PMC Links for GEO Profiles (Select 69989940) - PMC

Links from GEO Profiles

Items: 1 to 20 of 38

<< First< Prev

Page of 2

Select item 109681711.

Effects of Complete and Partial Loss of the 24S-Hydroxycholesterol-Generating Enzyme Cyp46a1 on Behavior and Hippocampal Transcription in Mouse

Hong-Jin Shu, Luke H. Ziolkowski, Sofia V. Salvatore, Ann M. Benz, David F. Wozniak, Carla M. Yuede, Steven M. Paul, Charles F. Zorumski, Steven Mennerick

Biomolecules. 2024 Mar; 14(3): 254. Published online 2024 Feb 21. doi: 10.3390/biom14030254

PMCID:: PMC10968171

Abstract Article PDF–2.8M

Select item 108078132.

CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice

María Latorre-Leal, Patricia Rodriguez-Rodriguez, Luca Franchini, Orestis Nikolidakis, Makrina Daniilidou, Ljerka Delac, Mukesh K. Varshney, Luis E. Arroyo-García, Francesca Eroli, Bengt Winblad, Kaj Blennow, Henrik Zetterberg, Miia Kivipelto, Manuela Pacciarini, Yuqin Wang, William J. Griffiths, Ingemar Björkhem, Anna Matton, Ivan Nalvarte, Paula Merino-Serrais, Angel Cedazo-Minguez, Silvia Maioli

Sci Adv. 2024 Jan 26; 10(4): eadj1354. Published online 2024 Jan 24. doi: 10.1126/sciadv.adj1354

PMCID:: PMC10807813

Abstract Article PDF–11M

Select item 107693503.

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders

Abdelhalim Loukil, Emma Ebright, Akiyoshi Uezu, Yudong Gao, Scott H Soderling, Sarah C. Goetz

Version 1. bioRxiv. Preprint. 2023 Dec 21. doi: 10.1101/2023.12.20.572700

PMCID:: PMC10769350

Abstract Article PDF–11M

Select item 106946654.

Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis

Afroditi Tsitsou-Kampeli, Stefano Suzzi, Mor Kenigsbuch, Akisawa Satomi, Romano Strobelt, Oded Singer, Ester Feldmesser, Maitreyee Purnapatre, Sarah Phoebeluc Colaiuta, Eyal David, Liora Cahalon, Oliver Hahn, Tony Wyss-Coray, Yosef Shaul, Ido Amit, Michal Schwartz

Cell Rep Med. 2023 Nov 21; 4(11): 101278. Published online 2023 Nov 8. doi: 10.1016/j.xcrm.2023.101278

PMCID:: PMC10694665

Abstract Article PDF–6.4M

Select item 87673175.

2-Hydroxypropyl-β-cyclodextrin reduces retinal cholesterol in wild type and Cyp27a1^-/-Cyp46a1^-/- mice with deficiency in the oxysterol production

Nicole El-Darzi, Natalia Mast, Alexey M. Petrov, Irina A. Pikuleva

Br J Pharmacol. Author manuscript; available in PMC 2022 Jan 19.

Published in final edited form as: Br J Pharmacol. 2021 Aug; 178(16): 3220–3234. Published online 2020 Aug 13. doi: 10.1111/bph.15209

PMCID:: PMC8767317

Abstract Article PDF–1.7M

Select item 86090746.

Brain Acetyl-CoA Production and Phosphorylation of Cytoskeletal Proteins Are Targets of CYP46A1 Activity Modulation and Altered Sterol Flux

Natalia Mast, Alexey M. Petrov, Erin Prendergast, Ilya Bederman, Irina A. Pikuleva

Neurotherapeutics. 2021 Jul; 18(3): 2040–2060. Published online 2021 Jul 7. doi: 10.1007/s13311-021-01079-6

PMCID:: PMC8609074

Abstract Article PDF–2.7M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 75539468.

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

Toshiya Nishi, Shinichi Kondo, Maki Miyamoto, Sayuri Watanabe, Shigeo Hasegawa, Shigeru Kondo, Jason Yano, Etsurou Watanabe, Tsuyoshi Ishi, Masato Yoshikawa, Haruhi Kamisaki Ando, William Farnaby, Shinji Fujimoto, Eiji Sunahara, Momoko Ohori, Matthew J. During, Takanobu Kuroita, Tatsuki Koike

Sci Rep. 2020; 10: 17081. Published online 2020 Oct 13. doi: 10.1038/s41598-020-74036-6

PMCID:: PMC7553946

Abstract Article PDF–1016K

Select item 70841079.

Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism

Eylan Yutuc, Roberto Angelini, Mark Baumert, Natalia Mast, Irina Pikuleva, Jillian Newton, Malcolm R. Clench, David O. F. Skibinski, Owain W. Howell, Yuqin Wang, William J. Griffiths

Proc Natl Acad Sci U S A. 2020 Mar 17; 117(11): 5749–5760. Published online 2020 Mar 4. doi: 10.1073/pnas.1917421117

PMCID:: PMC7084107

Abstract Article PDF–2.3M

Select item 666298010.

The key genes, phosphoproteins, processes, and pathways affected by efavirenz-activated CYP46A1 in the amyloid-decreasing paradigm of efavirenz treatment

Alexey M. Petrov, Natalia Mast, Yong Li, Irina A. Pikuleva

FASEB J. 2019 Aug; 33(8): 8782–8798. Published online 2019 May 7. doi: 10.1096/fj.201900092R

PMCID:: PMC6662980

Abstract Article

Select item 636035211.

Retinal Vascular Abnormalities and Microglia Activation in Mice with Deficiency in Cytochrome P450 46A1–Mediated Cholesterol Removal

Aicha Saadane, Natalia Mast, George Trichonas, Dibyendu Chakraborty, Sandra Hammer, Julia V. Busik, Maria B. Grant, Irina A. Pikuleva

Am J Pathol. 2019 Feb; 189(2): 405–425. doi: 10.1016/j.ajpath.2018.10.013

PMCID:: PMC6360352

Abstract Article

Select item 601915612.

Up-regulation of cholesterol 24-hydroxylase following hypoxia-ischemia in neonatal mouse brain

Fuxin Lu, Jun Zhu, Selena Guo, Brandon J Wong, Farid F. Chehab, Donna M. Ferriero, Xiangning Jiang

Pediatr Res. Author manuscript; available in PMC 2018 Nov 2.

Published in final edited form as: Pediatr Res. 2018 Jun; 83(6): 1218–1227. Published online 2018 May 2. doi: 10.1038/pr.2018.49

PMCID:: PMC6019156

Abstract Article PDF–2.0M

Select item 565817313.

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1)

Natalia Mast, Joseph B. Lin, Kyle W. Anderson, Ingemar Bjorkhem, Irina A. Pikuleva

PLoS One. 2017; 12(10): e0187168. Published online 2017 Oct 26. doi: 10.1371/journal.pone.0187168

Correction in:: PLoS One. 2018; 13(1): e0191058.

PMCID:: PMC5658173

Abstract Article PDF–2.7M

Select item 554623514.

Cholesterol-Metabolizing Enzyme Cytochrome P450 46A1 as a Pharmacologic Target for Alzheimer’s Disease

Natalia Mast, Aicha Saadane, Ana Valencia-Olvera, James Constans, Erin Maxfield, Hiroyuki Arakawa, Young Li, Gary Landreth, Irina A. Pikuleva

Neuropharmacology. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Neuropharmacology. 2017 Sep 1; 123: 465–476. Published online 2017 Jun 24. doi: 10.1016/j.neuropharm.2017.06.026

PMCID:: PMC5546235

Abstract Article PDF–2.4M

Select item 537780515.

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum

Natalia Mast, Kyle W. Anderson, Joseph B. Lin, Yong Li, Illarion V. Turko, Curtis Tatsuoka, Ingemar Bjorkhem, Irina A. Pikuleva

J Biol Chem. 2017 Mar 24; 292(12): 4913–4924. Published online 2017 Feb 11. doi: 10.1074/jbc.M116.774760

PMCID:: PMC5377805

Abstract Article PDF–2.5M

Select item 536782516.

24S-hydroxycholesterol and 25-hydroxycholesterol differentially impact hippocampal neuronal survival following oxygen-glucose deprivation

Min-Yu Sun, Amanda Taylor, Charles F. Zorumski, Steven Mennerick

PLoS One. 2017; 12(3): e0174416. Published online 2017 Mar 27. doi: 10.1371/journal.pone.0174416

PMCID:: PMC5367825

Abstract Article PDF–1.7M

Select item 503404017.

Retinal Hypercholesterolemia Triggers Cholesterol Accumulation and Esterification in Photoreceptor Cells

Aicha Saadane, Natalia Mast, Tung Dao, Baseer Ahmad, Irina A. Pikuleva

J Biol Chem. 2016 Sep 23; 291(39): 20427–20439. Published online 2016 Aug 11. doi: 10.1074/jbc.M116.744656

PMCID:: PMC5034040

Abstract Article PDF–3.7M

Select item 476637618.

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

Lydie Boussicault, Sandro Alves, Antonin Lamazière, Anabelle Planques, Nicolas Heck, Lara Moumné, Gaëtan Despres, Susanne Bolte, Amélie Hu, Christiane Pagès, Laurie Galvan, Francoise Piguet, Patrick Aubourg, Nathalie Cartier, Jocelyne Caboche, Sandrine Betuing

Brain. 2016 Mar; 139(3): 953–970. Published online 2016 Jan 29. doi: 10.1093/brain/awv384

PMCID:: PMC4766376

Abstract Article PDF–1.9M

Select item 418813419.

Retinal and Nonocular Abnormalities in Cyp27a1^−/−Cyp46a1^−/− Mice with Dysfunctional Metabolism of Cholesterol

Aicha Saadane, Natalia Mast, Casey D. Charvet, Saida Omarova, Wenchao Zheng, Suber S. Huang, Timothy S. Kern, Neal S. Peachey, Irina A. Pikuleva

Am J Pathol. 2014 Sep; 184(9): 2403–2419. doi: 10.1016/j.ajpath.2014.05.024

PMCID:: PMC4188134

Abstract Article PDF–6.5M

Select item 401514020.

Neuronal Expression and Subcellular Localization of Cholesterol 24-Hydroxylase in the Mouse Brain

DENISE M.O. RAMIREZ, STEFAN ANDERSSON, DAVID W. RUSSELL

J Comp Neurol. Author manuscript; available in PMC 2014 May 9.

Published in final edited form as: J Comp Neurol. 2008 Apr 10; 507(5): 1676–1693. doi: 10.1002/cne.21605

PMCID:: PMC4015140

Abstract Article PDF–2.5M

PMC

Result Filters

Article attributes

Text availability

Publication date

Custom date range

Research Funder

Additional filters

Display Settings:

Send to:

Links from GEO Profiles

Items: 1 to 20 of 38

Display Settings:

Send to:

Supplemental Content

Find related data

Recent activity