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Select item 108574341.

Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation

Jaakko Mattila, Arto Viitanen, Gaia Fabris, Tetiana Strutynska, Jerome Korzelius, Ville Hietakangas

Sci Adv. 2024 Feb 9; 10(6): eadi2671. Published online 2024 Feb 9. doi: 10.1126/sciadv.adi2671

PMCID:: PMC10857434

Abstract Article PDF–11M

Select item 106707272.

Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth

Anna Frappaolo, Maria Grazia Giansanti

Cells. 2023 Nov; 12(22): 2622. Published online 2023 Nov 14. doi: 10.3390/cells12222622

PMCID:: PMC10670727

Abstract Article PDF–1.8M

Select item 102049573.

TORC1 regulation of dendrite regrowth after pruning is linked to actin and exocytosis

Neeraja Sanal, Lorena Keding, Ulrike Gigengack, Esther Michalke, Sebastian Rumpf

PLoS Genet. 2023 May; 19(5): e1010526. Published online 2023 May 11. doi: 10.1371/journal.pgen.1010526

PMCID:: PMC10204957

Abstract Article PDF–4.4M

Select item 101698054.

Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators

Valeriya Privalova, Anna Maria Labecka, Ewa Szlachcic, Anna Sikorska, Marcin Czarnoleski

Sci Rep. 2023; 13: 7565. Published online 2023 May 9. doi: 10.1038/s41598-023-34674-y

PMCID:: PMC10169805

Abstract Article PDF–1.3M

Select item 100118315.

The mTORC2/AKT/VCP axis is associated with quality control of the stalled translation of poly(GR) dipeptide repeats in C9-ALS/FTD

Yu Li, Ji Geng, Suman Rimal, Haochuan Wang, Xiangguo Liu, Bingwei Lu, Shuangxi Li

J Biol Chem. 2023 Mar; 299(3): 102995. Published online 2023 Feb 9. doi: 10.1016/j.jbc.2023.102995

PMCID:: PMC10011831

Abstract Article PDF–2.4M

Select item 98600836.

Stress-induced reversible cell-cycle arrest requires PRC2/PRC1-mediated control of mitophagy in Drosophila germline stem cells and human iPSCs

Tommy H. Taslim, Abdiasis M. Hussein, Riya Keshri, Julien R. Ishibashi, Tung C. Chan, Bich N. Nguyen, Shuozhi Liu, Daniel Brewer, Stuart Harper, Scott Lyons, Ben Garver, Jimmy Dang, Nanditaa Balachandar, Samriddhi Jhajharia, Debra del Castillo, Julie Mathieu, Hannele Ruohola-Baker

Stem Cell Reports. 2023 Jan 10; 18(1): 269–288. Published online 2022 Dec 8. doi: 10.1016/j.stemcr.2022.11.004

PMCID:: PMC9860083

Abstract Article PDF–6.8M

Select item 93347927.

mTORC2 protects the heart from high-fat diet-induced cardiomyopathy through mitochondrial fission in Drosophila

Peiduo Liu, Kai Chang, Guillermo Requejo, Hua Bai

Front Cell Dev Biol. 2022; 10: 866210. Published online 2022 Jul 15. doi: 10.3389/fcell.2022.866210

PMCID:: PMC9334792

Abstract Article PDF–2.4M

Select item 91947498.

Autophagy–mediated plasma membrane removal promotes the formation of epithelial syncytia

Parisa Kakanj, Sourabh Bhide, Bernard Moussian, Maria Leptin

EMBO J. 2022 Jun; 41(12): e109992. Published online 2022 Mar 9. doi: 10.15252/embj.2021109992

PMCID:: PMC9194749

Abstract Article PDF–15M

Select item 88747099.

Circadian Gene cry Controls Tumorigenesis through Modulation of Myc Accumulation in Glioblastoma Cells

Patricia Jarabo, Carmen de Pablo, Amanda González-Blanco, Sergio Casas-Tintó

Int J Mol Sci. 2022 Feb; 23(4): 2043. Published online 2022 Feb 12. doi: 10.3390/ijms23042043

PMCID:: PMC8874709

Abstract Article PDF–2.8M

Select item 858057210.

Dissecting the biology of mTORC1 beyond rapamycin

Guang Yang, Deanne Francis, James R. Krycer, Mark Larance, Ziyang Zhang, Chris J. Novotny, Alexis Diaz-Vegas, Kevan M. Shokat, David E. James

Sci Signal. Author manuscript; available in PMC 2022 Mar 21.

Published in final edited form as: Sci Signal. 2021 Sep 21; 14(701): eabe0161. Published online 2021 Sep 21. doi: 10.1126/scisignal.abe0161

PMCID:: PMC8580572

Abstract Article PDF–1.7M

Select item 838662611.

TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2

Kai Chang, Ping Kang, Ying Liu, Kerui Huang, Ting Miao, Antonia P. Sagona, Ioannis P. Nezis, Rolf Bodmer, Karen Ocorr, Hua Bai

Autophagy. 2020; 16(10): 1807–1822. Published online 2019 Dec 29. doi: 10.1080/15548627.2019.1704117

PMCID:: PMC8386626

Abstract Article PDF–17M

Select item 782315912.

Drosophila Activin signaling promotes muscle growth through InR/TORC1-dependent and -independent processes

Myung-Jun Kim, Michael B. O'Connor

Development. 2021 Jan 1; 148(1): dev190868. Published online 2021 Jan 11. doi: 10.1242/dev.190868

PMCID:: PMC7823159

Abstract Article

Select item 755019213.

Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity

Tarun Kumar, Leo Blondel, Cassandra G Extavour

eLife. 2020; 9: e54082. Published online 2020 Sep 9. doi: 10.7554/eLife.54082

PMCID:: PMC7550192

Abstract Article PDF–2.8M

Select item 754724614.

Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD

Shuangxi Li, Zhihao Wu, Ishaq Tantray, Yu Li, Songjie Chen, Jason Dong, Steven Glynn, Hannes Vogel, Michael Snyder, Bingwei Lu

Proc Natl Acad Sci U S A. 2020 Oct 6; 117(40): 25104–25115. Published online 2020 Sep 21. doi: 10.1073/pnas.2005506117

PMCID:: PMC7547246

Abstract Article PDF–2.3M

Select item 746593715.

Insights into HP1a-Chromatin Interactions

Silvia Meyer-Nava, Victor E. Nieto-Caballero, Mario Zurita, Viviana Valadez-Graham

Cells. 2020 Aug; 9(8): 1866. Published online 2020 Aug 9. doi: 10.3390/cells9081866

PMCID:: PMC7465937

Abstract Article PDF–2.2M

Select item 732399316.

Comparative RNA-Seq analyses of Drosophila plasmatocytes reveal gene specific signatures in response to clean injury and septic injury

Elodie Ramond, Jan Paul Dudzic, Bruno Lemaitre

PLoS One. 2020; 15(6): e0235294. Published online 2020 Jun 29. doi: 10.1371/journal.pone.0235294

PMCID:: PMC7323993

Abstract Article PDF–1.6M

Select item 707569417.

Antagonistic regulation by insulin-like peptide and activin ensures the elaboration of appropriate dendritic field sizes of amacrine neurons

Jiangnan Luo, Chun-Yuan Ting, Yan Li, Philip McQueen, Tzu-Yang Lin, Chao-Ping Hsu, Chi-Hon Lee

eLife. 2020; 9: e50568. Published online 2020 Mar 16. doi: 10.7554/eLife.50568

PMCID:: PMC7075694

Abstract Article PDF–8.9M

Select item 696157818.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 695524219.

Sestrins are evolutionarily conserved mediators of exercise benefits

Myungjin Kim, Alyson Sujkowski, Sim Namkoong, Bondong Gu, Tyler Cobb, Boyoung Kim, Allison H. Kowalsky, Chun-Seok Cho, Ian Semple, Seung-Hyun Ro, Carol Davis, Susan V. Brooks, Michael Karin, Robert J. Wessells, Jun Hee Lee

Nat Commun. 2020; 11: 190. Published online 2020 Jan 13. doi: 10.1038/s41467-019-13442-5

PMCID:: PMC6955242

Abstract Article PDF–2.4M

Select item 682186420.

The neuronal ceroid lipofuscinosis protein Cln7 functions in the postsynaptic cell to regulate synapse development

Kyle J. Connolly, Megan B. O’Hare, Alamin Mohammed, Katelyn M. Aitchison, Niki C. Anthoney, Matthew J. Taylor, Bryan A. Stewart, Richard I. Tuxworth, Guy Tear

Sci Rep. 2019; 9: 15592. Published online 2019 Oct 30. doi: 10.1038/s41598-019-51588-w