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Select item 112290871.

Batf3⁺ DCs and the 4–1BB/4–1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy

Andrea Ziblat, Brendan L. Horton, Emily F. Higgs, Ken Hatogai, Anna Martinez, Jason W. Shapiro, Danny E.C. Kim, YuanYuan Zha, Randy F. Sweis, Thomas F. Gajewski

Cell Rep. Author manuscript; available in PMC 2024 Jul 8.

Published in final edited form as: Cell Rep. 2024 May 28; 43(5): 114141. Published online 2024 Apr 23. doi: 10.1016/j.celrep.2024.114141

PMCID:: PMC11229087

Abstract Article PDF–3.0M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 98969653.

Mechanisms of CD40-dependent cDC1 licensing beyond costimulation

Renee Wu, Ray A. Ohara, Suin Jo, Tian-Tian Liu, Stephen T. Ferris, Feiya Ou, Sunkyung Kim, Derek J. Theisen, David A. Anderson, III, Brian W. Wong, Timothy Gershon, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy

Nat Immunol. Author manuscript; available in PMC 2023 Feb 3.

Published in final edited form as: Nat Immunol. 2022 Nov; 23(11): 1536–1550. Published online 2022 Oct 21. doi: 10.1038/s41590-022-01324-w

PMCID:: PMC9896965

Abstract Article PDF–2.6M

Select item 97625524.

Targeting 4-1BB and PD-L1 induces potent and durable antitumor immunity in B-cell lymphoma

Yichen Wang, Xuyao Zhang, Caili Xu, Yanyang Nan, Jiajun Fan, Xian Zeng, Byoung S. Kwon, Dianwen Ju

Front Immunol. 2022; 13: 1004475. Published online 2022 Dec 5. doi: 10.3389/fimmu.2022.1004475

PMCID:: PMC9762552

Abstract Article PDF–7.7M

Select item 92796135.

CD137 Regulates Bone Loss via the p53 Wnt/β-Catenin Signaling Pathways in Aged Mice

Jiyu Han, Yanhong Wang, Haichao Zhou, Yingqi Zhang, Daqian Wan

Front Endocrinol (Lausanne) 2022; 13: 922501. Published online 2022 Jun 30. doi: 10.3389/fendo.2022.922501

PMCID:: PMC9279613

Abstract Article PDF–7.9M

Select item 86831566.

EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8⁺ T Cells

Christopher J. Stairiker, Sophia Xiao Pfister, Eleanore Hendrickson, Wenjing Yang, Tao Xie, Catherine Lee, Haikuo Zhang, Christopher Dillon, Graham D. Thomas, Shahram Salek-Ardakani

Front Immunol. 2021; 12: 770080. Published online 2021 Nov 24. doi: 10.3389/fimmu.2021.770080

PMCID:: PMC8683156

Abstract Article PDF–3.4M

Select item 86742797.

CD137 (4-1BB) costimulation of CD8⁺ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Itziar Otano, Arantza Azpilikueta, Javier Glez-Vaz, Maite Alvarez, José Medina-Echeverz, Ivan Cortés-Domínguez, Carlos Ortiz-de-Solorzano, Peter Ellmark, Sara Fritzell, Gabriela Hernandez-Hoyos, Michelle Hase Nelson, María Carmen Ochoa, Elixabet Bolaños, Doina Cuculescu, Patricia Jaúregui, Sandra Sanchez-Gregorio, Iñaki Etxeberria, María E. Rodriguez-Ruiz, Miguel F. Sanmamed, Álvaro Teijeira, Pedro Berraondo, Ignacio Melero

Nat Commun. 2021; 12: 7296. Published online 2021 Dec 15. doi: 10.1038/s41467-021-27613-w

PMCID:: PMC8674279

Abstract Article PDF–4.6M

Select item 84925178.

Self-renewing islet TCF1⁺ CD8 T cells undergo interleukin-27 controlled differentiation to become TCF1⁻ terminal effectors during the progression of type 1 diabetes

Ashley E. Ciecko, David M. Schauder, Bardees Foda, Galina Petrova, Moujtaba Y. Kasmani, Robert Burns, Chien-Wei Lin, William R. Drobyski, Weiguo Cui, Yi-Guang Chen

J Immunol. Author manuscript; available in PMC 2022 Oct 15.

Published in final edited form as: J Immunol. 2021 Oct 15; 207(8): 1990–2004. Published online 2021 Sep 10. doi: 10.4049/jimmunol.2100362

PMCID:: PMC8492517

Abstract Article PDF–2.3M

Select item 81024929.

Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice

Daqian Wan, Songtao Ai, Huoniu Ouyang, Liming Cheng

Exp Mol Med. 2021 Apr; 53(4): 654–666. Published online 2021 Apr 15. doi: 10.1038/s12276-021-00605-y

PMCID:: PMC8102492

Abstract Article PDF–2.1M

Select item 801951510.

Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice

Dina Montufar-Solis, Alexander Williams, Nadarajah Vigneswaran, John R. Klein

Biochem Biophys Res Commun. Author manuscript; available in PMC 2021 Apr 4.

Published in final edited form as: Biochem Biophys Res Commun. 2017 Jan 29; 483(1): 590–595. Published online 2016 Dec 21. doi: 10.1016/j.bbrc.2016.12.099

PMCID:: PMC8019515

Abstract Article PDF–1.4M

Select item 791490311.

Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis

Khang Luu, Mugdha Vijay Patwardhan, Qun Zeng, Stina L. Wickström, Andreas Lundqvist, Herbert Schwarz

Cells. 2021 Feb; 10(2): 353. Published online 2021 Feb 9. doi: 10.3390/cells10020353

PMCID:: PMC7914903

Abstract Article PDF–1.4M

Select item 775819112.

The Murine CD137/CD137 Ligand Signalosome: A Signal Platform Generating Signal Complexity

Beom K. Choi, Hyeon-Woo Lee

Front Immunol. 2020; 11: 553715. Published online 2020 Dec 10. doi: 10.3389/fimmu.2020.553715

PMCID:: PMC7758191

Abstract Article PDF–2.1M

Select item 760460413.

Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway

Bo Li, Yue Zhang, Runting Yin, Wei Zhong, Rui Chen, Jinchuan Yan

Mediators Inflamm. 2020; 2020: 1649453. Published online 2020 Oct 24. doi: 10.1155/2020/1649453

PMCID:: PMC7604604

Abstract Article PDF–3.0M

Select item 731355414.

4-1BBL regulates the polarization of macrophages and inhibition of 4-1BBL signaling alleviates imiquimod-induced psoriasis

Haruka Miki, Kyung Ho Han, David Scott, Michael Croft, Young Jun Kang

J Immunol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: J Immunol. 2020 Apr 1; 204(7): 1892–1903. Published online 2020 Feb 10. doi: 10.4049/jimmunol.1900983

PMCID:: PMC7313554

Abstract Article PDF–1.5M

Select item 726958515.

A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target

Zachary T. Freeman, Thomas R. Nirschl, Daniel H. Hovelson, Robert J. Johnston, John J. Engelhardt, Mark J. Selby, Christina M. Kochel, Ruth Y. Lan, Jingyi Zhai, Ali Ghasemzadeh, Anuj Gupta, Alyza M. Skaist, Sarah J. Wheelan, Hui Jiang, Alexander T. Pearson, Linda A. Snyder, Alan J. Korman, Scott A. Tomlins, Srinivasan Yegnasubramanian, Charles G. Drake

J Clin Invest. 2020 Mar 2; 130(3): 1405–1416. Published online 2020 Feb 4. doi: 10.1172/JCI128672

PMCID:: PMC7269585

Abstract Article PDF–6.4M

Select item 726681416.

CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus

Yujun Pei, Kun Wen, Zheng Xiang, Chunyu Huang, Xiwei Wang, Xiaofeng Mu, Liyan Wen, Yinping Liu, Wenwei Tu

Signal Transduct Target Ther. 2020; 5: 74. Published online 2020 Jun 3. doi: 10.1038/s41392-020-0174-2

PMCID:: PMC7266814

Abstract Article PDF–3.5M

Select item 717688317.

Exosome derived from CD137‐modified endothelial cells regulates the Th17 responses in atherosclerosis

Liangjie Xu, Tianxin Geng, Guangyao Zang, Li Bo, Yi Liang, Hong Zhou, Jinchuan Yan

J Cell Mol Med. 2020 Apr; 24(8): 4659–4667. Published online 2020 Mar 9. doi: 10.1111/jcmm.15130

PMCID:: PMC7176883

Abstract Article PDF–1.3M

Select item 702911718.

CD137 negatively affects “browning” of white adipose tissue during cold exposure

Raj Kamal Srivastava, Annalena Moliner, Ee-Soo Lee, Emily Nickles, Eunice Sim, Chang Liu, Herbert Schwarz, Carlos F. Ibáñez

J Biol Chem. 2020 Feb 14; 295(7): 2034–2042. Published online 2020 Jan 9. doi: 10.1074/jbc.AC119.011795

PMCID:: PMC7029117

Abstract Article PDF–2.9M

Select item 672609319.

Ethanol-Responsive Brain Region Expression Networks: Implications for Behavioral Responses to Acute Ethanol in DBA/2J versus C57BL/6J Mice

Robnet T. Kerns, Ajay Ravindranathan, Sajida Hassan, Mary P. Cage, Tim York, James M. Sikela, Robert W. Williams, Michael F. Miles

J Neurosci. 2005 Mar 2; 25(9): 2255–2266. doi: 10.1523/JNEUROSCI.4372-04.2005

PMCID:: PMC6726093

Abstract Article PDF–620K

Select item 662174620.

Development of Experimental Autoimmune Encephalomyelitis Critically Depends on CD137 Ligand Signaling

Julia M. Martínez Gómez, J. Ludovic Croxford, Kim Pin Yeo, Véronique Angeli, Herbert Schwarz, Stephan Gasser

J Neurosci. 2012 Dec 12; 32(50): 18246–18252. doi: 10.1523/JNEUROSCI.2473-12.2012

PMCID:: PMC6621746

Abstract Article PDF–1.3M

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