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Select item 105027251.

Interleukin-36γ is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice

Martina Anzaghe, Marc A. Niles, Eugenia Korotkova, Monica Dominguez, Stefanie Kronhart, Samira Ortega Iannazzo, Ingo Bechmann, Malte Bachmann, Heiko Mühl, Georg Kochs, Zoe Waibler

Front Immunol. 2023; 14: 1194733. Published online 2023 Sep 1. doi: 10.3389/fimmu.2023.1194733

PMCID:: PMC10502725

Abstract Article PDF–3.2M

Select item 99789602.

IL-36γ is a key regulator of neutrophil infiltration in the vaginal microenvironment and limits neuroinvasion in genital HSV-2 infection

Jameson K. Gardner, Alison Swaims-Kohlmeier, Melissa M. Herbst-Kralovetz

J Immunol. Author manuscript; available in PMC 2023 Mar 2.

Published in final edited form as: J Immunol. 2019 Nov 15; 203(10): 2655–2664. Published online 2019 Oct 2. doi: 10.4049/jimmunol.1900280

PMCID:: PMC9978960

Abstract Article PDF–1.8M

Select item 99240243.

Non-immune and immune functions of Interleukin-36γ suppress epithelial repair at the ocular surface

Sachin Shukla, WonKyung Cho, Elsayed Elbasiony, Rohan Bir Singh, Sharad K. Mittal, Sunil K. Chauhan

FASEB J. Author manuscript; available in PMC 2023 Feb 13.

Published in final edited form as: FASEB J. 2022 Aug; 36(8): 10.1096/fj.202200174RR. doi: 10.1096/fj.202200174RR

PMCID:: PMC9924024

Abstract Article PDF–2.2M

Select item 94342784.

IL-36γ is secreted through an unconventional pathway using the Gasdermin D and P2X7R membrane pores

Laura D. Manzanares-Meza, Claudia I. Gutiérrez-Román, Albertana Jiménez-Pineda, Felipe Castro-Martínez, Genaro Patiño-López, Eunice Rodríguez-Arellano, Ricardo Valle-Rios, Vianney F. Ortíz-Navarrete, Oscar Medina-Contreras

Front Immunol. 2022; 13: 979749. Published online 2022 Aug 18. doi: 10.3389/fimmu.2022.979749

PMCID:: PMC9434278

Abstract Article PDF–1.3M

Select item 89814875.

IL‐36γ and IL‐36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell–Matrix Adhesion Network and Wnt Signaling

Wei Yang, Hong‐Peng Dong, Peng Wang, Zhi‐Gao Xu, Jiahuan Xian, Jiachen Chen, Hai Wu, Yang Lou, Dandan Lin, Bo Zhong

Adv Sci (Weinh) 2022 Apr; 9(10): 2103035. Published online 2022 Feb 4. doi: 10.1002/advs.202103035

PMCID:: PMC8981487

Abstract Article PDF–11M

Select item 88636036.

Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages

Gema Frühbeck, Javier Gómez-Ambrosi, Beatriz Ramírez, Amaia Mentxaka, Amaia Rodríguez, Sara Becerril, Gabriel Reina, Victor Valentí, Rafael Moncada, Camilo Silva, Victoria Catalán

Front Immunol. 2022; 13: 832185. Published online 2022 Feb 9. doi: 10.3389/fimmu.2022.832185

Correction in:: Front Immunol. 2023; 14: 1138316.

PMCID:: PMC8863603

Abstract Article PDF–4.4M

Select item 80922897.

Thrombospondin-1 Restricts Interleukin-36γ-Mediated Neutrophilic Inflammation during Pseudomonas aeruginosa Pulmonary Infection

Hernán F. Peñaloza, Tolani F. Olonisakin, William G. Bain, Yanyan Qu, Rick van der Geest, Jill Zupetic, Mei Hulver, Zeyu Xiong, Michael W. Newstead, Chunbin Zou, Jonathan K. Alder, Joel A. Ybe, Theodore J. Standiford, Janet S. Lee

mBio. 2021 Mar-Apr; 12(2): e03336-20. Published online 2021 Apr 6. doi: 10.1128/mBio.03336-20

PMCID:: PMC8092289

Abstract Article PDF–3.9M

Select item 78709408.

IL36 is a critical upstream amplifier of neutrophilic lung inflammation in mice

Carolin K. Koss, Christian T. Wohnhaas, Jonathan R. Baker, Cornelia Tilp, Michèl Przibilla, Carmen Lerner, Silvia Frey, Martina Keck, Cara M. M. Williams, Daniel Peter, Meera Ramanujam, Jay Fine, Florian Gantner, Matthew Thomas, Peter J. Barnes, Louise E. Donnelly, Karim C. El Kasmi

Commun Biol. 2021; 4: 172. Published online 2021 Feb 8. doi: 10.1038/s42003-021-01703-3

PMCID:: PMC7870940

Abstract Article PDF–2.1M

Select item 72695699.

IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes

Takashi K. Satoh, Mark Mellett, Barbara Meier-Schiesser, Gabriele Fenini, Atsushi Otsuka, Hans-Dietmar Beer, Tamara Rordorf, Julia-Tatjana Maul, Jürg Hafner, Alexander A. Navarini, Emmanuel Contassot, Lars E. French

J Clin Invest. 2020 Mar 2; 130(3): 1417–1430. Published online 2020 Feb 4. doi: 10.1172/JCI128678

PMCID:: PMC7269569

Abstract Article PDF–2.1M

Select item 630064010.

Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against Murine Legionella pneumophila Pneumonia

Yuta Nanjo, Michael W. Newstead, Tetsuji Aoyagi, Xianying Zeng, Kazuhisa Takahashi, Fu Shin Yu, Kazuhiro Tateda, Theodore J. Standiford

Infect Immun. 2019 Jan; 87(1): e00583-18. Prepublished online 2018 Oct 15. Published online 2018 Dec 19. doi: 10.1128/IAI.00583-18

PMCID:: PMC6300640

Abstract Article PDF–1.9M

Select item 629101611.

IL-36γ induces a transient HSV-2 resistant environment that protects against genital disease and pathogenesis

Jameson K. Gardner, Melissa M. Herbst-Kralovetz

Cytokine. Author manuscript; available in PMC 2019 Nov 1.

Published in final edited form as: Cytokine. 2018 Nov; 111: 63–71. Published online 2018 Aug 15. doi: 10.1016/j.cyto.2018.07.034

PMCID:: PMC6291016

Abstract Article PDF–1020K

Select item 617660012.

IκBζ is a key transcriptional regulator of IL-36–driven psoriasis-related gene expression in keratinocytes

Anne Müller, André Hennig, Sebastian Lorscheid, Paula Grondona, Klaus Schulze-Osthoff, Stephan Hailfinger, Daniela Kramer

Proc Natl Acad Sci U S A. 2018 Oct 2; 115(40): 10088–10093. Published online 2018 Sep 17. doi: 10.1073/pnas.1801377115

PMCID:: PMC6176600

Abstract Article PDF–1.6M

Select item 608935513.

IL-36γ protects against severe influenza infection by promoting lung alveolar macrophage survival and limiting viral replication

Alexander N. Wein, Paul R. Dunbar, Sean R. McMaster, Zheng-Rong Tiger Li, Timothy L. Denning, Jacob E. Kohlmeier

J Immunol. Author manuscript; available in PMC 2019 Jul 15.

Published in final edited form as: J Immunol. 2018 Jul 15; 201(2): 573–582. Published online 2018 May 30. doi: 10.4049/jimmunol.1701796

PMCID:: PMC6089355

Abstract Article PDF–1.3M

Select item 598449914.

A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage

Vu L. Ngo, Hirohito Abo, Estera Maxim, Akihito Harusato, Duke Geem, Oscar Medina-Contreras, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning

Proc Natl Acad Sci U S A. 2018 May 29; 115(22): E5076–E5085. Published online 2018 May 14. doi: 10.1073/pnas.1718902115

PMCID:: PMC5984499

Abstract Article PDF–1.8M

Select item 575229715.

ICAM1⁺ neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitis

Ryder F. Whittaker Hawkins, Alexandre Patenaude, Aline Dumas, Rajiv Jain, Yodit Tesfagiorgis, Steven Kerfoot, Takeshi Matsui, Matthias Gunzer, Patrice E. Poubelle, Catherine Larochelle, Martin Pelletier, Luc Vallières

JCI Insight. 2017 Dec 7; 2(23): e96882. Published online 2017 Dec 7. doi: 10.1172/jci.insight.96882

PMCID:: PMC5752297

Abstract Article PDF–2.4M

Select item 561005216.

IL-36? signaling controls the induced regulatory T cell – T_H9 cell balance via NF?B activation and STAT transcription factors

Akihito Harusato, Hirohito Abo, Vu Le Ngo, Samuel Won-zu Yi, Kazunori Mitsutake, Satoru Osuka, Jacob E. Kohlmeier, Jian-Dong Li, Andrew T. Gewirtz, Asma Nusrat, Timothy L. Denning

Mucosal Immunol. Author manuscript; available in PMC 2017 Oct 18.

Published in final edited form as: Mucosal Immunol. 2017 Nov; 10(6): 1455–1467. Published online 2017 Mar 22. doi: 10.1038/mi.2017.21

PMCID:: PMC5610052

Abstract Article PDF–1.9M

Select item 554865917.

IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia

M A Kovach, B Singer, G Martinez-Colon, M W Newstead, X Zeng, P Mancuso, T A Moore, S L Kunkel, M Peters-Golden, B B Moore, T J Standiford

Mucosal Immunol. 2017 Sep; 10(5): 1320–1334. Published online 2017 Feb 8. doi: 10.1038/mi.2016.130

PMCID:: PMC5548659

Abstract Article PDF–1.6M

Select item 551748418.

Interleukin-36β provides protection against HSV-1 infection, but does not modulate initiation of adaptive immune responses

Katelynn A. Milora, Siva R. Uppalapati, Julio C. Sanmiguel, Wei Zou, Liselotte E. Jensen

Sci Rep. 2017; 7: 5799. Published online 2017 Jul 19. doi: 10.1038/s41598-017-05363-4

PMCID:: PMC5517484

Abstract Article PDF–5.3M

Select item 464868419.

Unprocessed interleukin-36a regulates psoriasis-like skin inflammation in co-operation with interleukin-1

Katelynn A. Milora, Hangfei Fu, Ornella Dubaz, Liselotte E. Jensen

J Invest Dermatol. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: J Invest Dermatol. 2015 Dec; 135(12): 2992–3000. Published online 2015 Jul 23. doi: 10.1038/jid.2015.289

PMCID:: PMC4648684

Abstract Article PDF–2.6M

Select item 461208720.

The role of group IIF-secreted phospholipase A₂ in epidermal homeostasis and hyperplasia

Kei Yamamoto, Yoshimi Miki, Mariko Sato, Yoshitaka Taketomi, Yasumasa Nishito, Choji Taya, Kazuaki Muramatsu, Kazutaka Ikeda, Hiroki Nakanishi, Ryo Taguchi, Naotomo Kambe, Kenji Kabashima, Gérard Lambeau, Michael H. Gelb, Makoto Murakami

J Exp Med. 2015 Oct 19; 212(11): 1901–1919. doi: 10.1084/jem.20141904