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Select item 113909061.

Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease

Ahmed Elwakiel, Dheerendra Gupta, Rajiv Rana, Jayakumar Manoharan, Moh’d Mohanad Al-Dabet, Saira Ambreen, Sameen Fatima, Silke Zimmermann, Akash Mathew, Zhiyang Li, Kunal Singh, Anubhuti Gupta, Surinder Pal, Alba Sulaj, Stefan Kopf, Constantin Schwab, Ronny Baber, Robert Geffers, Tom Götze, Bekas Alo, Christina Lamers, Paul Kluge, Georg Kuenze, Shrey Kohli, Thomas Renné, Khurrum Shahzad, Berend Isermann

Nat Commun. 2024; 15: 7963. Published online 2024 Sep 11. doi: 10.1038/s41467-024-52214-8

PMCID:: PMC11390906

Abstract Article PDF–7.3M

Select item 107663532.

Oral FXIIa inhibitor KV998086 suppresses FXIIa and single chain FXII mediated kallikrein kinin system activation

Allen C. Clermont, Nivetha Murugesan, Hannah J. Edwards, Daniel K. Lee, Natasha P. Bayliss, Edward J. Duckworth, Stephen J. Pethen, Sally L. Hampton, David Gailani, Edward P. Feener

Front Pharmacol. 2023; 14: 1287487. Published online 2023 Dec 19. doi: 10.3389/fphar.2023.1287487

PMCID:: PMC10766353

Abstract Article PDF–1.6M

Select item 101221073.

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease

Erica M. Sparkenbaugh, Michael W. Henderson, Megan Miller-Awe, Christina Abrams, Anton Ilich, Fatima Trebak, Nirupama Ramadas, Shantel Vital, Dillon Bohinc, Kara L. Bane, Chunsheng Chen, Margi Patel, Michael Wallisch, Thomas Renné, Andras Gruber, Brian Cooley, David Gailani, Malgorzata Kasztan, Gregory M. Vercellotti, John D. Belcher, Felicity E. Gavins, Evi X. Stavrou, Nigel S. Key, Rafal Pawlinski

Blood. 2023 Apr 13; 141(15): 1871–1883. Published online 2023 Feb 2. doi: 10.1182/blood.2022017074

PMCID:: PMC10122107

Abstract Article

Select item 81247584.

Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient Mice

Christian Stetter, Simon Lopez-Caperuchipi, Sarah Hopp-Krämer, Michael Bieber, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weißenberger

Int J Mol Sci. 2021 May; 22(9): 4855. Published online 2021 May 3. doi: 10.3390/ijms22094855

PMCID:: PMC8124758

Abstract Article PDF–3.3M

Select item 80181835.

FXII regulates the formation of deep vein thrombosis via the PI3K/AKT signaling pathway in mice

Yan Meng, Qian Yin, Qiang Ma, Hao Qin, Junbo Zhang, Bo Zhang, Honggang Pang, Hongyan Tian

Int J Mol Med. 2021 May; 47(5): 87. Published online 2021 Mar 23. doi: 10.3892/ijmm.2021.4920

PMCID:: PMC8018183

Abstract Article PDF–1.2M

Select item 71892776.

Coagulation factor XII contributes to hemostasis when activated by soil in wounds

Lih Jiin Juang, Nima Mazinani, Stefanie K. Novakowski, Emily N. P. Prowse, Martin Haulena, David Gailani, Leslie M. Lavkulich, Christian J. Kastrup

Blood Adv. 2020 Apr 28; 4(8): 1737–1745. Published online 2020 Apr 27. doi: 10.1182/bloodadvances.2019000425

PMCID:: PMC7189277

Abstract Article PDF–1.0M

Select item 65516247.

Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits

Dorit Farfara, Emily Feierman, Allison Richards, Alexey S. Revenko, Robert A. MacLeod, Erin H. Norris, Sidney Strickland

Glia. Author manuscript; available in PMC 2020 Jul 1.

Published in final edited form as: Glia. 2019 Jul; 67(7): 1359–1373. Published online 2019 Mar 18. doi: 10.1002/glia.23611

PMCID:: PMC6551624

Abstract Article PDF–2.5M

Select item 62051888.

Factor XII activation promotes platelet consumption in the presence of bacterial-type long-chain polyphosphate in vitro and in vivo

Jevgenia Zilberman-Rudenko, Stephanie E. Reitsma, Cristina Puy, Rachel A. Rigg, Stephanie A. Smith, Erik I. Tucker, Robert Silasi, Alona Merkulova, Keith R. McCrae, Coen Maas, Rolf T. Urbanus, David Gailani, James H. Morrissey, András Gruber, Florea Lupu, Alvin H. Schmaier, Owen J. T. McCarty

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2018 Aug; 38(8): 1748–1760. doi: 10.1161/ATVBAHA.118.311193

PMCID:: PMC6205188

Abstract Article PDF–1.7M

Select item 58248699.

Factor XII and uPAR upregulate neutrophil functions to influence wound healing

Evi X. Stavrou, Chao Fang, Kara L. Bane, Andy T. Long, Clément Naudin, Erdem Kucukal, Agharnan Gandhi, Adina Brett-Morris, Michele M. Mumaw, Sudeh Izadmehr, Alona Merkulova, Cindy C. Reynolds, Omar Alhalabi, Lalitha Nayak, Wen-Mei Yu, Cheng-Kui Qu, Howard J. Meyerson, George R. Dubyak, Umut A. Gurkan, Marvin T. Nieman, Anirban Sen Gupta, Thomas Renné, Alvin H. Schmaier

J Clin Invest. 2018 Mar 1; 128(3): 944–959. Published online 2018 Jan 29. doi: 10.1172/JCI92880

PMCID:: PMC5824869

Abstract Article PDF–9.6M

Select item 541863710.

Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice

Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland

Blood. 2017 May 4; 129(18): 2547–2556. Prepublished online 2017 Feb 27. doi: 10.1182/blood-2016-11-753202

PMCID:: PMC5418637

Abstract Article

Select item 539948111.

Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke

Fabrício Simão, Tuna Ustunkaya, Allen C. Clermont, Edward P. Feener

Blood. 2017 Apr 20; 129(16): 2280–2290. Prepublished online 2017 Jan 27. doi: 10.1182/blood-2016-09-740670

PMCID:: PMC5399481

Abstract Article

Select item 531905512.

Alleviation of secondary brain injury, posttraumatic inflammation, and brain edema formation by inhibition of factor XIIa

Sarah Hopp, Marc W. Nolte, Christian Stetter, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weissenberger

J Neuroinflammation. 2017; 14: 39. Published online 2017 Feb 20. doi: 10.1186/s12974-017-0815-8

PMCID:: PMC5319055

Abstract Article PDF–932K

Select item 487398213.

Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

Kerstin Göbel, Susann Pankratz, Chloi-Magdalini Asaridou, Alexander M. Herrmann, Stefan Bittner, Monika Merker, Tobias Ruck, Sarah Glumm, Friederike Langhauser, Peter Kraft, Thorsten F. Krug, Johanna Breuer, Martin Herold, Catharina C. Gross, Denise Beckmann, Adelheid Korb-Pap, Michael K. Schuhmann, Stefanie Kuerten, Ioannis Mitroulis, Clemens Ruppert, Marc W. Nolte, Con Panousis, Luisa Klotz, Beate Kehrel, Thomas Korn, Harald F. Langer, Thomas Pap, Bernhard Nieswandt, Heinz Wiendl, Triantafyllos Chavakis, Christoph Kleinschnitz, Sven G. Meuth

Nat Commun. 2016; 7: 11626. Published online 2016 May 18. doi: 10.1038/ncomms11626

PMCID:: PMC4873982

Abstract Article PDF–1.5M

Select item 482171614.

A Comparison of the Effects of Factor XII Deficiency and Prekallikrein Deficiency on Thrombus Formation

Yasin Kokoye, Ivan Ivanov, Qiufang Cheng, Anton Matafonov, S. Kent Dickeson, Shauna Mason, Daniel J. Sexton, Thomas Renné, Keith McCrae, Edward P. Feener, David Gailani

Thromb Res. Author manuscript; available in PMC 2017 Apr 1.

Published in final edited form as: Thromb Res. 2016 Apr; 140: 118–124. Published online 2016 Feb 18. doi: 10.1016/j.thromres.2016.02.020

PMCID:: PMC4821716

Abstract Article PDF–2.9M

Select item 456681215.

The polyphosphate–factor XII pathway drives coagulation in prostate cancer-associated thrombosis

Katrin F. Nickel, Göran Ronquist, Florian Langer, Linda Labberton, Tobias A. Fuchs, Carsten Bokemeyer, Guido Sauter, Markus Graefen, Nigel Mackman, Evi X. Stavrou, Gunnar Ronquist, Thomas Renné

Blood. 2015 Sep 10; 126(11): 1379–1389. Prepublished online 2015 Jul 7. doi: 10.1182/blood-2015-01-622811

PMCID:: PMC4566812

Abstract Article

Select item 456373816.

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

Jenny Björkqvist, Steven de Maat, Urs Lewandrowski, Antonio Di Gennaro, Chris Oschatz, Kai Schönig, Markus M. Nöthen, Christian Drouet, Hal Braley, Marc W. Nolte, Albert Sickmann, Con Panousis, Coen Maas, Thomas Renné

J Clin Invest. 2015 Aug 3; 125(8): 3132–3146. Published online 2015 Jul 20. doi: 10.1172/JCI77139

PMCID:: PMC4563738

Abstract Article PDF–7.7M

Select item 442544117.

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

Alexey S. Revenko, Dacao Gao, Jeff R. Crosby, Gourab Bhattacharjee, Chenguang Zhao, Chris May, David Gailani, Brett P. Monia, A. Robert MacLeod

Blood. 2011 Nov 10; 118(19): 5302–5311. Prepublished online 2011 Aug 5. doi: 10.1182/blood-2011-05-355248

PMCID:: PMC4425441

Abstract Article

Select item 438635518.

Activation of the factor XII-driven contact system in Alzheimer’s disease patient and mouse model plasma

Daria Zamolodchikov, Zu-Lin Chen, Brooke A. Conti, Thomas Renné, Sidney Strickland

Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13): 4068–4073. Published online 2015 Mar 16. doi: 10.1073/pnas.1423764112

PMCID:: PMC4386355

Abstract Article PDF–896K

Select item 430411519.

Reduced thrombosis in Klkb1^−/− mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor

Evi X. Stavrou, Chao Fang, Alona Merkulova, Omar Alhalabi, Nadja Grobe, Silvio Antoniak, Nigel Mackman, Alvin H. Schmaier

Blood. 2015 Jan 22; 125(4): 710–719. Prepublished online 2014 Oct 22. doi: 10.1182/blood-2014-01-550285

PMCID:: PMC4304115

Abstract Article

Select item 395405420.

Factor XII inhibition reduces thrombus formation in a primate thrombosis model

Anton Matafonov, Philberta Y. Leung, Adam E. Gailani, Stephanie L. Grach, Cristina Puy, Qiufang Cheng, Mao-fu Sun, Owen J. T. McCarty, Erik I. Tucker, Hiroaki Kataoka, Thomas Renné, James H. Morrissey, Andras Gruber, David Gailani

Blood. 2014 Mar 13; 123(11): 1739–1746. Prepublished online 2014 Jan 9. doi: 10.1182/blood-2013-04-499111

PMCID:: PMC3954054

Abstract Article

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