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Items: 1 to 20 of 26

1.
Maternal hyperglycemia inhibits pulmonary vasculogenesis during mouse fetal lung development by promoting GβL Ubiquitination-dependent mammalian target of Rapamycin assembly
Qingqing Luo, Xinqun Chai, Xiaoyan Xin, Weixiang Ouyang, Feitao Deng
Diabetol Metab Syndr. 2023; 15: 49. Published online 2023 Mar 17. doi: 10.1186/s13098-022-00974-y
PMCID:
PMC10021989
AbstractArticlePDF–1.5M
2.
Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death
Farrah El-Saafin, Maria I. Bergamasco, Yunshun Chen, Rose E. May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J. Davis, Andreas Strasser, Gordon K. Smyth, Tim Thomas, Anne K. Voss
Cell Death Differ. 2022 May; 29(5): 1013–1027. Published online 2022 Mar 31. doi: 10.1038/s41418-022-00982-5
PMCID:
PMC9091217
AbstractArticlePDF–7.2M
3.
Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
Anouk M Olthof, Alisa K White, Stephen Mieruszynski, Karen Doggett, Madisen F Lee, Almahdi Chakroun, Alice K Abdel Aleem, Justine Rousseau, Cinzia Magnani, Chaim M Roifman, Philippe M Campeau, Joan K Heath, Rahul N Kanadia
Nucleic Acids Res. 2021 Apr 6; 49(6): 3524–3545. Published online 2021 Feb 28. doi: 10.1093/nar/gkab118
PMCID:
PMC8034651
AbstractArticlePDF–7.2M
4.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
5.
mTOR Signaling in Growth, Metabolism, and Disease
Robert A. Saxton, David M. Sabatini
Cell. Author manuscript; available in PMC 2018 Mar 9.
Published in final edited form as: Cell. 2017 Mar 9; 168(6): 960–976. doi: 10.1016/j.cell.2017.02.004
Correction in:
Cell. 2017 Apr 6; 169(2): 361–371.
PMCID:
PMC5394987
AbstractArticlePDF–1.1M
6.
Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival
Laura J. Smithson, David H. Gutmann
Genes Dev. 2016 Jun 15; 30(12): 1383–1388. doi: 10.1101/gad.279661.116
PMCID:
PMC4926861
AbstractArticlePDF–500K
7.
mLST8 Promotes mTOR-Mediated Tumor Progression
Kyoko Kakumoto, Jun-ichiro Ikeda, Masato Okada, Eiichi Morii, Chitose Oneyama
PLoS One. 2015; 10(4): e0119015. Published online 2015 Apr 23. doi: 10.1371/journal.pone.0119015
PMCID:
PMC4408021
AbstractArticlePDF–6.9M
8.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
9.
Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses
Surinder Kaur, Antonella Sassano, Beata Majchrzak-Kita, Darren P. Baker, Bing Su, Eleanor N. Fish, Leonidas C. Platanias
Proc Natl Acad Sci U S A. 2012 May 15; 109(20): 7723–7728. Published online 2012 May 1. doi: 10.1073/pnas.1118122109
PMCID:
PMC3356630
AbstractArticlePDF–1.7M
10.
mTOR signaling in growth control and disease
Mathieu Laplante, David M. Sabatini
Cell. Author manuscript; available in PMC 2013 Apr 13.
Published in final edited form as: Cell. 2012 Apr 13; 149(2): 274–293. doi: 10.1016/j.cell.2012.03.017
PMCID:
PMC3331679
AbstractArticlePDF–3.8M
11.
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
Dudley W. Lamming, Lan Ye, Pekka Katajisto, Marcus D. Goncalves, Maki Saitoh, Deanna M. Stevens, James G. Davis, Adam B. Salmon, Arlan Richardson, Rexford S. Ahima, David A. Guertin, David M. Sabatini, Joseph A. Baur
Science. Author manuscript; available in PMC 2012 Apr 11.
Published in final edited form as: Science. 2012 Mar 30; 335(6076): 1638–1643. doi: 10.1126/science.1215135
PMCID:
PMC3324089
AbstractArticlePDF–797K
12.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
13.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
14.
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Katrin Düvel, Jessica L. Yecies, Suchithra Menon, Pichai Raman, Alex I. Lipovsky, Amanda L. Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver, Matthew G. Vander Heiden, Jeffrey P. MacKeigan, Peter M. Finan, Clary B. Clish, Leon O. Murphy, Brendan D. Manning
Mol Cell. Author manuscript; available in PMC 2011 Jul 30.
Published in final edited form as: Mol Cell. 2010 Jul 30; 39(2): 171–183. doi: 10.1016/j.molcel.2010.06.022
PMCID:
PMC2946786
AbstractArticlePDF–2.6M
15.
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
Hiroyuki Takai, Yihu Xie, Titia de Lange, Nikola P. Pavletich
Genes Dev. 2010 Sep 15; 24(18): 2019–2030. doi: 10.1101/gad.1956410
PMCID:
PMC2939364
AbstractArticlePDF–875K
16.
Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage
Partha Chakrabarti, Taylor English, Jun Shi, Cynthia M. Smas, Konstantin V. Kandror
Diabetes. 2010 Apr; 59(4): 775–781. Published online 2010 Jan 12. doi: 10.2337/db09-1602
PMCID:
PMC2844824
AbstractArticlePDF–325K
17.
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
Hui H. Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M. Squillace, Chin-Lee Wu, Brendan D. Manning
PLoS One. 2009; 4(7): e6189. Published online 2009 Jul 10. doi: 10.1371/journal.pone.0006189
PMCID:
PMC2703782
AbstractArticlePDF–3.6M
18.
The mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
David A. Guertin, Deanna M. Stevens, Maki Saitoh, Stephanie Kinkel, Katherine Crosby, Joon-Ho Sheen, David J. Mullholland, Mark A. Magnuson, Hong Wu, David M. Sabatini
Cancer Cell. Author manuscript; available in PMC 2009 Aug 3.
Published in final edited form as: Cancer Cell. 2009 Feb 3; 15(2): 148–159. doi: 10.1016/j.ccr.2008.12.017
PMCID:
PMC2701381
AbstractArticlePDF–2.8M
19.
Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein
Tatsuhiro Sato, Akio Nakashima, Lea Guo, Fuyuhiko Tamanoi
J Biol Chem. 2009 May 8; 284(19): 12783–12791. doi: 10.1074/jbc.M809207200
PMCID:
PMC2676008
AbstractArticlePDF–610K
20.
Syndecan-4 regulates subcellular localization of mTOR complex2 and Akt activation in a PKCα-dependent manner in endothelial cells
Chohreh Partovian, Rong Ju, Zhen W. Zhuang, Kathleen Martin, Michael Simons
Mol Cell. Author manuscript; available in PMC 2009 Oct 10.
Published in final edited form as: Mol Cell. 2008 Oct 10; 32(1): 140–149. doi: 10.1016/j.molcel.2008.09.010
PMCID:
PMC2578831
AbstractArticlePDF–2.7M

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