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Select item 111586731.

Erythropoietin‐producing hepatocyte B6 variant‐derived peptides with the ability to induce glioma‐reactive cytotoxic T lymphocytes in human leukocyte antigen‐A2⁺ glioma patients

Mingyue Jin, Yoshihiro Komohara, Shigeki Shichijo, Ryuya Yamanaka, Junichi Nikawa, Kyogo Itoh, Akira Yamada

Cancer Sci. 2008 Aug; 99(8): 1656–1662. Published online 2008 Aug 14. doi: 10.1111/j.1349-7006.2008.00866.x

PMCID:: PMC11158673

Abstract Article PDF–353K

Select item 93485762.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 91714113.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79970485.

Structure of the EphB6 receptor ectodomain

Emilia O. Mason, Yehuda Goldgur, Dorothea Robev, Andrew Freywald, Dimitar B. Nikolov, Juha P. Himanen

PLoS One. 2021; 16(3): e0247335. Published online 2021 Mar 26. doi: 10.1371/journal.pone.0247335

PMCID:: PMC7997048

Abstract Article PDF–2.1M

Select item 75869556.

Cataloguing the dead: breathing new life into pseudokinase research

Safal Shrestha, Dominic P. Byrne, John A. Harris, Natarajan Kannan, Patrick A. Eyers

FEBS J. 2020 Oct; 287(19): 4150–4169. Published online 2020 Mar 10. doi: 10.1111/febs.15246

PMCID:: PMC7586955

Abstract Article PDF–7.7M

Select item 74415717.

The gut microbiota regulates autism-like behavior by mediating vitamin B₆ homeostasis in EphB6-deficient mice

Ying Li, Zheng-Yi Luo, Yu-Ying Hu, Yue-Wei Bi, Jian-Ming Yang, Wen-Jun Zou, Yun-Long Song, Shi Li, Tong Shen, Shu-Ji Li, Lang Huang, Ai-Jun Zhou, Tian-Ming Gao, Jian-Ming Li

Microbiome. 2020; 8: 120. Published online 2020 Aug 20. doi: 10.1186/s40168-020-00884-z

PMCID:: PMC7441571

Abstract Article PDF–5.2M

Select item 73920038.

DNA methylation maintains the CLDN1-EPHB6-SLUG axis to enhance chemotherapeutic efficacy and inhibit lung cancer progression

Jia-En Wu, Yi-Ying Wu, Chia-Hao Tung, Yao-Tsung Tsai, Hsuan-Yu Chen, Yuh-Ling Chen, Tse-Ming Hong

Theranostics. 2020; 10(19): 8903–8923. Published online 2020 Jul 11. doi: 10.7150/thno.45785

PMCID:: PMC7392003

Abstract Article PDF–3.8M

Select item 71699839.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 676324210.

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development

Pu Wang, Feng Yan, Zhijun Li, Yanbao Yu, Scott E. Parnell, Yue Xiong

J Clin Invest. 2019 Oct 1; 129(10): 4393–4407. Published online 2019 Sep 9. doi: 10.1172/JCI129107

PMCID:: PMC6763242

Abstract Article PDF–12M

Select item 654769511.

EPHB6 mutation induces cell adhesion-mediated paclitaxel resistance via EPHA2 and CDH11 expression

Sarah Yoon, Ji-Hye Choi, Sung Joo Kim, Eun-Ju Lee, Masaud Shah, Sangdun Choi, Hyun Goo Woo

Exp Mol Med. 2019 Jun; 51(6): 61. Published online 2019 Jun 3. doi: 10.1038/s12276-019-0261-z

PMCID:: PMC6547695

Abstract Article PDF–2.3M

Select item 642983012.

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

Sean P. Kennedy, Jeremy Z. R. Han, Neil Portman, Max Nobis, Jordan F. Hastings, Kendelle J. Murphy, Sharissa L. Latham, Antonia L. Cadell, Dushan Miladinovic, Gabriella R. Marriott, Yolande E. I. O’Donnell, Robert F. Shearer, James T. Williams, Amaya Garcia Munoz, Thomas R. Cox, D. Neil Watkins, Darren N. Saunders, Paul Timpson, Elgene Lim, Walter Kolch, David R. Croucher

Breast Cancer Res. 2019; 21: 43. Published online 2019 Mar 21. doi: 10.1186/s13058-019-1127-y

PMCID:: PMC6429830

Abstract Article PDF–3.1M

Select item 616046813.

Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with hypertension risks in males with hypogonadism

Tao Wu, Bi-Qi Zhang, John Raelson, Yu-Mei Yao, Huan-Dong Wu, Zao-Xian Xu, Francois-christophe Marois-blanchet, Muhammad Ramzan Tahir, Yujia Wang, W. Edward Bradley, Hongyu Luo, Jiangping Wu, Jian-Zhong Sheng, Shen-Jiang Hu

Sci Rep. 2018; 8: 14497. Published online 2018 Sep 27. doi: 10.1038/s41598-018-32836-x

PMCID:: PMC6160468

Abstract Article PDF–1.2M

Select item 606249914.

EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours

Behzad M. Toosi, Amr El Zawily, Luke Truitt, Matthew Shannon, Odette Allonby, Mohan Babu, John DeCoteau, Darrell Mousseau, Mohsin Ali, Tanya Freywald, Amanda Gall, Frederick S. Vizeacoumar, Morgan W. Kirzinger, C. Ronald Geyer, Deborah H. Anderson, TaeHyung Kim, Alana L. Welm, Peter Siegel, Franco J. Vizeacoumar, Anthony Kusalik, Andrew Freywald

Oncogene. 2018; 37(30): 4073–4093. Published online 2018 Apr 27. doi: 10.1038/s41388-018-0228-x

PMCID:: PMC6062499

Abstract Article PDF–4.2M

Select item 567671115.

The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment

Amr El Zawily, Emily McEwen, Behzad Toosi, Frederick S. Vizeacoumar, Tanya Freywald, Franco J. Vizeacoumar, Andrew Freywald

Sci Rep. 2017; 7: 14767. Published online 2017 Nov 7. doi: 10.1038/s41598-017-15200-3

PMCID:: PMC5676711

Abstract Article PDF–3.0M

Select item 566346516.

A Global Analysis of The Receptor Tyrosine Kinase – Protein Phosphatase Interactome

Zhong Yao, Katelyn Darowski, Nicole St-Denis, Victoria Wong, Fabian Offensperger, Annabel Villedieu, Shahreen Amin, Ramy Malty, Hiroyuki Aoki, Hongbo Guo, Yang Xu, Caterina Iorio, Max Kotlyar, Andrew Emili, Igor Jurisica, Benjamin G Neel, Mohan Babu, Anne-Claude Gingras, Igor Stagljar

Mol Cell. Author manuscript; available in PMC 2017 Oct 31.

Published in final edited form as: Mol Cell. 2017 Jan 19; 65(2): 347–360. Published online 2017 Jan 5. doi: 10.1016/j.molcel.2016.12.004

PMCID:: PMC5663465

Abstract Article PDF–2.1M

Select item 536362717.

The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation

Amr M. El Zawily, Behzad M. Toosi, Tanya Freywald, Vijaya V. Indukuri, Franco J. Vizeacoumar, Scot C. Leary, Andrew Freywald

Oncotarget. 2016 Nov 22; 7(47): 77865–77877. Published online 2016 Oct 24. doi: 10.18632/oncotarget.12838

PMCID:: PMC5363627

Abstract Article PDF–7.4M

Select item 533798518.

Loss of the EPH receptor B6 contributes to colorectal cancer metastasis

Silvia Mateo-Lozano, Sarah Bazzocco, Paulo Rodrigues, Rocco Mazzolini, Elena Andretta, Higinio Dopeso, Yolanda Fernández, Edgar del Llano, Josipa Bilic, Lucía Suárez-López, Irati Macaya, Fernando Cartón-García, Rocio Nieto, Lizbeth M. Jimenez-Flores, Priscila Guimarães de Marcondes, Yaiza Nuñez, Elsa Afonso, Karina Cacci, Javier Hernández-Losa, Stefania Landolfi, Ibane Abasolo, Santiago Ramón y Cajal, John M. Mariadason, Simo Schwartz, Jr., Toshimitsu Matsui, Diego Arango

Sci Rep. 2017; 7: 43702. Published online 2017 Mar 6. doi: 10.1038/srep43702

PMCID:: PMC5337985

Abstract Article PDF–2.2M

Select item 522656619.

Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment

James M. Paul, Behzad Toosi, Frederick S. Vizeacoumar, Kalpana Kalyanasundaram Bhanumathy, Yue Li, Courtney Gerger, Amr El Zawily, Tanya Freywald, Deborah H. Anderson, Darrell Mousseau, Rani Kanthan, Zhaolei Zhang, Franco J. Vizeacoumar, Andrew Freywald

Oncotarget. 2016 Aug 2; 7(31): 50027–50042. Published online 2016 Jul 13. doi: 10.18632/oncotarget.10569

PMCID:: PMC5226566

Abstract Article PDF–12M

Select item 517303920.

NRAS and EPHB6 mutation rates differ in metastatic melanomas of patients in the North Island versus South Island of New Zealand

Angela M. Jones, Peter Ferguson, Jacqui Gardner, Serena Rooker, Tim Sutton, Antonio Ahn, Aniruddha Chatterjee, Vivienne M. Bickley, Makhdoom Sarwar, Patrick Emanuel, Diane Kenwright, Peter R. Shepherd, Michael R. Eccles

Oncotarget. 2016 Jul 5; 7(27): 41017–41030. Published online 2016 May 13. doi: 10.18632/oncotarget.9351

PMCID:: PMC5173039

Abstract Article PDF–4.5M

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