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Select item 107216691.

CD137L Inhibition Ameliorates Hippocampal Neuroinflammation and Behavioral Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

Fang Qiu, Yueming Liu, Yang Liu, Zhuyun Zhao, Lile Zhou, Pengfei Chen, Yunbo Du, Yanmei Wang, Huimin Sun, Changchun Zeng, Xiaokang Wang, Yuqiang Liu, Haobo Pan, Changneng Ke

Neuromolecular Med. 2023; 25(4): 616–631. Published online 2023 Oct 5. doi: 10.1007/s12017-023-08764-z

PMCID:: PMC10721669

Abstract Article PDF–2.2M

Select item 92916572.

Synergistic antitumor response with recombinant modified virus Ankara armed with CD40L and CD137L against peritoneal carcinomatosis

Ángela Bella, Leire Arrizabalaga, Claudia Augusta Di Trani, Assunta Cirella, Myriam Fernandez-Sendin, Celia Gomar, Joan Salvador Russo-Cabrera, Inmaculada Rodríguez, José González-Gomariz, Maite Alvarez, Álvaro Teijeira, José Medina-Echeverz, Maria Hinterberger, Hubertus Hochrein, Ignacio Melero, Pedro Berraondo, Fernando Aranda

Oncoimmunology. 2022; 11(1): 2098657. Published online 2022 Jul 13. doi: 10.1080/2162402X.2022.2098657

PMCID:: PMC9291657

Abstract Article PDF–5.3M

Select item 89414613.

4-1BBL–containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells

Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Sara De Biasi, Wioleta Dudka, Bac Viet Le, Agata Kominek, Salwador Cyranowski, Paulina Pilanc, Elyas Mohammadi, Dominik Cysewski, Ewa Kozlowska, Wioleta Grabowska-Pyrzewicz, Urszula Wojda, Grzegorz Basak, Jakub Mieczkowski, Tomasz Skorski, Andrea Cossarizza, Katarzyna Piwocka

Blood Adv. 2022 Mar 22; 6(6): 1879–1894. Published online 2022 Mar 17. doi: 10.1182/bloodadvances.2021006195

PMCID:: PMC8941461

Abstract Article PDF–2.6M

Select item 89014364.

Normality sensing licenses local T cells for innate-like tissue surveillance

Duncan R. McKenzie, Rosie Hart, Nourdine Bah, Dmitry S. Ushakov, Miguel Muñoz-Ruiz, Regina Feederle, Adrian C. Hayday

Nat Immunol. 2022; 23(3): 411–422. Published online 2022 Feb 14. doi: 10.1038/s41590-021-01124-8

PMCID:: PMC8901436

Abstract Article PDF–12M

Select item 79149035.

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis

Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L. Wickström, Andreas Lundqvist, Herbert Schwarz

Cells. 2021 Feb; 10(2): 353. Published online 2021 Feb 9. doi: 10.3390/cells10020353

PMCID:: PMC7914903

Abstract Article PDF–1.4M

Select item 77581916.

The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity

Beom K. Choi, Hyeon-Woo Lee

Front Immunol. 2020; 11: 553715. Published online 2020 Dec 10. doi: 10.3389/fimmu.2020.553715

PMCID:: PMC7758191

Abstract Article PDF–2.1M

Select item 75279747.

Activation of 4-1BBL⁺ B cells with CD40 agonism and IFNγ elicits potent immunity against glioblastoma

Catalina Lee-Chang, Jason Miska, David Hou, Aida Rashidi, Peng Zhang, Rachel A. Burga, Ignacio Jusué-Torres, Ting Xiao, Victor A. Arrieta, Daniel Y. Zhang, Aurora Lopez-Rosas, Yu Han, Adam M. Sonabend, Craig M. Horbinski, Roger Stupp, Irina V. Balyasnikova, Maciej S. Lesniak

J Exp Med. 2021 Jan 4; 218(1): e20200913. Published online 2020 Sep 29. doi: 10.1084/jem.20200913

PMCID:: PMC7527974

Abstract Article PDF–6.5M

Select item 72965888.

CD137 ligand is important for type 1 diabetes development but dispensable for the homeostasis of disease suppressive CD137⁺ FOXP3⁺ regulatory CD4 T cells

Bardees M. Foda, Ashley E. Ciecko, David V. Serreze, William M. Ridgway, Aron M. Geurts, Yi-Guang Chen

J Immunol. Author manuscript; available in PMC 2021 Jun 1.

Published in final edited form as: J Immunol. 2020 Jun 1; 204(11): 2887–2899. Published online 2020 Apr 15. doi: 10.4049/jimmunol.1900485

PMCID:: PMC7296588

Abstract Article PDF–995K

Select item 70291179.

CD137 negatively affects “browning” of white adipose tissue during cold exposure

Raj Kamal Srivastava, Annalena Moliner, Ee-Soo Lee, Emily Nickles, Eunice Sim, Chang Liu, Herbert Schwarz, Carlos F. Ibáñez

J Biol Chem. 2020 Feb 14; 295(7): 2034–2042. Published online 2020 Jan 9. doi: 10.1074/jbc.AC119.011795

PMCID:: PMC7029117

Abstract Article PDF–2.9M

Select item 662174610.

Development of Experimental Autoimmune Encephalomyelitis Critically Depends on CD137 Ligand Signaling

Julia M. Martínez Gómez, J. Ludovic Croxford, Kim Pin Yeo, Véronique Angeli, Herbert Schwarz, Stephan Gasser

J Neurosci. 2012 Dec 12; 32(50): 18246–18252. doi: 10.1523/JNEUROSCI.2473-12.2012

PMCID:: PMC6621746

Abstract Article PDF–1.3M

Select item 660794411.

Deletion of CD137 Ligand Exacerbates Renal and Cutaneous but Alleviates Cerebral Manifestations in Lupus

Anselm Mak, Bhushan Dharmadhikari, Nien Yee Kow, Thomas Paulraj Thamboo, Qianqiao Tang, Lik Wei Wong, Sreedharan Sajikumar, Hiu Yi Wong, Herbert Schwarz

Front Immunol. 2019; 10: 1411. Published online 2019 Jun 26. doi: 10.3389/fimmu.2019.01411

PMCID:: PMC6607944

Abstract Article PDF–1.2M

Select item 622310912.

Contribution of CD137L to Sensory Hypersensitivity in a Murine Model of Neuropathic Pain

Alexa A. Wakley, Reno Leeming, Jenn Malon, Taxiarhia J. Arabatzis, Woon Yuen Koh, Ling Cao

eNeuro. 2018 Sep-Oct; 5(5): ENEURO.0218-18.2018. Prepublished online 2018 Oct 29. Published online 2018 Nov 8. doi: 10.1523/ENEURO.0218-18.2018

PMCID:: PMC6223109

Abstract Article PDF–3.7M

Select item 578780813.

Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling

Aruna Bitra, Tzanko Doukov, Jing Wang, Gaelle Picarda, Chris A. Benedict, Michael Croft, Dirk M. Zajonc

J Biol Chem. 2018 Jan 26; 293(4): 1317–1329. Published online 2017 Dec 14. doi: 10.1074/jbc.M117.814905

PMCID:: PMC5787808

Abstract Article PDF–1.9M

Select item 441848614.

Inhibition of 4-1BBL-regulated TLR response in macrophages ameliorates endotoxin-induced sepsis in mice

Bo Ram Bang, Sang Jick Kim, Hideo Yagita, Michael Croft, Young Jun Kang

Eur J Immunol. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: Eur J Immunol. 2015 Mar; 45(3): 886–892. Published online 2015 Jan 21. doi: 10.1002/eji.201445174

PMCID:: PMC4418486

Abstract Article PDF–1.3M

Select item 440270915.

CD8⁺ T Cell Dysfunction and Increase in Murine Gammaherpesvirus Latent Viral Burden in the Absence of 4-1BB Ligand

Shinichiro Fuse, Sarah Bellfy, Hideo Yagita, Edward J. Usherwood

J Immunol. Author manuscript; available in PMC 2015 Apr 20.

Published in final edited form as: J Immunol. 2007 Apr 15; 178(8): 5227–5236. doi: 10.4049/jimmunol.178.8.5227

PMCID:: PMC4402709

Abstract Article PDF–1.8M

Select item 427292116.

4-1BB Ligand Signaling to T cells Limits T cell Activation

So-Young Eun, Seung-Woo Lee, Yanfei Xu, Michael Croft

J Immunol. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: J Immunol. 2015 Jan 1; 194(1): 134–141. Published online 2014 Nov 17. doi: 10.4049/jimmunol.1401383

PMCID:: PMC4272921

Abstract Article PDF–2.6M

Select item 407369217.

4-1BB (CD137) Ligand Enhanced Anti-Tumor Immune Response against Mouse Forestomach Carcinoma In Vivo

Qiaoxia Li, Jun Ai, Zhenchuan Song, Jie Liu, Baoen Shan

Cell Mol Immunol. 2008 Oct; 5(5): 379–384. doi: 10.1038/cmi.2008.47

PMCID:: PMC4073692

Abstract PDF–233K

Select item 400444418.

The Tumor Necrosis Family Member 4-1BBL Sustains Inflammation by Interacting with Mediators of Toll-Like Receptor Signaling

Jianhui Ma, Bo-Ram Bang, Jiawei Lu, So-Young Eun, Motoyuki Otsuka, Michael Croft, Peter Tobias, Jiahuai Han, Osamu Takeuchi, Shizuo Akira, Michael Karin, Hideo Yagita, Young Jun Kang

Sci Signal. Author manuscript; available in PMC 2014 Apr 29.

Published in final edited form as: Sci Signal. 2013 Oct 1; 6(295): ra87. Published online 2013 Oct 1. doi: 10.1126/scisignal.2004431

PMCID:: PMC4004444

Abstract Article PDF–1.4M

Select item 391978019.

CD137-CD137L Interaction Regulates Atherosclerosis via Cyclophilin A in Apolipoprotein E-Deficient Mice

Yuefeng Li, Jinchuan Yan, Chao Wu, Zhongqun Wang, Wei Yuan, Dongqing Wang

PLoS One. 2014; 9(2): e88563. Published online 2014 Feb 10. doi: 10.1371/journal.pone.0088563

PMCID:: PMC3919780

Abstract Article PDF–956K

Select item 388798020.

Involvement of CD137 Ligand Signaling in Neural Stem Cell Death

Chang Ho Yun, Hye Myeong Lee, Sang Chul Lee, Byung Sam Kim, Jeong Woo Park, Byung Ju Lee

Mol Cells. 2013 Sep 30; 36(3): 245–251. Published online 2013 Aug 7. doi: 10.1007/s10059-013-0137-3

PMCID:: PMC3887980

Abstract Article PDF–5.9M

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