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Items: 1 to 20 of 77

1.
Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin
Uttkarsh Ayyangar, Aneesh Karkhanis, Heather Tay, Aliya Farissa Binte Afandi, Oindrila Bhattacharjee, Lalitha KS, Sze Han Lee, James Chan, Srikala Raghavan
EMBO J. 2024 Apr; 43(7): 1113–1134. Published online 2024 Feb 28. doi: 10.1038/s44318-024-00039-y
PMCID:
PMC10987662
AbstractArticlePDF–12M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma
Xueqin Chen, Jun Liu, Yuqin Li, Yuequan Zeng, Fang Wang, Zexiong Cheng, Hao Duan, Guopeng Pan, Shangqi Yang, Yuling Chen, Qing Li, Xi Shen, Ying Li, Zixi Qin, Jiahong Chen, Youwei Huang, Xiangyu Wang, Yuli Lu, Minfeng Shu, Yubo Zhang, Guocai Wang, Kai Li, Xi Lin, Fan Xing, Haipeng Zhang
Nat Commun. 2023; 14: 6781. Published online 2023 Oct 25. doi: 10.1038/s41467-023-42545-3
PMCID:
PMC10600173
AbstractArticlePDF–11M
4.
Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation
Sinthu Pathmanapan, Raymond Poon, Tomasa Barrientos De Renshaw, Puviindran Nadesan, Makoto Nakagawa, Gireesh A. Seesankar, Adrian Kwan Ho Loe, Hongyuan H. Zhang, Joan J. Guinovart, Jordi Duran, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Cell Rep. Author manuscript; available in PMC 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Jun 27; 42(6): 112578. Published online 2023 Jun 1. doi: 10.1016/j.celrep.2023.112578
PMCID:
PMC10592452
AbstractArticlePDF–1.7M
5.
Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program
Junseong Park, Jin-Kyoung Shim, Mirae Lee, Dokyeong Kim, Seon-Jin Yoon, Ju Hyung Moon, Eui Hyun Kim, Jeong-Yoon Park, Jong Hee Chang, Seok-Gu Kang
Br J Cancer. 2023 Oct 19; 129(7): 1061–1070. Published online 2023 Aug 9. doi: 10.1038/s41416-023-02391-y
PMCID:
PMC10539507
AbstractArticlePDF–5.1M
6.
Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells
Jerome Fortin, Ming-Feng Chiang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran, Julie Leca, François Lemonnier, Wanda Y. Li, Miki S. Gams, Takashi Sakamoto, Mandy Chu, Chantal Tobin, Eric Laugesen, Troy M. Robinson, Annick You-Ten, Daniel J. Butler, Thorsten Berger, Mark D. Minden, Ross L. Levine, Cynthia J. Guidos, Ari M. Melnick, Christopher E. Mason, Tak W. Mak
Proc Natl Acad Sci U S A. 2023 Jan 24; 120(4): e2208176120. Published online 2023 Jan 18. doi: 10.1073/pnas.2208176120
PMCID:
PMC9942850
AbstractArticlePDF–9.0M
7.
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Laura Sánchez-Bellver, Andrea Férriz-Gordillo, Marc Carrillo-Pz, Laura Rabanal, Francesc R. Garcia-Gonzalo, Gemma Marfany
Int J Mol Sci. 2022 Oct; 23(20): 12527. Published online 2022 Oct 19. doi: 10.3390/ijms232012527
PMCID:
PMC9603860
AbstractArticlePDF–3.4M
8.
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
Diana D. Shi, Milan R. Savani, Michael M. Levitt, Adam C. Wang, Jennifer E. Endress, Cylaina E. Bird, Joseph Buehler, Sylwia A. Stopka, Michael S. Regan, Yu-Fen Lin, Vinesh T. Puliyappadamba, Wenhua Gao, Januka Khanal, Laura Evans, Joyce H. Lee, Lei Guo, Yi Xiao, Min Xu, Bofu Huang, Rebecca B. Jennings, Dennis M. Bonal, Misty S. Martin-Sandoval, Tammie Dang, Lauren C. Gattie, Amy B. Cameron, Sungwoo Lee, John M. Asara, Harley I. Kornblum, Tak W. Mak, Ryan E. Looper, Quang-De Nguyen, Sabina Signoretti, Stefan Gradl, Andreas Sutter, Michael Jeffers, Andreas Janzer, Mark A. Lehrman, Lauren G. Zacharias, Thomas P. Mathews, Julie-Aurore Losman, Timothy E. Richardson, Daniel P. Cahill, Ralph J. DeBerardinis, Keith L. Ligon, Lin Xu, Peter Ly, Nathalie Y.R. Agar, Kalil G. Abdullah, Isaac S. Harris, William G. Kaelin, Jr., Samuel K. McBrayer
Cancer Cell. Author manuscript; available in PMC 2022 Sep 28.
Published in final edited form as: Cancer Cell. 2022 Sep 12; 40(9): 939–956.e16. Published online 2022 Aug 18. doi: 10.1016/j.ccell.2022.07.011
PMCID:
PMC9515386
AbstractArticlePDF–4.1M
9.
ALS-linked loss of Cyclin-F function affects HSP90
Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends
Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359
PMCID:
PMC9481933
AbstractArticlePDF–3.5M
10.
Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis
Shikha Gupta, Oliver M. Dovey, Ana Filipa Domingues, Oliwia W. Cyran, Caitlin M. Cash, George Giotopoulos, Justyna Rak, Jonathan Cooper, Malgorzata Gozdecka, Liza Dijkhuis, Ryan J. Asby, Noor Al-Jabery, Victor Hernandez-Hernandez, Sudhakaran Prabakaran, Brian J. Huntly, George S. Vassiliou, Cristina Pina
Sci Adv. 2022 Aug; 8(31): eabn4886. Published online 2022 Aug 3. doi: 10.1126/sciadv.abn4886
PMCID:
PMC9348803
AbstractArticlePDF–2.2M
11.
Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
Meng-Ju Wu, Lei Shi, Juan Dubrot, Joshua Merritt, Vindhya Vijay, Ting-Yu Wei, Emily Kessler, Kira E. Olander, Ramzi Adil, Amaya Pankaj, Krishna Seshu Tummala, Vajira Weeresekara, Yuanli Zhen, Qibiao Wu, Meiqi Luo, William Shen, María García-Beccaria, Mirian Fernández-Vaquero, Christine Hudson, Sebastien Ronseaux, Yi Sun, Rodrigo Saad-Berreta, Russell W. Jenkins, Tong Wang, Mathias Heikenwälder, Cristina R. Ferrone, Lipika Goyal, Brandon Nicolay, Vikram Deshpande, Rahul M. Kohli, Hongwu Zheng, Robert T. Manguso, Nabeel Bardeesy
Cancer Discov. Author manuscript; available in PMC 2022 Sep 1.
Published in final edited form as: Cancer Discov. 2022 Mar 1; 12(3): 812–835. doi: 10.1158/2159-8290.CD-21-1077
PMCID:
PMC8904298
AbstractArticlePDF–3.2M
12.
Bmal1 inhibits phenotypic transformation of hepatic stellate cells in liver fibrosis via IDH1/α-KG-mediated glycolysis
Lei Xu, Tian-yu Yang, Yi-wen Zhou, Mei-fei Wu, Jie Shen, Jie-ling Cheng, Qing-xue Liu, Shi-yang Cao, Jian-qing Wang, Lei Zhang
Acta Pharmacol Sin. 2022 Feb; 43(2): 316–329. Published online 2021 Apr 13. doi: 10.1038/s41401-021-00658-9
Correction in:
Acta Pharmacol Sin. 2022 Mar; 43(3): 757–758.
PMCID:
PMC8792062
AbstractArticlePDF–7.4M
13.
Meta-analysis of whole-genome gene expression datasets assessing the effects of IDH1 and IDH2 mutations in isogenic disease models
Hans-Juergen Schulten, Fatima Al-Adwani, Haneen A. Bin Saddeq, Heba Alkhatabi, Nofe Alganmi, Sajjad Karim, Deema Hussein, Khalid B. Al-Ghamdi, Awatif Jamal, Jaudah Al-Maghrabi, Mohammed H. Al-Qahtani
Sci Rep. 2022; 12: 57. Published online 2022 Jan 7. doi: 10.1038/s41598-021-04214-7
PMCID:
PMC8741954
AbstractArticlePDF–4.6M
14.
Vulnerability of IDH1 mutant cancers to histone deacetylase inhibition via orthogonal suppression of DNA repair
Jonathan Dow, Adam Krysztofiak, Yanfeng Liu, Daniel A. Colon-Rios, Faye A. Rogers, Peter M. Glazer
Mol Cancer Res. Author manuscript; available in PMC 2022 Jun 1.
Published in final edited form as: Mol Cancer Res. 2021 Sep 17 : 10.1158/1541-7786.MCR-21-0456. Published online 2021 Sep 17. doi: 10.1158/1541-7786.MCR-21-0456
PMCID:
PMC8642278
AbstractArticlePDF–2.1M
15.
Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter
Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B. Sanz-Martos, Francisco Zafra
Cell Mol Life Sci. 2021 Dec; 78(23): 7733–7756. Published online 2021 Oct 28. doi: 10.1007/s00018-021-03998-1
PMCID:
PMC8629785
AbstractArticlePDF–10M
16.
Cancer-associated IDH mutations induce Glut1 expression and glucose metabolic disorders through a PI3K/Akt/mTORC1-Hif1α axis
Xun Liu, Kiyoshi Yamaguchi, Kiyoko Takane, Chi Zhu, Makoto Hirata, Yoko Hikiba, Shin Maeda, Yoichi Furukawa, Tsuneo Ikenoue
PLoS One. 2021; 16(9): e0257090. Published online 2021 Sep 13. doi: 10.1371/journal.pone.0257090
PMCID:
PMC8437293
AbstractArticlePDF–2.2M
17.
Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma
Yassene Mohammed, Sarah A. Michaud, Helena Pětrošová, Juncong Yang, Milan Ganguly, David Schibli, Ann M. Flenniken, Lauryl M. J. Nutter, Hibret A. Adissu, K. C. Kent Lloyd, Colin McKerlie, Christoph H. Borchers
NPJ Syst Biol Appl. 2021; 7: 25. Published online 2021 May 28. doi: 10.1038/s41540-021-00184-8
PMCID:
PMC8163790
AbstractArticlePDF–6.9M
18.
PEG3 controls lipogenesis through ACLY
Subash Ghimire, Joomyeong Kim
PLoS One. 2021; 16(5): e0252354. Published online 2021 May 28. doi: 10.1371/journal.pone.0252354
PMCID:
PMC8162686
AbstractArticlePDF–2.3M
19.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
20.
Withaferin A suppresses tumor promoter 12‐O‐tetradecanoylphorbol 13‐acetate‐induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells
Wenjuan Li, Yunfeng Zhao
Cancer Sci. 2013 Feb; 104(2): 143–148. Published online 2012 Dec 7. doi: 10.1111/cas.12051
PMCID:
PMC7657173
AbstractArticlePDF–549K

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