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Select item 105803381.

Single‐cell RNA‐sequencing analysis reveals enhanced non‐canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury

Xuecheng Qiu, Yaling Guo, Ming‐Feng Liu, Bingge Zhang, Jingzhen Li, Jian‐Feng Wei, Meng Li

CNS Neurosci Ther. 2023 Nov; 29(11): 3446–3459. Published online 2023 Jun 2. doi: 10.1111/cns.14278

PMCID:: PMC10580338

Abstract Article PDF–9.8M

Select item 105092782.

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents

Yachao He, Ibrahim Kaya, Reza Shariatgorji, Johan Lundkvist, Lars U. Wahlberg, Anna Nilsson, Dejan Mamula, Jan Kehr, Justyna Zareba-Paslawska, Henrik Biverstål, Karima Chergui, Xiaoqun Zhang, Per E. Andren, Per Svenningsson

Nat Commun. 2023; 14: 5804. Published online 2023 Sep 19. doi: 10.1038/s41467-023-41539-5

PMCID:: PMC10509278

Abstract Article PDF–4.8M

Select item 100976583.

Targeting neuronal lysosomal dysfunction caused by β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct

Alexandra Gehrlein, Vinod Udayar, Nadia Anastasi, Martino L. Morella, Iris Ruf, Doris Brugger, Sophia von der Mark, Ralf Thoma, Arne Rufer, Dominik Heer, Nina Pfahler, Anton Jochner, Jens Niewoehner, Luise Wolf, Matthias Fueth, Martin Ebeling, Roberto Villaseñor, Yanping Zhu, Matthew C. Deen, Xiaoyang Shan, Zahra Ehsaei, Verdon Taylor, Ellen Sidransky, David J. Vocadlo, Per-Ola Freskgård, Ravi Jagasia

Nat Commun. 2023; 14: 2057. Published online 2023 Apr 12. doi: 10.1038/s41467-023-37632-4

PMCID:: PMC10097658

Abstract Article PDF–3.6M

Select item 96183064.

Treatment of a genetic brain disease by CNS-wide microglia replacement

Yohei Shibuya, Kevin K Kumar, Marius Marc-Daniel Mader, Yongjin Yoo, Luis Angel Ayala, Mu Zhou, Manuel Alexander Mohr, Gernot Neumayer, Ishan Kumar, Ryo Yamamoto, Paul Marcoux, Benjamin Liou, F Chris Bennett, Hiromitsu Nakauchi, Ying Sun, Xiaoke Chen, Frank L. Heppner, Tony Wyss-Coray, Thomas C. Südhof, Marius Wernig

Sci Transl Med. Author manuscript; available in PMC 2022 Oct 30.

Published in final edited form as: Sci Transl Med. 2022 Mar 16; 14(636): eabl9945. Published online 2022 Mar 16. doi: 10.1126/scitranslmed.abl9945

PMCID:: PMC9618306

Abstract Article PDF–4.1M

Select item 95703885.

Decreased Prosaposin and Progranulin in the Cingulate Cortex Are Associated with Schizophrenia Pathophysiology

Yachao He, Xiaoqun Zhang, Ivana Flais, Per Svenningsson

Int J Mol Sci. 2022 Oct; 23(19): 12056. Published online 2022 Oct 10. doi: 10.3390/ijms231912056

PMCID:: PMC9570388

Abstract Article PDF–2.4M

Select item 79387706.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 73001757.

Neurofilament-Light Chain as Biomarker of Neurodegenerative and Rare Diseases With High Translational Value

Tina Loeffler, Irene Schilcher, Stefanie Flunkert, Birgit Hutter-Paier

Front Neurosci. 2020; 14: 579. Published online 2020 Jun 11. doi: 10.3389/fnins.2020.00579

PMCID:: PMC7300175

Abstract Article PDF–577K

Select item 69571548.

Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease

Victoria Schiffer, Estibaliz Santiago-Mujika, Stefanie Flunkert, Staffan Schmidt, Martina Farcher, Tina Loeffler, Irene Schilcher, Maria Posch, Joerg Neddens, Ying Sun, Jan Kehr, Birgit Hutter-Paier

PLoS One. 2020; 15(1): e0227077. Published online 2020 Jan 13. doi: 10.1371/journal.pone.0227077

PMCID:: PMC6957154

Abstract Article PDF–5.4M

Select item 66749599.

Progressive Deafness and Altered Cochlear Innervation in Knock-Out Mice Lacking Prosaposin

Omar Akil, Jolie Chang, Hakim Hiel, Jee-Hyun Kong, Eunyoung Yi, Elisabeth Glowatzki, Lawrence R. Lustig

J Neurosci. 2006 Dec 13; 26(50): 13076–13088. doi: 10.1523/JNEUROSCI.3746-06.2006

PMCID:: PMC6674959

Abstract Article PDF–730K

Select item 660559910.

Spiral Ganglion Degeneration and Hearing Loss as a Consequence of Satellite Cell Death in Saposin B-Deficient Mice

Omar Akil, Ying Sun, Sarath Vijayakumar, Wujuan Zhang, Tiffany Ku, Chi-Kyou Lee, Sherri Jones, Gregory A. Grabowski, Lawrence R. Lustig

J Neurosci. 2015 Feb 18; 35(7): 3263–3275. doi: 10.1523/JNEUROSCI.3920-13.2015

PMCID:: PMC6605599

Abstract Article PDF–6.3M

Select item 652170411.

GPR37 Signaling Modulates Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Cells in Mice

Hassan Saadi, Yufei Shan, Daniela Marazziti, Susan Wray

Front Cell Neurosci. 2019; 13: 200. Published online 2019 May 9. doi: 10.3389/fncel.2019.00200

PMCID:: PMC6521704

Abstract Article PDF–8.4M

Select item 644758012.

Combination of acid β-glucosidase mutation and Saposin C deficiency in mice reveals Gba1 mutation dependent and tissue-specific disease phenotype

Benjamin Liou, Wujuan Zhang, Venette Fannin, Brian Quinn, Huimin Ran, Kui Xu, Kenneth D. R. Setchell, David Witte, Gregory A. Grabowski, Ying Sun

Sci Rep. 2019; 9: 5571. Published online 2019 Apr 3. doi: 10.1038/s41598-019-41914-7

PMCID:: PMC6447580

Abstract Article PDF–7.4M

Select item 629804013.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 612457614.

Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state

Andreia S. Bernardo, Alice Jouneau, Hendrik Marks, Philip Kensche, Julianna Kobolak, Kristine Freude, Vanessa Hall, Anita Feher, Zsuzsanna Polgar, Chiara Sartori, Istvan Bock, Claire Louet, Tiago Faial, Hindrik H. D. Kerstens, Camille Bouissou, Gregory Parsonage, Kaveh Mashayekhi, James C. Smith, Giovanna Lazzari, Poul Hyttel, Hendrik G. Stunnenberg, Martijn Huynen, Roger A. Pedersen, Andras Dinnyes

Biol Open. 2018 Aug 15; 7(8): bio033282. Published online 2018 Jul 19. doi: 10.1242/bio.033282

PMCID:: PMC6124576

Abstract Article PDF–8.1M

Select item 607863515.

Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice

Benjamin Liou, Yanyan Peng, Ronghua Li, Venette Inskeep, Wujuan Zhang, Brian Quinn, Nupur Dasgupta, Rachel Blackwood, Kenneth D.R. Setchell, Sheila Fleming, Gregory A. Grabowski, John Marshall, Ying Sun

Hum Mol Genet. 2016 Dec 1; 25(23): 5126–5141. Published online 2016 Sep 20. doi: 10.1093/hmg/ddw322

PMCID:: PMC6078635

Abstract Article PDF–1.7M

Select item 593256716.

Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation

Tatyana Danyukova, Khandsuren Ariunbat, Melanie Thelen, Nahal Brocke-Ahmadinejad, Sara E Mole, Stephan Storch

Hum Mol Genet. 2018 May 15; 27(10): 1711–1722. Published online 2018 Mar 5. doi: 10.1093/hmg/ddy076

PMCID:: PMC5932567

Abstract Article PDF–710K

Select item 581698317.

Mechano-signal transduction in mesenchymal stem cells induces prosaposin secretion to drive the proliferation of breast cancer cells

Seiichiro Ishihara, David R. Inman, Wan-Ju Li, Suzanne M. Ponik, Patricia J. Keely

Cancer Res. Author manuscript; available in PMC 2018 Nov 15.

Published in final edited form as: Cancer Res. 2017 Nov 15; 77(22): 6179–6189. Published online 2017 Sep 28. doi: 10.1158/0008-5472.CAN-17-0569

PMCID:: PMC5816983

Abstract Article PDF–2.1M

Select item 563050018.

The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C

Xiaolai Zhou, Peter M. Sullivan, Lirong Sun, Fenghua Hu

J Neurochem. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: J Neurochem. 2017 Oct; 143(2): 236–243. Published online 2017 Aug 4. doi: 10.1111/jnc.14110

PMCID:: PMC5630500

Abstract Article PDF–2.2M

Select item 556949519.

Lysosomal processing of progranulin

Xiaolai Zhou, Daniel H. Paushter, Tuancheng Feng, Lirong Sun, Thomas Reinheckel, Fenghua Hu

Mol Neurodegener. 2017; 12: 62. Published online 2017 Aug 23. doi: 10.1186/s13024-017-0205-9

PMCID:: PMC5569495

Abstract Article PDF–1.0M

Select item 547751820.

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

Xiaolai Zhou, Lirong Sun, Oliver Bracko, Ji Whae Choi, Yan Jia, Alissa L. Nana, Owen Adam Brady, Jean C. Cruz Hernandez, Nozomi Nishimura, William W. Seeley, Fenghua Hu

Nat Commun. 2017; 8: 15277. Published online 2017 May 25. doi: 10.1038/ncomms15277

PMCID:: PMC5477518

Abstract Article PDF–8.6M

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