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Items: 1 to 20 of 160

1.
Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity
Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Jonathan Serody, Benjamin Vincent, Leo Luznik, Ivana Gojo, Joshua Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya-Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Lyna Luo, Ling Li
Nat Cancer. 2024; 5(4): 601–624. Published online 2024 Feb 27. doi: 10.1038/s43018-024-00736-x
PMCID:
PMC11056319
AbstractArticlePDF–33M
2.
Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression
Huan Cai, Makoto Kondo, Lakshmi Sandhow, Pingnan Xiao, Anne-Sofie Johansson, Takako Sasaki, Joanna Zawacka-Pankau, Karl Tryggvason, Johanna Ungerstedt, Julian Walfridsson, Marja Ekblom, Hong Qian
Blood. 2022 May 19; 139(20): 3040–3057. Published online 2021 Dec 29. doi: 10.1182/blood.2021011510
PMCID:
PMC11022969
AbstractArticle
3.
MLL1 regulates cytokine-driven cell migration and metastasis
Praful R. Nair, Ludmila Danilova, Estibaliz Gómez-de-Mariscal, Dongjoo Kim, Rong Fan, Arrate Muñoz-Barrutia, Elana J. Fertig, Denis Wirtz
Sci Adv. 2024 Mar 15; 10(11): eadk0785. Published online 2024 Mar 13. doi: 10.1126/sciadv.adk0785
PMCID:
PMC10936879
AbstractArticlePDF–12M
4.
Cell fate determinant Llgl1 is required for propagation of acute myeloid leukemia
Theresa Eifert, Chen-Jen Hsu, Alicia L. Becker, Sarah Graessle, Arik Horne, Franziska Bemmann, Qirui Zhang, Michael Heuser, Valeri Vasioukhin, Sebastian Scholl, Andreas Hochhaus, Florian Siegerist, Nicole Endlich, Lars Bullinger, Steven W. Lane, Simon Haas, Tina M. Schnoeder, Florian H. Heidel
Leukemia. 2023; 37(10): 2027–2035. Published online 2023 Aug 16. doi: 10.1038/s41375-023-02005-9
PMCID:
PMC10539176
AbstractArticlePDF–3.5M
5.
Long noncoding RNA Regulating ImMune Escape regulates mixed lineage leukaemia protein‐1‐H3K4me3‐mediated immune escape in oesophageal squamous cell carcinoma
Jia Liu, Wei‐Yi Zhou, Xiao‐Jing Luo, Yan‐Xing Chen, Chau‐Wei Wong, Ze‐Xian Liu, Jia‐ Bo Zheng, Hai‐ Yu Mo, Jun‐Quan Chen, Jia‐Jun Li, Ming Zhong, Yu‐Hong Xu, Qi‐Hua Zhang, Heng‐Ying Pu, Qi‐Nian Wu, Ying Jin, Zi‐Xian Wang, Rui‐Hua Xu, Hui‐Yan Luo
Clin Transl Med. 2023 Sep; 13(9): e1410. Published online 2023 Sep 15. doi: 10.1002/ctm2.1410
PMCID:
PMC10502462
AbstractArticlePDF–3.9M
6.
The chromatin regulator Mll1 supports T follicular helper cell differentiation by controlling expression of Bcl6, LEF-1, and TCF-1
Simon Bélanger, Sonya Haupt, Caterina E. Faliti, Adam Getzler, Jinyong Choi, Huitian Diao, Pabalu P. Karunadharma, Nicholas A. Bild, Matthew E. Pipkin, Shane Crotty
J Immunol. Author manuscript; available in PMC 2024 Jun 1.
Published in final edited form as: J Immunol. 2023 Jun 1; 210(11): 1752–1760. doi: 10.4049/jimmunol.2200927
PMCID:
PMC10334568
AbstractArticlePDF–2.8M
7.
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility
Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao
Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5
PMCID:
PMC10307852
AbstractArticlePDF–8.8M
8.
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle AC Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia
eLife. 2022; 11: e75908. Published online 2022 Sep 2. doi: 10.7554/eLife.75908
PMCID:
PMC9477493
AbstractArticlePDF–1.8M
9.
Missense variants causing Wiedemann-Steiner syndrome preferentially occur in the KMT2A-CXXC domain and are accurately classified using AlphaFold2
Tinna Reynisdottir, Kimberley Jade Anderson, Leandros Boukas, Hans Tomas Bjornsson
PLoS Genet. 2022 Jun; 18(6): e1010278. Published online 2022 Jun 21. doi: 10.1371/journal.pgen.1010278
PMCID:
PMC9249231
AbstractArticlePDF–1.7M
10.
MicroRNA networks in FLT3-ITD acute myeloid leukemia
Dinh Hoa Hoang, Dandan Zhao, Sergio Branciamore, Davide Maestrini, Ivan R. Rodriguez, Ya-Huei Kuo, Russell Rockne, Samer K. Khaled, Bin Zhang, Le Xuan Truong Nguyen, Guido Marcucci
Proc Natl Acad Sci U S A. 2022 Apr 19; 119(16): e2112482119. Published online 2022 Apr 11. doi: 10.1073/pnas.2112482119
PMCID:
PMC9169767
AbstractArticlePDF–3.0M
11.
Multi-omics reveals mitochondrial metabolism proteins susceptible for drug discovery in AML
Mika Caplan, Karli J. Wittorf, Kasidy K. Weber, Samantha A. Swenson, Tyler J. Gilbreath, R. Willow Hynes-Smith, Catalina Amador, R. Katherine Hyde, Shannon M. Buckley
Leukemia. 2022; 36(5): 1296–1305. Published online 2022 Feb 17. doi: 10.1038/s41375-022-01518-z
PMCID:
PMC9061297
AbstractArticlePDF–3.2M
12.
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Nature. Author manuscript; available in PMC 2022 Apr 18.
Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2
PMCID:
PMC9014559
AbstractArticlePDF–6.6M
13.
Cytoplasmic DROSHA and Non-canonical Mechanisms of MiR-155 Biogenesis in FLT3-ITD Acute Myeloid Leukemia
Le Xuan Truong Nguyen, Bin Zhang, Dinh Hoa Hoang, Dandan Zhao, Huafeng Wang, Herman Wu, Yu-Lin Su, Haojie Dong, Sonia Rodriguez-Rodriguez, Brian Armstrong, Lucy Y. Ghoda, Danilo Perrotti, Flavia Pichiorri, Jianjun Chen, Ling Li, Marcin Kortylewski, Russell C. Rockne, Ya-Huei Kuo, Samer Khaled, Nadia Carlesso, Guido Marcucci
Leukemia. Author manuscript; available in PMC 2022 Apr 1.
Published in final edited form as: Leukemia. 2021 Aug; 35(8): 2285–2298. Published online 2021 Feb 15. doi: 10.1038/s41375-021-01166-9
PMCID:
PMC8973317
AbstractArticlePDF–3.1M
14.
The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML
Emily B. Heikamp, Jill A. Henrich, Florian Perner, Eric M. Wong, Charles Hatton, Yanhe Wen, Sonali P. Barwe, Anilkumar Gopalakrishnapillai, Haiming Xu, Hannah J. Uckelmann, Sumiko Takao, Yaniv Kazansky, Yana Pikman, Gerard M. McGeehan, Edward A. Kolb, Alex Kentsis, Scott A. Armstrong
Blood. 2022 Feb 10; 139(6): 894–906. doi: 10.1182/blood.2021012806
PMCID:
PMC8832476
AbstractArticle
15.
Recruitment of MLL1 complex is essential for SETBP1 to induce myeloid transformation
Nhu Nguyen, Kristbjorn O. Gudmundsson, Anthony R. Soltis, Kevin Oakley, Kartik R. Roy, Yufen Han, Carmelo Gurnari, Jaroslaw P. Maciejewski, Gary Crouch, Patricia Ernst, Clifton L. Dalgard, Yang Du
iScience. 2022 Jan 21; 25(1): 103679. Published online 2021 Dec 25. doi: 10.1016/j.isci.2021.103679
PMCID:
PMC8749219
AbstractArticlePDF–3.6M
16.
MLL1 is required for maintenance of intestinal stem cells
Neha Goveas, Claudia Waskow, Kathrin Arndt, Julian Heuberger, Qinyu Zhang, Dimitra Alexopoulou, Andreas Dahl, Walter Birchmeier, Konstantinos Anastassiadis, A. Francis Stewart, Andrea Kranz
PLoS Genet. 2021 Dec; 17(12): e1009250. Published online 2021 Dec 3. doi: 10.1371/journal.pgen.1009250
PMCID:
PMC8641872
AbstractArticlePDF–3.6M
17.
Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements
Vasiliki Symeonidou, Hélène Jakobczyk, Salem Bashanfer, Camille Malouf, Foteini Fotopoulou, Rishi S. Kotecha, Richard A. Anderson, Andrew J. Finch, Katrin Ottersbach
Cell Rep. 2021 Oct 26; 37(4): 109900. Published online 2021 Oct 26. doi: 10.1016/j.celrep.2021.109900
PMCID:
PMC8567312
AbstractArticle
18.
Acute Myeloid Leukemia Alters Group 1 Innate Lymphoid Cell Differentiation from a Common Precursor
Matthew R Lordo, Kevin G Wu, Ekaterina Altynova, Nikolas Shilo, Parker Kronen, Ansel P Nalin, Christoph Weigel, Xiaoli Zhang, Jianhua Yu, Christopher C Oakes, Michael A Caligiuri, Aharon G Freud, Bethany L Mundy-Bosse
J Immunol. Author manuscript; available in PMC 2022 Sep 15.
Published in final edited form as: J Immunol. 2021 Sep 15; 207(6): 1672–1682. Published online 2021 Aug 20. doi: 10.4049/jimmunol.2100023
PMCID:
PMC8429221
AbstractArticlePDF–2.1M
19.
Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA
Hidetaka Niizuma, Adam C. Searleman, Shugaku Takeda, Scott A. Armstrong, Christopher Y. Park, Emily H. Cheng, James J. Hsieh
JCI Insight. 2021 Aug 9; 6(15): e149382. Published online 2021 Aug 9. doi: 10.1172/jci.insight.149382
PMCID:
PMC8410044
AbstractArticlePDF–5.8M
20.
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance
Nick van Gastel, Jessica B. Spinelli, Azeem Sharda, Amir Schajnovitz, Ninib Baryawno, Catherine Rhee, Toshihiko Oki, Eliane Grace, Heather J. Soled, Jelena Milosevic, David B. Sykes, Peggy P. Hsu, Matthew G. Vander Heiden, Charles Vidoudez, Sunia A. Trauger, Marcia C. Haigis, David T. Scadden
Cell Metab. Author manuscript; available in PMC 2021 Aug 27.
Published in final edited form as: Cell Metab. 2020 Sep 1; 32(3): 391–403.e6. Published online 2020 Aug 6. doi: 10.1016/j.cmet.2020.07.009
PMCID:
PMC8397232
AbstractArticlePDF–2.4M

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