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Items: 1 to 20 of 292

1.
Complementary and countervailing actions of Jak2 and Ikk2 in hematopoiesis in mice
Daniel A.C. Fisher, Angelo B.A. Laranjeira, Tim Kong, Steven C. Snyder, Kevin Shim, Mary C. Fulbright, Stephen T. Oh
Exp Hematol. Author manuscript; available in PMC 2024 Jul 6.
Published in final edited form as: Exp Hematol. 2023 Dec; 128: 48–66. Published online 2023 Aug 21. doi: 10.1016/j.exphem.2023.08.005
PMCID:
PMC11227100
AbstractArticlePDF–3.9M
2.
Loss of Dnmt3a increases self-renewal and resistance to pegIFN-α in JAK2-V617F–positive myeloproliferative neoplasms
Marc Usart, Jan Stetka, Damien Luque Paz, Nils Hansen, Quentin Kimmerlin, Tiago Almeida Fonseca, Melissa Lock, Lucia Kubovcakova, Riikka Karjalainen, Hui Hao-Shen, Anastasiya Börsch, Athimed El Taher, Jessica Schulz, Jean-Christophe Leroux, Stefan Dirnhofer, Radek C. Skoda
Blood. 2024 Jun 13; 143(24): 2490–2503. Published online 2024 Mar 18. doi: 10.1182/blood.2023020270
PMCID:
PMC11208296
AbstractArticle
3.
The Janus kinase 1 is critical for pancreatic cancer initiation and progression
Hridaya Shrestha, Patrick D. Rädler, Rayane Dennaoui, Madison N. Wicker, Nirakar Rajbhandari, Yunguang Sun, Amy R. Peck, Kerry Vistisen, Aleata A. Triplett, Rafic Beydoun, Esta Sterneck, Dieter Saur, Hallgeir Rui, Kay-Uwe Wagner
Cell Rep. Author manuscript; available in PMC 2024 Jun 23.
Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114202. Published online 2024 May 10. doi: 10.1016/j.celrep.2024.114202
PMCID:
PMC11194014
AbstractArticlePDF–3.3M
4.
Neutrophil-specific expression of JAK2-V617F or CALRmut induces distinct inflammatory profiles in myeloproliferative neoplasia
Tobias Ronny Haage, Emmanouil Charakopoulos, Vikas Bhuria, Conny K. Baldauf, Mark Korthals, Juliane Handschuh, Peter Müller, Juan Li, Kunjan Harit, Gopala Nishanth, Stephanie Frey, Martin Böttcher, Klaus-Dieter Fischer, Jan Dudeck, Anne Dudeck, Daniel B. Lipka, Burkhart Schraven, Anthony R. Green, Andreas J. Müller, Dimitrios Mougiakakos, Thomas Fischer
J Hematol Oncol. 2024; 17: 43. Published online 2024 Jun 9. doi: 10.1186/s13045-024-01562-5
PMCID:
PMC11163796
AbstractArticlePDF–10M
5.
The Janus kinase family of protein tyrosine kinases and their role in signaling
T. C. Yeh, S. Pellegrini
Cell Mol Life Sci. 1999 Sep; 55(12): 1523–1534. doi: 10.1007/s000180050392
PMCID:
PMC11146960
AbstractPDF–790K
6.
Cadherin 22 participates in the self-renewal of mouse female germ line stem cells via interaction with JAK2 and β-catenin
Xiaoyu Zhang, Yang Yang, Qin Xia, Hongfei Song, Rui Wei, Jingjing Wang, Kang Zou
Cell Mol Life Sci. 2018 Apr; 75(7): 1241–1253. Published online 2017 Oct 24. doi: 10.1007/s00018-017-2689-4
PMCID:
PMC11105442
AbstractArticlePDF–2.5M
7.
Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Andrew J. Dunbar, Robert L. Bowman, Young C. Park, Kavi O'Connor, Franco Izzo, Robert M. Myers, Abdul Karzai, Zachary Zaroogian, Won Jun Kim, Inés Fernández-Maestre, Michael R. Waarts, Abbas Nazir, Wenbin Xiao, Tamara Codilupi, Max Brodsky, Mirko Farina, Louise Cai, Sheng F. Cai, Benjamin Wang, Wenbin An, Julie L. Yang, Shoron Mowla, Shira E. Eisman, Amritha Varshini Hanasoge Somasundara, Jacob L. Glass, Tanmay Mishra, Remie Houston, Emily Guzzardi, Anthony R. Martinez Benitez, Aaron D. Viny, Richard P. Koche, Sara C. Meyer, Dan A. Landau, Ross L. Levine
Cancer Discov. 2024 May 1; 14(5): 737–751. Published online 2024 Jan 12. doi: 10.1158/2159-8290.CD-22-0952
PMCID:
PMC11061606
AbstractArticlePDF–20M
8.
IL-1β promotes MPN disease initiation by favoring early clonal expansion of JAK2-mutant hematopoietic stem cells
Shivam Rai, Yang Zhang, Elodie Grockowiak, Quentin Kimmerlin, Nils Hansen, Cedric B. Stoll, Marc Usart, Damien Luque Paz, Hui Hao-Shen, Yexuan Zhu, Julien Roux, Michael S. Bader, Stefan Dirnhofer, Christopher J. Farady, Timm Schroeder, Simón Méndez-Ferrer, Radek C. Skoda
Blood Adv. 2024 Mar 12; 8(5): 1234–1249. Published online 2024 Jan 13. doi: 10.1182/bloodadvances.2023011338
PMCID:
PMC10912850
AbstractArticlePDF–6.0M
9.
Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis
Trevor P. Fidler, Andrew Dunbar, Eunyoung Kim, Brian Hardaway, Jessica Pauli, Chenyi Xue, Sandra Abramowicz, Tong Xiao, Kavi O’Connor, Nadja Sachs, Nan Wang, Lars Maegdefessel, Ross Levine, Muredach Reilly, Alan R. Tall
Nat Cardiovasc Res. Author manuscript; available in PMC 2024 Feb 15.
Published in final edited form as: Nat Cardiovasc Res. 2024 Jan; 3(1): 60–75. Published online 2024 Jan 11. doi: 10.1038/s44161-023-00405-9
PMCID:
PMC10868728
AbstractArticlePDF–6.2M
10.
Calreticulin and JAK2V617F driver mutations induce distinct mitotic defects in myeloproliferative neoplasms
Kristin Holl, Nicolas Chatain, Susanne Krapp, Julian Baumeister, Tiago Maié, Sarah Schmitz, Anja Scheufen, Nathalie Brock, Steffen Koschmieder, Daniel Moreno-Andrés
Sci Rep. 2024; 14: 2810. Published online 2024 Feb 2. doi: 10.1038/s41598-024-53240-8
PMCID:
PMC10837458
AbstractArticlePDF–3.9M
11.
Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway
Yirou Lei, Jiaying He, Fang Hu, Hao Zhu, Jing Gu, Lijuan Tang, Man Luo
BMC Pulm Med. 2023; 23: 385. Published online 2023 Oct 12. doi: 10.1186/s12890-023-02656-5
PMCID:
PMC10568888
AbstractArticlePDF–3.1M
12.
Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms
Elodie Grockowiak, Claudia Korn, Justyna Rak, Veronika Lysenko, Adrien Hallou, Francesca M. Panvini, Matthew Williams, Claire Fielding, Zijian Fang, Eman Khatib-Massalha, Andrés García-García, Juan Li, Reema A. Khorshed, Sara González-Antón, E. Joanna Baxter, Anjali Kusumbe, Bridget S. Wilkins, Anna Green, Benjamin D. Simons, Claire N. Harrison, Anthony R. Green, Cristina Lo Celso, Alexandre P. A. Theocharides, Simón Méndez-Ferrer
Nat Cancer. 2023; 4(8): 1193–1209. Published online 2023 Aug 7. doi: 10.1038/s43018-023-00607-x
PMCID:
PMC10447237
AbstractArticlePDF–18M
13.
Osteoclast-Derived Exosomal miR-5134-5p Interferes with Alveolar Bone Homeostasis by Targeting the JAK2/STAT3 Axis
Lai Pan, Chenyi Zhang, Haizheng Zhang, Ting Ke, Mengyao Bian, Yuxuan Yang, Lili Chen, Jingyi Tan
Int J Nanomedicine. 2023; 18: 3727–3744. Published online 2023 Jul 7. doi: 10.2147/IJN.S413692
PMCID:
PMC10335290
AbstractArticlePDF–11M
14.
miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway
Wei Dong, Jin Chen, Yadong Wang, Junfei Weng, Xingxiang Du, Xu Fang, Wenyu Liu, Tao Long, Jiaxiang You, Wensheng Wang, Xiaoping Peng
Mol Cell Biochem. 2023 May 31 : 1–12. doi: 10.1007/s11010-023-04754-8 [Epub ahead of print]
Correction in:
Mol Cell Biochem. 2023 Jul 11
PMCID:
PMC10230473
AbstractArticlePDF–4.3M
15.
ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA axis-mediated neoplastic fibrocyte generation in myeloproliferative neoplasms
Zhongxun Shi, Jinqin Liu, Yingying Zhao, Lin Yang, Yanan Cai, Peihong Zhang, Zefeng Xu, Tiejun Qin, Shiqiang Qu, Lijuan Pan, Junying Wu, Xin Yan, Zexing Li, Wenjun Zhang, Yiru Yan, Huijun Huang, Gang Huang, Bing Li, Xudong Wu, Zhijian Xiao
Haematologica. 2023 May 1; 108(5): 1359–1373. Published online 2022 Aug 25. doi: 10.3324/haematol.2021.280320
PMCID:
PMC10153516
AbstractArticlePDF–5.4M
16.
M2型巨噬细胞来源的外泌体lncRNA NR_028113.1通过激活JAK2/STAT3通路促进巨噬细胞的极化
张 梦莹, 李 志, 裴 纬亚, 李 雪琴, 杨 辉, 朱 小龙, 吕 坤
Nan Fang Yi Ke Da Xue Xue Bao. 2023 Mar 20; 43(3): 393–399. Chinese. doi: 10.12122/j.issn.1673-4254.2023.03.08
PMCID:
PMC10122731
AbstractArticlePDF–2.0M
17.
The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells
Anne Marie Staehle, Jan Caspar Peeken, Georg Vladimirov, Mirjam Elisabeth Hoeness, Sarolta Bojtine Kovacs, Nikolaos Karantzelis, Albert Gruender, Christoph Koellerer, Jonas Samuel Jutzi, Heike Luise Pahl, Hans Felix Staehle
Leukemia. 2023; 37(4): 919–923. Published online 2023 Jan 28. doi: 10.1038/s41375-023-01826-y
PMCID:
PMC10079541
AbstractArticlePDF–1.6M
18.
Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models
Xu Han, Yang Mei, Rama K. Mishra, Honghao Bi, Atul D. Jain, Gary E. Schiltz, Baobing Zhao, Madina Sukhanova, Pan Wang, Arabela A. Grigorescu, Patricia C. Weber, John J. Piwinski, Miguel A. Prado, Joao A. Paulo, Len Stephens, Karen E. Anderson, Charles S. Abrams, Jing Yang, Peng Ji
J Clin Invest. 2023 Mar 15; 133(6): e159638. Published online 2023 Mar 15. doi: 10.1172/JCI159638
PMCID:
PMC10014099
AbstractArticlePDF–8.1M
19.
Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
Lindsay M. Gurska, Rachel Okabe, Alexandra Schurer, Meng Maxine Tong, Mark Soto, Daniel Choi, Kristina Ames, Shira Glushakow-Smith, Allison Montoya, Ellen Tein, Linde A. Miles, Haiying Cheng, Pamela Hankey-Giblin, Ross L. Levine, Swati Goel, Balazs Halmos, Kira Gritsman
Clin Cancer Res. Author manuscript; available in PMC 2023 Sep 1.
Published in final edited form as: Clin Cancer Res. 2023 Mar 1; 29(5): 943–956. doi: 10.1158/1078-0432.CCR-22-1763
PMCID:
PMC9992133
AbstractArticlePDF–1.6M
20.
BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation
Bing Li, Wenbin An, Hua Wang, Timour Baslan, Shoron Mowla, Aishwarya Krishnan, Wenbin Xiao, Richard P. Koche, Ying Liu, Sheng F. Cai, Zhijian Xiao, Andriy Derkach, Ilaria Iacobucci, Charles G. Mullighan, Kristian Helin, Scott W. Lowe, Ross L. Levine, Raajit K. Rampal
Blood. 2022 Jun 23; 139(25): 3630–3646. Published online 2022 Apr 18. doi: 10.1182/blood.2021014465
PMCID:
PMC9728578
AbstractArticle

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