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    Items: 1 to 20 of 61

    1.
    Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma
    Runjin Cai, Xiaoxiao Gong, Xiaozhao Li, Yuanyuan Jiang, Shuanglinzi Deng, Jiale Tang, Huan Ge, Chendong Wu, Huan Tang, Guo Wang, Lei Xie, Xuemei Chen, Xinyue Hu, Juntao Feng
    Respir Res. 2024; 25: 119. Published online 2024 Mar 8. doi: 10.1186/s12931-024-02743-z
    PMCID:
    PMC10921740
    ArticlePDF–13M
    2.
    Structural insights into cytokine cleavage by inflammatory caspase-4
    Pascal Devant, Ying Dong, Julian Mintseris, Weiyi Ma, Steven P. Gygi, Hao Wu, Jonathan C. Kagan
    Nature. Author manuscript; available in PMC 2024 Jun 1.
    Published in final edited form as: Nature. 2023 Dec; 624(7991): 451–459. Published online 2023 Nov 22. doi: 10.1038/s41586-023-06751-9
    Correction in:
    Nature. 2024 Jan 3
    PMCID:
    PMC10807405
    ArticlePDF–6.9M
    3.
    Inflammation in Hypervolemic Hemodialysis Patients: The Roles of RelB and Caspase-4
    Christof Ulrich, Zeynep Canim, Eva Herberger, Matthias Girndt, Roman Fiedler
    Int J Mol Sci. 2023 Dec; 24(24): 17550. Published online 2023 Dec 16. doi: 10.3390/ijms242417550
    PMCID:
    PMC10743509
    ArticlePDF–1.6M
    4.
    Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome
    Abby R. Kroken, Keith A. Klein, Patrick S. Mitchell, Vincent Nieto, Eric J. Jedel, David J. Evans, Suzanne M. J. Fleiszig
    mSphere. 2023 Sep-Oct; 8(5): e00351-23. Published online 2023 Aug 17. doi: 10.1128/msphere.00351-23
    PMCID:
    PMC10597407
    ArticlePDF–11M
    5.
    Testis cell pyroptosis mediated by CASP1 and CASP4: possible sertoli cell-only syndrome pathogenesis
    Wantao Liu, Xinan Li, Qiang Ma, Yongtong Zhu, Wenzhong Zhao, Yisheng Yang, Weiqiang Xiao, Daxiong Huang, Fengbo Cai, David Yiu Leung Chan, Shanchao Zhao, Qingjun Chu
    Reprod Biol Endocrinol. 2023; 21: 53. Published online 2023 Jun 9. doi: 10.1186/s12958-023-01101-w
    PMCID:
    PMC10250861
    ArticlePDF–6.4M
    6.
    Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells
    Nawar Naseer, Jenna Zhang, Renate Bauer, David A. Constant, Timothy J. Nice, Igor E. Brodsky, Isabella Rauch, Sunny Shin
    Infect Immun. 2022 Jul; 90(7): e00663-21. Published online 2022 Jun 9. doi: 10.1128/iai.00663-21
    PMCID:
    PMC9302179
    ArticlePDF–2.0M
    7.
    Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
    Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
    Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
    PMCID:
    PMC9279285
    ArticlePDF–2.5M
    8.
    Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
    Irene Fernández-Duran, Andrea Quintanilla, Núria Tarrats, Jodie Birch, Priya Hari, Fraser R. Millar, Anthony B. Lagnado, Vanessa Smer-Barreto, Morwenna Muir, Valerie G. Brunton, João F. Passos, Juan Carlos Acosta
    Cell Death Differ. 2022 Jun; 29(6): 1267–1282. Published online 2021 Dec 16. doi: 10.1038/s41418-021-00917-6
    PMCID:
    PMC9177556
    ArticlePDF–7.9M
    9.
    Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis
    Mostafa M. Eltobgy, Ashley Zani, Adam D. Kenney, Shady Estfanous, Eunsoo Kim, Asmaa Badr, Cierra Carafice, Kylene Daily, Owen Whitham, Maciej Pietrzak, Amy Webb, Jeffrey Kawahara, Adrian C. Eddy, Parker Denz, Mijia Lu, KC Mahesh, Mark E. Peeples, Jianrong Li, Jian Zhu, Jianwen Que, Richard Robinson, Oscar Rosas Mejia, Rachael E. Rayner, Luanne Hall-Stoodley, Stephanie Seveau, Mikhail A. Gavrilin, Xiaoli Zhang, Jeronay Thomas, Jacob E. Kohlmeier, Mehul S. Suthar, Eugene Oltz, Andrea Tedeschi, Frank H. Robledo-Avila, Santiago Partida-Sanchez, Emily A. Hemann, Eman Abdelrazik, Adriana Forero, Shahid M. Nimjee, Prosper N. Boyaka, Estelle Cormet-Boyaka, Jacob S. Yount, Amal O. Amer
    Proc Natl Acad Sci U S A. 2022 May 24; 119(21): e2202012119. Published online 2022 May 19. doi: 10.1073/pnas.2202012119
    PMCID:
    PMC9173818
    ArticlePDF–3.5M
    10.
    The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion
    Shanshan Wang, France Moreau, Kris Chadee
    PLoS Pathog. 2022 Mar; 18(3): e1010415. Published online 2022 Mar 18. doi: 10.1371/journal.ppat.1010415
    PMCID:
    PMC8967020
    ArticlePDF–4.7M
    11.
    The role of caspase-1, caspase-4 and NLRP3 in regulating the host cell response evoked by uropathogenic Escherichia coli
    Anna Lindblad, Charlotte Johansson, Katarina Persson, Isak Demirel
    Sci Rep. 2022; 12: 2005. Published online 2022 Feb 7. doi: 10.1038/s41598-022-06052-7
    PMCID:
    PMC8821701
    ArticlePDF–4.6M
    12.
    Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4
    Jing Meng, Xiaoying Song, Guoliang Yan, Haihui Wang, Haitao Li, Danfei Lou
    Bioengineered. 2021; 12(1): 4452–4463. Published online 2021 Jul 24. doi: 10.1080/21655979.2021.1956672
    PMCID:
    PMC8806451
    ArticlePDF–3.6M
    13.
    Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β converting enzyme
    Pascal Devant, Anh Cao, Jonathan C. Kagan
    Sci Immunol. Author manuscript; available in PMC 2022 Feb 10.
    Published in final edited form as: Sci Immunol. 2021 Aug 10; 6(62): eabh3567. doi: 10.1126/sciimmunol.abh3567
    PMCID:
    PMC8559778
    ArticlePDF–2.3M
    14.
    Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
    Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
    Cell. Author manuscript; available in PMC 2022 May 27.
    Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
    PMCID:
    PMC8165030
    ArticlePDF–2.2M
    15.
    Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis
    Chuang Yuan, Ming Wu, Qicai Xiao, Wang Zhao, Hongli Li, Yanjun Zhong, Minyi Zhao, Cheng Li, Yang Li, Xinyu Yang
    Signal Transduct Target Ther. 2021; 6: 92. Published online 2021 Feb 28. doi: 10.1038/s41392-021-00483-w
    PMCID:
    PMC7914254
    ArticlePDF–1.4M
    16.
    Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions
    Miriam Kutsch, Linda Sistemich, Cammie F Lesser, Marcia B Goldberg, Christian Herrmann, Jörn Coers
    EMBO J. 2020 Jul 1; 39(13): e104926. Published online 2020 Jun 8. doi: 10.15252/embj.2020104926
    PMCID:
    PMC7327485
    ArticlePDF–5.6M
    17.
    Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility
    Lan Ye, Ge Li, Anna Goebel, Abhinav V. Raju, Feng Kong, Yanfei Lv, Kailin Li, Yuanjun Zhu, Shreya Raja, Peijian He, Fang Li, Simon Musyoka Mwangi, Wenhui Hu, Shanthi Srinivasan
    J Clin Invest. 2020 Jul 1; 130(7): 3621–3636. Published online 2020 Jun 2. doi: 10.1172/JCI130176
    PMCID:
    PMC7324173
    ArticlePDF–11M
    18.
    Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria
    José Carlos Santos, Dave Boucher, Larisa Kapinos Schneider, Benjamin Demarco, Marisa Dilucca, Kateryna Shkarina, Rosalie Heilig, Kaiwen W. Chen, Roderick Y. H. Lim, Petr Broz
    Nat Commun. 2020; 11: 3276. Published online 2020 Jun 24. doi: 10.1038/s41467-020-16889-z
    PMCID:
    PMC7314798
    ArticlePDF–3.7M
    19.
    GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity
    Qin Chen, Peiliang Shi, Yufang Wang, Dayuan Zou, Xiuwen Wu, Dingyu Wang, Qiongyuan Hu, Yujie Zou, Zan Huang, Jianan Ren, Zhaoyu Lin, Xiang Gao
    J Mol Cell Biol. 2019 Jun; 11(6): 496–508. Published online 2018 Oct 15. doi: 10.1093/jmcb/mjy056
    PMCID:
    PMC6734491
    ArticlePDF–1.2M
    20.
    Caspase-11 signaling enhances graft-versus-host disease
    Yanyan Lu, Ran Meng, Xiangyu Wang, Yajing Xu, Yiting Tang, Jianfeng Wu, Qianqian Xue, Songlin Yu, Mingwu Duan, Dongyong Shan, Qingde Wang, Haichao Wang, Timothy R. Billiar, Xianzhong Xiao, Fangping Chen, Ben Lu
    Nat Commun. 2019; 10: 4044. Published online 2019 Sep 6. doi: 10.1038/s41467-019-11895-2
    Correction in:
    Nat Commun. 2020; 11: 1349.
    PMCID:
    PMC6731232
    ArticlePDF–2.1M

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