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Select item 115301341.

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang Zhao

JCI Insight. 2024 Oct 22; 9(20): e177926. Published online 2024 Sep 24. doi: 10.1172/jci.insight.177926

PMCID:: PMC11530134

Abstract Article PDF–21M

Select item 114677932.

The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context

Marie Piecyk, Mouna Triki, Pierre‐Alexandre Laval, Cedric Duret, Joelle Fauvre, Laura Cussonneau, Christelle Machon, Jerôme Guitton, Nicolas Rama, Benjamin Gibert, Gabriel Ichim, Frederic Catez, Fleur Bourdelais, Sebastien Durand, Jean‐Jacques Diaz, Isabelle Coste, Toufic Renno, Serge N. Manié, Nicolas Aznar, Stephane Ansieau, Carole Ferraro‐Peyret, Cedric Chaveroux

Mol Oncol. 2024 Sep; 18(9): 2111–2135. Published online 2023 Aug 18. doi: 10.1002/1878-0261.13491

PMCID:: PMC11467793

Abstract Article PDF–2.7M

Select item 113360633.

Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension

Giulia Emanuelli, JiaYi Zhu, Wei Li, Nicholas W Morrell, Stefan J Marciniak

Hum Mol Genet. 2024 Sep 1; 33(17): 1495–1505. Published online 2024 May 22. doi: 10.1093/hmg/ddae082

PMCID:: PMC11336063

Abstract Article PDF–1.6M

Select item 112379304.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 111136965.

The eIF2α kinases: their structures and functions

Neysan Donnelly, Adrienne M. Gorman, Sanjeev Gupta, Afshin Samali

Cell Mol Life Sci. 2013 Oct; 70(19): 3493–3511. Published online 2013 Jan 26. doi: 10.1007/s00018-012-1252-6

PMCID:: PMC11113696

Abstract Article PDF–964K

Select item 111131816.

Activation of GCN2 upon HIV-1 infection and inhibition of translation

Ophélie Cosnefroy, Anaïs Jaspart, Christina Calmels, Vincent Parissi, Hervé Fleury, Michel Ventura, Sandrine Reigadas, Marie-Line Andréola

Cell Mol Life Sci. 2013 Jul; 70(13): 2411–2421. Published online 2013 Feb 17. doi: 10.1007/s00018-013-1272-x

PMCID:: PMC11113181

Abstract Article PDF–873K

Select item 108997737.

Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions

Jagannath Misra, Kenneth R Carlson, Dan F Spandau, Ronald C Wek

Nucleic Acids Res. 2024 Feb 28; 52(4): 1830–1846. Published online 2024 Jan 28. doi: 10.1093/nar/gkae006

PMCID:: PMC10899773

Abstract Article PDF–2.7M

Select item 105658768.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 103089509.

Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival

Amit Kumar, Chandru Subramani, Shivani Raj, C. T. Ranjith-Kumar, Milan Surjit

J Virol. 2023 Jun; 97(6): e00347-23. Published online 2023 May 18. doi: 10.1128/jvi.00347-23

PMCID:: PMC10308950

Abstract Article PDF–2.3M

Select item 1023742210.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1012769311.

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

Corey M. Knowles, David Goich, Amanda L. M. Bloom, Murat C. Kalem, John C. Panepinto

mBio. 2023 Mar-Apr; 14(2): e00196-23. Published online 2023 Apr 5. doi: 10.1128/mbio.00196-23

PMCID:: PMC10127693

Abstract Article PDF–3.8M

Select item 1007290612.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 1000201313.

Multiple Roles of the Stress Sensor GCN2 in Immune Cells

Chenxu Zhao, Han Guo, Yangxiao Hou, Tong Lei, Dong Wei, Yong Zhao

Int J Mol Sci. 2023 Mar; 24(5): 4285. Published online 2023 Feb 21. doi: 10.3390/ijms24054285

PMCID:: PMC10002013

Abstract Article PDF–2.3M

Select item 999446214.

An E3 ligase network engages GCN1 to promote degradation of translation factors on stalled ribosomes

Keely Oltion, Jordan D. Carelli, Tangpo Yang, Stephanie K. See, Hao-Yuan Wang, Martin Kampmann, Jack Taunton

Cell. Author manuscript; available in PMC 2024 Jan 19.

Published in final edited form as: Cell. 2023 Jan 19; 186(2): 346–362.e17. Published online 2023 Jan 12. doi: 10.1016/j.cell.2022.12.025

PMCID:: PMC9994462

Abstract Article PDF–2.4M

Select item 992246815.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 977534916.

Lipidomic Profile Analysis of Lung Tissues Revealed Lipointoxication in Pulmonary Veno-Occlusive Disease

Spiro Khoury, Antoine Beauvais, Jenny Colas, Anaïs Saint-Martin Willer, Frédéric Perros, Marc Humbert, Clarisse Vandebrouck, David Montani, Thierry Ferreira, Fabrice Antigny

Biomolecules. 2022 Dec; 12(12): 1878. Published online 2022 Dec 14. doi: 10.3390/biom12121878

PMCID:: PMC9775349

Abstract Article PDF–1.9M

Select item 977255817.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 976969818.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 966873219.

A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling

Johanna B. Brüggenthies, Alessandra Fiore, Marion Russier, Christina Bitsina, Julian Brötzmann, Susanne Kordes, Sascha Menninger, Alexander Wolf, Elena Conti, Jan E. Eickhoff, Peter J. Murray

J Biol Chem. 2022 Dec; 298(12): 102629. Published online 2022 Oct 20. doi: 10.1016/j.jbc.2022.102629

PMCID:: PMC9668732

Abstract Article PDF–2.3M

Select item 957871420.

GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis

Ricardo A Cordova, Jagannath Misra, Parth H Amin, Anglea J Klunk, Nur P Damayanti, Kenneth R Carlson, Andrew J Elmendorf, Hyeong-Geug Kim, Emily T Mirek, Bennet D Elzey, Marcus J Miller, X Charlie Dong, Liang Cheng, Tracy G Anthony, Roberto Pili, Ronald C Wek, Kirk A Staschke

eLife. 2022; 11: e81083. Published online 2022 Sep 15. doi: 10.7554/eLife.81083

PMCID:: PMC9578714

Abstract Article PDF–16M

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