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Select item 109453441.

Myocardin reverses insulin resistance and ameliorates cardiomyopathy by increasing IRS-1 expression in a murine model of lipodystrophy caused by adipose deficiency of vacuolar H⁺-ATPase V0d1 subunit

Wenlin Yuan, Hui Lin, Yuan Sun, Lihuan Liu, Meijuan Yan, Yujuan Song, Xiaofan Zhang, Xiangling Lu, Yipei Xu, Qiyue He, Kunfu Ouyang, Chenglin Zhang, Yong Pan, Yu Huang, Ying Li, Xifeng Lu, Jie Liu

Theranostics. 2024; 14(5): 2246–2264. Published online 2024 Mar 11. doi: 10.7150/thno.93192

PMCID:: PMC10945344

Abstract Article PDF–7.8M

Select item 109176602.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 104080573.

Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is attenuated following cecal ligation and puncture in mice

Deepa Mathew, Julia Barillas-Cerritos, Ana Nedeljkovic-Kurepa, Mabel Abraham, Matthew D. Taylor, Clifford S. Deutschman

Mol Med. 2023; 29: 106. Published online 2023 Aug 7. doi: 10.1186/s10020-023-00703-9

PMCID:: PMC10408057

Abstract Article PDF–1.0M

Select item 99463564.

Reduced insulin signaling in neurons induces sex-specific health benefits

Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J. Withers, Sebastian Grönke, Linda Partridge

Sci Adv. 2023 Feb; 9(8): eade8137. Published online 2023 Feb 22. doi: 10.1126/sciadv.ade8137

PMCID:: PMC9946356

Abstract Article PDF–1.8M

Select item 95837145.

Insulin and Insulin-Like Growth Factor 1 Signaling Preserves Sarcomere Integrity in the Adult Heart

Christian Riehle, Eric T. Weatherford, Nicholas S. McCarty, Alec Seei, Bharat P. Jaishy, Rajkumar Manivel, Paolo Galuppo, Chantal Allamargot, Tariq Hameed, Ryan L. Boudreau, Johann Bauersachs, Robert M. Weiss, E. Dale Abel

Mol Cell Biol. 2022 Oct; 42(10): e00163-22. Published online 2022 Sep 20. doi: 10.1128/mcb.00163-22

PMCID:: PMC9583714

Abstract Article PDF–4.4M

Select item 93823896.

Paternal obesity induces placental hypoxia and sex-specific impairments in placental vascularization and offspring metabolism

Patrycja A Jazwiec, Violet S Patterson, Tatiane A Ribeiro, Erica Yeo, Katherine M Kennedy, Paulo C F Mathias, Jim J Petrik, Deborah M Sloboda

Biol Reprod. 2022 Aug; 107(2): 574–589. Published online 2022 Apr 4. doi: 10.1093/biolre/ioac066

PMCID:: PMC9382389

Abstract Article PDF–1.7M

Select item 92878887.

H19 inhibition increases HDAC6 and regulates IRS1 levels and insulin signaling in the skeletal muscle during diabetes

Amit Kumar, Malabika Datta

Mol Med. 2022; 28: 81. Published online 2022 Jul 16. doi: 10.1186/s10020-022-00507-3

PMCID:: PMC9287888

Abstract Article PDF–2.9M

Select item 92670668.

G6PD Deficiency Is Crucial for Insulin Signaling Activation in Skeletal Muscle

Aiwen Jiang, Hongyun Guo, Xiaoyu Jiang, Jingli Tao, Wangjun Wu, Honglin Liu

Int J Mol Sci. 2022 Jul; 23(13): 7425. Published online 2022 Jul 4. doi: 10.3390/ijms23137425

PMCID:: PMC9267066

Abstract Article PDF–5.5M

Select item 89780079.

Cathepsin K activity controls cachexia‐induced muscle atrophy via the modulation of IRS1 ubiquitination

Xiangkun Meng, Zhe Huang, Aiko Inoue, Hailong Wang, Ying Wan, Xueling Yue, Shengnan Xu, Xueying Jin, Guo‐Ping Shi, Masafumi Kuzuya, Xian Wu Cheng

J Cachexia Sarcopenia Muscle. 2022 Apr; 13(2): 1197–1209. Published online 2022 Jan 30. doi: 10.1002/jcsm.12919

PMCID:: PMC8978007

Abstract Article PDF–5.8M

Select item 883297310.

Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization

Cheng Chen, Lijie Gu, David J. Matye, Yung-Dai Clayton, Mohammad Nazmul Hasan, Yifeng Wang, Jacob E. Friedman, Tiangang Li

Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2111737119. Published online 2022 Feb 3. doi: 10.1073/pnas.2111737119

PMCID:: PMC8832973

Abstract Article PDF–2.2M

Select item 852995311.

FoxO1 suppresses Fgf21 during hepatic insulin resistance to impair peripheral glucose utilization and acute cold tolerance

Oliver Stöhr, Rongya Tao, Ji Miao, Kyle D. Copps, Morris F. White

Cell Rep. Author manuscript; available in PMC 2021 Oct 21.

Published in final edited form as: Cell Rep. 2021 Mar 23; 34(12): 108893. doi: 10.1016/j.celrep.2021.108893

PMCID:: PMC8529953

Abstract Article PDF–1.4M

Select item 831323912.

Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development

Francesco Bedogni, Robert F. Hevner

Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034

PMCID:: PMC8313239

Abstract Article PDF–1.6M

Select item 813192813.

Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice

Tomozumi Takatani, Jun Shirakawa, Kimitaka Shibue, Manoj K. Gupta, Hyunki Kim, Shusheng Lu, Jiang Hu, Morris F. White, Robert T. Kennedy, Rohit N. Kulkarni

J Biol Chem. 2021 Jan-Jun; 296: 100646. Published online 2021 Apr 9. doi: 10.1016/j.jbc.2021.100646

PMCID:: PMC8131928

Abstract Article PDF–2.7M

Select item 802011214.

SUR1, newly expressed in astrocytes, mediates neuropathic pain in a mouse model of peripheral nerve injury

Orest Tsymbalyuk, Volodymyr Gerzanich, Aaida Mumtaz, Sanketh Andhavarapu, Svetlana Ivanova, Tapas K Makar, Charles A Sansur, Asaf Keller, Yumiko Nakamura, Joseph Bryan, J Marc Simard

Mol Pain. 2021; 17: 17448069211006603. Published online 2021 Mar 31. doi: 10.1177/17448069211006603

PMCID:: PMC8020112

Abstract Article PDF–2.3M

Select item 790189015.

FoxO1 Is a Novel Regulator of 20S Proteasome Subunits Expression and Activity

Marianna Kapetanou, Tobias Nespital, Luke S. Tain, Andre Pahl, Linda Partridge, Efstathios S. Gonos

Front Cell Dev Biol. 2021; 9: 625715. Published online 2021 Feb 5. doi: 10.3389/fcell.2021.625715

PMCID:: PMC7901890

Abstract Article PDF–1.6M

Select item 771410016.

Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics

Seiji Hashimoto, Tomochika Maoka, Tetsuya Kawata, Toshio Mochizuki, Takao Koike, Takashi Shigematsu

PLoS One. 2020; 15(12): e0242332. Published online 2020 Dec 3. doi: 10.1371/journal.pone.0242332

PMCID:: PMC7714100

Abstract Article PDF–1.2M

Select item 737022217.

Rab5a activates IRS1 to coordinate IGF-AKT-mTOR signaling and myoblast differentiation during muscle regeneration

Xiao Xia Cong, Xiu Kui Gao, Xi Sheng Rao, Jie Wen, Xiao Ceng Liu, Yin Pu Shi, Min Yi He, Wei Liang Shen, Yue Shen, Hongwei Ouyang, Ping Hu, Boon Chuan Low, Zhuo Xian Meng, Yue Hai Ke, Ming Zhu Zheng, Lin Rong Lu, Yong Heng Liang, Li Ling Zheng, Yi Ting Zhou

Cell Death Differ. 2020 Aug; 27(8): 2344–2362. Published online 2020 Feb 12. doi: 10.1038/s41418-020-0508-1

PMCID:: PMC7370222

Abstract Article PDF–8.4M

Select item 721380318.

Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling

Christian Riehle, Eric T. Weatherford, Adam R. Wende, Bharat P. Jaishy, Alec W. Seei, Nicholas S. McCarty, Monika Rech, Qian Shi, Gopireddy R. Reddy, William J. Kutschke, Karen Oliveira, Karla Maria Pires, Joshua C. Anderson, Nikolaos A. Diakos, Robert M. Weiss, Morris F. White, Stavros G. Drakos, Yang K. Xiang, E. Dale Abel

JCI Insight. 2020 Mar 26; 5(6): e134920. Published online 2020 Mar 26. doi: 10.1172/jci.insight.134920

PMCID:: PMC7213803

Abstract Article PDF–32M

Select item 682731719.

Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation

Scott Frendo-Cumbo, Javier R. Jaldin-Fincati, Etienne Coyaud, Estelle M. N. Laurent, Logan K. Townsend, Joel M. J. Tan, Ramnik J. Xavier, Nicolas J. Pillon, Brian Raught, David C. Wright, John Hunter Brumell, Amira Klip

J Biol Chem. 2019 Nov 1; 294(44): 16172–16185. Published online 2019 Sep 12. doi: 10.1074/jbc.RA119.009110

PMCID:: PMC6827317

Abstract Article PDF–1.5M

Select item 674067220.

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation

Markus Schubert, Derek P. Brazil, Deborah J. Burks, Jake A. Kushner, Jing Ye, Carrie L. Flint, Janet Farhang-Fallah, Pieter Dikkes, Xavier M. Warot, Carlos Rio, Gabriel Corfas, Morris F. White

J Neurosci. 2003 Aug 6; 23(18): 7084–7092. doi: 10.1523/JNEUROSCI.23-18-07084.2003

PMCID:: PMC6740672

Abstract Article PDF–461K

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