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Items: 1 to 20 of 131

1.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
2.
TUSC4/NPRL2, a novel PDK1‐interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling
Atsuo Kurata, Ryohei Katayama, Toshiki Watanabe, Takashi Tsuruo, Naoya Fujita
Cancer Sci. 2008 Sep; 99(9): 1827–1834. Published online 2008 Jul 4. doi: 10.1111/j.1349-7006.2008.00874.x
PMCID:
PMC11159638
AbstractArticlePDF–402K
3.
Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells
Giovanni Di Maira, Francesca Brustolon, Lorenzo A. Pinna, Maria Ruzzene
Cell Mol Life Sci. 2009 Oct; 66(20): 3363–3373. Published online 2009 Aug 8. doi: 10.1007/s00018-009-0108-1
PMCID:
PMC11115639
AbstractArticlePDF–492K
4.
K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer
Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740
PMCID:
PMC11109483
AbstractArticlePDF–2.9M
5.
Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
Sarah A. Streeter, Alexandria G. Williams, James R. Evans, Jing Wang, Alissa D. Guarnaccia, Andrea C. Florian, Rafet Al-Tobasei, Qi Liu, William P. Tansey, April M. Weissmiller
BMC Genomics. 2024; 25: 360. Published online 2024 Apr 11. doi: 10.1186/s12864-024-10282-6
PMCID:
PMC11007937
AbstractArticlePDF–8.6M
6.
CPT1A mediates the succinylation of SP5 which activates transcription of PDPK1 to promote the viability and glycolysis of prostate cancer cells
Shufeng Liu, Xiaoguang Chen, Liqi Zhang, Bo Lu
Cancer Biol Ther. 2024; 25(1): 2329372. Published online 2024 Mar 17. doi: 10.1080/15384047.2024.2329372
PMCID:
PMC10950282
AbstractArticlePDF–18M
7.
Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy
Dong Han, Wei Wang, Julie Heejin Jeon, Tao Shen, Xiangsheng Huang, Ping Yi, Bingning Dong, Feng Yang
PLoS Biol. 2023 Aug; 21(8): e3002227. Published online 2023 Aug 2. doi: 10.1371/journal.pbio.3002227
PMCID:
PMC10395914
AbstractArticlePDF–4.5M
8.
SDC2 Stabilization by USP14 Promotes Gastric Cancer Progression through Co-option of PDK1
Li You, Yi Dou, Yu Zhang, Hongwei Xiao, Hong Lv, Gong-Hong Wei, Dazhi Xu
Int J Biol Sci. 2023; 19(11): 3483–3498. Published online 2023 Jul 9. doi: 10.7150/ijbs.84331
PMCID:
PMC10367555
AbstractArticlePDF–10M
9.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
10.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
11.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
12.
Hsa_circ_0000081 promotes the function of gastric cancer through sponging hsa-miR-423-5p to influence 3-phosphoinositide-dependent kinase 1 expression
Fei Jiang, Xueju Hu, Hongyong Cao, Xiaobing Shen
Bioengineered. 2022; 13(4): 8277–8290. Published online 2022 Mar 18. doi: 10.1080/21655979.2022.2053796
PMCID:
PMC9162021
AbstractArticlePDF–2.0M
13.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
14.
A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro
Henry Querfurth, John Marshall, Keykavous Parang, Mengia S. Rioult-Pedotti, Rakesh Tiwari, Bumsup Kwon, Steve Reisinger, Han-Kyu Lee
PLoS One. 2022; 17(1): e0261696. Published online 2022 Jan 21. doi: 10.1371/journal.pone.0261696
Correction in:
PLoS One. 2024; 19(5): e0304731.
PMCID:
PMC8782417
AbstractArticlePDF–2.0M
15.
TMEM116 is required for lung cancer cell motility and metastasis through PDK1 signaling pathway
Suhong Zhang, Haiting Dai, Wenya Li, Runming Wang, Hanyu Wu, Ming Shen, Ye Hu, Lixin Xie, Yiming Xing
Cell Death Dis. 2021 Dec; 12(12): 1086. Published online 2021 Nov 16. doi: 10.1038/s41419-021-04369-1
PMCID:
PMC8599864
AbstractArticlePDF–5.8M
16.
PDPK1 regulates autophagosome biogenesis by binding to PIK3C3
Boli Hu, Yina Zhang, Tingjuan Deng, Jinyan Gu, Juan Liu, Hui Yang, Yuting Xu, Yan Yan, Fan Yang, Heng Zhang, Yulan Jin, Jiyong Zhou
Autophagy. 2021; 17(9): 2166–2183. Published online 2020 Sep 10. doi: 10.1080/15548627.2020.1817279
PMCID:
PMC8496706
AbstractArticlePDF–10M
17.
Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner
Jianping Guo, Ji Cheng, Nana Zheng, Xiaomei Zhang, Xiaoming Dai, Linli Zhang, Changjiang Hu, Xueji Wu, Qiwei Jiang, Depei Wu, Hitoshi Okada, Pier Paolo Pandolfi, Wenyi Wei
Adv Sci (Weinh) 2021 Sep; 8(18): 2004303. Published online 2021 Jul 18. doi: 10.1002/advs.202004303
PMCID:
PMC8456201
AbstractArticlePDF–3.1M
18.
SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in Cells
Yujie Ren, An Wang, Yuan Fang, Ting Shu, Di Wu, Chong Wang, Muhan Huang, Juan Min, Liang Jin, Wei Zhou, Yang Qiu, Xi Zhou
Front Cell Infect Microbiol. 2021; 11: 706252. Published online 2021 Aug 25. doi: 10.3389/fcimb.2021.706252
PMCID:
PMC8425412
AbstractArticlePDF–3.4M
19.
Binding of Avibirnavirus VP3 to the PIK3C3-PDPK1 complex inhibits autophagy by activating the AKT-MTOR pathway
Yina Zhang, Boli Hu, Yahui Li, Tingjuan Deng, Yuting Xu, Jing Lei, Jiyong Zhou
Autophagy. 2020; 16(9): 1697–1710. Published online 2019 Dec 29. doi: 10.1080/15548627.2019.1704118
PMCID:
PMC8386615
AbstractArticlePDF–3.6M
20.
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y
PMCID:
PMC8352964
AbstractArticlePDF–4.5M

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