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Items: 1 to 20 of 52

1.
KLF1 Activates RAC3 to Mediate Fatty Acid Synthesis and Enhance Cisplatin Resistance in Bladder Cancer Cells
Lide Song, Qi Xu, Rong Chen, Wanghong Sun, Jianfei Zhan
Am J Mens Health. 2024 Sep-Oct; 18(5): 15579883241273305. Published online 2024 Oct 7. doi: 10.1177/15579883241273305
PMCID:
PMC11459471
AbstractArticlePDF–2.6M
2.
Targeted next-generation sequencing and long-read HiFi sequencing provide novel insights into clinically significant KLF1 variants
Luyi Ye, Chen Wang, Aijing Li, Minghao Li, Yan Pi, Jingmin Yang, Ziyan Zhu, Daru Lu
BMC Genomics. 2024; 25: 230. Published online 2024 Mar 1. doi: 10.1186/s12864-024-10148-x
PMCID:
PMC10908068
AbstractArticlePDF–2.3M
3.
Severe anemia caused by dominant mutations in Krüppel-like factor 1 (KLF1)
Klaudia Kulczynska-Figurny, James J. Bieker, Miroslawa Siatecka
Mutat Res Rev Mutat Res. Author manuscript; available in PMC 2023 May 20.
Published in final edited form as: Mutat Res Rev Mutat Res. 2020 Oct-Dec; 786: 108336. Published online 2020 Oct 9. doi: 10.1016/j.mrrev.2020.108336
PMCID:
PMC10199782
AbstractArticlePDF–960K
4.
Identification of a genomic DNA sequence that quantitatively modulates KLF1 transcription factor expression in differentiating human hematopoietic cells
M. N. Gnanapragasam, A. Planutis, J. A. Glassberg, J. J. Bieker
Sci Rep. 2023; 13: 7589. Published online 2023 May 10. doi: 10.1038/s41598-023-34805-5
PMCID:
PMC10172341
AbstractArticlePDF–4.1M
5.
Krüppel-like factor 1 (KLF1) promoted the proliferation, migration and invasion of human lens epithelial cells by enhancing the expression of Zinc Finger and BTB Domain Containing 7A (ZBTB7A) and activating Wnt/β-catenin pathway
Guangming Shi, Feng Yang
Bioengineered. 2021; 12(1): 4374–4384. Published online 2021 Jul 24. doi: 10.1080/21655979.2021.1953901
PMCID:
PMC8806501
AbstractArticlePDF–3.5M
6.
Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts
Steven Heshusius, Laura Grech, Nynke Gillemans, Rutger W. W. Brouwer, Xander T. den Dekker, Wilfred F. J. van IJcken, Benjamin Nota, Alex E. Felice, Thamar B. van Dijk, Marieke von Lindern, Joseph Borg, Emile van den Akker, Sjaak Philipsen
Sci Rep. 2022; 12: 336. Published online 2022 Jan 10. doi: 10.1038/s41598-021-04126-6
PMCID:
PMC8748495
AbstractArticlePDF–4.4M
7.
Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals
Jesse Eernstman, Barbera Veldhuisen, Peter Ligthart, Marieke von Lindern, C. Ellen van der Schoot, Emile van den Akker
Sci Rep. 2021; 11: 18557. Published online 2021 Sep 17. doi: 10.1038/s41598-021-97149-y
PMCID:
PMC8448862
AbstractArticlePDF–2.9M
8.
Comparative targeting analysis of KLF1, BCL11A, and HBG1/2 in CD34+ HSPCs by CRISPR/Cas9 for the induction of fetal hemoglobin
Andrés Lamsfus-Calle, Alberto Daniel-Moreno, Justin S. Antony, Thomas Epting, Lukas Heumos, Praveen Baskaran, Jakob Admard, Nicolas Casadei, Ngadhnjim Latifi, Darina M. Siegmund, Michael S. D. Kormann, Rupert Handgretinger, Markus Mezger
Sci Rep. 2020; 10: 10133. Published online 2020 Jun 23. doi: 10.1038/s41598-020-66309-x
PMCID:
PMC7311455
AbstractArticlePDF–3.4M
9.
KLF1/EKLF expression in acute leukemia is correlated with chromosomal abnormalities
Adnan Mansoor, Mohammad Omer Mansoor, Jay L Patel, Shuchun Zhao, Yasodha Natkunam, James J Bieker
Blood Cells Mol Dis. Author manuscript; available in PMC 2021 Jul 1.
Published in final edited form as: Blood Cells Mol Dis. 2020 Jul; 83: 102434. Published online 2020 Apr 13. doi: 10.1016/j.bcmd.2020.102434
PMCID:
PMC7269198
AbstractArticlePDF–1.2M
10.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
11.
A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity
Klaudia Kulczynska, James J. Bieker, Miroslawa Siatecka
Mol Cell Biol. 2020 Mar; 40(5): e00444-19. Prepublished online 2019 Dec 9. Published online 2020 Feb 12. doi: 10.1128/MCB.00444-19
PMCID:
PMC7020642
AbstractArticlePDF–4.2M
12.
A novel mutation in the erythroid transcription factor KLF1 is likely responsible for ameliorating β‐thalassemia major
Pavlos Fanis, Ioanna Kousiappa, Marios Phylactides, Andreani Kyrri, Michael Hadjigavriel, Soteroula Christou, Maria Sitarou, Marina Kleanthous
Hum Mutat. 2019 Oct; 40(10): 1768–1780. Published online 2019 Jun 24. doi: 10.1002/humu.23817
PMCID:
PMC6790707
AbstractArticlePDF–1.5M
13.
Downregulation of Krüppel-like factor 1 inhibits the metastasis and invasion of cervical cancer cells
Bisheng Zhu, Qisheng Liu, Qi Han, Bohang Zeng, Jingqi Chen, Qiuju Xiao
Mol Med Rep. 2018 Oct; 18(4): 3932–3940. Published online 2018 Aug 20. doi: 10.3892/mmr.2018.9401
PMCID:
PMC6131627
AbstractArticlePDF–1.9M
14.
Survey and evaluation of mutations in the human KLF1 transcription unit
Merlin Nithya Gnanapragasam, John D. Crispino, Abdullah M. Ali, Rona Weinberg, Ronald Hoffman, Azra Raza, James J. Bieker
Sci Rep. 2018; 8: 6587. Published online 2018 Apr 26. doi: 10.1038/s41598-018-24962-3
PMCID:
PMC5920080
AbstractArticlePDF–1.5M
15.
Epigenetic dysregulation of the erythropoietic transcription factor KLF1 and the β-like globin locus in juvenile myelomonocytic leukemia
Silvia Fluhr, Christopher Felix Krombholz, Angelina Meier, Thomas Epting, Oliver Mücke, Christoph Plass, Charlotte M. Niemeyer, Christian Flotho
Epigenetics. 2017; 12(8): 715–723. Published online 2017 Jul 27. doi: 10.1080/15592294.2017.1356959
PMCID:
PMC5687323
AbstractArticlePDF–952K
16.
Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells
Cheng‐Tao Yang, Rui Ma, Richard A. Axton, Melany Jackson, A. Helen Taylor, Antonella Fidanza, Lamin Marenah, Jan Frayne, Joanne C. Mountford, Lesley M. Forrester
Stem Cells. 2017 Apr; 35(4): 886–897. Published online 2017 Jan 19. doi: 10.1002/stem.2562
PMCID:
PMC5396323
AbstractArticlePDF–791K
17.
Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants
Andrew Perkins, Xiangmin Xu, Douglas R. Higgs, George P. Patrinos, Lionel Arnaud, James J. Bieker, Sjaak Philipsen, the KLF1 Consensus Workgroup
Blood. 2016 Apr 14; 127(15): 1856–1862. Prepublished online 2016 Feb 22. doi: 10.1182/blood-2016-01-694331
PMCID:
PMC4832505
AbstractArticle
18.
Krüppel-Like Transcription Factor KLF1 Is Required for Optimal γ- and β-Globin Expression in Human Fetal Erythroblasts
Divya S. Vinjamur, Yousef N. Alhashem, Safa F. Mohamad, Parth Amin, David C. Williams, Jr., Joyce A. Lloyd
PLoS One. 2016; 11(2): e0146802. Published online 2016 Feb 3. doi: 10.1371/journal.pone.0146802
PMCID:
PMC4739742
AbstractArticlePDF–1.3M
19.
Compound heterozygosity for KLF1 mutations is associated with microcytic hypochromic anemia and increased fetal hemoglobin
Jiwei Huang, Xinhua Zhang, Dun Liu, Xiaofeng Wei, Xuan Shang, Fu Xiong, Lihua Yu, Xiaolin Yin, Xiangmin Xu
Eur J Hum Genet. 2015 Oct; 23(10): 1341–1348. Published online 2015 Jan 14. doi: 10.1038/ejhg.2014.291
PMCID:
PMC4592085
AbstractArticlePDF–2.1M
20.
The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells
Felix Lohmann, Mohan Dangeti, Shefali Soni, Xiaoyong Chen, Antanas Planutis, Margaret H. Baron, Kyunghee Choi, James J. Bieker
Mol Cell Biol. 2015 Nov; 35(21): 3726–3738. Prepublished online 2015 Aug 24. Published online 2015 Sep 30. doi: 10.1128/MCB.00382-15
PMCID:
PMC4589598
AbstractArticlePDF–2.9M

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