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Select item 113770611.

Mir221/222 drive synovial hyperplasia and arthritis by targeting cell cycle inhibitors and chromatin remodeling components

Fani Roumelioti, Christos Tzaferis, Dimitris Konstantopoulos, Dimitra Papadopoulou, Alejandro Prados, Maria Sakkou, Anastasios Liakos, Panagiotis Chouvardas, Theodore Meletakos, Yiannis Pandis, Niki Karagianni, Maria C Denis, Maria Fousteri, Maria Armaka, George Kollias

eLife. 2024; 13: e84698. Published online 2024 Sep 5. doi: 10.7554/eLife.84698

PMCID:: PMC11377061

Article PDF–9.3M

Select item 109248442.

MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes

Keyan Hu, Lei Liu, Songtao Tang, Xin Zhang, Hongfeng Chang, Wenyang Chen, Taotao Fan, Lesha Zhang, Bing Shen, Qiu Zhang

Commun Biol. 2024; 7: 300. Published online 2024 Mar 9. doi: 10.1038/s42003-024-05986-0

PMCID:: PMC10924844

Article PDF–18M

Select item 106953763.

The miR-221/222 cluster regulates hematopoietic stem cell quiescence and multipotency by suppressing both Fos/AP-1/IEG pathway activation and stress-like differentiation to granulocytes

Peter K. Jani, Georg Petkau, Yohei Kawano, Uwe Klemm, Gabriela Maria Guerra, Gitta Anne Heinz, Frederik Heinrich, Pawel Durek, Mir-Farzin Mashreghi, Fritz Melchers

PLoS Biol. 2023 Nov; 21(11): e3002015. Published online 2023 Nov 20. doi: 10.1371/journal.pbio.3002015

PMCID:: PMC10695376

Article PDF–3.3M

Select item 100139494.

microRNA‐221 rescues the loss of dopaminergic neurons in a mouse model of Parkinson's disease

Yufang Yao, Zhiyue Zhao, Fubo Zhang, Na Miao, Nan Wang, Xin Xu, Chaoping Yang

Brain Behav. 2023 Mar; 13(3): e2921. Published online 2023 Feb 16. doi: 10.1002/brb3.2921

PMCID:: PMC10013949

Article PDF–962K

Select item 89954405.

miR‐221 promotes keratinocyte proliferation and migration by targeting SOCS7 and is regulated by YB‐1

Xiao Feng, Lei Zhang, Wei Feng, Ce Zhang, Tingting Jin, Jingyu Li, Jincai Guo

J Cell Mol Med. 2022 Apr; 26(8): 2299–2311. Published online 2022 Feb 24. doi: 10.1111/jcmm.17250

PMCID:: PMC8995440

Article PDF–2.3M

Select item 87622936.

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

Satoshi Yamaguchi, Dongxiao Zhang, Akihiro Katayama, Naoko Kurooka, Ryosuke Sugawara, Haya Hamed Hassan Albuayjan, Atsuko Nakatsuka, Jun Eguchi, Jun Wada

Front Endocrinol (Lausanne) 2021; 12: 750261. Published online 2022 Jan 3. doi: 10.3389/fendo.2021.750261

PMCID:: PMC8762293

Article PDF–10M

Select item 86562357.

miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury

Jing Yang, Hanh Chi Do-Umehara, Qiao Zhang, Huashan Wang, Changchun Hou, Huali Dong, Edith A. Perez, Marc A. Sala, Kishore R. Anekalla, James M. Walter, Shuwen Liu, Richard G. Wunderink, G.R. Scott Budinger, Jing Liu

Front Immunol. 2021; 12: 700933. Published online 2021 Nov 25. doi: 10.3389/fimmu.2021.700933

PMCID:: PMC8656235

Article PDF–5.8M

Select item 84858588.

MicroRNA-directed pathway discovery elucidates an miR-221/222–mediated regulatory circuit in class switch recombination

Eric J. Wigton, Yohei Mikami, Ryan J. McMonigle, Carlos A. Castellanos, Adam K. Wade-Vallance, Simon K. Zhou, Robin Kageyama, Adam Litterman, Suparna Roy, Daisuke Kitamura, Emily C. Dykhuizen, Christopher D.C. Allen, Hui Hu, John J. O’Shea, K. Mark Ansel

J Exp Med. 2021 Nov 1; 218(11): e20201422. Published online 2021 Sep 29. doi: 10.1084/jem.20201422

PMCID:: PMC8485858

Article PDF–4.7M

Select item 84362309.

miR221 regulates TGF-β1-induced HSC activation through inhibiting autophagy by directly targeting LAMP2

Ran Cheng, Hao Xu, Yang Hong

Mol Med Rep. 2021 Nov; 24(5): 777. Published online 2021 Sep 7. doi: 10.3892/mmr.2021.12417

PMCID:: PMC8436230

Article PDF–1.0M

Select item 802583810.

MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of Interleukin-23

Yohei Mikami, Rachael L. Philips, Giuseppe Sciumè, Franziska Petermann, Françoise Meylan, Hiroyuki Nagashima, Chen Yao, Fred P. Davis, Stephen R. Brooks, Hong-Wei Sun, Hayato Takahashi, Amanda C. Poholek, Han-Yu Shih, Behdad Afzali, Stefan A. Muljo, Markus Hafner, Yuka Kanno, John J. O’Shea

Immunity. Author manuscript; available in PMC 2022 Mar 9.

Published in final edited form as: Immunity. 2021 Mar 9; 54(3): 514–525.e6. Published online 2021 Mar 2. doi: 10.1016/j.immuni.2021.02.015

PMCID:: PMC8025838

Article PDF–2.3M

Select item 774480711.

MicroRNA-221/222 Mediates ADSC-Exosome-Induced Cardioprotection Against Ischemia/Reperfusion by Targeting PUMA and ETS-1

Tsai-Chun Lai, Tzu-Lin Lee, Yu-Chun Chang, Yu-Chen Chen, Shu-Rung Lin, Shu-Wha Lin, Chi-Ming Pu, Jaw-Shiun Tsai, Yuh-Lien Chen

Front Cell Dev Biol. 2020; 8: 569150. Published online 2020 Dec 3. doi: 10.3389/fcell.2020.569150

PMCID:: PMC7744807

Article PDF–7.7M

Select item 705860312.

miR-221 and -222 target CACNA1C and KCNJ5 leading to altered cardiac ion channel expression and current density

Stephanie Binas, Maria Knyrim, Julia Hupfeld, Udo Kloeckner, Sindy Rabe, Sigrid Mildenberger, Katja Quarch, Nicole Strätz, Danny Misiak, Michael Gekle, Claudia Grossmann, Barbara Schreier

Cell Mol Life Sci. 2020 Mar; 77(5): 903–918. Published online 2019 Jul 16. doi: 10.1007/s00018-019-03217-y

PMCID:: PMC7058603

Article PDF–1.5M

Select item 690266813.

Perivascular adipose tissue–derived extracellular vesicle miR-221-3p mediates vascular remodeling

Xinzhi Li, Laurel L. Ballantyne, Ying Yu, Colin D. Funk

FASEB J. 2019 Nov; 33(11): 12704–12722. Published online 2019 Aug 30. doi: 10.1096/fj.201901548R

PMCID:: PMC6902668

Article

Select item 668177414.

Inhibition of miR-221 alleviates LPS-induced acute lung injury via inactivation of SOCS1/NF-κB signaling pathway

Tao Wang, Lihua Jiang, Xiaoyong Wei, Zhenghua Dong, Bo Liu, Junbo Zhao, Lijuan Wang, Peilin Xie, Yuxia Wang, Shangyou Zhou

Cell Cycle. 2019; 18(16): 1893–1907. Published online 2019 Jul 11. doi: 10.1080/15384101.2019.1632136

PMCID:: PMC6681774

Article PDF–3.8M

Select item 634371415.

MiR-221 is involved in depression by regulating Wnt2/CREB/BDNF axis in hippocampal neurons

Nan Lian, Qihui Niu, Yang Lei, Xue Li, Youhui Li, Xueqin Song

Cell Cycle. 2018; 17(24): 2745–2755. Published online 2018 Dec 27. doi: 10.1080/15384101.2018.1556060

PMCID:: PMC6343714

Article PDF–1.6M

Select item 628435216.

Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in mice

Xiuli Jiang, Lei Jiang, Aijing Shan, Yutong Su, Yulong Cheng, Dalong Song, He Ji, Guang Ning, Weiqing Wang, Yanan Cao

EBioMedicine. 2018 Nov; 37: 307–321. Published online 2018 Oct 10. doi: 10.1016/j.ebiom.2018.09.051

PMCID:: PMC6284352

Article PDF–7.8M

Select item 609252717.

The Parkinson's disease gene product DJ-1 modulates miR-221 to promote neuronal survival against oxidative stress

Stephanie E. Oh, Hye-Jin Park, Liqiang He, Catherine Skibiel, Eunsung Junn, M. Maral Mouradian

Redox Biol. 2018 Oct; 19: 62–73. Published online 2018 Aug 3. doi: 10.1016/j.redox.2018.07.021

PMCID:: PMC6092527

Article PDF–2.5M

Select item 608250218.

MiR-221 negatively regulates innate anti-viral response

Hongqiang Du, Shuang Cui, Yunfei Li, Guang Yang, Peiyan Wang, Erol Fikrig, Fuping You

PLoS One. 2018; 13(8): e0200385. Published online 2018 Aug 8. doi: 10.1371/journal.pone.0200385

PMCID:: PMC6082502

Article PDF–2.8M

Select item 581282319.

Upregulation of miR-221 and -222 in response to increased extracellular signal-regulated kinases 1/2 activity exacerbates neointimal hyperplasia in diabetes mellitus

Daniel J. Lightell, Jr., Stephanie C. Moss, T. Cooper Woods

Atherosclerosis. Author manuscript; available in PMC 2019 Feb 1.

Published in final edited form as: Atherosclerosis. 2018 Feb; 269: 71–78. Published online 2017 Dec 9. doi: 10.1016/j.atherosclerosis.2017.12.016

PMCID:: PMC5812823

Article PDF–2.8M

Select item 556173620.

Lung epithelial cell-derived microvesicles regulate macrophage migration via microRNA-17/221-induced integrin beta1 recycling

Heedoo Lee, Duo Zhang, Jingxuan Wu, Leo E. Otterbein, Yang Jin

J Immunol. Author manuscript; available in PMC 2018 Aug 15.

Published in final edited form as: J Immunol. 2017 Aug 15; 199(4): 1453–1464. Published online 2017 Jul 3. doi: 10.4049/jimmunol.1700165

PMCID:: PMC5561736

Article PDF–2.8M

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