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Items: 1 to 20 of 79

1.
Deletion of a conserved genomic region associated with adolescent idiopathic scoliosis leads to vertebral rotation in mice
Jeremy McCallum-Loudeac, Edward Moody, Jack Williams, Georgia Johnstone, Kathleen J Sircombe, Andrew N Clarkson, Megan J Wilson
Hum Mol Genet. 2024 May 1; 33(9): 787–801. Published online 2024 Jan 27. doi: 10.1093/hmg/ddae011
PMCID:
PMC11031364
AbstractArticlePDF–1.8M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH
Raquel Fernández-Ginés, José Antonio Encinar, Maribel Escoll, Daniel Carnicero-Senabre, José Jiménez-Villegas, Ángel J. García-Yagüe, Águeda González-Rodríguez, Irma Garcia-Martinez, Ángela M Valverde, Ana I. Rojo, Antonio Cuadrado
Redox Biol. 2024 Feb; 69: 103027. Published online 2024 Jan 3. doi: 10.1016/j.redox.2024.103027
PMCID:
PMC10808969
AbstractArticlePDF–7.7M
4.
Exosomal GPT2 derived from triple‐negative breast cancer cells promotes metastasis by activating BTRC
Mingqing Cui, Jiawei Peng, Yuanyuan Zhou, Xixi Wang, Daxiang Cui
Thorac Cancer. 2023 Jul; 14(21): 2018–2025. Published online 2023 Jun 7. doi: 10.1111/1759-7714.14984
PMCID:
PMC10363803
AbstractArticlePDF–7.5M
5.
Combinatorial effects on gene expression at the Lbx1/Fgf8 locus resolve split-hand/foot malformation type 3
Giulia Cova, Juliane Glaser, Robert Schöpflin, Cesar Augusto Prada-Medina, Salaheddine Ali, Martin Franke, Rita Falcone, Miriam Federer, Emanuela Ponzi, Romina Ficarella, Francesca Novara, Lars Wittler, Bernd Timmermann, Mattia Gentile, Orsetta Zuffardi, Malte Spielmann, Stefan Mundlos
Nat Commun. 2023; 14: 1475. Published online 2023 Mar 17. doi: 10.1038/s41467-023-37057-z
Correction in:
Nat Commun. 2023; 14: 2839.
PMCID:
PMC10020157
AbstractArticlePDF–3.8M
6.
circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR
Fengzhi Ding, Lin Lu, Chengjie Wu, Xiangbin Pan, Bin Liu, Yu Zhang, Yanli Wang, Weiliang Wu, Bing Yan, Yuqing Zhang, Xi-Yong Yu, Yangxin Li
Theranostics. 2022; 12(17): 7550–7566. Published online 2022 Oct 31. doi: 10.7150/thno.77630
PMCID:
PMC9691369
AbstractArticlePDF–2.7M
7.
Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization
Qi Zhang, Bingqiu Xiu, Liyi Zhang, Ming Chen, Weiru Chi, Lun Li, Rong Guo, Jingyan Xue, Benlong Yang, Xiaoyan Huang, Zhi-Ming Shao, Shenglin Huang, Yayun Chi, Jiong Wu
J Immunother Cancer. 2022; 10(10): e004666. Published online 2022 Oct 17. doi: 10.1136/jitc-2022-004666
PMCID:
PMC9577936
AbstractArticlePDF–11M
8.
The β-TrCP-Mediated Pathway Cooperates with the Keap1-Mediated Pathway in Nrf2 Degradation In Vivo
Ayumi Kuga, Kouhei Tsuchida, Harit Panda, Makoto Horiuchi, Akihito Otsuki, Keiko Taguchi, Fumiki Katsuoka, Mikiko Suzuki, Masayuki Yamamoto
Mol Cell Biol. 2022 Jul; 42(7): e00563-21. Published online 2022 Jun 8. doi: 10.1128/mcb.00563-21
PMCID:
PMC9302178
AbstractArticlePDF–7.9M
9.
Bu-Shen-Zhu-Yun decoction induces PRLR deubiquitination and JAK2/STAT5 activation via CSN5 in vitro
Hua Feng, Huifang Zhou, Jianxia Lu, Qing Zhang, Xingran Tang, Yujie Shang
Aging (Albany NY) 2021 Aug 31; 13(16): 20418–20437. Published online 2021 Aug 23. doi: 10.18632/aging.203426
PMCID:
PMC8436908
AbstractArticlePDF–2.1M
10.
YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3
Dan Wang, Yening Zhang, Xueming Xu, Jianfeng Wu, Yue Peng, Jing Li, Ruiheng Luo, Lingmin Huang, Liping Liu, Songlin Yu, Ningjie Zhang, Ben Lu, Kai Zhao
Nat Commun. 2021; 12: 2674. Published online 2021 May 11. doi: 10.1038/s41467-021-22987-3
PMCID:
PMC8113592
AbstractArticlePDF–3.6M
11.
PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the maternal‐to‐zygotic transition
Long‐Wen Zhao, Ye‐Zhang Zhu, Hao Chen, Yun‐Wen Wu, Shuai‐Bo Pi, Lu Chen, Li Shen, Heng‐Yu Fan
EMBO Rep. 2020 Aug 5; 21(8): e49956. Published online 2020 Jun 17. doi: 10.15252/embr.201949956
PMCID:
PMC7403729
AbstractArticlePDF–5.2M
12.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
13.
β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling
Jin Liu, Yukang Yuan, Jing Xu, Kui Xiao, Ying Xu, Tingting Guo, Liting Zhang, Jun Wang, Hui Zheng
Front Immunol. 2018; 9: 2930. Published online 2018 Dec 13. doi: 10.3389/fimmu.2018.02930
PMCID:
PMC6300488
AbstractArticlePDF–2.4M
14.
Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice
Buqing Ye, Benyu Liu, Lu Hao, Xiaoxiao Zhu, Liuliu Yang, Shuo Wang, Pengyan Xia, Ying Du, Shu Meng, Guanling Huang, Xiwen Qin, Yanying Wang, Xinlong Yan, Chong Li, Junfeng Hao, Pingping Zhu, Luyun He, Yong Tian, Zusen Fan
Nat Commun. 2018; 9: 1261. Published online 2018 Mar 28. doi: 10.1038/s41467-018-03008-2
PMCID:
PMC5871780
AbstractArticlePDF–4.7M
15.
Regulation of mitosis-meiosis transition by the ubiquitin ligase β-TrCP in male germ cells
Tadashi Nakagawa, Teng Zhang, Ryo Kushi, Seiji Nakano, Takahiro Endo, Makiko Nakagawa, Noriko Yanagihara, David Zarkower, Keiko Nakayama
Development. 2017 Nov 15; 144(22): 4137–4147. doi: 10.1242/dev.158485
PMCID:
PMC5719248
AbstractArticle
16.
Stability of wake-sleep cycles requires robust degradation of the PERIOD protein
Matthew D'Alessandro, Stephen Beesley, Jae Kyoung Kim, Zachary Jones, Rongmin Chen, Julie Wi, Kathleen Kyle, Daniel Vera, Michele Pagano, Richard Nowakowski, Choogon Lee
Curr Biol. Author manuscript; available in PMC 2018 Nov 20.
Published in final edited form as: Curr Biol. 2017 Nov 20; 27(22): 3454–3467.e8. Published online 2017 Nov 2. doi: 10.1016/j.cub.2017.10.014
PMCID:
PMC5698108
AbstractArticlePDF–1.1M
17.
Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages
Fansheng Kong, Zhiwei Liu, Viral G. Jain, Kenjiro Shima, Takuji Suzuki, Louis J. Muglia, Daniel T. Starczynowski, Chandrashekhar Pasare, Sandip Bhattacharyya
J Immunol. 2017 Nov 15; 199(10): 3654–3667. Published online 2017 Oct 16. doi: 10.4049/jimmunol.1700443
PMCID:
PMC5672817
AbstractArticlePDF–1.9M
18.
Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors
Susitha Premarathne, Mariyam Murtaza, Nicholas Matigian, Lachlan A. Jolly, Stephen A. Wood
Sci Rep. 2017; 7: 8109. Published online 2017 Aug 14. doi: 10.1038/s41598-017-05451-5
PMCID:
PMC5556043
AbstractArticlePDF–11M
19.
BRCA1 regulates transforming growth factor‐β (TGF‐β1) signaling through Gadd45a by enhancing the protein stability of Smad4
Dan Li, Nan Kang, Junfang Ji, Qimin Zhan
Mol Oncol. 2015 Oct; 9(8): 1655–1666. Published online 2015 May 14. doi: 10.1016/j.molonc.2015.05.002
PMCID:
PMC5528796
AbstractArticlePDF–1.8M
20.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M

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