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Items: 1 to 20 of 26

1.
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
Ozan Baytas, Shawn M. Davidson, Julie A. Kauer, Eric M. Morrow
Mol Brain. 2024; 17: 87. Published online 2024 Nov 27. doi: 10.1186/s13041-024-01154-x
PMCID:
PMC11600823
AbstractArticlePDF–2.7M
2.
Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
Nicole K.H. Yiew, Stanislaw Deja, Daniel Ferguson, Kevin Cho, Chaowapong Jarasvaraparn, Miriam Jacome-Sosa, Andrew J. Lutkewitte, Sandip Mukherjee, Xiaorong Fu, Jason M. Singer, Gary J. Patti, Shawn C. Burgess, Brian N. Finck
iScience. 2023 Nov 17; 26(11): 108196. Published online 2023 Oct 12. doi: 10.1016/j.isci.2023.108196
PMCID:
PMC10628847
AbstractArticlePDF–4.6M
3.
Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill
Mol Metab. 2023 Nov; 77: 101808. Published online 2023 Sep 15. doi: 10.1016/j.molmet.2023.101808
PMCID:
PMC10561123
AbstractArticlePDF–2.6M
4.
Exosomal GPT2 derived from triple‐negative breast cancer cells promotes metastasis by activating BTRC
Mingqing Cui, Jiawei Peng, Yuanyuan Zhou, Xixi Wang, Daxiang Cui
Thorac Cancer. 2023 Jul; 14(21): 2018–2025. Published online 2023 Jun 7. doi: 10.1111/1759-7714.14984
PMCID:
PMC10363803
AbstractArticlePDF–7.5M
5.
The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development
Sebastian Gehlen-Breitbach, Theresa Schmid, Franziska Fröb, Gabriele Rodrian, Matthias Weider, Michael Wegner, Lina Gölz
Int J Oral Sci. 2023; 15: 16. Published online 2023 Apr 6. doi: 10.1038/s41368-023-00222-7
PMCID:
PMC10079831
AbstractArticlePDF–4.8M
6.
The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis
Na Li, Xiang Xu, Dan Liu, Jiaxin Gao, Ying Gao, Xufeng Wu, Huiming Sheng, Qun Li, Jun Mi
Theranostics. 2023; 13(4): 1355–1369. Published online 2023 Feb 21. doi: 10.7150/thno.80544
PMCID:
PMC10008743
AbstractArticlePDF–9.2M
7.
Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus
Ozan Baytas, Julie A. Kauer, Eric M. Morrow
Neurobiol Dis. Author manuscript; available in PMC 2022 Nov 17.
Published in final edited form as: Neurobiol Dis. 2022 Oct 15; 173: 105831. Published online 2022 Jul 28. doi: 10.1016/j.nbd.2022.105831
PMCID:
PMC9669404
AbstractArticlePDF–4.2M
8.
Silencing alanine transaminase 2 in diabetic liver attenuates hyperglycemia by reducing gluconeogenesis from amino acids
Michael R. Martino, Manuel Gutiérrez-Aguilar, Nicole K.H. Yiew, Andrew J. Lutkewitte, Jason M. Singer, Kyle S. McCommis, Daniel Ferguson, Kim H.H. Liss, Jun Yoshino, M. Katie Renkemeyer, Gordon I. Smith, Kevin Cho, Justin A. Fletcher, Samuel Klein, Gary J. Patti, Shawn C. Burgess, Brian N. Finck
Cell Rep. Author manuscript; available in PMC 2022 May 20.
Published in final edited form as: Cell Rep. 2022 Apr 26; 39(4): 110733. doi: 10.1016/j.celrep.2022.110733
Correction in:
Cell Rep. 2022 Nov 15; 41(7): 111633.
PMCID:
PMC9121396
AbstractArticlePDF–1.8M
9.
Thyroid hormone regulates glutamine metabolism and anaplerotic fluxes by inducing mitochondrial glutamate aminotransferase GPT2
Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Emery Di Cicco, Caterina Miro, Melania Murolo, Mariano Stornaiuolo, Monica Dentice
Cell Rep. 2022 Feb 22; 38(8): 110409. Published online 2022 Feb 22. doi: 10.1016/j.celrep.2022.110409
Correction in:
Cell Rep. 2022 Mar 22; 38(12): 110562.
PMCID:
PMC8889437
AbstractArticle
10.
Mitochondrial enzyme GPT2 regulates metabolic mechanisms required for neuron growth and motor function in vivo
Ozan Baytas, Shawn M Davidson, Ralph J DeBerardinis, Eric M Morrow
Hum Mol Genet. 2022 Feb 15; 31(4): 587–603. Published online 2021 Sep 14. doi: 10.1093/hmg/ddab269
PMCID:
PMC8863424
AbstractArticlePDF–2.5M
11.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
12.
Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
Cell. Author manuscript; available in PMC 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025
Correction in:
Cell. 2019 Jul 11; 178(2): 507–508.
PMCID:
PMC6298040
AbstractArticlePDF–1.2M
13.
The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes
Fan Liu, Philip Lössl, Beverley M. Rabbitts, Robert S. Balaban, Albert J. R. Heck
Mol Cell Proteomics. 2018 Feb; 17(2): 216–232. Published online 2017 Dec 8. doi: 10.1074/mcp.RA117.000470
PMCID:
PMC5795388
AbstractArticlePDF–4.4M
14.
Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry
Devin K. Schweppe, Juan D. Chavez, Chi Fung Lee, Arianne Caudal, Shane E. Kruse, Rudy Stuppard, David J. Marcinek, Gerald S. Shadel, Rong Tian, James E. Bruce
Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7): 1732–1737. Published online 2017 Jan 27. doi: 10.1073/pnas.1617220114
PMCID:
PMC5321032
AbstractArticlePDF–1.1M
15.
Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features
Qing Ouyang, Tojo Nakayama, Ozan Baytas, Shawn M. Davidson, Chendong Yang, Michael Schmidt, Sofia B. Lizarraga, Sasmita Mishra, Malak EI-Quessny, Saima Niaz, Mirrat Gul Butt, Syed Imran Murtaza, Afzal Javed, Haroon Rashid Chaudhry, Dylan J. Vaughan, R. Sean Hill, Jennifer N. Partlow, Seung-Yun Yoo, Anh-Thu N. Lam, Ramzi Nasir, Muna Al-Saffar, A. James Barkovich, Matthew Schwede, Shailender Nagpal, Anna Rajab, Ralph J. DeBerardinis, David E. Housman, Ganeshwaran H. Mochida, Eric M. Morrow
Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38): E5598–E5607. Published online 2016 Sep 6. doi: 10.1073/pnas.1609221113
PMCID:
PMC5035873
AbstractArticlePDF–1.6M
16.
Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level
Kun Qian, Shao Zhong, Keming Xie, Daozhan Yu, Rongze Yang, Da-Wei Gong
Diabetes Metab Res Rev. Author manuscript; available in PMC 2016 Sep 1.
Published in final edited form as: Diabetes Metab Res Rev. 2015 Sep; 31(6): 562–571. Published online 2015 Jun 17. doi: 10.1002/dmrr.2655
PMCID:
PMC4696510
AbstractArticlePDF–4.4M
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
19.
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio
PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582
PMCID:
PMC3022534
AbstractArticlePDF–3.8M
20.
A mitochondrial protein compendium elucidates complex I disease biology
David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha
Cell. Author manuscript; available in PMC 2009 Nov 18.
Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016
PMCID:
PMC2778844
AbstractArticlePDF–1.2M

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