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex
Penghui Bao, Cindy L. Will, Henning Urlaub, Kum-Loong Boon, Reinhard Lührmann
Genes Dev. 2017 Dec 1; 31(23-24): 2416–2429. doi: 10.1101/gad.308163.117
PMCID:
PMC5795787
AbstractArticlePDF–7.6M
5.
A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex
Margaret L. Rodgers, Allison L. Didychuk, Samuel E. Butcher, David A. Brow, Aaron A. Hoskins
Nucleic Acids Res. 2016 Dec 15; 44(22): 10912–10928. Published online 2016 Aug 2. doi: 10.1093/nar/gkw686
PMCID:
PMC5159527
AbstractArticlePDF–2.6M
6.
Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity
Sarah Ledoux, Christine Guthrie
J Biol Chem. 2016 Jun 3; 291(23): 11954–11965. Published online 2016 Apr 12. doi: 10.1074/jbc.M115.710848
PMCID:
PMC4933248
AbstractArticlePDF–845K
7.
Single molecule analysis reveals reversible and irreversible steps during spliceosome activation
Aaron A Hoskins, Margaret L Rodgers, Larry J Friedman, Jeff Gelles, Melissa J Moore
eLife. 2016; 5: e14166. Published online 2016 May 31. doi: 10.7554/eLife.14166
PMCID:
PMC4922858
AbstractArticlePDF–2.9M
8.
Structural analysis of multi-helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA
Gabriel Cornilescu, Allison L. Didychuk, Margaret L. Rodgers, Lauren A. Michael, Jordan E. Burke, Eric J. Montemayor, Aaron A. Hoskins, Samuel E. Butcher
J Mol Biol. Author manuscript; available in PMC 2017 Feb 27.
Published in final edited form as: J Mol Biol. 2016 Feb 27; 428(5 Pt A): 777–789. Published online 2015 Dec 2. doi: 10.1016/j.jmb.2015.11.026
PMCID:
PMC4790120
AbstractArticlePDF–758K
9.
CryoEM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution
Thi Hoang Duong Nguyen, Wojciech P. Galej, Xiao-chen Bai, Chris Oubridge, Andrew J. Newman, Sjors H. W. Scheres, Kiyoshi Nagai
Nature. Author manuscript; available in PMC 2016 Aug 18.
Published in final edited form as: Nature. 2016 Feb 18; 530(7590): 298–302. Published online 2016 Feb 1. doi: 10.1038/nature16940
PMCID:
PMC4762201
AbstractArticlePDF–6.1M
10.
Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly
Allison L. Didychuk, Eric J. Montemayor, David A. Brow, Samuel E. Butcher
Nucleic Acids Res. 2016 Feb 18; 44(3): 1398–1410. Published online 2015 Dec 15. doi: 10.1093/nar/gkv1374
PMCID:
PMC4756825
AbstractArticlePDF–9.3M
11.
Target selection by natural and redesigned PUF proteins
Douglas F. Porter, Yvonne Y. Koh, Brett VanVeller, Ronald T. Raines, Marvin Wickens
Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52): 15868–15873. Published online 2015 Dec 14. doi: 10.1073/pnas.1508501112
PMCID:
PMC4703012
AbstractArticlePDF–1.3M
12.
Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET
John W. Hardin, Chandani Warnasooriya, Yasushi Kondo, Kiyoshi Nagai, David Rueda
Nucleic Acids Res. 2015 Dec 15; 43(22): 10963–10974. Published online 2015 Oct 25. doi: 10.1093/nar/gkv1011
PMCID:
PMC4678811
AbstractArticlePDF–1.6M
13.
NUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins
Jonathan Bizarro, Maxime Dodré, Alexandra Huttin, Bruno Charpentier, Florence Schlotter, Christiane Branlant, Céline Verheggen, Séverine Massenet, Edouard Bertrand
Nucleic Acids Res. 2015 Oct 15; 43(18): 8973–8989. Published online 2015 Oct 10. doi: 10.1093/nar/gkv809
PMCID:
PMC4605303
AbstractArticlePDF–11M
14.
The architecture of the spliceosomal U4/U6.U5 tri-snRNP
Thi Hoang Duong Nguyen, Wojciech P. Galej, Xiao-chen Bai, Christos G. Savva, Andrew J. Newman, Sjors H. W. Scheres, Kiyoshi Nagai
Nature. Author manuscript; available in PMC 2016 Jan 2.
Published in final edited form as: Nature. 2015 Jul 2; 523(7558): 47–52. Published online 2015 Jun 24. doi: 10.1038/nature14548
PMCID:
PMC4536768
AbstractArticlePDF–6.7M
15.
Spliceosome assembly in the absence of stable U4/U6 RNA pairing
Jordan E. Burke, Samuel E. Butcher, David A. Brow
RNA. 2015 May; 21(5): 923–934. doi: 10.1261/rna.048421.114
PMCID:
PMC4408799
AbstractArticlePDF–1.1M
16.
Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding
Lingdi Zhang, Xueni Li, Ryan C. Hill, Yan Qiu, Wenzheng Zhang, Kirk C. Hansen, Rui Zhao
Nucleic Acids Res. 2015 Mar 31; 43(6): 3286–3297. Published online 2015 Feb 10. doi: 10.1093/nar/gkv062
PMCID:
PMC4381053
AbstractArticlePDF–5.3M
17.
A novel mechanism for Prp5 function in prespliceosome formation and proofreading the branch site sequence
Wen-Wei Liang, Soo-Chen Cheng
Genes Dev. 2015 Jan 1; 29(1): 81–93. doi: 10.1101/gad.253708.114
PMCID:
PMC4281567
AbstractArticlePDF–910K
18.
Sad1 Counteracts Brr2-Mediated Dissociation of U4/U6.U5 in Tri-snRNP Homeostasis
Yu-Hsin Huang, Che-Sheng Chung, Der-I Kao, Tzu-Chung Kao, Soo-Chen Cheng
Mol Cell Biol. 2014 Jan; 34(2): 210–220. doi: 10.1128/MCB.00837-13
PMCID:
PMC3911299
AbstractArticlePDF–2.1M
19.
An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8
Argenta M. Price, Janina Görnemann, Christine Guthrie, David A. Brow
RNA. 2014 Jan; 20(1): 46–60. doi: 10.1261/rna.041970.113
PMCID:
PMC3866644
AbstractArticlePDF–536K
20.
Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5′ splice site and branch site
Daniel J. Crawford, Aaron A. Hoskins, Larry J. Friedman, Jeff Gelles, Melissa J. Moore
Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17): 6783–6788. Published online 2013 Apr 8. doi: 10.1073/pnas.1219305110
PMCID:
PMC3637735
AbstractArticlePDF–1.0M

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