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Select item 113033541.

GP100 expression is variable in intensity in melanoma

Jacqueline E. Mann, Nitzan Hasson, David G. Su, Adebowale J. Adeniran, Keiran S. M. Smalley, Dijana Djureinovic, Lucia B. Jilaveanu, David A. Schoenfeld, Harriet M. Kluger

Cancer Immunol Immunother. 2024 Oct; 73(10): 191. Published online 2024 Aug 6. doi: 10.1007/s00262-024-03776-5

PMCID:: PMC11303354

Abstract Article PDF–987K

Select item 110378312.

Analysis of Pmel17/gp100 expression in primary human tissue specimens: implications for melanoma immuno- and gene-therapy

S. N. Wagner, Christine Wagner, Thomas Schultewolter, Manfred Goos

Cancer Immunol Immunother. 1997 Jun; 44(4): 239–247. doi: 10.1007/s002620050379

PMCID:: PMC11037831

Abstract Article PDF–1.2M

Select item 82736973.

Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins

Paul W. Chrystal, Tim Footz, Elizabeth D. Hodges, Justin A. Jensen, Michael A. Walter, W. Ted Allison

Molecules. 2021 Jun; 26(12): 3529. Published online 2021 Jun 9. doi: 10.3390/molecules26123529

PMCID:: PMC8273697

Abstract Article PDF–10M

Select item 82252324.

PMEL as a Prognostic Biomarker and Negatively Associated With Immune Infiltration in Skin Cutaneous Melanoma (SKCM)

Shuguang Zhang, Kun Chen, Huanmei Liu, Changyou Jing, Xinxin Zhang, Chunfeng Qu, Shengji Yu

J Immunother. 2021 Jul-Aug; 44(6): 214–223. Published online 2021 May 24. doi: 10.1097/CJI.0000000000000374

PMCID:: PMC8225232

Abstract Article PDF–588K

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80327166.

Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL

Susan M. Mitchell, Morven Graham, Xinran Liu, Ralf M. Leonhardt

Sci Rep. 2021; 11: 7730. Published online 2021 Apr 8. doi: 10.1038/s41598-021-87259-y

PMCID:: PMC8032716

Abstract Article PDF–6.9M

Select item 75027347.

Defining an amyloid link Between Parkinson’s disease and melanoma

Dexter N. Dean, Jennifer C. Lee

Proc Natl Acad Sci U S A. 2020 Sep 15; 117(37): 22671–22673. Published online 2020 Aug 31. doi: 10.1073/pnas.2009702117

PMCID:: PMC7502734

Abstract Article PDF–1.0M

Select item 72472978.

Modulating functional amyloid formation via alternative splicing of the premelanosomal protein PMEL17

Dexter N. Dean, Jennifer C. Lee

J Biol Chem. 2020 May 22; 295(21): 7544–7553. Published online 2020 Apr 10. doi: 10.1074/jbc.RA120.013012

PMCID:: PMC7247297

Abstract Article PDF–2.6M

Select item 67007439.

pH-Dependent Fibril Maturation of a Pmel17 Repeat Domain Isoform Revealed by Tryptophan Fluorescence

Dexter N. Dean, Jennifer C. Lee

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2019 Oct; 1867(10): 961–969. Published online 2019 Feb 2. doi: 10.1016/j.bbapap.2019.01.012

PMCID:: PMC6700743

Abstract Article PDF–2.0M

Select item 667712910.

Lysophospholipids induce Fibrillation of the Repeat domain of Pmel17 through intermediate core-shell structures

Jannik Nedergaard Pedersen, Zhiping Jiang, Gunna Christiansen, Jennifer C. Lee, Jan Skov Pedersen, Daniel E. Otzen

Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2019 May; 1867(5): 519–528. Published online 2018 Nov 22. doi: 10.1016/j.bbapap.2018.11.007

PMCID:: PMC6677129

Article PDF–2.0M

Select item 645220611.

Non-Synonymous variants in premelanosome protein (PMEL) cause ocular pigment dispersion and pigmentary glaucoma

Adrian A Lahola-Chomiak, Tim Footz, Kim Nguyen-Phuoc, Gavin J Neil, Baojian Fan, Keri F Allen, David S Greenfield, Richard K Parrish, Kevin Linkroum, Louis R Pasquale, Ralf M Leonhardt, Robert Ritch, Shari Javadiyan, Jamie E Craig, W T Allison, Ordan J Lehmann, Michael A Walter, Janey L Wiggs

Hum Mol Genet. 2019 Apr 15; 28(8): 1298–1311. Published online 2018 Dec 17. doi: 10.1093/hmg/ddy429

PMCID:: PMC6452206

Abstract Article PDF–49M

Select item 636953512.

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting

Clare Y. Slaney, Bianca von Scheidt, Alexander J. Davenport, Paul A. Beavis, Jennifer A. Westwood, Sherly Mardiana, David C. Tscharke, Sarah Ellis, H. Miles Prince, Joseph A. Trapani, Ricky W. Johnstone, Mark J. Smyth, Michele W. Teng, Aesha Ali, Zhiya Yu, Steven A. Rosenberg, Nicholas P. Restifo, Paul Neeson, Phillip K. Darcy, Michael H. Kershaw

Clin Cancer Res. Author manuscript; available in PMC 2019 Feb 11.

Published in final edited form as: Clin Cancer Res. 2017 May 15; 23(10): 2478–2490. Published online 2016 Dec 13. doi: 10.1158/1078-0432.CCR-16-1860

PMCID:: PMC6369535

Abstract Article PDF–2.2M

Select item 584026613.

Insights into the ubiquitin-proteasome system of human embryonic stem cells

Isabel Saez, Seda Koyuncu, Ricardo Gutierrez-Garcia, Christoph Dieterich, David Vilchez

Sci Rep. 2018; 8: 4092. Published online 2018 Mar 6. doi: 10.1038/s41598-018-22384-9

PMCID:: PMC5840266

Abstract Article PDF–2.9M

Select item 562943314.

Polyfunctional response by ImmTAC (IMCgp100) redirected CD8⁺ and CD4⁺ T cells

Caroline Boudousquie, Giovanna Bossi, Jacob M. Hurst, Karolina A. Rygiel, Bent K. Jakobsen, Namir J. Hassan

Immunology. 2017 Nov; 152(3): 425–438. Published online 2017 Aug 2. doi: 10.1111/imm.12779

PMCID:: PMC5629433

Abstract Article PDF–1000K

Select item 553161115.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 486146316.

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen

Valentina Bianchi, Anna Bulek, Anna Fuller, Angharad Lloyd, Meriem Attaf, Pierre J. Rizkallah, Garry Dolton, Andrew K. Sewell, David K. Cole

J Biol Chem. 2016 Apr 22; 291(17): 8951–8959. Published online 2016 Feb 25. doi: 10.1074/jbc.M115.707414

PMCID:: PMC4861463

Abstract Article PDF–1.8M

Select item 475139817.

The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation

Tina Ho, Brenda Watt, Lynn A. Spruce, Steven H. Seeholzer, Michael S. Marks

J Biol Chem. 2016 Feb 12; 291(7): 3595–3612. Published online 2015 Dec 22. doi: 10.1074/jbc.M115.692442

PMCID:: PMC4751398

Abstract Article PDF–3.3M

Select item 468326418.

The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing

Kathrin Textoris-Taube, Christin Keller, Juliane Liepe, Petra Henklein, John Sidney, Alessandro Sette, Peter M. Kloetzel, Michele Mishto

J Biol Chem. 2015 Dec 18; 290(51): 30417–30428. Published online 2015 Oct 27. doi: 10.1074/jbc.M115.695189

PMCID:: PMC4683264

Abstract Article PDF–2.0M

Select item 462977919.

Sorting of Pmel17 to melanosomes through the plasma membrane by AP1 and AP2: evidence for the polarized nature of melanocytes

Julio C. Valencia, Hidenori Watabe, An Chi, Francois Rouzaud, Kevin G. Chen, Wilfred D. Vieira, Kaoruko Takahashi, Yuji Yamaguchi, Werner Berens, Kunio Nagashima, Jeffrey Shabanowitz, Donald F. Hunt, Ettore Appella, Vincent J. Hearing

J Cell Sci. Author manuscript; available in PMC 2015 Nov 2.

Published in final edited form as: J Cell Sci. 2006 Mar 15; 119(0 6): 1080–1091. Published online 2006 Feb 21. doi: 10.1242/jcs.02804

PMCID:: PMC4629779

Abstract Article PDF–1.2M

Select item 431072620.

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Tomomitsu Hirota, Atsushi Takahashi, Michiaki Kubo, Tatsuhiko Tsunoda, Kaori Tomita, Satoru Doi, Kimie Fujita, Akihiko Miyatake, Tadao Enomoto, Takehiko Miyagawa, Mitsuru Adachi, Hiroshi Tanaka, Akio Niimi, Hisako Matsumoto, Isao Ito, Hironori Masuko, Tohru Sakamoto, Nobuyuki Hizawa, Masami Taniguchi, John J. Lima, Charles G. Irvin, Stephen P. Peters, Blanca E. Himes, Augusto A. Litonjua, Kelan G. Tantisira, Scott T. Weiss, Naoyuki Kamatani, Yusuke Nakamura, Mayumi Tamari

Nat Genet. Author manuscript; available in PMC 2015 Jan 29.

Published in final edited form as: Nat Genet. 2011 Sep; 43(9): 893–896. Published online 2011 Jul 31. doi: 10.1038/ng.887

PMCID:: PMC4310726

Article PDF–376K

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