PMC Links for GEO Profiles (Select 68430164) - PMC

Timothy D. Calamaras, Suchita Pande, Robert A.U. Baumgartner, Seung Kyum Kim, Joseph C. McCarthy, Gregory L. Martin, Kelly Tam, Angela L. McLaughlin, Guang-rong Wang, Mark J. Aronovitz, Weiyu Lin, Jonathan I. Aguirre, Paulina Baca, Peiwen Liu, Daniel A. Richards, Roger J. Davis, Richard H. Karas, Iris Z. Jaffe, Robert M. Blanton

JCI Insight. 2021 Sep 22; 6(18): e149075. Published online 2021 Sep 22. doi: 10.1172/jci.insight.149075

PMCID:: PMC8492323

Abstract Article PDF–3.6M

Select item 74159914.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 73824805.

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

Junyan Wang, Bo Deng, Qing Liu, Yusheng Huang, Weitao Chen, Jing Li, Zheng Zhou, Lu Zhang, Birong Liang, Jiaqi He, Zixin Chen, Cui Yan, Zhongqi Yang, Shaoxiang Xian, Lingjun Wang

Cell Death Dis. 2020 Jul; 11(7): 574. Published online 2020 Jul 24. doi: 10.1038/s41419-020-02777-3

PMCID:: PMC7382480

Abstract Article PDF–4.9M

Select item 71493896.

Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity

Sandeep Kumar, Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Subhash C. Sinha, Rajyasree Emmadi, Kent Hoskins, Oana Danciu, Gregory R. J. Thatcher, Basabi Rana, Ajay Rana

Proc Natl Acad Sci U S A. 2020 Apr 7; 117(14): 7961–7970. Published online 2020 Mar 24. doi: 10.1073/pnas.1921325117

PMCID:: PMC7149389

Abstract Article PDF–2.4M

Select item 63833567.

Mixed lineage kinase-3 prevents cardiac dysfunction and structural remodeling with pressure overload

Timothy D. Calamaras, Robert A. Baumgartner, Mark J. Aronovitz, Angela L. McLaughlin, Kelly Tam, Daniel A. Richards, Craig W. Cooper, Nathan Li, Wendy E. Baur, Xiaoying Qiao, Guang-Rong Wang, Roger J. Davis, Navin K. Kapur, Richard H. Karas, Robert M. Blanton

Am J Physiol Heart Circ Physiol. 2019 Jan 1; 316(1): H145–H159. Published online 2018 Oct 26. doi: 10.1152/ajpheart.00029.2018

PMCID:: PMC6383356

Abstract Article

Select item 56592858.

A protein scaffold coordinates SRC-mediated JNK activation in response to metabolic stress

Shashi Kant, Claire L. Standen, Caroline Morel, Dae Young Jung, Jason K. Kim, Wojciech Swat, Richard A. Flavell, Roger J. Davis

Cell Rep. Author manuscript; available in PMC 2017 Oct 27.

Published in final edited form as: Cell Rep. 2017 Sep 19; 20(12): 2775–2783. doi: 10.1016/j.celrep.2017.08.025

PMCID:: PMC5659285

Abstract Article PDF–1.6M

Select item 55503299.

Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity

Kyoko Tomita, Ayano Kabashima, Brittany L. Freeman, Steven F. Bronk, Petra Hirsova, Samar H. Ibrahim

J Cell Biochem. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: J Cell Biochem. 2017 Oct; 118(10): 3249–3259. Published online 2017 May 15. doi: 10.1002/jcb.25973

PMCID:: PMC5550329

Abstract Article PDF–966K

Select item 532325610.

Glycogen Synthase Kinase-3β Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3

Rajakishore Mishra, Manoj K. Barthwal, Gautam Sondarva, Basabi Rana, Lucas Wong, Malay Chatterjee, James R. Woodgett, Ajay Rana

J Biol Chem. Author manuscript; available in PMC 2017 Feb 23.

Published in final edited form as: J Biol Chem. 2007 Oct 19; 282(42): 30393–30405. Published online 2007 Aug 21. doi: 10.1074/jbc.M705895200

PMCID:: PMC5323256

Abstract Article PDF–1.9M

Select item 499931211.

Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development

Kasmir Ramo, Koichi Sugamura, Siobhan Craige, John F Keaney, Jr, Roger J Davis

eLife. 2016; 5: e18414. Published online 2016 Aug 9. doi: 10.7554/eLife.18414

PMCID:: PMC4999312

Abstract Article PDF–12M

Select item 479434312.

Fibroblast growth factor 21 mediates glycemic regulation by hepatic JNK

Santiago Vernia, Julie Cavanagh-Kyros, Tamera Barrett, Cathy Tournier, Roger J. Davis

Cell Rep. Author manuscript; available in PMC 2016 Mar 16.

Published in final edited form as: Cell Rep. 2016 Mar 15; 14(10): 2273–2280. Published online 2016 Mar 3. doi: 10.1016/j.celrep.2016.02.026

PMCID:: PMC4794343

Abstract Article PDF–1.5M

Select item 476886513.

Maternal Hyperglycemia Activates an ASK1–FoxO3a–Caspase 8 Pathway That Leads to Embryonic Neural Tube Defects

Peixin Yang, Xuezheng Li, Cheng Xu, Richard L. Eckert, E. Albert Reece, Horst Ronald Zielke, Fang Wang

Sci Signal. Author manuscript; available in PMC 2016 Feb 26.

Published in final edited form as: Sci Signal. 2013 Aug 27; 6(290): ra74. Published online 2013 Aug 27. doi: 10.1126/scisignal.2004020

PMCID:: PMC4768865

Abstract Article PDF–675K

Select item 476442114.

Mixed Lineage Kinase 3 Mediates Release of C-X-C Motif Ligand 10-Bearing Chemotactic Extracellular Vesicles from Lipotoxic Hepatocytes

Samar H. Ibrahim, Petra Hirsova, Kyoko Tomita, Steven F. Bronk, Nathan W. Werneburg, Stephen A. Harrison, Val S. Goodfellow, Harmeet Malhi, Gregory J. Gores

Hepatology. Author manuscript; available in PMC 2017 Mar 1.

Published in final edited form as: Hepatology. 2016 Mar; 63(3): 731–744. Published online 2015 Dec 11. doi: 10.1002/hep.28252

PMCID:: PMC4764421

Abstract Article PDF–1.2M

Select item 467859315.

MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells

U Knackmuss, S E Lindner, T Aneichyk, B Kotkamp, Z Knust, A Villunger, S Herzog

Cell Death Differ. 2016 Feb; 23(2): 242–252. Published online 2015 Jul 3. doi: 10.1038/cdd.2015.87

PMCID:: PMC4678593

Abstract Article PDF–2.9M

Select item 420800716.

Loss of TRB3 Alters Dynamics of MLK3-JNK Signaling and Inhibits Cytokine-activated Pancreatic Beta Cell Death

Rohan K. Humphrey, Anamika Ray, Sumati Gonuguntla, Ergeng Hao, Ulupi S. Jhala

J Biol Chem. 2014 Oct 24; 289(43): 29994–30004. Published online 2014 Sep 9. doi: 10.1074/jbc.M114.575613

PMCID:: PMC4208007

Abstract Article PDF–1.6M

Select item 408468317.

Mixed Lineage Kinase 3 Deficiency Promotes Neointima Formation through Increased Activation of the RhoA Pathway in Vascular Smooth Muscle Cells

Vidya Gadang, Eddy Konaniah, David Y. Hui, Anja Jaeschke

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Jul; 34(7): 1429–1436. Published online 2014 May 1. doi: 10.1161/ATVBAHA.114.303439

PMCID:: PMC4084683

Abstract Article PDF–1.3M

Select item 403217718.

Discovery, Synthesis and Characterization of an Orally Bioavailable, Brain Penetrant Inhibitor of Mixed Lineage Kinase 3

Val S. Goodfellow, Colin J. Loweth, Satheesh B. Ravula, Torsten Wiemann, Thong Nguyen, Yang Xu, Daniel E. Todd, David Sheppard, Scott Pollack, Oksana Polesskaya, Daniel F. Marker, Stephen Dewhurst, Harris A. Gelbard

J Med Chem. Author manuscript; available in PMC 2014 Oct 24.

Published in final edited form as: J Med Chem. 2013 Oct 24; 56(20): 8032–8048. Published online 2013 Oct 3. doi: 10.1021/jm401094t

PMCID:: PMC4032177

Abstract Article PDF–1.5M

Select item 394681119.

MLK3 regulates fMLP-stimulated neutrophil motility

Oksana Polesskaya, Christopher Wong, Luis Lebron, Jeffrey M. Chamberlain, Harris A. Gelbard, Val Goodfellow, Minsoo Kim, John L. Daiss, Stephen Dewhurst

Mol Immunol. Author manuscript; available in PMC 2015 Apr 1.

Published in final edited form as: Mol Immunol. 2014 Apr; 58(2): 214–222. Published online 2014 Jan 3. doi: 10.1016/j.molimm.2013.11.016