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Select item 73672041.

Cdk9 and H2Bub1 signal to Clr6-CII/Rpd3S to suppress aberrant antisense transcription

Miriam Sansó, Pabitra K Parua, Daniel Pinto, J Peter Svensson, Viviane Pagé, Danny A Bitton, Sarah MacKinnon, Patricia Garcia, Elena Hidalgo, Jürg Bähler, Jason C Tanny, Robert P Fisher

Nucleic Acids Res. 2020 Jul 27; 48(13): 7154–7168. Published online 2020 Jun 4. doi: 10.1093/nar/gkaa474

PMCID:: PMC7367204

Abstract Article PDF–4.6M

Select item 63972412.

Systematic analysis reveals the prevalence and principles of bypassable gene essentiality

Jun Li, Hai-Tao Wang, Wei-Tao Wang, Xiao-Ran Zhang, Fang Suo, Jing-Yi Ren, Ying Bi, Ying-Xi Xue, Wen Hu, Meng-Qiu Dong, Li-Lin Du

Nat Commun. 2019; 10: 1002. Published online 2019 Mar 1. doi: 10.1038/s41467-019-08928-1

PMCID:: PMC6397241

Abstract Article PDF–1.2M

Select item 62331443.

RNA polymerase II CTD interactome with 3′ processing and termination factors in fission yeast and its impact on phosphate homeostasis

Ana M. Sanchez, Stewart Shuman, Beate Schwer

Proc Natl Acad Sci U S A. 2018 Nov 6; 115(45): E10652–E10661. Published online 2018 Oct 24. doi: 10.1073/pnas.1810711115

PMCID:: PMC6233144

Abstract Article PDF–1.4M

Select item 60211994.

A Cdk9-PP1 switch regulates the elongation-termination transition of RNA polymerase II

Pabitra K. Parua, Gregory T. Booth, Miriam Sansó, Bradley Benjamin, Jason C. Tanny, John T. Lis, Robert P. Fisher

Nature. Author manuscript; available in PMC 2018 Dec 13.

Published in final edited form as: Nature. 2018 Jun; 558(7710): 460–464. Published online 2018 Jun 13. doi: 10.1038/s41586-018-0214-z

PMCID:: PMC6021199

Abstract Article PDF–6.9M

Select item 58032475.

Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast

Gregory T. Booth, Pabitra K. Parua, Miriam Sansó, Robert P. Fisher, John T. Lis

Nat Commun. 2018; 9: 543. Published online 2018 Feb 7. doi: 10.1038/s41467-018-03006-4

PMCID:: PMC5803247

Abstract Article PDF–2.1M

Select item 53217446.

Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation

Junwoo Lee, Eun Shik Choi, Hogyu David Seo, Keunsoo Kang, Joshua M. Gilmore, Laurence Florens, Michael P. Washburn, Joonho Choe, Jerry L. Workman, Daeyoup Lee

Nat Commun. 2017; 8: 14527. Published online 2017 Feb 20. doi: 10.1038/ncomms14527

PMCID:: PMC5321744

Abstract Article PDF–1.4M

Select item 47877877.

Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification

Jean Mbogning, Viviane Pagé, Jillian Burston, Emily Schwenger, Robert P. Fisher, Beate Schwer, Stewart Shuman, Jason C. Tanny

Nucleic Acids Res. 2015 Nov 16; 43(20): 9766–9775. Published online 2015 Aug 14. doi: 10.1093/nar/gkv837

PMCID:: PMC4787787

Abstract Article PDF–5.5M

Select item 45747538.

RNA polymerase II CTD phospho-sites Ser5 and Ser7 govern phosphate homeostasis in fission yeast

Beate Schwer, Ana M. Sanchez, Stewart Shuman

RNA. 2015 Oct; 21(10): 1770–1780. doi: 10.1261/rna.052555.115

PMCID:: PMC4574753

Abstract Article PDF–704K

Select item 43872089.

Fission Yeast Cdk7 Controls Gene Expression through both Its CAK and C-Terminal Domain Kinase Activities

Maxime Devos, Elise Mommaerts, Valerie Migeot, Harm van Bakel, Damien Hermand

Mol Cell Biol. 2015 May; 35(9): 1480–1490. Prepublished online 2015 Feb 17. Published online 2015 Apr 6. doi: 10.1128/MCB.00024-15

PMCID:: PMC4387208

Abstract Article PDF–1.2M

Select item 402464110.

Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex

Emily D. Egan, Craig R. Braun, Steven P. Gygi, Danesh Moazed

RNA. 2014 Jun; 20(6): 867–881. doi: 10.1261/rna.044479.114

PMCID:: PMC4024641

Abstract Article PDF–1.8M

Select item 387323211.

The PAF Complex and Prf1/Rtf1 Delineate Distinct Cdk9-Dependent Pathways Regulating Transcription Elongation in Fission Yeast

Jean Mbogning, Stephen Nagy, Viviane Pagé, Beate Schwer, Stewart Shuman, Robert P. Fisher, Jason C. Tanny

PLoS Genet. 2013 Dec; 9(12): e1004029. Published online 2013 Dec 26. doi: 10.1371/journal.pgen.1004029

PMCID:: PMC3873232

Abstract Article PDF–4.1M

Select item 343448912.

Separate Domains of Fission Yeast Cdk9 (P-TEFb) Are Required for Capping Enzyme Recruitment and Primed (Ser7-Phosphorylated) Rpb1 Carboxyl-Terminal Domain Substrate Recognition

Courtney V. St. Amour, Miriam Sansó, Christian A. Bösken, Karen M. Lee, Stéphane Larochelle, Chao Zhang, Kevan M. Shokat, Matthias Geyer, Robert P. Fisher

Mol Cell Biol. 2012 Jul; 32(13): 2372–2383. doi: 10.1128/MCB.06657-11

PMCID:: PMC3434489

Abstract Article PDF–1.5M

Select item 341085413.

A Positive Feedback Loop Links Opposing Functions of P-TEFb/Cdk9 and Histone H2B Ubiquitylation to Regulate Transcript Elongation in Fission Yeast

Miriam Sansó, Karen M. Lee, Laia Viladevall, Pierre-Étienne Jacques, Viviane Pagé, Stephen Nagy, Ariane Racine, Courtney V. St. Amour, Chao Zhang, Kevan M. Shokat, Beate Schwer, François Robert, Robert P. Fisher, Jason C. Tanny

PLoS Genet. 2012 Aug; 8(8): e1002822. Published online 2012 Aug 2. doi: 10.1371/journal.pgen.1002822

PMCID:: PMC3410854

Abstract Article PDF–2.5M

Select item 338063614.

Hierarchical modularity and the evolution of genetic interactomes across species

Colm J. Ryan, Assen Roguev, Kristin Patrick, Jiewei Xu, Harlizawati Jahari, Zongtian Tong, Pedro Beltrao, Michael Shales, Hong Qu, Sean R. Collins, Joseph I. Kliegman, Lingli Jiang, Dwight Kuo, Elena Tosti, Hyun-Soo Kim, Winfried Edelmann, Michael-Christopher Keogh, Derek Greene, Chao Tang, Pádraig Cunningham, Kevan M. Shokat, Gerard Cagney, J. Peter Svensson, Christine Guthrie, Peter J. Espenshade, Trey Ideker, Nevan J. Krogan

Mol Cell. Author manuscript; available in PMC 2013 Jun 8.

Published in final edited form as: Mol Cell. 2012 Jun 8; 46(5): 691–704. doi: 10.1016/j.molcel.2012.05.028

PMCID:: PMC3380636

Abstract Article PDF–2.1M

Select item 275325115.

Conservation and Rewiring of Functional Modules Revealed by an Epistasis Map in Fission Yeast

Assen Roguev, Sourav Bandyopadhyay, Martin Zofall, Ke Zhang, Tamas Fischer, Sean R. Collins, Hongjing Qu, Michael Shales, Han-Oh Park, Jacqueline Hayles, Kwang-Lae Hoe, Dong-Uk Kim, Trey Ideker, Shiv I. Grewal, Jonathan S. Weissman, Nevan J. Krogan

Science. Author manuscript; available in PMC 2009 Sep 28.

Published in final edited form as: Science. 2008 Oct 17; 322(5900): 405–410. Published online 2008 Sep 25. doi: 10.1126/science.1162609

PMCID:: PMC2753251

Abstract Article PDF–4.2M

Select item 269312116.

TFIIH and P-TEFb Coordinate Transcription with Capping Enzyme Recruitment at Specific Genes in Fission Yeast

Laia Viladevall, Courtney V. St. Amour, Adam Rosebrock, Susanne Schneider, Chao Zhang, Jasmina J. Allen, Kevan M. Shokat, Beate Schwer, Janet K. Leatherwood, Robert P. Fisher

Mol Cell. Author manuscript; available in PMC 2009 Sep 27.

Published in final edited form as: Mol Cell. 2009 Mar 27; 33(6): 738–751. doi: 10.1016/j.molcel.2009.01.029