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Select item 99315001.

ALKBH5‐mediated m⁶A demethylation of TIRAP mRNA promotes radiation‐induced liver fibrosis and decreases radiosensitivity of hepatocellular carcinoma

Yuhan Chen, Peitao Zhou, Yixun Deng, Xinni Cai, Mingrui Sun, Yining Sun, Dehua Wu

Clin Transl Med. 2023 Feb; 13(2): e1198. Published online 2023 Feb 15. doi: 10.1002/ctm2.1198

PMCID:: PMC9931500

Abstract Article PDF–5.6M

Select item 94073942.

TIRAP Rs8177376, Rs611953, Rs3802814, and Rs8177374 Polymorphisms and Their Association with Cervical Cancer Phenotype and Prognosis

Justina Bekampytė, Aistė Savukaitytė, Agnė Bartnykaitė, Rasa Ugenskienė, Eglė Žilienė, Arturas Inčiūra, Elona Juozaitytė

Genes (Basel) 2022 Aug; 13(8): 1365. Published online 2022 Jul 29. doi: 10.3390/genes13081365

PMCID:: PMC9407394

Abstract Article PDF–732K

Select item 87409623.

Association of genetic variations in ACE2, TIRAP and factor X with outcomes in COVID-19

Marissa J. M. Traets, Roel H. T. Nijhuis, Servaas A. Morré, Sander Ouburg, Jasper A. Remijn, Bastiaan A. Blok, Bas de Laat, Eefje Jong, Gerarda J. M. Herder, Aernoud T. L. Fiolet, Stephan P. Verweij

PLoS One. 2022; 17(1): e0260897. Published online 2022 Jan 7. doi: 10.1371/journal.pone.0260897

PMCID:: PMC8740962

Abstract Article PDF–1.1M

Select item 84664894.

Prognostic Impact of Genetic Variants of MECP2 and TIRAP on Clinical Outcomes of Systemic Lupus Erythematosus with and without Nephritis

Safaa I. Tayel, Nashwa M. Muharram, Dina S. Fotoh, Hany S. Elbarbary, Huda I. Abd-Elhafiz, Eman A. El-Masry, Ahmed E. Taha, Shimaa E. Soliman

Biomolecules. 2021 Sep; 11(9): 1378. Published online 2021 Sep 18. doi: 10.3390/biom11091378

PMCID:: PMC8466489

Abstract Article PDF–1.0M

Select item 82975485.

TIRAP in the Mechanism of Inflammation

Sajjan Rajpoot, Kishore K. Wary, Rachel Ibbott, Dongfang Liu, Uzma Saqib, Teresa L. M. Thurston, Mirza S. Baig

Front Immunol. 2021; 12: 697588. Published online 2021 Jul 8. doi: 10.3389/fimmu.2021.697588

PMCID:: PMC8297548

Abstract Article PDF–1.4M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80592157.

Structural basis of TIR-domain assembly formation in MyD88/MAL-dependent TLR4 signaling

Thomas Ve, Parimala R. Vajjhala, Andrew Hedger, Tristan Croll, Frank DiMaio, Shane Horsefield, Xiong Yu, Peter Lavrencic, Zahid Hassan, Garry P. Morgan, Ashley Mansell, Mehdi Mobli, Ailis O’Carroll, Brieuc Chauvin, Yann Gambin, Emma Sierecki, Michael J. Landsberg, Katryn J. Stacey, Edward H. Egelman, Bostjan Kobe

Nat Struct Mol Biol. Author manuscript; available in PMC 2021 Apr 21.

Published in final edited form as: Nat Struct Mol Biol. 2017 Sep; 24(9): 743–751. Published online 2017 Jul 31. doi: 10.1038/nsmb.3444

PMCID:: PMC8059215

Abstract Article PDF–3.1M

Select item 75062648.

HSV-1/TLR9-Mediated IFNβ and TNFα Induction Is Mal-Dependent in Macrophages

Joanna Zyzak, Małgorzata Mitkiewicz, Ewa Leszczyńska, Patryk Reniewicz, Paul N. Moynagh, Jakub Siednienko

J Innate Immun. 2020 Sep; 12(5): 387–398. Published online 2019 Dec 18. doi: 10.1159/000504542

PMCID:: PMC7506264

Abstract Article PDF–1007K

Select item 64429819.

TIRAP p.R81C is a novel lymphoma risk variant which enhances cell proliferation via NF-κB mediated signaling in B-cells

Regula Burkhard, Irene Keller, Miroslav Arambasic, Darius Juskevicius, Alexandar Tzankov, Pontus Lundberg, Rémy Bruggmann, Stephan Dirnhofer, Ramin Radpour, Urban Novak

Haematologica. 2019 Apr; 104(4): 766–777. Prepublished online 2018 Oct 31. doi: 10.3324/haematol.2018.201590

PMCID:: PMC6442981

Abstract Article PDF–3.1M

Select item 643306610.

The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation

Subathra Murugan, Padmaja Jakka, Swapna Namani, Varadendra Mujumdar, Girish Radhakrishnan

J Biol Chem. 2019 Mar 22; 294(12): 4596–4607. Published online 2019 Jan 15. doi: 10.1074/jbc.RA118.005543

PMCID:: PMC6433066

Abstract Article PDF–3.0M

Select item 619263311.

GPR108, an NF-κB activator suppressed by TIRAP, negatively regulates TLR-triggered immune responses

Danfeng Dong, Haisheng Zhou, Soon-Young Na, Rasma Niedra, Yibing Peng, Huajun Wang, Brian Seed, Guo Ling Zhou

PLoS One. 2018; 13(10): e0205303. Published online 2018 Oct 17. doi: 10.1371/journal.pone.0205303

PMCID:: PMC6192633

Abstract Article PDF–6.1M

Select item 609003412.

Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein 180L Single-Nucleotide Polymorphism Is Associated With Susceptibility to Recurrent Pneumococcal Lower Respiratory Tract Infections in Children

Johan N. Siebert, Lutz Hamann, Charlotte M. Verolet, Cécile Gameiro, Stéphane Grillet, Claire-Anne Siegrist, Klara M. Posfay-Barbe

Front Immunol. 2018; 9: 1780. Published online 2018 Aug 7. doi: 10.3389/fimmu.2018.01780

PMCID:: PMC6090034

Abstract Article PDF–3.1M

Select item 603950113.

CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia

Qing-Yun Wu, Yuan-Yuan Zhu, Yang Liu, Fang Wei, Yu-Xue Tong, Jiang Cao, Ping Zhou, Ming-Shan Niu, Zhen-Yu Li, Ling-Yu Zeng, Feng Li, Kai-Lin Xu

Cell Death Dis. 2018 Jul; 9(7): 774. Published online 2018 Jul 10. doi: 10.1038/s41419-018-0812-6

PMCID:: PMC6039501

Abstract Article PDF–2.7M

Select item 599210414.

Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins

James E. Tomkins, Sybille Dihanich, Alexandra Beilina, Raffaele Ferrari, Nicolò Ilacqua, Mark R. Cookson, Patrick A. Lewis, Claudia Manzoni

Proteomics. 2018 May; 18(10): 1700444. Published online 2018 Apr 17. doi: 10.1002/pmic.201700444

PMCID:: PMC5992104

Abstract Article PDF–1.2M

Select item 555900615.

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

Mark M. Hughes, Peter Lavrencic, Rebecca C. Coll, Thomas Ve, Dylan G. Ryan, Niamh C. Williams, Deepthi Menon, Ashley Mansell, Philip G. Board, Mehdi Mobli, Bostjan Kobe, Luke A. J. O’Neill

Proc Natl Acad Sci U S A. 2017 Aug 8; 114(32): E6480–E6489. Published online 2017 Jul 24. doi: 10.1073/pnas.1701868114

PMCID:: PMC5559006

Abstract Article PDF–1.2M

Select item 553161116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 549447117.

A Pseudomonas aeruginosa TIR effector mediates immune evasion by targeting UBAP1 and TLR adaptors

Paul RC Imbert, Arthur Louche, Jean‐Baptiste Luizet, Teddy Grandjean, Sarah Bigot, Thomas E Wood, Stéphanie Gagné, Amandine Blanco, Lydia Wunderley, Laurent Terradot, Philip Woodman, Steve Garvis, Alain Filloux, Benoit Guery, Suzana P Salcedo

EMBO J. 2017 Jul 3; 36(13): 1869–1887. Published online 2017 May 8. doi: 10.15252/embj.201695343

PMCID:: PMC5494471

Abstract Article PDF–1.8M

Select item 532052218.

Membrane targeting of TIRAP is negatively regulated by phosphorylation in its phosphoinositide-binding motif

Xiaolin Zhao, Wen Xiong, Shuyan Xiao, Tuo-Xian Tang, Jeffrey F. Ellena, Geoffrey S. Armstrong, Carla V. Finkielstein, Daniel G. S. Capelluto

Sci Rep. 2017; 7: 43043. Published online 2017 Feb 22. doi: 10.1038/srep43043

PMCID:: PMC5320522

Abstract Article PDF–1.8M

Select item 524173919.

Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome

Samer Halabi, Eiki Sekine, Brett Verstak, Nicholas J. Gay, Martin C. Moncrieffe

J Biol Chem. 2017 Jan 13; 292(2): 652–660. Published online 2016 Dec 1. doi: 10.1074/jbc.M116.761528

PMCID:: PMC5241739

Abstract Article PDF–1.4M

Select item 490724420.

HIV-1 Tat Protein Activates both the MyD88 and TRIF Pathways To Induce Tumor Necrosis Factor Alpha and Interleukin-10 in Human Monocytes

Rémi Planès, Nawal Ben Haij, Kaoutar Leghmari, Manutea Serrero, Lbachir BenMohamed, Elmostafa Bahraoui

J Virol. 2016 Jul 1; 90(13): 5886–5898. Prepublished online 2016 Apr 6. Published online 2016 Jun 10. doi: 10.1128/JVI.00262-16

PMCID:: PMC4907244

Abstract Article PDF–1.9M

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