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Select item 97654501.

Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States

Bradley Benjamin, Yehuda Goldgur, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman

mBio. 2022 Nov-Dec; 13(6): e03087-22. Published online 2022 Dec 5. doi: 10.1128/mbio.03087-22

PMCID:: PMC9765450

Abstract Article PDF–4.4M

Select item 92392642.

Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression

Bradley Benjamin, Angad Garg, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman

mBio. 2022 May-Jun; 13(3): e01034-22. Published online 2022 May 10. doi: 10.1128/mbio.01034-22

PMCID:: PMC9239264

Abstract Article PDF–3.0M

Select item 89449283.

Mitotic spindle formation in the absence of Polo kinase

Juyoung Kim, Gohta Goshima

Proc Natl Acad Sci U S A. 2022 Mar 22; 119(12): e2114429119. Published online 2022 Mar 14. doi: 10.1073/pnas.2114429119

PMCID:: PMC8944928

Abstract Article PDF–3.1M

Select item 87890434.

Genetic screen for suppression of transcriptional interference reveals fission yeast 14–3–3 protein Rad24 as an antagonist of precocious Pol2 transcription termination

Angad Garg, Stewart Shuman, Beate Schwer

Nucleic Acids Res. 2022 Jan 25; 50(2): 803–819. Published online 2021 Dec 30. doi: 10.1093/nar/gkab1263

PMCID:: PMC8789043

Abstract Article PDF–5.6M

Select item 83799845.

Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1

Beate Schwer, Angad Garg, Agata Jacewicz, Stewart Shuman

Proc Natl Acad Sci U S A. 2021 Aug 17; 118(33): e2108105118. Published online 2021 Aug 13. doi: 10.1073/pnas.2108105118

PMCID:: PMC8379984

Abstract Article PDF–1.8M

Select item 80389936.

The Asp1 pyrophosphatase from S. pombe hosts a [2Fe-2S]²⁺ cluster in vivo

Hannah Rosenbach, Eva Walla, George E. Cutsail, III, James A. Birrell, Marina Pascual-Ortiz, Serena DeBeer, Ursula Fleig, Ingrid Span

J Biol Inorg Chem. 2021; 26(1): 93–108. Published online 2021 Feb 5. doi: 10.1007/s00775-020-01840-w

PMCID:: PMC8038993

Abstract Article PDF–2.3M

Select item 76417567.

A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination

Angad Garg, Stewart Shuman, Beate Schwer

Nucleic Acids Res. 2020 Nov 4; 48(19): 10739–10752. Published online 2020 Oct 3. doi: 10.1093/nar/gkaa776

PMCID:: PMC7641756

Abstract Article PDF–5.9M

Select item 68952738.

Inositol pyrophosphates impact phosphate homeostasis via modulation of RNA 3′ processing and transcription termination

Ana M Sanchez, Angad Garg, Stewart Shuman, Beate Schwer

Nucleic Acids Res. 2019 Sep 19; 47(16): 8452–8469. Published online 2019 Jul 5. doi: 10.1093/nar/gkz567

PMCID:: PMC6895273

Abstract Article PDF–6.3M

Select item 63972419.

Systematic analysis reveals the prevalence and principles of bypassable gene essentiality

Jun Li, Hai-Tao Wang, Wei-Tao Wang, Xiao-Ran Zhang, Fang Suo, Jing-Yi Ren, Ying Bi, Ying-Xi Xue, Wen Hu, Meng-Qiu Dong, Li-Lin Du

Nat Commun. 2019; 10: 1002. Published online 2019 Mar 1. doi: 10.1038/s41467-019-08928-1

PMCID:: PMC6397241

Abstract Article PDF–1.2M

Select item 590259310.

Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe

Marina Pascual-Ortiz, Adolfo Saiardi, Eva Walla, Visnja Jakopec, Natascha A. Künzel, Ingrid Span, Anand Vangala, Ursula Fleig

Mol Cell Biol. 2018 May 1; 38(9): e00047-18. Prepublished online 2018 Feb 12. Published online 2018 Apr 16. doi: 10.1128/MCB.00047-18

PMCID:: PMC5902593

Abstract Article PDF–5.3M

Select item 535460511.

A central role for TOR signalling in a yeast model for juvenile CLN3 disease

Michael E. Bond, Rachel Brown, Charalampos Rallis, Jürg Bähler, Sara E. Mole

Microb Cell. 2015 Dec 7; 2(12): 466–480. Published online 2015 Nov 11. doi: 10.15698/mic2015.12.241

PMCID:: PMC5354605

Abstract Article PDF–2.1M

Select item 534509512.

Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes

Charalampos Rallis, StJohn Townsend, Jürg Bähler

Sci Rep. 2017; 7: 44257. Published online 2017 Mar 10. doi: 10.1038/srep44257

Correction in:: Sci Rep. 2017; 7: 46857.

PMCID:: PMC5345095

Abstract Article PDF–1.5M

Select item 532174413.

Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation

Junwoo Lee, Eun Shik Choi, Hogyu David Seo, Keunsoo Kang, Joshua M. Gilmore, Laurence Florens, Michael P. Washburn, Joonho Choe, Jerry L. Workman, Daeyoup Lee

Nat Commun. 2017; 8: 14527. Published online 2017 Feb 20. doi: 10.1038/ncomms14527

PMCID:: PMC5321744

Abstract Article PDF–1.4M

Select item 512629814.

Inositol Pyrophosphate Kinase Asp1 Modulates Chromosome Segregation Fidelity and Spindle Function in Schizosaccharomyces pombe

Boris Topolski, Visnja Jakopec, Natascha A. Künzel, Ursula Fleig

Mol Cell Biol. 2016 Dec 15; 36(24): 3128–3140. Prepublished online 2016 Oct 3. Published online 2016 Nov 28. doi: 10.1128/MCB.00330-16

PMCID:: PMC5126298

Abstract Article PDF–2.5M

Select item 464144115.

Asp1 from Schizosaccharomyces pombe Binds a [2Fe-2S]²⁺ Cluster Which Inhibits Inositol Pyrophosphate 1-Phosphatase Activity

Huanchen Wang, Vasudha S. Nair, Ashley A. Holland, Samanta Capolicchio, Henning J. Jessen, Michael K. Johnson, Stephen B. Shears

Biochemistry. Author manuscript; available in PMC 2016 Oct 27.

Published in final edited form as: Biochemistry. 2015 Oct 27; 54(42): 6462–6474. Published online 2015 Oct 9. doi: 10.1021/acs.biochem.5b00532

PMCID:: PMC4641441

Abstract Article PDF–838K

Select item 417767216.

The Vip1 Inositol Polyphosphate Kinase Family Regulates Polarized Growth and Modulates the Microtubule Cytoskeleton in Fungi

Jennifer Pöhlmann, Carmen Risse, Constanze Seidel, Thomas Pohlmann, Visnja Jakopec, Eva Walla, Pascal Ramrath, Norio Takeshita, Sebastian Baumann, Michael Feldbrügge, Reinhard Fischer, Ursula Fleig

PLoS Genet. 2014 Sep; 10(9): e1004586. Published online 2014 Sep 25. doi: 10.1371/journal.pgen.1004586

PMCID:: PMC4177672

Abstract Article PDF–7.2M

Select item 347565817.

Cytokinesis-Based Constraints on Polarized Cell Growth in Fission Yeast

K. Adam Bohnert, Kathleen L. Gould

PLoS Genet. 2012 Oct; 8(10): e1003004. Published online 2012 Oct 18. doi: 10.1371/journal.pgen.1003004

Correction in:: PLoS Genet. 2013 Aug; 9(8): 10.1371/annotation/e5f64e2d-7587-43d1-a0af-bc6d6244889c.

PMCID:: PMC3475658

Abstract Article PDF–12M

Select item 338063618.

Hierarchical modularity and the evolution of genetic interactomes across species

Colm J. Ryan, Assen Roguev, Kristin Patrick, Jiewei Xu, Harlizawati Jahari, Zongtian Tong, Pedro Beltrao, Michael Shales, Hong Qu, Sean R. Collins, Joseph I. Kliegman, Lingli Jiang, Dwight Kuo, Elena Tosti, Hyun-Soo Kim, Winfried Edelmann, Michael-Christopher Keogh, Derek Greene, Chao Tang, Pádraig Cunningham, Kevan M. Shokat, Gerard Cagney, J. Peter Svensson, Christine Guthrie, Peter J. Espenshade, Trey Ideker, Nevan J. Krogan

Mol Cell. Author manuscript; available in PMC 2013 Jun 8.

Published in final edited form as: Mol Cell. 2012 Jun 8; 46(5): 691–704. doi: 10.1016/j.molcel.2012.05.028

PMCID:: PMC3380636

Abstract Article PDF–2.1M

Select item 293753219.

Asp1, a Conserved 1/3 Inositol Polyphosphate Kinase, Regulates the Dimorphic Switch in Schizosaccharomyces pombe

Jennifer Pöhlmann, Ursula Fleig

Mol Cell Biol. 2010 Sep; 30(18): 4535–4547. Published online 2010 Jul 12. doi: 10.1128/MCB.00472-10

PMCID:: PMC2937532

Abstract Article PDF–1.9M

Select item 269159920.

Evolution of Phosphoregulation: Comparison of Phosphorylation Patterns across Yeast Species

Pedro Beltrao, Jonathan C. Trinidad, Dorothea Fiedler, Assen Roguev, Wendell A. Lim, Kevan M. Shokat, Alma L. Burlingame, Nevan J. Krogan

PLoS Biol. 2009 Jun; 7(6): e1000134. Published online 2009 Jun 23. doi: 10.1371/journal.pbio.1000134

Correction in:: PLoS Biol. 2009 Nov; 7(11): 10.1371/annotation/66479889-5e57-4213-bf25-c4e8cf3d933b.

PMCID:: PMC2691599

Abstract Article PDF–659K

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