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Select item 111294091.

Inhibition of P21-activated kinases 1 and 4 synergistically suppresses the growth of pancreatic cancer by stimulating anti-tumour immunity

Yi Ma, Chelsea Dumesny, Li Dong, Ching-Seng Ang, Khashayar Asadi, Yifan Zhan, Mehrdad Nikfarjam, Hong He

Cell Commun Signal. 2024; 22: 287. Published online 2024 May 27. doi: 10.1186/s12964-024-01670-2

PMCID:: PMC11129409

Abstract Article PDF–2.6M

Select item 104355192.

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1

Min Yan Shi, Hwang Chan Yu, Chang Yeob Han, In Hyuk Bang, Ho Sung Park, Kyu Yun Jang, Sangkyu Lee, Jeong Bum Son, Nam Doo Kim, Byung-Hyun Park, Eun Ju Bae

Nat Commun. 2023; 14: 4987. Published online 2023 Aug 17. doi: 10.1038/s41467-023-40597-z

Correction in:: Nat Commun. 2023; 14: 7007.

PMCID:: PMC10435519

Abstract Article PDF–3.6M

Select item 100974243.

Targeting PAK4 to reprogram the vascular microenvironment and improve CAR-T immunotherapy for glioblastoma

Wenjuan Ma, Yanling Wang, Rongxin Zhang, Fan Yang, Duo Zhang, Menggui Huang, Lin Zhang, Jay F. Dorsey, Zev A. Binder, Donald M. O’Rourke, Joseph A. Fraietta, Yanqing Gong, Yi Fan

Nat Cancer. Author manuscript; available in PMC 2023 Apr 12.

Published in final edited form as: Nat Cancer. 2021 Jan; 2(1): 83–97. Published online 2020 Nov 30. doi: 10.1038/s43018-020-00147-8

PMCID:: PMC10097424

Abstract Article PDF–3.6M

Select item 95859034.

P21-Activated Kinase 4 Pak4 Maintains Embryonic Stem Cell Pluripotency via Akt Activation

Fangyuan Cheng, Mingyue Li, Rick Francis Thorne, Guangzhi Liu, Yuwei Zhang, Mian Wu, Lianxin Liu

Stem Cells. 2022 Oct; 40(10): 892–905. Published online 2022 Aug 1. doi: 10.1093/stmcls/sxac050

PMCID:: PMC9585903

Abstract Article PDF–11M

Select item 92470775.

p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1

So-Yoon Won, Jung-Jin Park, Soon-Tae You, Jong-A Hyeun, Hyong-Kyu Kim, Byung Kwan Jin, Catriona McLean, Eun-Young Shin, Eung-Gook Kim

Cell Death Dis. 2022 Jun; 13(6): 575. Published online 2022 Jun 30. doi: 10.1038/s41419-022-05030-1

PMCID:: PMC9247077

Abstract Article PDF–4.6M

Select item 87180366.

p21‐activated kinase 4 phosphorylates peroxisome proliferator‐activated receptor Υ and suppresses skeletal muscle regeneration

Yuancheng Mao, Chang Yeob Han, Lihua Hao, In Hyuk Bang, Eun Ju Bae, Byung‐Hyun Park

J Cachexia Sarcopenia Muscle. 2021 Dec; 12(6): 1776–1788. Published online 2021 Aug 24. doi: 10.1002/jcsm.12774

PMCID:: PMC8718036

Abstract Article PDF–12M

Select item 83408527.

PAK4 inhibition improves PD-1 blockade immunotherapy

Gabriel Abril-Rodriguez, Davis Y. Torrejon, Wei Liu, Jesse M. Zaretsky, Theodore S. Nowicki, Jennifer Tsoi, Cristina Puig-Saus, Ignacio Baselga-Carretero, Egmidio Medina, Michael J. Quist, Alejandro J. Garcia, William Senapedis, Erkan Baloglu, Anusha Kalbasi, Gardenia Cheung-Lau, Beata Berent-Maoz, Begoña Comin-Anduix, Siwen Hu-Lieskovan, Cun-Yu Wang, Catherine S. Grasso, Antoni Ribas

Nat Cancer. Author manuscript; available in PMC 2021 Aug 5.

Published in final edited form as: Nat Cancer. 2020; 1(1): 46–58. Published online 2019 Dec 9. doi: 10.1038/s43018-019-0003-0

PMCID:: PMC8340852

Abstract Article PDF–4.2M

Select item 80166438.

PAK4 suppresses motor neuron degeneration in hSOD1^G93A‐linked amyotrophic lateral sclerosis cell and rat models

Chaohua Cong, Weiwei Liang, Chunting Zhang, Ying Wang, Yueqing Yang, Xudong Wang, Shuyu Wang, Di Huo, Hongyong Wang, Di Wang, Honglin Feng

Cell Prolif. 2021 Apr; 54(4): e13003. Published online 2021 Feb 21. doi: 10.1111/cpr.13003

PMCID:: PMC8016643

Abstract Article PDF–2.7M

Select item 79387709.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 678343410.

Normal mammary gland development after MMTV-Cre mediated conditional PAK4 gene depletion

Parisa Rabieifar, Ting Zhuang, Tânia D. F. Costa, Miao Zhao, Staffan Strömblad

Sci Rep. 2019; 9: 14436. Published online 2019 Oct 8. doi: 10.1038/s41598-019-50819-4

PMCID:: PMC6783434

Abstract Article PDF–4.0M

Select item 668909111.

PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer

Tânia D. F. Costa, Ting Zhuang, Julie Lorent, Emilia Turco, Helene Olofsson, Miriam Masia-Balague, Miao Zhao, Parisa Rabieifar, Neil Robertson, Raoul Kuiper, Jonas Sjölund, Matthias Spiess, Pablo Hernández-Varas, Uta Rabenhorst, Pernilla Roswall, Ran Ma, Xiaowei Gong, Johan Hartman, Kristian Pietras, Peter D. Adams, Paola Defilippi, Staffan Strömblad

Nat Commun. 2019; 10: 3589. Published online 2019 Aug 9. doi: 10.1038/s41467-019-11510-4

PMCID:: PMC6689091

Abstract Article PDF–2.6M

Select item 574230212.

PAK4 crystal structures suggest unusual kinase conformational movements

Eric Y. Zhang, Byung Hak Ha, Titus J. Boggon

Biochim Biophys Acta. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Biochim Biophys Acta. 2018 Feb; 1866(2): 356–365. Published online 2017 Oct 7. doi: 10.1016/j.bbapap.2017.10.004

PMCID:: PMC5742302

Abstract Article PDF–1018K

Select item 553920113.

Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

Miao Zhao, Parisa Rabieifar, Tânia D. F. Costa, Ting Zhuang, Audrey Minden, Matthias Löhr, Rainer Heuchel, Staffan Strömblad

Sci Rep. 2017; 7: 7031. Published online 2017 Aug 1. doi: 10.1038/s41598-017-07322-5

PMCID:: PMC5539201

Abstract Article PDF–2.1M

Select item 531643114.

Increased Circulating Endothelial Microparticles Associated with PAK4 Play a Key Role in Ventilation-Induced Lung Injury Process

Shuming Pan, Aihua Fei, Lihong Jing, Xiangyu Zhang, Chengjin Gao

Biomed Res Int. 2017; 2017: 4902084. Published online 2017 Feb 5. doi: 10.1155/2017/4902084

PMCID:: PMC5316431

Abstract Article PDF–4.3M

Select item 451059215.

The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling

Hemabindu Chintala, Izabela Krupska, Lulu Yan, Lester Lau, Maria Grant, Brahim Chaqour

Development. 2015 Jul 1; 142(13): 2364–2374. doi: 10.1242/dev.121913

PMCID:: PMC4510592

Abstract Article

Select item 447212516.

High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes

Robert Brommage, Jeff Liu, Gwenn M Hansen, Laura L Kirkpatrick, David G Potter, Arthur T Sands, Brian Zambrowicz, David R Powell, Peter Vogel

Bone Res. 2014; 2: 14034. Published online 2014 Oct 28. doi: 10.1038/boneres.2014.34

PMCID:: PMC4472125

Abstract Article PDF–1.6M

Select item 373457017.

Systems-wide Analysis of K-Ras, Cdc42, and PAK4 Signaling by Quantitative Phosphoproteomics

Florian Gnad, Amy Young, Wei Zhou, Karen Lyle, Christy C. Ong, Matthew P. Stokes, Jeffrey C. Silva, Marcia Belvin, Lori S. Friedman, Hartmut Koeppen, Audrey Minden, Klaus P. Hoeflich

Mol Cell Proteomics. 2013 Aug; 12(8): 2070–2080. Published online 2013 Apr 22. doi: 10.1074/mcp.M112.027052

PMCID:: PMC3734570

Abstract Article PDF–1.5M

Select item 361930218.

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486

Bridget M. Dolan, Sergio G. Duron, David A. Campbell, Benedikt Vollrath, B. S. Shankaranarayana Rao, Hui-Yeon Ko, Gregory G. Lin, Arvind Govindarajan, Se-Young Choi, Susumu Tonegawa

Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14): 5671–5676. Published online 2013 Mar 18. doi: 10.1073/pnas.1219383110

PMCID:: PMC3619302

Abstract Article PDF–454K

Select item 325246519.

Oct4 links multiple epigenetic pathways to the pluripotency network

Junjun Ding, Huilei Xu, Francesco Faiola, Avi Ma'ayan, Jianlong Wang

Cell Res. 2012 Jan; 22(1): 155–167. Published online 2011 Nov 15. doi: 10.1038/cr.2011.179

PMCID:: PMC3252465

Abstract Article PDF–2.7M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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