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Select item 114726431.

Exercise, disease state and sex influence the beneficial effects of Fn14-depletion on survival and muscle pathology in the SOD1^G93A amyotrophic lateral sclerosis (ALS) mouse model

Gareth Hazell, Eve McCallion, Nina Ahlskog, Emma R. Sutton, Magnus Okoh, Emad I. H. Shaqoura, Joseph M. Hoolachan, Taylor Scaife, Sara Iqbal, Amarjit Bhomra, Anna J. Kordala, Frederique Scamps, Cedric Raoul, Matthew J. A. Wood, Melissa Bowerman

Skelet Muscle. 2024; 14: 23. Published online 2024 Oct 14. doi: 10.1186/s13395-024-00356-0

PMCID:: PMC11472643

Abstract Article PDF–4.5M

Select item 105878542.

Targeted ablation of Fn14 receptor improves exercise capacity and inhibits neurogenic muscle atrophy

Meiricris Tomaz da Silva, Aniket S. Joshi, Tatiana E. Koike, Anirban Roy, Kavya Mathukumalli, Danesh H. Sopariwala, Vihang A. Narkar, Ashok Kumar

FASEB J. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: FASEB J. 2022 Dec; 36(12): e22666. doi: 10.1096/fj.202201583R

PMCID:: PMC10587854

Abstract Article PDF–2.5M

Select item 105617653.

Fn14 promotes myoblast fusion during regenerative myogenesis

Meiricris Tomaz da Silva, Aniket S Joshi, Micah B Castillo, Tatiana E Koike, Anirban Roy, Preethi H Gunaratne, Ashok Kumar

Life Sci Alliance. 2023 Dec; 6(12): e202302312. Published online 2023 Oct 9. doi: 10.26508/lsa.202302312

PMCID:: PMC10561765

Abstract Article PDF–5.2M

Select item 105314674.

Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone Modification and Prevents Cancer-Induced Cachexia

Bryan I. Ruiz, Xazmin H. Lowman, Ying Yang, Qi Fan, Tianhong Wang, Hongmei Wu, Eric A. Hanse, Mei Kong

Genes (Basel) 2023 Sep; 14(9): 1818. Published online 2023 Sep 19. doi: 10.3390/genes14091818

PMCID:: PMC10531467

Abstract Article PDF–2.6M

Select item 95865695.

Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-κB signaling

Michael A. Ortega, Ross K. Villiger, Malia Harrison-Chau, Suzanna Lieu, Kadee-Kalia Tamashiro, Amanda J. Lee, Brent A. Fujimoto, Geetika Y. Patwardhan, Joshua Kepler, Ben Fogelgren

Dis Model Mech. 2022 Oct 1; 15(10): dmm049785. Published online 2022 Oct 12. doi: 10.1242/dmm.049785

PMCID:: PMC9586569

Abstract Article

Select item 93385866.

Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice

Xin-Xin Guan, Hui-Hui Yang, Wen-Jing Zhong, Jia-Xi Duan, Chen-Yu Zhang, Hui-Ling Jiang, Yang Xiang, Yong Zhou, Cha-Xiang Guan

Mol Med. 2022; 28: 85. Published online 2022 Jul 30. doi: 10.1186/s10020-022-00514-4

PMCID:: PMC9338586

Abstract Article PDF–5.9M

Select item 93310727.

Dysregulation of Tweak and Fn14 in skeletal muscle of spinal muscular atrophy mice

Katharina E. Meijboom, Emma R. Sutton, Eve McCallion, Emily McFall, Daniel Anthony, Benjamin Edwards, Sabrina Kubinski, Ines Tapken, Ines Bünermann, Gareth Hazell, Nina Ahlskog, Peter Claus, Kay E. Davies, Rashmi Kothary, Matthew J. A. Wood, Melissa Bowerman

Skelet Muscle. 2022; 12: 18. Published online 2022 Jul 28. doi: 10.1186/s13395-022-00301-z

PMCID:: PMC9331072

Abstract Article PDF–4.0M

Select item 87567718.

TWEAK Functions with TNF and IL-17 on Keratinocytes and is a Potential Target for Psoriasis Therapy

Rinkesh K. Gupta, Donald T. Gracias, Daniela Salgado Figueroa, Haruka Miki, Jacqueline Miller, Kai Fung, Ferhat Ay, Linda Burkly, Michael Croft

Sci Immunol. Author manuscript; available in PMC 2022 May 19.

Published in final edited form as: Sci Immunol. 2021 Nov 19; 6(65): eabi8823. Published online 2021 Nov 19. doi: 10.1126/sciimmunol.abi8823

PMCID:: PMC8756771

Abstract Article PDF–1.2M

Select item 84905259.

Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI

Yin Ni, Bang-Chuan Hu, Guo-Hua Wu, Zi-Qiang Shao, Yang Zheng, Run Zhang, Jun Jin, Jun Hong, Xiang-Hong Yang, Ren-Hua Sun, Jin-Quan Liu, Shi-Jing Mo

Theranostics. 2021; 11(19): 9431–9451. Published online 2021 Sep 13. doi: 10.7150/thno.61902

PMCID:: PMC8490525

Abstract Article PDF–3.8M

Select item 845527210.

TWEAK Signaling Pathway Blockade Slows Cyst Growth and Disease Progression in Autosomal Dominant Polycystic Kidney Disease

Adrian Cordido, Laura Nuñez-Gonzalez, Julio M. Martinez-Moreno, Olaya Lamas-Gonzalez, Laura Rodriguez-Osorio, Maria Vanessa Perez-Gomez, Diego Martin-Sanchez, Patricia Outeda, Marco Chiaravalli, Terry Watnick, Alessandra Boletta, Candido Diaz, Angel Carracedo, Ana B. Sanz, Alberto Ortiz, Miguel A. Garcia-Gonzalez

J Am Soc Nephrol. 2021 Aug; 32(8): 1913–1932. Published online 2021 Aug. doi: 10.1681/ASN.2020071094

PMCID:: PMC8455272

Abstract Article

Select item 801793311.

Developmental synaptic regulator, TWEAK/Fn14 signaling, is a determinant of synaptic function in models of stroke and neurodegeneration

Dávid Nagy, Katelin A. Ennis, Ru Wei, Susan C. Su, Christopher A. Hinckley, Rong-Fang Gu, Benbo Gao, Ramiro H. Massol, Chris Ehrenfels, Luke Jandreski, Ankur M. Thomas, Ashley Nelson, Stefka Gyoneva, Mihály Hajós, Linda C. Burkly

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2001679118. Published online 2021 Feb 1. doi: 10.1073/pnas.2001679118

PMCID:: PMC8017933

Abstract Article PDF–1.9M

Select item 791645012.

Remodeling of Neurotransmission, Chemokine, and PI3K-AKT Signaling Genomic Fabrics in Neuropsychiatric Systemic Lupus Erythematosus

Dumitru Iacobas, Jing Wen, Sanda Iacobas, Noa Schwartz, Chaim Putterman

Genes (Basel) 2021 Feb; 12(2): 251. Published online 2021 Feb 10. doi: 10.3390/genes12020251

PMCID:: PMC7916450

Abstract Article PDF–3.6M

Select item 734942113.

MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI

Jun Hong, Bang-Chuan Hu, Liang Xu, Yang Zheng, Zi-Qiang Shao, Run Zhang, Xiang-Hong Yang, Ren-Hua Sun, Shi-Jing Mo

Anal Cell Pathol (Amst) 2020; 2020: 2894650. Published online 2020 Jul 1. doi: 10.1155/2020/2894650

PMCID:: PMC7349421

Abstract Article PDF–1.5M

Select item 690466014.

Experimental atopic dermatitis is dependent on the TWEAK/Fn14 signaling pathway

Q. Liu, H. Wang, X. Wang, M. Lu, X. Tan, L. Peng, F. Tan, T. Xiao, S. Xiao, Y. Xia

Clin Exp Immunol. 2020 Jan; 199(1): 56–67. Published online 2019 Sep 17. doi: 10.1111/cei.13373

PMCID:: PMC6904660

Abstract Article PDF–1.4M

Select item 674047515.

Fibroblast Growth Factor-Inducible-14 Is Induced in Axotomized Neurons and Promotes Neurite Outgrowth

Katsuhisa Tanabe, Iris Bonilla, Jeffrey A. Winkles, Stephen M. Strittmatter

J Neurosci. 2003 Oct 22; 23(29): 9675–9686. doi: 10.1523/JNEUROSCI.23-29-09675.2003

PMCID:: PMC6740475

Abstract Article PDF–845K

Select item 673279316.

TRAF3IP2 mediates TWEAK/TWEAKR-induced pro-fibrotic responses in cultured cardiac fibroblasts and the heart

Nitin A. Das, Andrea J. Carpenter, Tadashi Yoshida, Senthil A. Kumar, Sandeep Gautam, Ricardo Mostany, Reza Izadpanah, Ashok Kumar, Srinivas Mummidi, Ulrich Siebenlist, Bysani Chandrasekar

J Mol Cell Cardiol. Author manuscript; available in PMC 2019 Sep 9.

Published in final edited form as: J Mol Cell Cardiol. 2018 Aug; 121: 107–123. Published online 2018 Jul 5. doi: 10.1016/j.yjmcc.2018.07.003

PMCID:: PMC6732793

Abstract Article PDF–3.2M

Select item 672817117.

Fn14 participates in neuropathic pain through NF-κB pathway in primary sensory neurons

Li-Na Huang, Yun Zou, Shao-Gen Wu, Hong-Hong Zhang, Qing-Xiang Mao, Jin-Bao Li, Yuan-Xiang Tao

Mol Neurobiol. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Mol Neurobiol. 2019 Oct; 56(10): 7085–7096. Published online 2019 Apr 11. doi: 10.1007/s12035-019-1545-y

PMCID:: PMC6728171

Abstract Article PDF–1.2M

Select item 631184818.

Fn14 Deficiency Ameliorates Anti-dsDNA IgG-Induced Glomerular Damage in SCID Mice

Jiawen Wu, Xiaoyun Min, Li Wang, Jie Yang, Ping Wang, Xingyin Liu, Yumin Xia

J Immunol Res. 2018; 2018: 1256379. Published online 2018 Dec 16. doi: 10.1155/2018/1256379

PMCID:: PMC6311848

Abstract Article PDF–5.2M

Select item 611187019.

TWEAK/Fn14 mediates atrial‐derived HL‐1 myocytes hypertrophy via JAK2/STAT3 signalling pathway

Li Hao, Manyi Ren, Bing Rong, Fei Xie, Ming‐jie Lin, Ya‐chao Zhao, Xin Yue, Wen‐qiang Han, Jing‐quan Zhong

J Cell Mol Med. 2018 Sep; 22(9): 4344–4353. Published online 2018 Jul 4. doi: 10.1111/jcmm.13724

PMCID:: PMC6111870

Abstract Article PDF–947K

Select item 610165120.

Visual experience-dependent expression of Fn14 is required for retinogeniculate refinement

Lucas Cheadle, Christopher P. Tzeng, Brian T. Kalish, David A. Harmin, Samuel Rivera, Emi Ling, M. Aurel Nagy, Sinisa Hrvatin, Linda Hu, Hume Stroud, Linda Burkly, Chinfei Chen, Michael E. Greenberg

Neuron. Author manuscript; available in PMC 2019 Aug 8.

Published in final edited form as: Neuron. 2018 Aug 8; 99(3): 525–539.e10. Published online 2018 Jul 19. doi: 10.1016/j.neuron.2018.06.036